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Biological effects of exosomes derived from 2D and 3D culture adipose stem cells on JEC Cell proliferation and migration. 2D和3D培养脂肪干细胞外泌体对JEC细胞增殖和迁移的生物学影响。
IF 4.3 3区 工程技术
Frontiers in Bioengineering and Biotechnology Pub Date : 2025-07-10 eCollection Date: 2025-01-01 DOI: 10.3389/fbioe.2025.1541150
Yifen Li, Gangwei Wang, Yi Zhang, Tao Xu, Xuefeng Jiang
{"title":"Biological effects of exosomes derived from 2D and 3D culture adipose stem cells on JEC Cell proliferation and migration.","authors":"Yifen Li, Gangwei Wang, Yi Zhang, Tao Xu, Xuefeng Jiang","doi":"10.3389/fbioe.2025.1541150","DOIUrl":"https://doi.org/10.3389/fbioe.2025.1541150","url":null,"abstract":"<p><strong>Objective: </strong>To explore the biological impacts of exosomes derived from adipose stem cells cultured under two-dimensional (2D) and three-dimensional (3D) conditions on endometrial adenocarcinoma cells (JEC cells).</p><p><strong>Materials and methods: </strong>Exosomes were isolated and extracted from adipose stem cells grown in 2D and 3D cultures. JEC cells were allocated into three categories: a control group, a 2D group, and a 3D group. Cultivation of JEC cells occurred with distinct media (supplemented with or without 2D/3D adipose-derived stem cell exosomes) per group. Endometrial cancer cell viability was evaluated by a Cell Counting Kit-8 (CCK-8) assay. Scratch assays gauged the migratory behavior of endometrial adenocarcinoma cells. A Transwell assay quantified cellular invasiveness.</p><p><strong>Results: </strong>The 3D group exhibited amplified cell proliferation (p < 0.05). Higher wound closure rates at 72 h were observed in the 3D group (p < 0.05). The Transwell assay demonstrated a substantial rise in the number of JEC cells traversing the Transwell chamber within the 3D group at 48 h (p < 0.05).</p><p><strong>Conclusion: </strong>Exosomes obtained from 2D and 3D adipose stem cells significantly bolstered cell proliferation, invasion, and migration. Exosomes sourced from 3D adipose-derived stem cells displayed greater efficacy than their 2D counterparts.</p>","PeriodicalId":12444,"journal":{"name":"Frontiers in Bioengineering and Biotechnology","volume":"13 ","pages":"1541150"},"PeriodicalIF":4.3,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12287758/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144706962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A rapid-release pure iodine coating on titanium implants to mitigate acute periprosthetic infections. 一种快速释放的纯碘涂层在钛种植体上减轻急性假体周围感染。
IF 4.3 3区 工程技术
Frontiers in Bioengineering and Biotechnology Pub Date : 2025-07-10 eCollection Date: 2025-01-01 DOI: 10.3389/fbioe.2025.1590411
Yong-Quan Zhang, Jie Liang, Qing-Quan Chen, Xiao-Li Huang, Wan-Ming Wang, Jin-Shui Chen, Xiu Yang
{"title":"A rapid-release pure iodine coating on titanium implants to mitigate acute periprosthetic infections.","authors":"Yong-Quan Zhang, Jie Liang, Qing-Quan Chen, Xiao-Li Huang, Wan-Ming Wang, Jin-Shui Chen, Xiu Yang","doi":"10.3389/fbioe.2025.1590411","DOIUrl":"https://doi.org/10.3389/fbioe.2025.1590411","url":null,"abstract":"<p><strong>Background: </strong>Periprosthetic infections remain a significant challenge in orthopedic surgeries, primarily due to bacterial biofilm formation on implant surfaces. To address this issue, we developed a novel iodine-based coating on titanium implants designed to rapidly release iodine, thereby preventing acute infections. The efficacy and safety of this coating were assessed through both <i>in vitro</i> experiments and an <i>in vivo</i> rabbit model.</p><p><strong>Methods: </strong>The iodine coating was applied to titanium implants using electrophoretic deposition. The coated implants were characterized using scanning electron microscopy (SEM), X-ray fluorescence spectroscopy (XRF), and energy-dispersive spectroscopy (EDS). <i>In vitro</i> studies included antibacterial assays, iodine release kinetics, and hemolysis tests. Additionally, an acute periprosthetic infection model in rabbits was established to evaluate the coating's performance <i>in vivo</i>.</p><p><strong>Results: </strong>The electrophoretic deposition technique successfully produced a uniform iodine coating with high iodine content and rapid release kinetics. <i>In vitro</i> tests demonstrated significant antibacterial activity against <i>Staphylococcus aureus</i> and <i>Escherichia coli</i>. The rabbit model showed a marked reduction in infection rates compared to uncoated implants, with no adverse effects on bone integration.</p><p><strong>Conclusion: </strong>This study introduces a promising iodine-based coating for titanium implants, offering a rapid and effective solution to prevent acute periprosthetic infections while maintaining biocompatibility and supporting bone healing.</p>","PeriodicalId":12444,"journal":{"name":"Frontiers in Bioengineering and Biotechnology","volume":"13 ","pages":"1590411"},"PeriodicalIF":4.3,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12287049/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144706961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The effects of 12 weeks of high-intensity interval rope skipping training on speed and power indexes in male soccer players. 12周高强度间歇跳绳训练对男子足球运动员速度和力量指标的影响。
IF 4.3 3区 工程技术
Frontiers in Bioengineering and Biotechnology Pub Date : 2025-07-10 eCollection Date: 2025-01-01 DOI: 10.3389/fbioe.2025.1579535
Bo Wei, Wenhu Cheng, Jiangang Qiu
{"title":"The effects of 12 weeks of high-intensity interval rope skipping training on speed and power indexes in male soccer players.","authors":"Bo Wei, Wenhu Cheng, Jiangang Qiu","doi":"10.3389/fbioe.2025.1579535","DOIUrl":"https://doi.org/10.3389/fbioe.2025.1579535","url":null,"abstract":"<p><strong>Research purpose: </strong>Speed ability is an important determinant of a soccer player's competitive performance in a game, and it also affects the athlete's sports life and upper limit of competitive level. Power is the core of the soccer player physical ability construction and its influence on the speed of permeate, confrontation, technology, endurance and injury prevention and so on each linThe main objective was to investigate physiological adaptations induced by HIIRS on soccer-specific speed and power qualities of soccer players.</p><p><strong>Research method: </strong>Twenty-five elite soccer players underwent a 12-week jump rope training program (three 45-min sessions weekly). Participants were randomly assigned to an, EG (n = 13) performing high-intensity intermittent rope skipping (75%-85% HRmax with active intervals at 40%-70% HRmax) and a CG (n = 12) maintaining conventional training (75%-85% HRmax), both monitored via heart rate bands. Pre and post-intervention assessments included: sprint speed (30-m sprint), reaction speed (Optojump 5-s rapid frequency test), visual reaction speed (Optojump visual test), change-of-direction speed (T-test), and explosive power (standing long jump). Data were analyzed via paired samples T-tests.</p><p><strong>Research results: </strong>Research Results. The results of the study found that both high-intensity interval rope skipping (HIIRS) training and traditional training significantly improved sprint speed (HIIRS: P < 0.001; Traditional: P = 0.0009), change of direction speed (HIIRS: P = 0.0103; Traditional:P = 0.0130), and explosive speed (HIIRS:P = 0.0315; Traditional: P = 0.0002). Additionally, HIIRS training significantly improved movement speed (P = 0.0405) and visual reaction speed (P = 0.0441), which were not significantly enhanced by traditional training. Further, HIIRS training demonstrated superior effectiveness compared to traditional training specifically forsprint speed (P = 0.0326) and visual reaction speed (P = 0.0101). This study integrates HIIT principles with rope skipping's biomechanical SSC action to target neuromuscular adaptations.</p><p><strong>Research conclusion: </strong>This finding enriches the functionality of the sport of jumping rope and provides an optional training tool for soccer players to develop their speed qualities.</p>","PeriodicalId":12444,"journal":{"name":"Frontiers in Bioengineering and Biotechnology","volume":"13 ","pages":"1579535"},"PeriodicalIF":4.3,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12287092/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144706964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Insights into bone and cartilage responses to pulsed electromagnetic field stimulation: a review with quantitative comparisons. 深入了解骨和软骨响应脉冲电磁场刺激:回顾与定量比较。
IF 4.3 3区 工程技术
Frontiers in Bioengineering and Biotechnology Pub Date : 2025-07-10 eCollection Date: 2025-01-01 DOI: 10.3389/fbioe.2025.1557572
Beatrice Masante, Stefano Gabetti, Joao C Silva, Giovanni Putame, Simone Israel, Cristina Bignardi, Diana Massai
{"title":"Insights into bone and cartilage responses to pulsed electromagnetic field stimulation: a review with quantitative comparisons.","authors":"Beatrice Masante, Stefano Gabetti, Joao C Silva, Giovanni Putame, Simone Israel, Cristina Bignardi, Diana Massai","doi":"10.3389/fbioe.2025.1557572","DOIUrl":"https://doi.org/10.3389/fbioe.2025.1557572","url":null,"abstract":"<p><p>Bone fractures and cartilage pathologies represent a heavy socioeconomic burden for the national healthcare systems worldwide. Pulsed electromagnetic field (PEMF) stimulation has become a widely recognized treatment for enhancing bone fracture healing and reducing tissue inflammation, thereby supporting bone tissue regeneration. More recently, its effectiveness in treating cartilage degeneration and osteoarthritis has also been demonstrated. However, the effects of PEMF, particularly the underlying mechanisms related to the activation of specific signaling pathways, are not yet fully known neither correlated with the specific PEMF parameters applied. As a result, standardized protocols for PEMF treatment are lacking in clinical practice, leading to empirical application of PEMF stimulation and heterogeneity in treatment protocols. For these reasons, over the past three decades, the biological effects of PEMF on bone and cartilage tissues have been extensively investigated through both <i>in vitro</i> and <i>in vivo</i> experiments. The aim of this review is to provide a detailed overview of the performed studies, focusing on the applied PEMF stimulation parameters and the induced effects on bone and cartilage tissues. Furthermore, to enable comparisons across various published protocols and to aid in understanding the correlation between applied PEMF parameters and their resulting biological effects, we propose, for the first time, a quantitative descriptor for PEMF stimulation, termed PEMF dose, which accounts for magnetic field intensity, stimulation waveform, and exposure duration. The use of this comprehensive descriptor enabled the identification of common features across different studies and, in the future, it could serve as a valuable tool for refining PEMF stimulation protocols and establishing standardized guidelines to support bone and cartilage repair.</p>","PeriodicalId":12444,"journal":{"name":"Frontiers in Bioengineering and Biotechnology","volume":"13 ","pages":"1557572"},"PeriodicalIF":4.3,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12287613/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144706963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction: Effects of mental fatigue on biomechanical characteristics and risk associated with non-contact anterior cruciate ligament injuries during landing. 修正:着陆过程中精神疲劳对生物力学特征和非接触性前交叉韧带损伤风险的影响。
IF 4.3 3区 工程技术
Frontiers in Bioengineering and Biotechnology Pub Date : 2025-07-09 eCollection Date: 2025-01-01 DOI: 10.3389/fbioe.2025.1641483
Bosong Zheng, Zeyang Zhang, Zeyi Zhang, Youping Sun, Yao Xiao, Mengjie Li
{"title":"Correction: Effects of mental fatigue on biomechanical characteristics and risk associated with non-contact anterior cruciate ligament injuries during landing.","authors":"Bosong Zheng, Zeyang Zhang, Zeyi Zhang, Youping Sun, Yao Xiao, Mengjie Li","doi":"10.3389/fbioe.2025.1641483","DOIUrl":"https://doi.org/10.3389/fbioe.2025.1641483","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.3389/fbioe.2025.1582873.].</p>","PeriodicalId":12444,"journal":{"name":"Frontiers in Bioengineering and Biotechnology","volume":"13 ","pages":"1641483"},"PeriodicalIF":4.3,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12284400/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144698034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of occupant and restraint variability in reclined positions on submarining probability in frontal car crash scenarios. 汽车正面碰撞场景中乘员和约束变化对潜航概率的影响。
IF 4.3 3区 工程技术
Frontiers in Bioengineering and Biotechnology Pub Date : 2025-07-09 eCollection Date: 2025-01-01 DOI: 10.3389/fbioe.2025.1570572
Erik Brynskog, Jonas Östh, Karl-Johan Larsson, Johan Iraeus
{"title":"Effect of occupant and restraint variability in reclined positions on submarining probability in frontal car crash scenarios.","authors":"Erik Brynskog, Jonas Östh, Karl-Johan Larsson, Johan Iraeus","doi":"10.3389/fbioe.2025.1570572","DOIUrl":"https://doi.org/10.3389/fbioe.2025.1570572","url":null,"abstract":"<p><strong>Introduction: </strong>In future autonomous vehicles, a greater seat back recline angle has been suggested to accommodate a more relaxed occupant position. Due to the reclined position, the pelvis rotates rearward resulting in less favorable in-crash pelvis to lap belt interaction. In a crash, this issue can increase the likelihood of the lap belt disengaging from the pelvis and instead loading the abdomen, <i>i.e.</i>, submarining. Hence, to enable assessment of submarining prevention measures for reclined occupants in frontal car crash scenarios, it is motivated to enhance the understanding of pelvis to lap belt interaction.</p><p><strong>Method: </strong>In this simulation study, the submarining outcome of a population of reclined 50%ile (in terms of height and weight) male occupants, subjected to restraint variability in a semi-rigid seat setup, was analyzed through finite element human body model (FE-HBM) simulations (n = 369). To account for the substantial individual variability associated with pelvic shape, a statistical shape model was utilized to predict a large set of random 50%ile male pelvises. Based on select measurements, a sub-sample was drawn from this set (n = 78) for inclusion in the analysis. The simulated submarining outcome and corresponding occupant/restraint parameters were used to generate a metamodel predicting probability of submarining.</p><p><strong>Results: </strong>The results showed that random variations of a 50%ile male can be comparable with restraint design variability on submarining outcome for reclined occupants. Significant predictors included three from the occupant (pelvis angle, iliac spine hook angle, and H-Point forward/rearward position), and three from the restraint (buckle angle, seat friction, and seat pan angle). Non-significant predictors included occupant soft tissue thickness and fat stiffness, shoulder belt load limit force, and inclusion/exclusion of single lap belt pre-tensioning.</p><p><strong>Discussion: </strong>In conclusion, this study implies that future vehicle safety ratings, using different versions of a 50%ile male FE-HBM, may be subject to variation in submarining outcome if harmonization of the target occupant anatomy/posture is not established. In addition, based on the response in a semi-rigid seat setup, this study also indicates that to achieve robust submarining protection for reclined occupants, the current legal requirements on buckle angle might need a shift towards more vertical angles.</p>","PeriodicalId":12444,"journal":{"name":"Frontiers in Bioengineering and Biotechnology","volume":"13 ","pages":"1570572"},"PeriodicalIF":4.3,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12283681/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144697960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recent advances and future directions on GLA-producing organisms. 产gla生物的研究进展及未来发展方向。
IF 4.3 3区 工程技术
Frontiers in Bioengineering and Biotechnology Pub Date : 2025-07-09 eCollection Date: 2025-01-01 DOI: 10.3389/fbioe.2025.1567840
Mojgan Latifi, Foroozan Jalali Bidgoli, Helia Hajihassani, Danial Hassani, Pär K Ingvarsson, Naser Farrokhi
{"title":"Recent advances and future directions on GLA-producing organisms.","authors":"Mojgan Latifi, Foroozan Jalali Bidgoli, Helia Hajihassani, Danial Hassani, Pär K Ingvarsson, Naser Farrokhi","doi":"10.3389/fbioe.2025.1567840","DOIUrl":"https://doi.org/10.3389/fbioe.2025.1567840","url":null,"abstract":"<p><p>Gamma-linolenic acid (GLA) is a biologically active omega-6 fatty acid with anti-inflammatory, immunomodulatory, and cardiovascular protective effects. It is a vital constituent of human health and is finding more widespread applications in nutritional supplements, medications, and functional foods. GLA can be derived from many different natural sources, including plants, fungi, and microorganisms. This review paper presents an overview of the current advances in the discovery, metabolic engineering, and GLA-producing organism optimization. We further present a discussion on new biotechnological approaches-such as culture medium optimization, genetic engineering, and genome editing-that can be employed to enhance GLA production. The paper also presents new trends and directions in the commercial exploitation of GLA-containing products, unveiling new, health-oriented applications.</p>","PeriodicalId":12444,"journal":{"name":"Frontiers in Bioengineering and Biotechnology","volume":"13 ","pages":"1567840"},"PeriodicalIF":4.3,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12283596/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144697964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Case Report: Buccal shifted flap with palatal "C" shape ridge split to facilitate the palatal bone augmentation without compromising the buccal vestibular depth: Report on three cases. 病例报告:在不影响颊前庭深度的情况下,将腭“C”形脊裂的颊移位皮瓣用于腭骨增强:附3例报告。
IF 4.3 3区 工程技术
Frontiers in Bioengineering and Biotechnology Pub Date : 2025-07-09 eCollection Date: 2025-01-01 DOI: 10.3389/fbioe.2025.1594325
Mingfu Ye, Zhaozhao Chen, Wenjun Liu, Hom-Lay Wang
{"title":"Case Report: Buccal shifted flap with palatal \"C\" shape ridge split to facilitate the palatal bone augmentation without compromising the buccal vestibular depth: Report on three cases.","authors":"Mingfu Ye, Zhaozhao Chen, Wenjun Liu, Hom-Lay Wang","doi":"10.3389/fbioe.2025.1594325","DOIUrl":"https://doi.org/10.3389/fbioe.2025.1594325","url":null,"abstract":"<p><p>Due to its dense connective tissue structure, the coronal advancement of the palatal flap is not feasible, making the reconstruction of single-site palatal bone defects particularly challenging. This case report describes the effectiveness and efficacy of an innovative technique combining the buccal shifted flap and palatal \"C\"-shaped ridge split together during bone augmentation procedures in the posterior maxilla. The described approach not only facilitates obtaining reliable bone regeneration without compromising the vestibular depth, but also surprisingly increases the horizontal contour.</p>","PeriodicalId":12444,"journal":{"name":"Frontiers in Bioengineering and Biotechnology","volume":"13 ","pages":"1594325"},"PeriodicalIF":4.3,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12283592/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144698032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Coronal lumbar horizontal shift and lower limb force line in patients with knee osteoarthritis: a correlation study. 膝关节骨性关节炎患者腰冠状位水平移位与下肢力线的相关性研究。
IF 4.3 3区 工程技术
Frontiers in Bioengineering and Biotechnology Pub Date : 2025-07-09 eCollection Date: 2025-01-01 DOI: 10.3389/fbioe.2025.1600020
Yong-Wang Zhang, Pei-Yu Du, Xi Li, Lu Liu, Yun-Tao Yan, Yi-Cong Bai, Xin-Yu Tian, Shuang-Qing Du
{"title":"Coronal lumbar horizontal shift and lower limb force line in patients with knee osteoarthritis: a correlation study.","authors":"Yong-Wang Zhang, Pei-Yu Du, Xi Li, Lu Liu, Yun-Tao Yan, Yi-Cong Bai, Xin-Yu Tian, Shuang-Qing Du","doi":"10.3389/fbioe.2025.1600020","DOIUrl":"https://doi.org/10.3389/fbioe.2025.1600020","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study is to explore the correlation between the horizontal deviation of the coronal lumbar spine and the lower limb force line in knee osteoarthritis (KOA).</p><p><strong>Methods: </strong>A retrospective analysis of 233 KOA cases (47 male patients and 186 female patients, aged 50-83 years, with an average of 61.55 ± 8.72 years) admitted from 1 October 2022 to 31 December 2023 was conducted. Bilateral hip, knee, and ankle (HKA) angles; mechanical axis offset distance (MAD); joint line convergence angle (JLCA); lumbar-knee offset distance (LKOD, a self-tested angle reflecting the difference in the position of the bilateral knee joint relative to the lumbar vertebra); Western Ontario and McMaster Universities Arthritis Index (WOMAC) score; and baseline data records were assessed for all patients.</p><p><strong>Results: </strong>The WOMAC score was correlated with L1, L2, and L3 in LKOD (<i>P</i> < 0.05; r = 0.240, 0.362, and 0.386) but not with L4 and L5 (<i>P</i> > 0.05). WOMAC was also associated with HKA, MAD, and JLCA on the affected side (<i>P</i> < 0.05; r = -0.127, 0.140, and 0.135). The unaffected side and d-values were not associated with HKA, MAD, and JLCA (the d-value represents the absolute value of the difference between the unaffected and affected sides, which represents the overall change in both lower limbs) (<i>P</i> > 0.05). L1-L5 in LKOD was associated with HKA and MAD d-values (<i>P</i> < 0.05); LKOD was not correlated with HKA, MAD, and JLCA on the affected side.</p><p><strong>Conclusion: </strong>Lumbar horizontal deviation is a risk factor affecting all angles in both lower limbs and may aggravate knee bone and joint symptoms. The influence of horizontal direction changes in the lumbar spine on KOA, especially change in L3, should be prioritized in the clinical treatment and research of KOA.</p>","PeriodicalId":12444,"journal":{"name":"Frontiers in Bioengineering and Biotechnology","volume":"13 ","pages":"1600020"},"PeriodicalIF":4.3,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12283583/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144698033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development of an upper limb muscle strength rehabilitation assessment system using particle swarm optimisation. 基于粒子群优化的上肢肌力康复评估系统的开发。
IF 4.3 3区 工程技术
Frontiers in Bioengineering and Biotechnology Pub Date : 2025-07-09 eCollection Date: 2025-01-01 DOI: 10.3389/fbioe.2025.1619411
Chuangan Zhou, Siqi Wang, Meiyi Wu, Wei Lai, Junyu Yao, Xingyue Gou, Hui Ye, Jun Yi, Dong Cao
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