Frontiers in Bioengineering and Biotechnology最新文献

{"title":"Nanoarchitecting intelligently encapsulated designs for improved cancer therapy.","authors":"Ying-Tong Ye, Hong-Ying Xia, Jie Li, Shi-Bin Wang, Ai-Zheng Chen, Ranjith Kumar Kankala","doi":"10.3389/fbioe.2025.1587178","DOIUrl":"https://doi.org/10.3389/fbioe.2025.1587178","url":null,"abstract":"<p><p>Despite the success in exploring various aspects of origination and therapeutic strategies, cancer has remained one of the most dreadful metabolic disorders due to failure to eradicate tumors comprehensively and frequent recurrence because of acquired resistance to the drugs. Recently, several advancements have been evidenced in the fabrication of various smart nanocarriers encapsulated with multiple components. Several reasons for smart nanoencapsulation include the enhancement of the bioavailability of drugs, precise targetability to reduce adverse effects on normal cells, and the ability to enable controlled drug release rates at the tumor sites. In addition, these smart nanocarriers protect encapsulated therapeutic cargo from deactivation, responsively delivering it based on the physiological or pathological characteristics of tumors. In this review, we present various smart approaches for cancer therapy, including organic materials, inorganic components, and their composites, as well as biomembrane-based nanoencapsulation strategies. These nanoencapsulation strategies, along with practical applications and their potential in cancer treatment, are discussed in depth, highlighting advantages and disadvantages, as well as aiming to reveal the ultimate prospects of nanoencapsulation in enhancing drug delivery efficiency and targeted cancer therapy.</p>","PeriodicalId":12444,"journal":{"name":"Frontiers in Bioengineering and Biotechnology","volume":"13 ","pages":"1587178"},"PeriodicalIF":4.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12078215/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Engineering extracellular matrix-based hydrogels for intervertebral disc regeneration.","authors":"Mwafaq Kmail, Rusydi Razak, Isma Liza Mohd Isa","doi":"10.3389/fbioe.2025.1601154","DOIUrl":"https://doi.org/10.3389/fbioe.2025.1601154","url":null,"abstract":"<p><p>Lower back pain (LBP) is a major health concern, especially in older adults. A key aetiological factor is intervertebral disc (IVD) degeneration. It is mediated by dysregulation of extracellular matrix (ECM) and inflammation. In recent years, regenerative therapies have garnered attention for their potential to restore disc function by addressing the underlying biological alterations within the IVD. This review focuses on the comprehensive understanding of the anatomy and physiology of the IVD, highlighting its life cycle from embryonic development, and maturation to degenerative phenotype. We describe current treatments for managing LBP caused by IVD degeneration. This review emphasizes on the recent advancements in hydrogel engineering, highlighting natural, synthetic, and composite hydrogels and their application in ECM-targeted regenerative therapy for IVD degeneration. By exploring innovations in hydrogel technology, including improvements in crosslinking techniques and controlled degradation rates-we discuss how these materials could enhance IVD regeneration and potentially be used for the management of LBP. With their enhanced biomimicry, hydrogel-based ECM mimics offer a promising pathway for developing effective, durable therapies that address the root causes of disc degeneration, providing new hope for individuals living with chronic LBP.</p>","PeriodicalId":12444,"journal":{"name":"Frontiers in Bioengineering and Biotechnology","volume":"13 ","pages":"1601154"},"PeriodicalIF":4.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12078266/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Studying the effects of McRoberts and neonate-focused maneuvers on the neonatal brachial plexus during shoulder dystocia.","authors":"Joy A Iaconianni, Rania Bakhri, Bernard Gonik, Sriram Balasubramanian, Anita Singh","doi":"10.3389/fbioe.2025.1474154","DOIUrl":"https://doi.org/10.3389/fbioe.2025.1474154","url":null,"abstract":"<p><p>This study investigates the effects of clinical delivery maneuvers on neonatal brachial plexus (BP) during complicated birthing scenarios such as shoulder dystocia. Shoulder dystocia occurs when the anterior shoulder of the neonate is obstructed behind the maternal symphysis pubis and prevents the delivery of the neonate. Maneuvers such as McRoberts, application of suprapubic pressure (SPP), oblique positioning, and posterior arm delivery are performed sequentially to alleviate the obstruction. This study used MADYMO, a computer software program, to simulate these maneuvers during shoulder dystocia while maternal endogenous forces (82N and 129N) were applied. The recorded outcomes were the magnitude of neonatal BP stretch during delivery and the amount of clinician-applied traction (CAT) force, if required, to achieve delivery. The lithotomy position was treated as the baseline and compared to the McRoberts position, at 82N and 129N maternal forces. Additionally, in McRoberts position, at 82N and 129N maternal forces, neonate-focused maneuvers were applied, and the clinician applied traction (CAT) force, if required, to achieve delivery was recorded along with the resulting neonatal BP stretch. The simulations, at 82N maternal force, reported a decrease in required CAT force in the McRoberts position compared to the lithotomy position. The results of the neonate-focused maneuvers reported a further decrease in the CAT force and the resulting BP stretch. Furthermore, increasing SPP from 40N to 100N reported no required CAT force for delivery along with decreased BP stretch. Oblique positioning further decreased the BP stretch, and the posterior arm delivery of the neonate resulted in the least amount of BP stretch. No CAT forces were required during these maneuvers. The simulations, at 129N maternal force, reported similar trends of reduced BP stretch during delivery except no CAT forces were required during any simulated conditions. Findings from this study help understand the effects of McRoberts position and neonate-focused maneuvers on neonatal brachial plexus during complicated shoulder dystocia delivery. The reported required delivery forces, both maternal and CAT also lay the groundwork for clinician training and education while guiding the development of preventative approaches that can limit neonatal injuries.</p>","PeriodicalId":12444,"journal":{"name":"Frontiers in Bioengineering and Biotechnology","volume":"13 ","pages":"1474154"},"PeriodicalIF":4.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12078281/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond clinical scales: an observational study on instrumental gait analysis and biomechanical patterns in patients with Parkinson's disease.","authors":"Paolo De Pasquale, Mirjam Bonanno, Cristiano De Marchis, Luca Pergolizzi, Antonino Lombardo Facciale, Giuseppe Paladina, Maria Grazia Maggio, Federica Impellizzeri, Irene Ciancarelli, Angelo Quartarone, Rocco Salvatore Calabrò","doi":"10.3389/fbioe.2025.1541240","DOIUrl":"https://doi.org/10.3389/fbioe.2025.1541240","url":null,"abstract":"<p><strong>Introduction: </strong>Parkinson's disease (PD), a common neurodegenerative disorder affecting motor functions, is associated with abnormal gait patterns characterized by altered kinematic, kinetic, and electrophysiological parameters. This observational study aims to instrumentally identify and quantify these gait dysfunctions in PD patients compared to normal values from healthy subjects.</p><p><strong>Methods: </strong>Sixty-nine PD patients underwent clinical and instrumental evaluations to assess gait. Demographic and clinical data were collected before motor assessment. Clinical scales evaluated the level of impairment, gait, balance, risk of falls and ability to complete activities of daily living. Instrumental evaluations were conducted using optoelectronic, force plates and electromyographic (EMG) systems in a motion analysis laboratory. Statistical analysis involved a non-parametric test to compare pathological and normal data, clustering methods to identify groups based on clinical evaluations, and a combination of non-parametric analysis and linear models to assess dependencies on clinical scales.</p><p><strong>Results: </strong>The results showed that PD patients had significant gait kinematic differences compared to normal values, with increased temporal and shortened spatial parameters. In addition, PD patients were grouped into four clusters based on clinical scales. While some gait features were influenced by clinical scales reflecting impairment, gait and balance, and independence, others were more affected by the perceived fear of falling (FoF).</p><p><strong>Discussion: </strong>In conclusion, the study identified specific biomechanical gait dysfunctions in kinematic, kinetic, and electrophysiological parameters in PD patients, undetectable by standard clinical scales. Additionally, higher FoF was associated with dysfunctional biomechanical patterns, independent of impairment severity, gait and balance dysfunction, or overall independence.</p>","PeriodicalId":12444,"journal":{"name":"Frontiers in Bioengineering and Biotechnology","volume":"13 ","pages":"1541240"},"PeriodicalIF":4.3,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12075126/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144075929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intensification of 2'-Fucosyllactose biosynthesis pathway by using a novel fucosyltransferase from <i>Bacillus cereus</i>.","authors":"Kainuo Zhang, Miaomiao Gao, Chenqi Cao, Mengxin Zhang, Waqar Ahmad, Ahmed Rady, Badr Aldahmash, Tianze Zhu, Shahin Shah Khan, Luo Liu","doi":"10.3389/fbioe.2025.1569597","DOIUrl":"https://doi.org/10.3389/fbioe.2025.1569597","url":null,"abstract":"<p><strong>Introduction: </strong>2'-Fucosyllactose (2'-FL) is an oligosaccharide that can be synthesized in the human body and is known for its health-promoting and prebiotic effects. The biosynthesis of 2'-FL using microorganisms has received attention recently due to its increased application in nutritional and medical infant formulations.</p><p><strong>Methods: </strong>This work attempts the new application of <i>Bacillus cereus</i> α-1,2-fucosyltransferase (FutCB) in the <i>de novo</i> synthesis of 2'-FL in <i>Escherichia coli</i> (<i>E. coli</i>). Additionally, knocking out the <i>LacZ</i> and <i>WaaF</i> genes alongside overexpression of the key gmd, manB, wcaG, and manC genes enhances the availability of the necessary precursors GDP-L-fucose and lactose for the synthesis of 2'-FL.</p><p><strong>Results and discussion: </strong>The use of constitutive promoters achieved better control over the production of 2'-FL during fed-batch fermentation. After 64 h of fermentation, the modified <i>E. coli</i> strains produced 121.4 g/L 2'-FL with a yield of 1.90 g/L/h, resulting in an impressive 2'-FL output. These results together indicate the potential of large-scale, high-yield production of 2'-FL and form a basis of much more refinement to be done. The next step will focus on maximum substrate utilization, alteration of gene regulation, and improvement of commercial-scale synthesis.</p>","PeriodicalId":12444,"journal":{"name":"Frontiers in Bioengineering and Biotechnology","volume":"13 ","pages":"1569597"},"PeriodicalIF":4.3,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12075129/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of cell density variations on nanoparticle uptake across bioprinted A549 gradients.","authors":"Luigi Di Stolfo, Wang Sik Lee, Dimitri Vanhecke, Sandor Balog, Patricia Taladriz-Blanco, Alke Petri-Fink, Barbara Rothen-Rutishauser","doi":"10.3389/fbioe.2025.1584635","DOIUrl":"https://doi.org/10.3389/fbioe.2025.1584635","url":null,"abstract":"<p><strong>Introduction: </strong>The safe-by-design of engineered nanoparticles (NPs) for any application requires a detailed understanding of how the particles interact with single cells. Most studies are based on two-dimensional, uniformly dense cell cultures, which do not represent the diverse and inhomogeneous cell environments found <i>in situ</i>. <i>In-vitro</i> models that accurately represent tissue complexity, including realistic cell densities, are essential to increase the predictive accuracy of studies on cell-NP interactions. This study uses a bioprinted cell gradient model to examine the relation between cell density and NP uptake in one dish.</p><p><strong>Method: </strong>A549 lung epithelial cell density gradients within single inserts were produced with a bioprinter by modulating inter-droplet distances. After two days in culture, cells were exposed to Cy5-labeled silica NPs (SiO₂ NPs, ∼112 nm, 20 μg/mL) for up to 48 h. Confocal fluorescence microscopy and 3D image analysis were used to quantify NP uptake, cell surface area, and cell volume. The relationship between NP uptake and the other parameters was then investigated statistically.</p><p><strong>Results: </strong>Bioprinting enabled the creation of reproducible linear cell density gradients, allowing controlled modeling of density variations while preserving cell viability throughout the experiment. Increasing inter-droplet distances, from 0.1 mm to 0.6 mm, were used to achieve uniformly decreasing cell densities. SiO₂ NP uptake per cell was around 50% higher in low-density regions compared to high-density areas across all time points, i.e., 6, 24, and 48 h post-exposure. This inverse relationship correlated with greater average cell surface area in lower-density regions, while differences in the proliferation rates of the A549 cells at varying densities did not significantly impact uptake, did not significantly impact uptake.</p><p><strong>Conclusion: </strong>SiO₂ NP uptake is significantly enhanced at lower cell densities, mainly due to the increased available surface area, revealing potential cell-NP interaction differences in tissues that present cell density variability. Our drop-on-demand bioprinting gradient model successfully supports the implementation of cell density gradients in <i>in-vitro</i> models to increase their relevance as new approach methodologies (NAMs) for next-generation risk assessment strategies.</p>","PeriodicalId":12444,"journal":{"name":"Frontiers in Bioengineering and Biotechnology","volume":"13 ","pages":"1584635"},"PeriodicalIF":4.3,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12075422/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanotechnology in cancer treatment: revolutionizing strategies against drug resistance.","authors":"Shazia Sabir, Ali Salman Bin Thani, Qamar Abbas","doi":"10.3389/fbioe.2025.1548588","DOIUrl":"https://doi.org/10.3389/fbioe.2025.1548588","url":null,"abstract":"<p><p>A notable increase in cancer-related fatalities and morbidity worldwide is attributed to drug resistance. The factors contributing to drug resistance include drug efflux via ABC transporters, apoptosis evasion, epigenetic alterations, DNA repair mechanisms, and the tumor microenvironment, among others. Systemic toxicities and resistance associated with conventional cancer diagnostics and therapies have led to the development of alternative approaches, such as nanotechnology, to enhance diagnostic precision and improve therapeutic outcomes. Nanomaterial, including carbon nanotubes, dendrimers, polymeric micelles, and liposomes, have shown significant benefits in cancer diagnosis and treatment due to their unique physicochemical properties, such as biocompatibility, stability, enhanced permeability, retention characteristics, and targeted delivery. Building on these advantages, this review is conducted through comprehensive analysis of recent literature to explore the principal mechanisms of drug resistance, the potential of nanomaterials to revolutionize selective drug delivery and cancer treatment. Additionally, the strategies employed by nanomaterials to overcome drug resistance in tumors, such as efflux pump inhibition, multidrug loading, targeted delivery to the tumor microenvironment, and gene silencing therapies are discussed in detail. Furthermore, we examine the challenges associated with nanomaterials that limit their application and impede their transition to clinical use.</p>","PeriodicalId":12444,"journal":{"name":"Frontiers in Bioengineering and Biotechnology","volume":"13 ","pages":"1548588"},"PeriodicalIF":4.3,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12075138/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Superparamagnetic polyhemoglobin-tyrosinase nanocapsules: a novel biotherapeutic with enhanced tumor suppression with control by external magnetic field.","authors":"ChenHui Zhao, Thomas Ming Swi Chang","doi":"10.3389/fbioe.2025.1562145","DOIUrl":"https://doi.org/10.3389/fbioe.2025.1562145","url":null,"abstract":"<p><strong>Introduction: </strong>Our recent study shows nanobiotherepeutic Polyhemoglobin-Tyrosinase-Nanocapsules (PolyHb-Tyr-Nano) have strong anti-tumor abilities in multiple cancer lines. However, despite their tumor inhibitory potential, some internal tumor sites can be difficult to reach.</p><p><strong>Methods: </strong>In this paper, based on Chang's original finding that artificial cells containing magnetic material can be controlled by external magnetic fields, using nanoprecipitation methods, we modified this biotechnological nanotherapeutic with superparamagnetic properties, which shown to be attracted and guided by external magnets.</p><p><strong>Results: </strong>By fluorescence microscopy, we show that external magnetic field improved the local deposition of the nanorobotic superparamagnetic PolyHb-Tyr-nano at the tumor microenvironment (TME), significantly preventing their clearance, to stay at the tumor site despite repeated washings. This allowed time for them to enter the tumor cells to act intracellularly. In cell proliferation tests and tumor migration study, their tumor inhibitory action on the four cancer cell lines: Hepa 1-6 liver cancer line, A549 lung cancer line, HeLa cervical cancer line, and MCF7 breast cancer line are also retained effective, a low cell viability and tumor migration was observed. Furthermore, the addition of superparamagnetic property has enhanced the nanocapsules uptake and tumor inhibitory abilities, significantly improved their drug effect on tumor cells. Via cell viability test, PAL assay, oxidative stress detection, and mitochondria membrane potential studies, the PolyHb-Tyr-nano has shown improved tumor killing, by amino acid reduction, reactive oxygen species (ROS) generation, to mitochondria activity reduction in the presence of external magnetic fields.</p><p><strong>Discussion: </strong>Our results showed the efficacy of the nanorobotic superparamagnetic PolyHb-Tyr-nano on anti-tumor effect in multiple cancer lines. This novel nanobiotherapeutic has the potential for future cancer therapy, and can enhance drug localization, targeted delivery, and combination therapies.</p>","PeriodicalId":12444,"journal":{"name":"Frontiers in Bioengineering and Biotechnology","volume":"13 ","pages":"1562145"},"PeriodicalIF":4.3,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12075141/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An identification method of human joint interaction torque based on discrete EMG signals.","authors":"Liangchuang Liao, Ding Yan, Guoan Zhang","doi":"10.3389/fbioe.2025.1596180","DOIUrl":"10.3389/fbioe.2025.1596180","url":null,"abstract":"<p><strong>Introduction: </strong>The interactive joint torque serves as a critical biomechanical parameter for intent recognition in exoskeleton motion control systems, enabling adaptive control capabilities within the human-in-the-loop (HITL) closed-loop framework. While this interactive torque fundamentally differs from the actual output torque of joints, empirical studies have demonstrated a quantifiable linear correlation between these two metrics. Consequently, real-time monitoring of joint output torque provides actionable insights into human motion intention, serving as a critical feedback mechanism for intention-driven control strategies in lower-limb exoskeleton applications.</p><p><strong>Method: </strong>This paper proposes a method for extracting the interactive joint torque of the human body based on the collection of discrete electromyography (EMG) signals. In order to detect and analyze the interactive joint torque, based on the acquisition of human EMG signals, the human joint motion is discretized within a continuous range using a discrete prediction method. Then, the results of discrete learning are converted into a continuous form to establish a numerical relationship between human muscle movement and interactive joint torque.</p><p><strong>Result: </strong>This identification method has high accuracy under different motion states of the human body. The mean square error of all experiments is 0.1502, the mean coefficient of determination is 0.8616, and the mean coefficient of correlation is 0.9365.</p><p><strong>Discussion: </strong>A discrete prediction technology of human joint interaction torque based on EMG acquisition is established, which is helpful to deeply understand the relationship between muscle activity and joint motion, and provides a feasible method for extracting human joint torque.</p>","PeriodicalId":12444,"journal":{"name":"Frontiers in Bioengineering and Biotechnology","volume":"13 ","pages":"1596180"},"PeriodicalIF":4.3,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12070000/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143976362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between the performance of vertical jump and accelerative sprint in elite sprinters.","authors":"Junliang He, Ming Li, Qiuping Zhang, Zhiye Zhang","doi":"10.3389/fbioe.2025.1539197","DOIUrl":"10.3389/fbioe.2025.1539197","url":null,"abstract":"<p><strong>Objective: </strong>The purpose of this study is to investigate the relationship between components of the Sprint Profile during acceleration and kinematic and kinetic measures of the Counter Movement Jump (CMJ) and Squat Jump (SJ), to determine whether jump performance can monitor acceleration performance in sprinting.</p><p><strong>Methods: </strong>Eight elite sprinters offered to participate in the study (mean ± SD: age 21.43 ± 3.6 years; height 171.58 ± 7.76 cm; weight 54.71 ± 6.05 kg). The training age of athletes was 8.86 ± 4.30 years, which included SJ, CMJ, and accelerative sprint tests.</p><p><strong>Results: </strong>Significant negative correlations were found between propulsion time and braking time during sprint acceleration and CMJ metrics, including flight time, jump height, vertical take-off velocity, and push impulse (r = -0.598 to -0.721, <i>p</i> < 0.01). Similar associations were observed for SJ variables, though generally with slightly lower correlation strength. Ground contact time during sprinting was positively correlated with CMJ and SJ metrics (<i>p</i> < 0.05). Additionally, several sprint-phase kinetic variables-such as horizontal and vertical propulsion impulses-showed significant negative correlations with both CMJ and SJ outcomes. These findings suggest that specific jump performance measures, particularly from CMJ, may serve as effective monitor of acceleration sprint performance.</p><p><strong>Conclusion: </strong>This study confirms that key countermovement jump and squat jump metrics, especially jump height and flight time, are significantly associated with sprint acceleration in elite athletes. These findings support the use of jump tests as practical tools to monitor and enhance acceleration performance through targeted lower-limb power training.</p>","PeriodicalId":12444,"journal":{"name":"Frontiers in Bioengineering and Biotechnology","volume":"13 ","pages":"1539197"},"PeriodicalIF":4.3,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12070001/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143992110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}