A fully coupled fluid-structure interaction model for patient-specific analysis of bioprosthetic aortic valve haemodynamics.

IF 4.8 3区工程技术 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Frontiers in Bioengineering and Biotechnology Pub Date : 2025-05-29 eCollection Date: 2025-01-01 DOI:10.3389/fbioe.2025.1584509

Zhongjie Yin, Chlöe Armour, Selene Pirola, Harkamaljot Kandail, Xiaoxin Kan, Pankaj Garg, Rui Li, Toufan Bahrami, Saeed Mirsadraee, Xiao Yun Xu

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引用次数: 0

Abstract

Background: Bioprosthetic aortic valves (BPAV) have been increasingly used for surgical aortic valve replacement (SAVR), but long-term complications associated with structural valve deterioration remain a concern. The structural behaviour of the valve and its surrounding haemodynamics play a key role in the long-term outcome of SAVR, and these can be quantitively analysed by means of fluid-structure interaction (FSI) simulation. The aim of this study was to develop a fully coupled FSI model for patient-specific analysis of BPAV haemodynamics.

Methods: Using the Edwards Magna Ease valve as an example, the workflow included reconstruction of the aortic root from CT images and the creation of valve geometric model based on available measurements made on the device. Two-way fully coupled FSI simulations were performed under patient-specific flow conditions derived from 4D flow magnetic resonance imaging (MRI), the latter also provided data for model validation.

Results: The simulation results were in good agreement with haemodynamic features extracted from 4D flow MRI and relevant data in the literature. Furthermore, the FSI model provided additional information that cannot be measured in vivo, including wall shear stress and its derivatives on the valve leaflets and in the aortic root.

Conclusion: The FSI workflow presented in this study offers a promising tool for patient-specific assessment of aortic valve haemodynamics, and the results may help elucidate the role of haemodynamics in structural valve deterioration.

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生物假体主动脉瓣血流动力学患者特异性分析的全耦合流固耦合模型。

背景：生物假体主动脉瓣（BPAV）越来越多地用于外科主动脉瓣置换术（SAVR），但与结构性瓣膜恶化相关的长期并发症仍然是一个问题。瓣膜的结构行为及其周围的血流动力学在SAVR的长期结果中起着关键作用，这些可以通过流固耦合（FSI）模拟进行定量分析。本研究的目的是建立一个完全耦合的FSI模型，用于BPAV血流动力学的患者特异性分析。方法：以Edwards Magna Ease瓣膜为例，工作流程包括从CT图像重建主动脉根部，并根据设备上的可用测量数据创建瓣膜几何模型。双向全耦合FSI模拟在患者特定的流动条件下进行，该条件来自4D流动磁共振成像（MRI），后者也为模型验证提供了数据。结果：模拟结果与4D血流MRI提取的血流动力学特征及文献相关数据吻合较好。此外，FSI模型提供了体内无法测量的额外信息，包括瓣膜小叶和主动脉根部的壁剪切应力及其衍生物。结论：本研究提出的FSI工作流程为患者特异性评估主动脉瓣血流动力学提供了一个有希望的工具，结果可能有助于阐明血流动力学在结构性瓣膜恶化中的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Bioengineering and Biotechnology Chemical Engineering-Bioengineering

CiteScore

8.30

自引率

5.30%

发文量

2270

审稿时长

12 weeks

期刊介绍： The translation of new discoveries in medicine to clinical routine has never been easy. During the second half of the last century, thanks to the progress in chemistry, biochemistry and pharmacology, we have seen the development and the application of a large number of drugs and devices aimed at the treatment of symptoms, blocking unwanted pathways and, in the case of infectious diseases, fighting the micro-organisms responsible. However, we are facing, today, a dramatic change in the therapeutic approach to pathologies and diseases. Indeed, the challenge of the present and the next decade is to fully restore the physiological status of the diseased organism and to completely regenerate tissue and organs when they are so seriously affected that treatments cannot be limited to the repression of symptoms or to the repair of damage. This is being made possible thanks to the major developments made in basic cell and molecular biology, including stem cell science, growth factor delivery, gene isolation and transfection, the advances in bioengineering and nanotechnology, including development of new biomaterials, biofabrication technologies and use of bioreactors, and the big improvements in diagnostic tools and imaging of cells, tissues and organs. In today`s world, an enhancement of communication between multidisciplinary experts, together with the promotion of joint projects and close collaborations among scientists, engineers, industry people, regulatory agencies and physicians are absolute requirements for the success of any attempt to develop and clinically apply a new biological therapy or an innovative device involving the collective use of biomaterials, cells and/or bioactive molecules. “Frontiers in Bioengineering and Biotechnology” aspires to be a forum for all people involved in the process by bridging the gap too often existing between a discovery in the basic sciences and its clinical application.