Frontiers in Bioengineering and Biotechnology最新文献

{"title":"Injectable organic-inorganic hybrid hydrogels for bone defect repair.","authors":"Huan Zhang, Shuo Ding, Huai Xue, Shuguang Wang, Xiaoyu Quan, Dong Zhang, Xiao Liu, Hai Tang","doi":"10.3389/fbioe.2025.1563546","DOIUrl":"https://doi.org/10.3389/fbioe.2025.1563546","url":null,"abstract":"<p><p>Bone defects caused by trauma, tumor resection, and surgery present significant clinical challenges, often resulting in complications such as delayed union, nonunion, and even long-term functional impairment. Current treatments, including autografts and allografts, are limited by donor site morbidity, immune rejection, and pathogen transmission, highlighting the need for developing reliable synthetic alternatives. To address these challenges, we report a binary composite hydrogel combining gelatin methacryloyl (GelMA) and κ-Carrageenan, reinforced with calcium phosphate cements (CPC). GelMA ensures rapid gelation and biocompatibility, κ-carrageenan improves injectability, and CPC enhances mechanical strength and osteogenic activity, collectively creating a robust and versatile hydrogel system. Furthermore, the hydrogel's injectable, adaptive, and self-healing characteristics enable it to conform to irregular bone defect sites, providing mechanical support and osteogenic stimulation. It also releases bioactive components to accelerate bone regeneration. With exceptional toughness and resilience, this hydrogel recovers its shape after deformation, positioning it as a promising candidate for clinical bone defect repair applications.</p>","PeriodicalId":12444,"journal":{"name":"Frontiers in Bioengineering and Biotechnology","volume":"13 ","pages":"1563546"},"PeriodicalIF":4.3,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11959084/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The triadic relationship between spinal posture, loading, and degeneration.","authors":"Marie-Rosa Fasser, Pascal R Furrer, Luca Fisler, Lukas Urbanschitz, Jess G Snedeker, Mazda Farshad, Jonas Widmer","doi":"10.3389/fbioe.2025.1444540","DOIUrl":"https://doi.org/10.3389/fbioe.2025.1444540","url":null,"abstract":"<p><strong>Introduction: </strong>Degenerative changes in the lumbar spine may affect many structures, among them the intervertebral discs and the facet joints. The individual load distribution within the spine linked to posture and mass distribution is a probable cause of disease. This study had a dual aim: first, to systematically summarize previously reported associations between sagittal balance parameters and the occurrence of lumbar spine degeneration. Second, to complement these insights with additional biomechanical findings meant to elucidate the link between spine load and alignment as well as selected demographic descriptors.</p><p><strong>Methods: </strong>A systematic literature search was performed on PubMed to identify clinical studies that quantified the association between spinal alignment and the occurrence of disc herniation, disc degeneration, facet joint degeneration, and spondylolisthesis. Further, a previously published musculoskeletal model was used to link sagittal spinal alignment and subject characteristics to joint loading within the lumbar spine for a cohort of 144 subjects.</p><p><strong>Results: </strong>The literature review yielded 49 publications evaluating the relationship between spinal alignment and the occurrence of pathologies in the lumbar spine. The results indicate that a straight spine might negatively affect the health status of the intervertebral disc, likely because of a lack of damping and associated high compressive loads. These loads further show a major dependence on body weight. On the other hand, facet degeneration and spondylolisthesis may be linked to higher anterior-posterior shear forces acting on the relevant spinal structures because of a generally more sagittally curved spine. A straight lumbar spine is more likely to stress the disc, whereas highly curved spines with a high pelvic incidence are more likely to stress the posterior structures. The biggest influencing factors on the resulting force and consequently potentially the wear of the anatomical structures are the intervertebral inclination from an anatomical point of view and the weight from a demographic point of view.</p><p><strong>Discussion: </strong>Information concerning spinal loading resulting from spinal alignment and body descriptors could impact both conservative treatment and operative planning for patients afflicted by spine disease through targeted changes in posture.</p>","PeriodicalId":12444,"journal":{"name":"Frontiers in Bioengineering and Biotechnology","volume":"13 ","pages":"1444540"},"PeriodicalIF":4.3,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11959076/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomechanical effects of screw loosening after lumbar PEEK rod and titanium rod fixation: a finite element analysis.","authors":"Guozheng Jiang, Shuyang Wang, Luchun Xu, Zeyu Li, Ningning Feng, Ziye Qiu, Yongdong Yang, Xing Yu","doi":"10.3389/fbioe.2025.1533088","DOIUrl":"10.3389/fbioe.2025.1533088","url":null,"abstract":"<p><strong>Objective: </strong>Screw loosening is a common complication following lumbar spine fixation surgery, yet the biomechanical outcomes after screw loosening remain rarely reported. This study aims to utilize finite element (FE) models to compare the biomechanical performance of PEEK rod dynamic fixation and titanium rod rigid fixation in the postoperative lumbar spine, exploring potential biomechanical mechanisms for re-stabilization of loosened screws.</p><p><strong>Methods: </strong>A FE model of the lumbar spine from L3 to the sacrum was developed using CT image segmentation. Four L4-S1 fixation models were constructed: PEEK rod dynamic fixation (PEEK model), titanium rod rigid fixation (titanium model), PEEK rod with pedicle screw loosening (PEEK-PSL model), and titanium rod with pedicle screw loosening (titanium -PSL model). A preload of 300 N was applied to the superior surface of L3. Stress distributions in the intervertebral discs, facet joints, pedicle screws, and rods were calculated to evaluate the biomechanical effects of different fixation methods.</p><p><strong>Results: </strong>Across four physiological loading conditions, the stress differences in intervertebral discs, facet joints, and nucleus pulposus between the PEEK model and titanium model were minimal. However, vertebral body stress was significantly higher in the PEEK model, whereas screw and rod stresses were greater in the titanium model. Screw loosening further increased stress in all models. The S1 screw in the PEEK-PSL model exhibited lower and more uniform stress, while stress was concentrated at the screw-rod junction in the titanium-PSL model.</p><p><strong>Conclusion: </strong>The PEEK rod fixation system demonstrated superior stress distribution, reducing stress concentration risks and improving stability while minimizing screw loosening rates. In contrast, the titanium rod system offers advantages in scenarios requiring high rigidity, potentially making it more suitable for patients with greater stability needs.</p>","PeriodicalId":12444,"journal":{"name":"Frontiers in Bioengineering and Biotechnology","volume":"13 ","pages":"1533088"},"PeriodicalIF":4.3,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11955707/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MRI monitoring of USPIO-labeled BMSCs combined with alginate scaffold for cartilage defect repair.","authors":"Shanyu Lu, Zhenyu Liu, Meiling Qi, Haocheng Zhen, Jing Luo, Yingchao Wang, Le Chang, Xiaolong Bai, Yingguang Jiao, Xinyao Chen, Junping Zhen","doi":"10.3389/fbioe.2025.1554292","DOIUrl":"10.3389/fbioe.2025.1554292","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to evaluate the effectiveness of bone marrow mesenchymal stem cells (BMSCs) combined with sodium alginate scaffolds in repairing knee cartilage defects in New Zealand rabbits. Additionally, it assessed the potential of functional magnetic resonance imaging (fMRI) for non-invasive monitoring of the dynamic repair process.</p><p><strong>Methods: </strong>Rabbits were randomly divided into four groups: Group A (control), Group B (sodium alginate scaffold), Group C (BMSCs-sodium alginate scaffold), and Group D (USPIO-labeled BMSCs-sodium alginate scaffold). A cartilage defect model was created, and the respective materials were implanted into the defect regions. T2 mapping MRI was performed at weeks 1, 2, and 4 post-surgery to evaluate the repair process, followed by histological analysis to confirm the outcomes.</p><p><strong>Results: </strong>BMSCs significantly promoted cartilage defect repair and accelerated the degradation of sodium alginate scaffolds. Macroscopic and histological evaluations revealed repair tissue formation in Groups C and D by week 1, with most defect regions filled with new cartilage by week 4. T2 mapping analysis showed a gradual decline in T2 values in Group B, a more pronounced decrease in Group C, and consistently lower T2 values in Group D compared to Group C, with a slow upward trend over time.</p><p><strong>Conclusion: </strong>This study demonstrated that BMSCs exhibit significant regenerative potential for cartilage defect repair. USPIO labeling enables non-invasive, dynamic monitoring of the repair process without adverse effects on cell viability or differentiation. These findings provide experimental evidence supporting the application of BMSCs combined with magnetic labeling technology in cartilage regeneration.</p>","PeriodicalId":12444,"journal":{"name":"Frontiers in Bioengineering and Biotechnology","volume":"13 ","pages":"1554292"},"PeriodicalIF":4.3,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11955663/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of an active ankle exoskeleton on the walking biomechanics of healthy men.","authors":"Sridevi Nagaraja, Jose E Rubio, Junfei Tong, Aravind Sundaramurthy, Anup Pant, Meredith K Owen, Michael A Samaan, Brian Noehren, Jaques Reifman","doi":"10.3389/fbioe.2025.1533001","DOIUrl":"10.3389/fbioe.2025.1533001","url":null,"abstract":"<p><p>Active lower-body exoskeleton devices can decrease the energy requirement of the human body by providing mechanical assistance to lower-body muscles. However, they also alter gait kinematics and kinetics, and it is not well understood whether such alterations are detrimental or beneficial to the human body. In this pilot study, we investigated the impact of walking with an ankle exoskeleton device on the biomechanics of men while carrying a heavy load. We collected computed tomography images and motion-capture data for five young, healthy men who walked 5 km (∼60 min) with a 22.7-kg load, with and without an active ankle exoskeleton (the ExoBoot EB60). We developed personalized musculoskeletal models and calculated the joint kinematics and kinetics for each participant under each walking condition. Without the ExoBoot, at 5 km compared to 0 km, on average, the peak trunk flexion angle increased by ∼35% and the stride length increased by ∼3.5%. In contrast, with the ExoBoot, the magnitude of the corresponding increases was smaller (∼16% and ∼2%, respectively). After the 5-km walk, compared to walking without the ExoBoot, its use considerably altered hip-related biomechanical parameters, e.g., it increased hip abduction angle by ∼17%, increased hip flexion moment by ∼3.5%, and decreased hip adduction moment by ∼19%. Finally, irrespective of distance, ExoBoot use significantly increased the stance duration and peak ankle plantarflexion angle (<i>p</i> < 0.001). Overall, the use of the ExoBoot induced beneficial alterations in stride length and trunk-, ankle-, and hip-related parameters for men walking with load carriage. The quantitative analysis provided by this pilot study should help guide future investigations and inform the development of standards for safe and effective use of emerging exoskeleton technologies.</p>","PeriodicalId":12444,"journal":{"name":"Frontiers in Bioengineering and Biotechnology","volume":"13 ","pages":"1533001"},"PeriodicalIF":4.3,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11949874/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Tissue engineering and regenerative medicine: advances, controversies, and future directions.","authors":"Stanislav Žiaran, Ľuboš Danišovič, Niels Hammer","doi":"10.3389/fbioe.2025.1568490","DOIUrl":"10.3389/fbioe.2025.1568490","url":null,"abstract":"","PeriodicalId":12444,"journal":{"name":"Frontiers in Bioengineering and Biotechnology","volume":"13 ","pages":"1568490"},"PeriodicalIF":4.3,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11949865/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel approach for engineering DHCM/GelMA microgels: application in hepatocellular carcinoma cell encapsulation and chemoresistance research.","authors":"Dandan Zhou, Xiaoxiao Li, Wencun Liu, Mingjun Zhang, Ying Cheng, Zhousong Xu, Jian Gao, Yiyang Wang","doi":"10.3389/fbioe.2025.1564543","DOIUrl":"10.3389/fbioe.2025.1564543","url":null,"abstract":"<p><p>Liver cancer, a highly aggressive malignancy, continues to present significant challenges in therapeutic management due to its pronounced chemoresistance. This resistance, which undermines the efficacy of conventional chemotherapy and targeted therapies, is driven by multifaceted mechanisms, with increasing emphasis placed on the protective role of the tumor microenvironment (TME). The hepatocellular carcinoma extracellular matrix (ECM), a primary non-cellular component of the TME, has emerged as a critical regulator in cancer progression and drug resistance, particularly in hepatocellular carcinoma cell (HCC). In this study, a hybrid biomimetic hydrogel was engineered by integrating decellularized hepatocellular carcinoma matrix (DHCM) with gelatin methacrylate (GelMA) precursors. This composite DHCM/GelMA hydrogel was designed to replicate the physicochemical and functional properties of the hepatocellular carcinoma ECM, thereby offering a biomimetic platform to explore the interactions between HCCs and their microenvironment. Leveraging a custom-designed microfluidic 3D printing platform, we achieved high-throughput fabrication of HCC-encapsulated DHCM/GelMA microgels, characterized by enhanced uniformity, biocompatibility, and scalability. These microgels facilitated the construction of hepatocellular carcinoma microtissues, which were subsequently employed for chemoresistance studies. Our findings revealed that DHCM/GelMA microgels closely mimic the hepatocellular carcinoma tumor microenvironment, effectively recapitulating key features of ECM-mediated drug resistance. Mechanistic studies further demonstrated that DHCM significantly upregulates the expression of Aquaporin 3 (AQP3) in the encapsulated HCCs. This upregulation potentially activates mTOR signaling-associated autophagy pathways, thereby enhancing chemoresistance in HCCs. These biomimetic models provide a robust and versatile platform for studying the underlying mechanisms of drug resistance and evaluating therapeutic interventions. This innovative approach highlights the potential of DHCM/GelMA microgels as a transformative tool in cancer-associated tissue engineering and anticancer drug screening. By enabling detailed investigations into the role of ECM in chemoresistance, this study contributes to advancing therapeutic research and offers promising strategies to overcome drug resistance, ultimately improving clinical outcomes in liver cancer treatment.</p>","PeriodicalId":12444,"journal":{"name":"Frontiers in Bioengineering and Biotechnology","volume":"13 ","pages":"1564543"},"PeriodicalIF":4.3,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11949893/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mitochondria targeted nanoparticles for the treatment of mitochondrial dysfunction-associated brain disorders.","authors":"Amy Claire Buck, Gerald J Maarman, Admire Dube, Soraya Bardien","doi":"10.3389/fbioe.2025.1563701","DOIUrl":"10.3389/fbioe.2025.1563701","url":null,"abstract":"<p><p>Mitochondria play a significant role in several cellular activities and their function in health and disease has become an important area of research. Since the brain is a high-energy-demanding organ, it is particularly vulnerable to mitochondrial dysfunction. This has been implicated in several brain disorders including neurodegenerative, psychiatric and neurological disorders, e.g., Parkinson's disease and schizophrenia. Significant efforts are underway to develop mitochondria-targeting pharmaceutical interventions. However, the complex mitochondrial membrane network restricts the entry of therapeutic compounds into the mitochondrial matrix. Nanoparticles (NPs) present a novel solution to this limitation, while also increasing the stability of the therapeutic moieties and improving their bioavailability. This article provides a detailed overview of studies that have investigated the treatment of mitochondrial dysfunction in brain disorders using either targeted or non-targeted NPs as drug delivery systems. All the NPs showed improved mitochondrial functioning including a reduction in reactive oxygen species (ROS) production, an improvement in overall mitochondrial respiration and a reversal of toxin-induced mitochondrial damage. However, the mitochondrial-targeted NPs showed an advantage over the non-targeted NPs as they were able to improve or rescue mitochondrial dynamics and biogenesis, and they required a lower concentration of the <i>in vivo</i> therapeutic dosage of the drug load to show an effect. Consequently, mitochondria-targeted NPs are a promising therapeutic approach. Future studies should exploit advances in nanotechnology, neuroscience and chemistry to design NPs that can cross the blood-brain barrier and selectively target dysfunctional mitochondria, to improve treatment outcomes.</p>","PeriodicalId":12444,"journal":{"name":"Frontiers in Bioengineering and Biotechnology","volume":"13 ","pages":"1563701"},"PeriodicalIF":4.3,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11937128/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143718253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"2D speckle-tracking echocardiography assessment of left atrial and left ventricular mechanics: outcomes in patients with atrial fibrillation treated with hybrid ablation and left atrial appendage surgical closure.","authors":"Andrea Maria Paparella, Luigi Pannone, Gianni Pedrizzetti, Giacomo Talevi, Domenico Giovanni Della Rocca, Antonio Sorgente, Rani Kronenberger, Gaetano Paparella, Ingrid Overeinder, Gezim Bala, Alexandre Almorad, Erwin Ströker, Juan Sieira, Mark La Meir, Andrea Sarkozy, Pedro Brugada, Gian Battista Chierchia, Ali Gharaviri, Carlo De Asmundis","doi":"10.3389/fbioe.2025.1538809","DOIUrl":"10.3389/fbioe.2025.1538809","url":null,"abstract":"<p><strong>Background and aims: </strong>Hybrid atrial fibrillation (AF) ablation is a therapeutic option in non-paroxysmal AF. Our study examines cardiac mechanics changes after hybrid AF ablation plus epicardial closure of left atrial appendage (LAA).</p><p><strong>Methods: </strong>All consecutive patients undergoing hybrid AF ablation at UZ Brussel were evaluated. They received pulmonary vein isolation (PVI), posterior wall isolation (LAPWI), and epicardial LAA closure. Left atrium (LA) and Left ventricle (LV) mechanics were analyzed, with the following measures obtained at baseline, post-ablation, and follow-up: 1) volumes (EDV, ESV); 2) ejection fraction (EF); 3) strain (ENDO GCS, ENDO GLS); 4) forces (LVLF, LVsysLF, LVim, LVs).</p><p><strong>Results: </strong>A total of 50 patients were included. At follow-up, LAEDV decreased from baseline [44.7 mL vs 53.8 mL, <i>P</i> = 0.025]. LA ENDO GCS and GLS increased post-ablation, with further GLS improvement at follow-up. LV ENDO GCS and LV ENDO GLS also rose post-ablation [-26.7% vs. -22.5%, <i>P</i> < 0.001] and [-20.57% vs. -16.6%, <i>P</i> < 0.001], respectively. LVEF increased post-ablation [54.6% vs 46.3%, <i>P</i> < 0.001]. There was an increase in all LV hemodynamic forces (HDFs) and in particular: LVLF and LVsysLF increased post-ablation [15.5% vs 10.4%, <i>P</i> < 0.001] and [21.5% vs 14.11%, <i>P</i> < 0.001], respectively. LVim also increased post-ablation [19.6% vs 12.8%, <i>P</i> < 0.001]. Finally, there was an increase in LVs post-ablation compared to baseline [10.6% vs 5.4%, <i>P</i> < 0.001].</p><p><strong>Conclusion: </strong>In patients undergoing hybrid AF ablation, there was a significant and persistent improvement in the mechanical and hemodynamic functions of both LA and LV.</p>","PeriodicalId":12444,"journal":{"name":"Frontiers in Bioengineering and Biotechnology","volume":"13 ","pages":"1538809"},"PeriodicalIF":4.3,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11937039/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143718216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanomaterials targeting iron homeostasis: a promising strategy for cancer treatment.","authors":"Bin Li, Bing Zhang, Ziyue Cheng, Yantao Lou, Shuqiu Chen","doi":"10.3389/fbioe.2025.1511197","DOIUrl":"10.3389/fbioe.2025.1511197","url":null,"abstract":"<p><p>Iron is essential for vital cellular processes, including DNA synthesis, repair, and proliferation, necessitating enhanced iron uptake and intracellular accumulation. Tumor cells, in particular, exhibit a pronounced elevation in iron uptake to sustain their continuous proliferation, migration and invasion. This elevated iron acquisition is facilitated predominantly through the upregulation of transferrin receptors, which are closely associated with tumorigenesis and tumor progression. Incorporating transferrin into drug delivery systems has been shown to enhance cytotoxic effects in drug-sensitive cancer cells, offering a potential method to surpass the limitations of current cancer therapies. Intracellular iron predominantly exists as ferritin heavy chain (FTH), ferritin light chain (FTL), and labile iron pool (LIP). The innovation of nanocarriers incorporating iron chelating agents has attracted considerable interest. Iron chelators such as Deferoxamine (DFO), Deferasirox (DFX), and Dp44mT have demonstrated significant promise in cancer treatment by inducing iron deficiency within tumor cells. This review explores recent advancements in nanotechnology aimed at targeting iron metabolism in cancer cells and discusses their potential applications in cancer treatment strategies.</p>","PeriodicalId":12444,"journal":{"name":"Frontiers in Bioengineering and Biotechnology","volume":"13 ","pages":"1511197"},"PeriodicalIF":4.3,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11937013/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143718299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}