Frontiers in Bioengineering and Biotechnology最新文献

{"title":"Choroidal thickness and peripapillary RNFL in relation to axial length and progression in myopic children.","authors":"Zixun Wang, Xiaoxue Hu, Xiaoling Zhang, Yuhang Wang, Zhiqing Li, Zheng Guo","doi":"10.3389/fbioe.2026.1777062","DOIUrl":"https://doi.org/10.3389/fbioe.2026.1777062","url":null,"abstract":"<p><strong>Background: </strong>Axial length (AL) elongation is a key structural hallmark of myopia progression in children. Identifying early ocular structural characteristics associated with AL growth may help improve risk stratification, although robust predictive models remain limited.</p><p><strong>Purpose: </strong>To explore cross-sectional associations between baseline ocular structural parameters and AL, and to preliminarily evaluate the predictive potential of these parameters for rapid AL progression in myopic children.</p><p><strong>Methods: </strong>A total of 463 myopic children were retrospectively followed for 1 year. Baseline assessments included cycloplegic refraction, ocular biometry, and optical coherence tomography (OCT)-derived measurements of choroidal thickness (ChT) and retinal nerve fiber layer (RNFL). Rapid AL progression was defined as an AL increase of >0.2 mm over 1 year. Cross-sectional correlations between baseline AL, ChT, and RNFL parameters were analyzed. Least absolute shrinkage and selection operator (Lasso) regression with 10-fold cross-validation was used for feature selection, followed by the development and validation of a logistic regression model. Model performance was assessed using the area under the receiver operating characteristic curve (AUC), calibration analysis, and decision curve analysis (DCA).</p><p><strong>Results: </strong>At baseline, AL showed significant cross-sectional associations with ChT and multiple RNFL parameters, with the strongest correlations observed for ChT and nasal-inferior RNFL thickness (RNFL[NI]). Lasso regression retained age, baseline AL, ChT, and RNFL[NI] as candidate predictors of rapid AL progression. In the validation set, the final model demonstrated modest discriminative performance (AUC = 0.703, 95% CI: 0.598-0.801) with acceptable calibration. Decision curve analysis indicated limited but consistent net clinical benefit across a range of threshold probabilities.</p><p><strong>Conclusion: </strong>This study provides exploratory evidence that posterior segment structural parameters are associated with AL and may be useful for predicting subsequent AL progression in myopic children. Although the model's predictive performance was modest, the findings support the hypothesis that OCT-derived biomarkers could contribute to future risk-stratification strategies, warranting further validation and refinement.</p>","PeriodicalId":12444,"journal":{"name":"Frontiers in Bioengineering and Biotechnology","volume":"14 ","pages":"1777062"},"PeriodicalIF":4.8,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13143951/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147835879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The light at the other end of the tunnel: heeding two decades of regeneration research to reclaim natural tooth preservation.","authors":"Samer H Zaky, Rania El Backly","doi":"10.3389/fbioe.2026.1810083","DOIUrl":"https://doi.org/10.3389/fbioe.2026.1810083","url":null,"abstract":"<p><p>Despite advancements in biomimetic and regenerative dentistry, contemporary prosthetic restorations, though clinically successful, remain fundamentally imperfect replications of the natural tooth's inherent biological perfection. Crucially, while these advancements remain vital, the dental discipline has increasingly shifted from preventive focus to a reparative focus. Given that dental decay-the primary concern in a dental practice-is a highly predictable and preventable condition and that tooth loss is a largely avoidable outcome, we propose that the future of the discipline lies in transitioning focus from substitution of lost or damaged tooth parts to the preservation of what is hitherto biologically irreplaceable. Reviewing current dental practice and research, this perspective article challenges the dental community to maximize tooth longevity by acknowledging that in dentistry-more than any other medical discipline-prevention remains the cure. Our challenge invokes the 'paradox of knowledge'-where expanded understanding unveils deeper unknown-to bring to the fore that the more we uncover the intricacies of the dental bioarchitecture, the clearer it becomes that preservation of the invaluable and irreproducible natural tooth structure, rather than its repair, is the achievable path forward. This realization warrants a paradigm \"U-turn\" towards the light at the starting end of the reparative tunnel. We contend that a successful shift from tooth replacement or regeneration to tooth preservation is twofold: it requires a mindful appraisal of contemporary scientific knowledge concerning the tooth mechano-biology as an unparalleled organ in the body, as well as a fundamental reexamination of the values of a profession existing to alleviate people's suffering.</p>","PeriodicalId":12444,"journal":{"name":"Frontiers in Bioengineering and Biotechnology","volume":"14 ","pages":"1810083"},"PeriodicalIF":4.8,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13147158/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147835891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hemodynamic factors of aortic dilatation after thoracic endovascular aortic repair for type-B aortic dissection.","authors":"Qian-Hui Tang, Zhen Long, Ping Dai, Han Yang, Zhong Qin, Xuan-An Su, Yu-Lin Wang, Xing-Ning Mao, Jing Chen, Hai-Ying Zhang, Xiao Qin","doi":"10.3389/fbioe.2026.1780047","DOIUrl":"https://doi.org/10.3389/fbioe.2026.1780047","url":null,"abstract":"<p><strong>Objective: </strong>We aimed to investigate the hemodynamic factors associated with aortic dilatation following thoracic endovascular aortic repair (TEVAR) for type-B aortic dissection (TBAD).</p><p><strong>Methods: </strong>This retrospective study enrolled patients who developed aortic dilatation following TEVAR for TBAD, patients who did not develop aortic dilatation following TEVAR for TBAD, and healthy control subjects. Computed tomography angiography (CTA) images for the dilatation group were acquired at three time points: pre-TEVAR (Group A), 1-week post-TEVAR (Group B), and the most recent follow-up (Group C). For the non-dilatation group, CTA images were acquired pre-TEVAR (Group D) and 1 week post-TEVAR (Group E). The control group underwent a single CTA examination (Group F). Three-dimensional (3D) models were reconstructed from CTA images, and computational fluid dynamics (CFD) simulations were performed. The oscillatory shear index (OSI) at the ostia of the major arterial branches was defined as the primary CFD endpoint.</p><p><strong>Results: </strong>In the dilatation group, the pressures at the ostia of the brachiocephalic trunk, left common carotid artery, left subclavian artery, celiac trunk, superior mesenteric artery, bilateral renal arteries, inferior mesenteric artery, and bilateral common iliac arteries were lower in Group B than in Groups A and C. In the non-dilatation group, the pressures at the ostia of the brachiocephalic trunk, left common carotid artery, left subclavian artery, celiac trunk, superior mesenteric artery, left renal artery, inferior mesenteric artery, and right common iliac artery were higher in Group E than in Group D. The false lumen in Group B exhibited a larger region of high OSI compared with that in Group E.</p><p><strong>Conclusion: </strong>Elevated OSI in the false lumen is associated with a greater tendency toward aortic dilatation following TEVAR for TBAD. Patients with reduced true lumen pressure in the early post-TEVAR period show a corresponding trend toward subsequent aortic dilatation.</p>","PeriodicalId":12444,"journal":{"name":"Frontiers in Bioengineering and Biotechnology","volume":"14 ","pages":"1780047"},"PeriodicalIF":4.8,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13143993/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147835901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uncovering the mechanisms of homologous point acupuncture on knee osteoarthritis through an integrated study of metabolomics and proteomics.","authors":"Wu Liu, Min Tang, Qi Zhang, Zhaoduan Hu, Rui Peng, Mi Huang","doi":"10.3389/fbioe.2026.1791109","DOIUrl":"https://doi.org/10.3389/fbioe.2026.1791109","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;The incidence and prevalence of knee osteoarthritis (KOA) are on the rise, with the intricate etiology and pathogenesis of the disease posing significant challenges to global health. Although acupuncture has significant promise in modulating the body's metabolism and inflammatory reactions, the efficacy of various acupuncture methods for treating KOA remains uncertain. In this research, we evaluated the efficacy of homologous point acupuncture compared to conventional acupuncture for KOA and investigated the potential therapeutic mechanisms of homologous point acupuncture through a rat model.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Rat models of KOA were established by intra-articular injection of monosodium iodoacetate. The successfully modeled rats were allocated into three groups: KOA group (model group, injected with MIA), conventional acupuncture group (AP), and homologous point acupuncture group (HAP). Additionally, healthy rats were designated as a normal control group (Control), with ten rats in each group. Following 4 weeks of consecutive acupuncture treatment, joint swelling and Lequesne MG scores were assessed in each group of rats. Subsequently, blood samples were obtained from the abdominal aorta to assess the expression levels of IL-6, IL-1β, TNF-α, and LDH. Integrated metabolomics and proteomics reveal the mechanism of homologous point acupuncture in KOA rats. Validation of these mechanisms included staining with hematoxylin and eosin, ELISA, biochemical kit, and Western blotting.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Behavioral assessments revealed that, compared to the control group, Lequesne MG scores and degree of joint swelling were significantly increased in the KOA group, whereas both AP and HAP treatment significantly decreased these parameters. Histopathological examination indicates that the cartilage layer in KOA rat models exhibits thinning, irregular surface texture, and indistinct tidemark. In contrast to the KOA group, both AP and HAP exhibited reduced articular cartilage surface irregularity and mitigated cartilage degeneration, and a notable decrease in the levels of IL-6, IL-1β, TNF-α, and LDH in the rat serum following treatment. Further analysis through metabolomics and proteomics reveal that HAP exerts its therapeutic effects by modulating pathways associated with immunity and metabolism, with specific emphasis on Arachidonic acid metabolism and glycolytic processes. Western blot analysis demonstrated that HAP decreased the expression levels of proteins involved in glycolysis, NLRP3 inflammasome activation, and autophagy and apoptosis, and increased the levels of proteins that promote autophagy and prevent apoptosis.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;HAP significantly reduced pain-related responses and joint swelling in KOA rats. Specifically, HAP manifests inhibitory effects on inflammatory response in KOA and alleviates knee joint damage in a rat model. These effects are associated with the","PeriodicalId":12444,"journal":{"name":"Frontiers in Bioengineering and Biotechnology","volume":"14 ","pages":"1791109"},"PeriodicalIF":4.8,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13147163/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147835353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metal nanozyme sensors with different modes: biomedical applications and research advances.","authors":"Banghui Wang, Tianyi Zhang, Meiling Zhao, Weiwei Song, Maojin Tian","doi":"10.3389/fbioe.2026.1795569","DOIUrl":"https://doi.org/10.3389/fbioe.2026.1795569","url":null,"abstract":"<p><p>In recent years, with the continuous advancement of nanotechnology, nanozymes have demonstrated tremendous potential in biomedical applications. By mimicking the catalytic activities of biological enzymes such as oxidases, peroxidases, and superoxide dismutases, nanozymes can be employed to detect various analytes, enabling their application in sensors. In the research of nanozymes, owing to their unique electronic structures and abundant surface active sites, endow metal nanozymes with both tunable high activity and strong stability. They can not only efficiently mimic the catalytic functions of various natural enzymes such as peroxidases, oxidases, and superoxide dismutases, but some types also exhibit high catalytic efficiency, even surpassing the natural enzymes themselves. This ability to mimic enzymatic activity endows nanozymes with distinctive properties. Signal conversion modes for metal nanozymes encompass multiple forms, including colorimetric, electrochemical, Surface-Enhanced Raman Scattering, and fluorescent detection. Herein, this review categorizes metal nanozyme sensors with different sensing modes into three major types: single-mode, dual-mode, and multi-mode. It summarizes the application potential of various sensor modes in scenarios such as biomarker detection, pathogen screening, and disease diagnosis, while analyzing current challenges including catalytic specificity and mode-to-mode synergy. Furthermore, this review explores the core challenges confronting metal nanozyme sensors and outlines future development directions, providing insights for the research and development of novel sensing technologies and their biomedical applications.</p>","PeriodicalId":12444,"journal":{"name":"Frontiers in Bioengineering and Biotechnology","volume":"14 ","pages":"1795569"},"PeriodicalIF":4.8,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13144114/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147835877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the efficacy of different lung biopsy modalities in solitary pulmonary nodules.","authors":"Wei Zhao, Chen Liu, Yajie Hu, Yanhong Du, Yunhui Zhang","doi":"10.3389/fbioe.2026.1743070","DOIUrl":"https://doi.org/10.3389/fbioe.2026.1743070","url":null,"abstract":"<p><strong>Introduction: </strong>This study compared the diagnostic performance and safety of computed tomography (CT)-guided percutaneous transthoracic needle biopsy (PTNB) and virtual bronchoscopic navigation (VBN)-guided transbronchial lung biopsy (TBLB) in patients with solitary pulmonary nodules (SPNs).</p><p><strong>Methods: </strong>A retrospective analysis was conducted on 204 SPN patients, divided into CT-guided (n = 102) and VBN-guided (n = 102) groups. Parameters, including diagnostic yield, procedure time, and complication rates, were compared between the two methods.</p><p><strong>Results: </strong>After applying rigorous diagnostic criteria per ATS/ACCP guidelines, the overall diagnostic yield was higher in the VBN group (64.7%, 66/102) than in the CT group (59.8%, 61/102), though the difference was not statistically significant (P = 0.472). In exploratory subgroup analyses, VBN demonstrated higher diagnostic yield for smaller nodules (8-20 mm) and those located closer to the pleura (2-3 cm) (both P < 0.05). For larger nodules (20-30 mm) or those further from the pleura (3-5 cm), diagnostic rates were comparable between groups. The VBN group had significantly shorter procedure times, including lesion localization (6.62 ± 0.93 vs. 9.27 ± 1.05 min) and total procedure duration (22.04 ± 2.36 vs. 38.16 ± 4.29 min) (P < 0.01). The complication rate was significantly lower in the VBN group (9.80% vs. 29.41%, P < 0.01), with the CT group showing higher incidences of pneumothorax, hemoptysis, and chest pain in nodules 2-3 cm from the pleura. Multivariate analysis identified several factors significantly associated with diagnostic outcomes. Additionally, the VBN group incurred lower medical costs and shorter hospital stays (P < 0.01).</p><p><strong>Conclusion: </strong>VBN-guided biopsy was associated with higher diagnostic yield, fewer complications, shorter procedure times, and lower costs compared to CT-guided biopsy. These findings warrant confirmation in prospective randomized trials.</p>","PeriodicalId":12444,"journal":{"name":"Frontiers in Bioengineering and Biotechnology","volume":"14 ","pages":"1743070"},"PeriodicalIF":4.8,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13144010/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147835936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Finite element analysis of long proximal femoral bionic nail (PFBN) fixation for femoral shaft fractures combined with ipsilateral femoral neck fractures.","authors":"Zixi Fan, Kai Ding, Wei Liu, Biyou Luo, Tailong Shi, Yuqin Zhang, Qi Zhang, Wei Chen","doi":"10.3389/fbioe.2026.1799331","DOIUrl":"https://doi.org/10.3389/fbioe.2026.1799331","url":null,"abstract":"<p><strong>Objective: </strong>Femoral reconstruction nails (RN) and three cannulated screws combined with a plate (TCP) are commonly employed for the treatment of ipsilateral femoral neck and shaft fractures (IFNSF). However, these fixation strategies are associated with a considerable incidence of postoperative complications, reflecting the biomechanical challenges of this fracture pattern. Therefore, this study aims to compare the biomechanical performance of a novel long proximal femoral bionic nail (PFBN) with these conventional fixation methods for the treatment of this complex fracture pattern.</p><p><strong>Methods: </strong>Computed tomography (CT) data of the femur were obtained from a healthy adult male volunteer to reconstruct a three-dimensional femoral model using Mimics 21.0 and Geomagic Studio 2013. A combined femoral shaft and ipsilateral femoral neck fracture model was then established in UG 12.0. Three internal fixation constructs-the long PFBN, RN, and TCP-were designed and assembled to simulate surgical fixation. Finite element analysis was subsequently performed using Abaqus 2022 to evaluate stress distribution and displacement characteristics among the three fixation constructs.</p><p><strong>Results: </strong>Under the three loading conditions, the long PFBN exhibited lower or comparable stress and displacement within the fixation constructs. Compared with the TCP construct, the long PFBN showed a more uniform stress distribution. In most loading scenarios, its mechanical performance was comparable to, or slightly better than, that of the RN construct. Analysis of fracture-site micromotion indicated that tangential micromotion at the femoral neck fracture interface in the long PFBN construct was intermediate between that of the RN and TCP constructs.</p><p><strong>Conclusion: </strong>In this finite element analysis, the long PFBN demonstrated relatively favorable biomechanical performance under axial, bending, and torsional loading conditions. These findings may provide preliminary biomechanical insights into the comparative performance of different fixation strategies for this complex fracture pattern.</p>","PeriodicalId":12444,"journal":{"name":"Frontiers in Bioengineering and Biotechnology","volume":"14 ","pages":"1799331"},"PeriodicalIF":4.8,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13147159/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147835939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The vertebro-subclavian artery angle modulates hemodynamic mechanisms of atherosclerosis in vertebral artery origin: a combined clinical and computational fluid dynamics study.","authors":"Ligang Chen, Bin Hou, Chuangzhong Li, Yuan Cao, Xiaogang Wang, Guobiao Liang","doi":"10.3389/fbioe.2026.1775214","DOIUrl":"https://doi.org/10.3389/fbioe.2026.1775214","url":null,"abstract":"<p><strong>Objective: </strong>By dictating local hemodynamics, vascular geometry played a critical role in atherosclerosis (AS). The objective of this research was to clarify how the vertebro-subclavian artery (VA-SCA) angle affected local blood flow patterns in the pathophysiology of AS at the vertebral artery origin (VAO).</p><p><strong>Methods: </strong>This research integrated clinical retrospective analysis with computational fluid dynamics (CFD) simulation. The clinical component examined 364 VAs and classified them into Plaque/Stenosis-free and Plaque/Stenosis groups based on DSA images. Baseline data and morphological parameters (VAO length, tortuosity, VA-SCA angles, and lateralisation) were analysed and compared between the two groups. For the CFD component, idealised geometric models with variable VA-SCA angles were established, and a comprehensive investigation was conducted to elucidate the effects of angle variations on the medial and lateral walls of the VAO region with respect to time-averaged wall shear stress (TAWSS), oscillatory shear index (OSI), and hemodynamic flow field characteristics. Furthermore, these hemodynamic trends derived from parametric modelling have been validated by patient-specific data.</p><p><strong>Results: </strong>In this retrospective clinical study, multivariate regression analysis revealed that a larger VA-SCA angle (<i>OR</i> = 1.84, <i>95% CI</i>: 1.46-2.33, <i>P</i> < 0.001) and severe curvature (<i>OR</i> = 2.35, <i>95% CI:</i> 1.21-4.56, <i>P</i> = 0.011) were independent risk factors for AS at the VAO. CFD simulations indicated that across all angle configurations, the lateral VAO wall consistently showed lower TAWSS and higher OSI than the medial wall, with vortex formation observed in all models. With an increase in the VA-SCA angle, the lateral wall TAWSS initially decreased before increasing again, attaining its minimum at 50°, whereas the OSI displayed an opposite trend, peaking at 70°. Analysis of patient-specific data further confirmed that, as the VA-SCA angle increases, TAWSS initially decreases, then increases. At the same time, OSI shows an initial increase followed by a decline.</p><p><strong>Conclusion: </strong>The VA-SCA angle may influence the pathogenesis of AS at the VAO through hemodynamic factors and could serve as a new imaging biomarker to assess hemodynamics in this context.</p>","PeriodicalId":12444,"journal":{"name":"Frontiers in Bioengineering and Biotechnology","volume":"14 ","pages":"1775214"},"PeriodicalIF":4.8,"publicationDate":"2026-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13139123/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147835849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of digital image correlation to study the activity and functional heterogeneity of the human temporalis muscle <i>in vivo</i> during unilateral chewing: a preliminary study.","authors":"Przemysław Stróżyk","doi":"10.3389/fbioe.2026.1767695","DOIUrl":"https://doi.org/10.3389/fbioe.2026.1767695","url":null,"abstract":"<p><strong>Introduction: </strong>This study aimed to demonstrate the usefulness of digital image correlation (DIC) for analysing the activity and heterogeneity of the temporalis muscle based on its displacements. While the standard measure for superficial muscles traditionally relies on muscle force determined via electrical biopotentials and numerical simulations, this paper presents results indicating that a kinematic parameter (muscle displacement) can effectively assess muscle function.</p><p><strong>Methods: </strong>The temporalis muscle was selected as the primary object of investigation, with <i>in vivo</i> measurements taken on both the working and non-working sides during unilateral chewing of three selected foods. The study group consisted of 8 healthy adult males aged 36.6 ± 9.4 years (BMI: 24.7 ± 0.8 kg/m²). A Dantec Q400 non-contact measurement system based on DIC was utilised. Reference images were captured at the mandible's physiological resting position. The technique enabled continuous full-field mapping across the skin surface, while the final analysis was precisely confined to the area corresponding to the muscle fibres.</p><p><strong>Results and discussion: </strong>The study demonstrated that the temporalis muscle's functioning is complex and structurally heterogeneous. Specifically, the analysis revealed two distinct kinematic patterns: an asymmetric cycle (AC) in the anterior and middle parts responsible for force generation, and a fluctuating cycle (FC) in the posterior part serving as a dynamic stabiliser for the temporomandibular joint (TMJ). Furthermore, muscle kinematics were significantly modulated by both the chewing side and food texture. Spatial activation patterns suggest a task-specific biomechanical strategy, where the working side presses the mandible, while the non-working side stabilises it against excessive rotation. Ultimately, the results confirm that skin surface displacement can serve as a reliable, high-resolution measure of temporalis muscle activity.</p>","PeriodicalId":12444,"journal":{"name":"Frontiers in Bioengineering and Biotechnology","volume":"14 ","pages":"1767695"},"PeriodicalIF":4.8,"publicationDate":"2026-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13139331/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147835913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical efficacy of guided tissue regeneration combined with orthodontic treatment on periodontitis.","authors":"Fengjuan Wang, Feng Yang, Chun Yao, Yanxiao Du","doi":"10.3389/fbioe.2026.1803582","DOIUrl":"https://doi.org/10.3389/fbioe.2026.1803582","url":null,"abstract":"<p><strong>Background: </strong>Periodontitis is a common chronic inflammatory disorder caused by bacterial plaque. Our study aims to evaluate the clinical efficacy of guided tissue regeneration with orthodontic treatment (GTRO) in patients with periodontitis.</p><p><strong>Methods: </strong>Propensity score matching was performed based on gender, age, periodontitis duration, dental malformation, sulcus bleeding index, and gingival index. Clinical efficacy, gingival index (GI), sulcus bleeding index (SBI), probing depth (PD), clinical attachment loss (CAL), and depth of bone defect were assessed 6 months post-treatment. The NLR family pyrin domain containing 3 (NLRP3), IL-1β, and IL-18 levels in gingival crevicular fluid (GCF) were determined using ELISA.</p><p><strong>Results: </strong>A total of 131 patients were included in the final analysis, including 64 in the GTR group and 67 in the GTRO group. The GTRO group demonstrated better outcomes, including higher recovery and total efficacy rates. Post-treatment, the GTRO group exhibited greater improvements in GI and SBI, PD, CAL, and depth of bone defect than the GTR group. Levels of NLRP3, IL-1β, and IL-18 in GCF significantly decreased in both groups, with more pronounced reductions observed in the GTRO group.</p><p><strong>Conclusion: </strong>GTRO improved clinical and anti-inflammatory outcomes and was associated with better periodontal health and bone defect repair than GTR alone at 6 months.</p>","PeriodicalId":12444,"journal":{"name":"Frontiers in Bioengineering and Biotechnology","volume":"14 ","pages":"1803582"},"PeriodicalIF":4.8,"publicationDate":"2026-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13139106/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147835911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}