Frontiers in Bioengineering and Biotechnology最新文献

{"title":"Biomechanically optimized 3D-Printed titanium prostheses with stiffener arrangement for critical femoral diaphyseal defects: early weight-bearing capacity and combat readiness validated through integrated biomechanical-FEA approach.","authors":"Guo-Sen Li, Hao Li, Da Liu, Rui Yi, Yi Cui, Hong-Da Lao, Xiao-Yang Nie, Min Zhao, Cheng-Fei Du, Yong-Qing Xu, Jiang-Jun Zhou","doi":"10.3389/fbioe.2025.1642787","DOIUrl":"https://doi.org/10.3389/fbioe.2025.1642787","url":null,"abstract":"<p><strong>Introduction: </strong>Critical femoral diaphyseal defects exceeding 3 cm present significant challenges in trauma and military orthopedics, particularly in blast injury scenarios requiring rapid rehabilitation.</p><p><strong>Methods: </strong>The purpose of this experiment was to evaluate the biomechanical <i>in vitro</i> performance of two personalized prostheses (Groups A and B) designed explicitly for critical femoral diaphyseal defects through integrated biomechanical testing and finite element analysis (FEA). Using fourth-generation composite femurs simulating 10 cm defects (n = 16), we compared axial compression, torsion, four-point bending stiffness, and cyclic fatigue performance against intact bones (Group D) and diaphyseal fractures without defects (Group C).</p><p><strong>Results: </strong>Key findings demonstrate comparable compressive stiffness between prostheses groups (Group A: 764.12±112.63 N/mm; Group B: 693.63±136.31 N/mm) and intact femurs (808.59±18.1 N/mm, p>0.05). The torsional stiffness is comparable between prostheses groups (Group A: 2.28±0.15 Nm/°; Group B: 2.18±0.22 Nm/°) versus diaphyseal fractures without defects (2.01±0.19 Nm/°). The stiffness results comply with mobilization requirements. FEA revealed maximum von Mises stresses in prosthesis fixation systems below the yield strength of Ti6Al4V, with digital image correlation validating the stress distribution patterns. The porous scaffold design achieved optimal modulus (1,132.85 MPa) between cortical and cancellous bone, reducing the \"stress shielding\" effect. Both prostheses endured 1800 N cyclic loading (100,000 cycles ≈, 13.3 years of physiological use) without structural failure.</p><p><strong>Discussion: </strong>These customized prostheses address critical military medical needs by enabling immediate weight-bearing, reducing surgical complexity compared to bone transport techniques, and maintaining long-term mechanical integrity. The stiffener design philosophy and additive manufacturing flexibility provide adaptable solutions for complex combat-related trauma, significantly advancing early functional recovery in resource-constrained environments.</p>","PeriodicalId":12444,"journal":{"name":"Frontiers in Bioengineering and Biotechnology","volume":"13 ","pages":"1642787"},"PeriodicalIF":4.8,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12484202/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145212082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Performance study of ZnO-TPU/CS bilayer composite electrospinning scaffold in skin wound healing.","authors":"Jinlong Wang, Guoxing Huang, Quan Qin, Nianhua Dan, Xinlou Li, Kai Sun, Yuan Yang, Meng Wang","doi":"10.3389/fbioe.2025.1636932","DOIUrl":"https://doi.org/10.3389/fbioe.2025.1636932","url":null,"abstract":"<p><strong>Introduction: </strong>The high incidence of skin injuries and the limitations of conventional dressings highlight the need for advanced wound care materials. Electrospun nanofibrous scaffolds, with their extracellular matrix-like architecture, offer potential to enhance healing.</p><p><strong>Methods: </strong>A bilayer nanofibrous scaffold of thermoplastic polyurethane (TPU) and chitosan loaded with zinc oxide nanoparticles (ZnO) (TPU/CS@ZnO) was fabricated via electrospinning. The scaffold consisted of a hydrophobic TPU outer layer for waterproof protection and a hydrophilic TPU/CS@ZnO inner layer for bioactivity. Physicochemical properties were characterized by morphology, mechanical strength, and wettability. Cytocompatibility was evaluated in vitro, and wound healing efficacy was tested in vivo using a full-thickness skin defect model.</p><p><strong>Results: </strong>The scaffold displayed uniform fibres with a base-layer diameter of 231.81 ± 44.85 nm, tensile strength of 8.42 ± 0.58 MPa, and Young's modulus of 17.96 ± 0.78 MPa. Water contact angles confirmed hydrophilic and hydrophobic layer characteristics (52.68° ± 4.46° vs. 113.60° ± 2.85°). In vitro studies showed enhanced cell proliferation and adhesion, while in vivo experiments demonstrated over 90% wound closure at day 14, significantly faster than untreated groups. Histological analysis indicated contributions from cellular adhesion, angiogenesis, and immunomodulation.</p><p><strong>Discussion: </strong>The bilayer TPU/CS@ZnO scaffold integrates structural protection with biological activity, accelerating wound repair through multiple mechanisms. These findings support its potential as a multifunctional wound dressing, while further studies are needed to clarify molecular pathways and advance clinical application.</p>","PeriodicalId":12444,"journal":{"name":"Frontiers in Bioengineering and Biotechnology","volume":"13 ","pages":"1636932"},"PeriodicalIF":4.8,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12484145/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145212157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomimetic optimization of silicone breast implant integration: insights into wound healing and the foreign body response.","authors":"Kevin Dzobo, Traci A Wilgus, Vanessa Zamora Mora, Audry Zoncsich, Roberto de Mezerville, Nonhlanhla Khumalo, Ardeshir Bayat","doi":"10.3389/fbioe.2025.1668930","DOIUrl":"https://doi.org/10.3389/fbioe.2025.1668930","url":null,"abstract":"<p><p>Breast augmentation is the most prevalent aesthetic surgical procedure worldwide. While silicone breast implants have evolved in terms of safety and biocompatibility, they inevitably trigger a foreign body response (FBR). This complex process can lead to fibrous encapsulation, capsular contracture, and other complications, often necessitating invasive revision surgeries. This review comprehensively analyzes the molecular and cellular mechanisms underlying FBR, emphasizing the crucial role of implant surface properties. We demonstrate how these properties, including topography, hydrophobicity, and charge, govern the initial protein adsorption patterns, effectively establishing a \"molecular fingerprint\" that dictates subsequent cellular interactions. This, in turn, orchestrates immune cell activation, notably macrophages, which exhibit plasticity in their polarization into pro-inflammatory (M1) and pro-fibrotic (M2) phenotypes. The balance between these phenotypes influences the extent of fibrosis and capsular contracture. We explored the five distinct phases of FBR: protein adsorption, acute inflammation, chronic inflammation, foreign body giant cell (FBGC) formation, and encapsulation. The impact of implant surface properties on each phase was elucidated, highlighting the dynamic interplay between macrophages, lymphocytes, and matrix. The phenomenon of \"frustrated phagocytosis,\" where macrophages fail to engulf the implant, leading to FBGC formation and chronic inflammation, is also examined. Finally, we explore promising strategies to modulate FBR and enhance implant biocompatibility, including biomimetic coatings, the use of decellularized matrices, and therapies aimed at disrupting specific molecular pathways involved in fibrosis. This review provides insights into the development of next-generation implants that can harmoniously integrate with the body, minimizing FBR and ensuring long-term clinical success.</p>","PeriodicalId":12444,"journal":{"name":"Frontiers in Bioengineering and Biotechnology","volume":"13 ","pages":"1668930"},"PeriodicalIF":4.8,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12484225/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145212079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Translational development of tailored implants via advanced processing and surface modifications for tissue regeneration.","authors":"Mike Barbeck, Sebastian Stammkötter, Rumen Krastev, Frank Walther","doi":"10.3389/fbioe.2025.1686388","DOIUrl":"https://doi.org/10.3389/fbioe.2025.1686388","url":null,"abstract":"","PeriodicalId":12444,"journal":{"name":"Frontiers in Bioengineering and Biotechnology","volume":"13 ","pages":"1686388"},"PeriodicalIF":4.8,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12484139/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145212124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sustainable production of microalgal nanoparticles through green synthesis towards cancer treatment.","authors":"Vijay Kumar Garlapati, Swati Sharma, Deepak Sharma, S P Jeevan Kumar, Samuel Jacob, Arindam Kuila, Ashok Kumar Gupta, Abhishek Chaudhary","doi":"10.3389/fbioe.2025.1621876","DOIUrl":"https://doi.org/10.3389/fbioe.2025.1621876","url":null,"abstract":"<p><p>Nanoparticle-based treatment is one of the rapidly growing research domains in cancer treatment due to its associated structural, targeted, and stability features. The conventional (chemical and physical) nanoparticle (NP) synthesis suffers from drawbacks such as toxicity, cost, and unsustainable process methodologies, which necessitate the urgent need for sustainable green approaches to nanoparticle synthesis for envisioned cancer treatment options. The green synthesis of microalgal NPs is a promising approach for obtaining NPs for cancer treatment. As a result, this review presents the synthesis mechanism of microalgal NPs and the factors affecting their green synthesis. The mechanism of action of microalgal NPs in cancer treatment has been discussed in relation to their cytotoxic effects. The sustainability features, probable quality control regime of green-synthesized microlgal NPs, along with the prospects of incorporating synthetic biology and utilizing genetically engineered microalgae, have been highlighted in the context of cancer treatment.</p>","PeriodicalId":12444,"journal":{"name":"Frontiers in Bioengineering and Biotechnology","volume":"13 ","pages":"1621876"},"PeriodicalIF":4.8,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12484175/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145212114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differences in lower extremity biomechanics, shank muscle activation and medial gastrocnemius-tendon unit behavior between novice and experienced non-rearfoot strike runners.","authors":"Bokai Suo, Zeyu Lu, Jichao Wang, Kaicheng Wu, Liqin Deng, Lu Li, Yunjian Zhong, Weijie Fu","doi":"10.3389/fbioe.2025.1641666","DOIUrl":"https://doi.org/10.3389/fbioe.2025.1641666","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to investigate the differences in lower extremity kinematics and kinetics, shank muscle activation, and medial gastrocnemius-tendon unit behavior between habitual rearfoot strike (RFS) runners and habitual non-rearfoot strike (NRFS) runners when adopting an NRFS pattern.</p><p><strong>Methods: </strong>Twelve male habitual RFS runners (novice NRFS runners, NN) and twelve male habitual NRFS runners (experienced NRFS runners, EN) were recruited. All participants were required to run at 9 km/h on the split-belt 3D instrumented treadmill using an NRFS pattern. 3D lower extremity kinematics and kinetics, surface electromyography (sEMG) signals of medial and lateral gastrocnemius (MG and LG), soleus (SOL), and tibialis anterior (TA), as well as dynamic ultrasound imaging of MG tendon unit behavior during running were collected synchronously. Intergroup comparisons were performed using independent samples t-tests and Mann-Whitney U tests, with Significance levels (<i>α</i>) adjusted via Bonferroni correction.</p><p><strong>Results: </strong>Compared to EN, NN exhibited significantly greater fascicle shortening lengths (NN: 1.54 ± 0.66 cm; EN: 0.94 ± 0.23 cm; <i>p</i> = 0.013) and muscle-tendon unit (MTU) shortening lengths (NN: 3.45 ± 0.51 cm; EN: 1.96 ± 0.23 cm; <i>p</i> < 0.001) of MG. No intergroup differences were observed in lower extremity kinematics, kinetics, or shank muscle activation.</p><p><strong>Conclusion: </strong>While novice and experienced NRFS runners exhibited similar kinematic, kinetic and muscle activation characteristics, the increased fascicle and muscle-tendon unit shortening lengths of medial gastrocnemius in novice NRFS runners potentially reflect reduced muscle contraction efficiency.</p>","PeriodicalId":12444,"journal":{"name":"Frontiers in Bioengineering and Biotechnology","volume":"13 ","pages":"1641666"},"PeriodicalIF":4.8,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12484226/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145212142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Construction and validation of a U-type finite element model of an osteoporotic vertebral compression fracture.","authors":"Pengfei Li, Jihao Mu, Zhao Wang, Xiaochong Zhang, Yingze Zhang, Dengxiang Liu, Ao Li","doi":"10.3389/fbioe.2025.1617208","DOIUrl":"https://doi.org/10.3389/fbioe.2025.1617208","url":null,"abstract":"<p><strong>Background: </strong>An osteoporotic vertebral compression fracture (OVCF) is recognized as a common complication of osteoporosis. Biomechanical alterations in the affected and adjacent vertebrae have a significant influence on patient symptoms, treatment strategies, and clinical outcomes. Nevertheless, establishing an accurate model of OVCF remains a highly challenging task. In this study, a novel finite-element model of OVCF was developed and validated, and a comprehensive biomechanical analysis was conducted.</p><p><strong>Methods: </strong>Computed tomography data of the thoracolumbar spine (T12-L2) were collected from an OVCF patient and a healthy volunteer to establish the OVCF and normal models, respectively. Based on the normal model, U-type, V-type, and double-V-type finite element models were constructed. Intervertebral disks and articular cartilage were generated through a combination of appropriate materials and assemblies, followed by the development of three-dimensional finite-element biomechanical models. The magnitude and distribution of stress and displacement in these three models were evaluated and compared with those of the OVCF model under various directions of motion.</p><p><strong>Results: </strong>In the force distribution contour diagrams, the U-type model at the T12 vertebra most closely resembled the OVCF model, particularly in the directions of forward flexion, backward extension, left lateral bending, and left rotation. Force distribution patterns and stress concentration areas in all six directions were generally consistent between the U-type and OVCF models. At the L2 vertebra, the U-type model demonstrated the greatest similarity to the OVCF model in the direction of left lateral bending. At the T12/L1 intervertebral disk, no significant differences in the force distribution were observed among the four models. At the L1/2 intervertebral disk, the U-type and OVCF models showed the closest correspondence in the direction of forward flexion. In the displacement contour diagrams, the maximum displacements of the U-type model were found to be 1.7876 mm (forward flexion), 6.1564 mm (posterior extension), 4.6520 mm (left lateral bending), 6.2224 mm (right lateral bending), 3.4119 mm (left rotation), and 3.1601 mm (right rotation). Notably, in the direction of left lateral bending, the U-type model most closely approximated the displacement distribution of the OVCF model.</p><p><strong>Conclusion: </strong>The U-type finite-element model more accurately reproduces the biomechanical characteristics of OVCF and demonstrates high applicability.</p>","PeriodicalId":12444,"journal":{"name":"Frontiers in Bioengineering and Biotechnology","volume":"13 ","pages":"1617208"},"PeriodicalIF":4.8,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12485499/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145212090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biosynthetic polyphosphate enhances osteogenesis of human periodontal ligament stem cells and promotes periodontal bone regeneration in a murine periodontal bone defect model.","authors":"Jiaqi Chen, Dongying Lei, Xinyi Liu, Zipeng Chen, Jiaying Li, Liang Huang, Huifen Liu, Xuebin Yang, Wei Wei, Sijing Xie","doi":"10.3389/fbioe.2025.1672295","DOIUrl":"https://doi.org/10.3389/fbioe.2025.1672295","url":null,"abstract":"<p><strong>Introduction: </strong>Periodontal bone regeneration remains a significant challenge in clinical dentistry due to the complex structure of periodontal tissues and their limited intrinsic regenerative capacity. Innovative biomaterial-based strategies are therefore required. Polyphosphates (Poly(P)) have shown promising regenerative potential; however, conventional chemical synthesis methods are limited by high costs and product impurity concerns.</p><p><strong>Methods: </strong>We established an eco-friendly biosynthetic strategy using a genetically engineered environmental bacterium overexpressing polyphosphate kinase (PPK1) to produce high-purity polyphosphates (Bio-Poly P) from wastewater-derived phosphate sources. Structural characterization was performed to confirm physicochemical properties. The effects of Bio-Poly P on human periodontal ligament stem cells (hPDLSCs) were assessed by CCK8 assays, qRT-PCR, alkaline phosphatase (ALP) activity, and Alizarin Red staining. <i>In vivo</i> osteogenic potential was evaluated using a murine periodontal bone defect model with micro-CT analysis after 4 weeks of implantation.</p><p><strong>Results: </strong><i>In vitro</i>, Bio-Poly P at 1.25 and 2.5 mg/ml did not reduce hPDLSC proliferation at 24, 48, and 72 h, whereas higher concentrations (≥5 mg/ml) significantly inhibited proliferation (P < 0.0001). At day 7, Bio-Poly P at 0.25, 1.25, and 2.5 mg/ml significantly upregulated <i>COL1A1</i> expression (P < 0.0001), while only 1.25 mg/ml enhanced OCN (P < 0.0001) and OPN (P < 0.01). No effect was observed on RUNX2 at this time point. By day 14, all three concentrations significantly increased the expression of <i>RUNX2, OCN, OPN</i>, and <i>COL1A1</i>. Enhanced ALP activity and calcium deposition were confirmed by biochemical assays and Alizarin Red staining, with the 1.25 mg/ml group showing the greatest mineralization. <i>In vivo</i>, Bio-Poly P significantly improved bone mineral density, bone volume/tissue volume ratio, and trabecular thickness compared with untreated defects, with regenerative outcomes comparable to the clinical control Bio-Oss® (P > 0.05).</p><p><strong>Discussion: </strong>This study demonstrates that Bio-Poly P possesses favorable biosafety and osteoinductive properties, effectively enhancing osteogenic differentiation of hPDLSCs <i>in vitro</i> and promoting periodontal bone regeneration <i>in vivo</i>. By leveraging a cost-effective and sustainable biosynthetic production method, Bio-Poly P represents a promising alternative to chemically synthesized polyphosphates for clinical periodontal regeneration.</p>","PeriodicalId":12444,"journal":{"name":"Frontiers in Bioengineering and Biotechnology","volume":"13 ","pages":"1672295"},"PeriodicalIF":4.8,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12484173/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145212127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Vitamin D and curcumin-loaded PCL nanofibrous for engineering osteogenesis and immunomodulatory scaffold.","authors":"Abdullrahman M Al-Bishari, Bilal A Al-Shaaobi, Aisha A Al-Bishari, Mohammed A Al-Baadani, Liang Yu, Jiating Shen, Lei Cai, Yiding Shen, Zhennan Deng, Peng Gao","doi":"10.3389/fbioe.2025.1664137","DOIUrl":"https://doi.org/10.3389/fbioe.2025.1664137","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.3389/fbioe.2022.975431.].</p>","PeriodicalId":12444,"journal":{"name":"Frontiers in Bioengineering and Biotechnology","volume":"13 ","pages":"1664137"},"PeriodicalIF":4.8,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12481168/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145206066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Development of three-dimensional primary human myospheres as culture model of skeletal muscle cells for metabolic studies.","authors":"Andrea Dalmao-Fernandez, Aleksandra Aizenshtadt, Hege G Bakke, Stefan Krauss, Arild C Rustan, G Hege Thoresen, Eili Tranheim Kase","doi":"10.3389/fbioe.2025.1687822","DOIUrl":"https://doi.org/10.3389/fbioe.2025.1687822","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.3389/fbioe.2023.1130693.].</p>","PeriodicalId":12444,"journal":{"name":"Frontiers in Bioengineering and Biotechnology","volume":"13 ","pages":"1687822"},"PeriodicalIF":4.8,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12481026/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145206077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}