Frontiers in Bioengineering and Biotechnology最新文献

{"title":"Rapid neuralized and vascularized osteogenesis in infected bone defect using biomimetic biomineralized and antibacterial hydrogels.","authors":"Yuhao Deng, Song Chen, Maimaitiaili Tuerxun, Xuekang Xiong, Jianfei Tang","doi":"10.3389/fbioe.2025.1611639","DOIUrl":"10.3389/fbioe.2025.1611639","url":null,"abstract":"<p><p>Infected bone defects represent one of the most prevalent clinical conditions, affecting millions of patients annually. The local infection and necrosis associated with these defects exacerbate the injury, prolong healing times, and result in significant localized pain, presenting a substantial challenge for clinical repair. In this study, we developed a biomimetic mineralized and antibacterial imCOL1MA hydrogel by employing methacrylated COL1, composite native bone inorganic salts (CNBIS), and Magainin II-PLGA microspheres (mMicrospheres), which was further loaded with bone marrow stem cells (BMSCs) to form osteogenic engineered bone for infected bone defects repair. Briefly, we first optimized the concentration of COL1MA for BMSCs survival, then adjusted proportion of CNBIS to create an appropriate osteoinductive microenvironment, and encapsulated Magainin II in poly (lactic-co-glycolic acid) (PLGA) microsphere for long-term antimicrobial function. Consequently, the promising mineralized and antibacterial imCOL1MA was prepared using 10% COL1MA, 2% CNBIS, and 1% mMicrospheres. The imCOL1MA scaffold served as significant antimicrobial efficacy, excellent biodegradability, good biocompatibility, and osteoinductive microenvironment. As a result, the engineered bone could achieve rapid (only 4 weeks) vascularized and neuralized bone regeneration in a rabbit model of infected bone defects.</p>","PeriodicalId":12444,"journal":{"name":"Frontiers in Bioengineering and Biotechnology","volume":"13 ","pages":"1611639"},"PeriodicalIF":4.3,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12134066/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144224880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Flexible wearable biosensors from poly (ionic liquid) for real-time signal monitoring.","authors":"Yao Liu, Siyu Han, Panpan Gu, Bai Wang, Shiyan Tian, Xiaoxu Xu, Chunmei Yang, Shujun Liu, Jianshe Hu","doi":"10.3389/fbioe.2025.1610197","DOIUrl":"10.3389/fbioe.2025.1610197","url":null,"abstract":"<p><strong>Introduction: </strong>Modern wearable electronics demand materials that are simultaneously stretchable, conductive, and environmentally robust. Hydrogels meet some of these requirements but dehydrate or freeze easily. To overcome these limitations, we prepared a poly-ionic-liquid (PIL) ionogel that integrates high elasticity with stable ionic conductivity, aiming to enable reliable, skin-compatible strain and biopotential sensing.</p><p><strong>Methods: </strong>1-Vinyl-3-butyl-imidazolium hexafluorophosphate and 1-butyl-3-methyl-imidazolium hexafluorophosphate were mixed at optimized mass ratios, followed by N,N'-methylenebis-acrylamide (cross-linker) and Irgacure-2959 (photoinitiator). The homogeneous precursor was UV-cured for 6 min to obtain a PIL ionogel (PIL-1 - PIL-4 series). Structural, thermal, mechanical, rheological, adhesive, and electrical characteristics were analysed by FT-IR, SEM, TGA/DSC, uniaxial tensile testing, rheometry, 90° peel tests, and real-time resistance measurements. Applications were evaluated by attaching the gel to human joints and by recording EMG/ECG signals.</p><p><strong>Results: </strong>The UV one-step process yielded a dense multi-cross-linked network that combined covalent and ionic interactions. The optimised sample (PIL-2) showed a fracture stress of ∼390 kPa with 320% elongation, sustaining a 500 g load without failure. It retained mass and softness after 30 days and adhered strongly (up to 90° peel strength >4 N) to glass, metals, and skin-even underwater. Electrical tests gave a gauge factor of 1.94 (0-100%), 3.98 (100-200%), and 4.04 (200-320%), with 400 ms response and 500 ms recovery. The gel monitored finger (30°/90°), wrist, and elbow motions reproducibly, functioned as a bioelectrode capturing stable EMG/ECG with clear PQRST waves, and reliably transmitted Morse code via hand gestures.</p><p><strong>Discussion: </strong>The solvent-free PIL ionogel couples mechanical toughness, wide-range elasticity, and stable ionic pathways, outperforming water-rich hydrogels in thermal/long-term stability. Its strong, humidity-tolerant adhesion eliminates extra fixatives, while rapid, high-gain strain transduction and low-impedance skin contact enable multimodal biosensing. These attributes position the material for next-generation flexible electronics, real-time health monitoring, and gesture-based human-machine interfaces.</p>","PeriodicalId":12444,"journal":{"name":"Frontiers in Bioengineering and Biotechnology","volume":"13 ","pages":"1610197"},"PeriodicalIF":4.3,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12133815/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144224866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioinspired piezoelectric patch design for sonodynamic therapy: a preclinical mechanistic evaluation of rotator cuff repair and functional regeneration.","authors":"Rui Shi, Fei Liu, Qihuang Qin, Pinxue Li, Ziqi Huo, You Zhou, Chunyan Jiang","doi":"10.3389/fbioe.2025.1565347","DOIUrl":"10.3389/fbioe.2025.1565347","url":null,"abstract":"<p><strong>Indroduction: </strong>The rotator cuff tendon-bone interface exhibits a gradient histological composition, including graded mineral content and interwoven collagen fibers. Following rotator cuff injury repair, the lack of a compositional, structural, and functional gradient at the interface results in stress concentration and a high rate of postoperative re-tears. Piezoelectric materials, known for modulating cellular functions and promoting stem cell proliferation and differentiation, have garnered increasing attention in tissue repair applications.</p><p><strong>Methods: </strong>In this study, a biomimetic piezoelectric patch with progressive compositional and structural variations was designed and fabricated. The patch, composed of gelatin/PLGA/nHA/BTO, integrates aligned and random fiber structures. The aligned layer mimics the tendon-side structure of the rotator cuff tendon-bone interface, while the random layer replicates the bone-side structure.</p><p><strong>Results: </strong>The bioinspired patch exhibits excellent biocompatibility. The piezoelectric signals generated under ultrasound stimulation can induce osteogenic and tenogenic differentiation of stem cells, as well as regulate M2 polarization of macrophages, thereby promoting the repair and regeneration of supraspinatus tendon injury in a rabbit model of rotator cuff injury.</p><p><strong>Discussion: </strong>This study highlights the potential of biomimetic piezoelectric patches in orthopedic rotator cuff repair and offers new possibilities for developing advanced materials to regenerate the rotator cuff tendon-bone interface.</p>","PeriodicalId":12444,"journal":{"name":"Frontiers in Bioengineering and Biotechnology","volume":"13 ","pages":"1565347"},"PeriodicalIF":4.3,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12133869/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144224864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel nail-plate construct for the treatment of AO/OTA 31-A3.3 intertrochanteric fractures: a finite element analysis.","authors":"Jixing Fan, Yuan Cao, Zengzhen Cui, Shan Gao, Yang Lv, Fang Zhou","doi":"10.3389/fbioe.2025.1559765","DOIUrl":"10.3389/fbioe.2025.1559765","url":null,"abstract":"<p><strong>Background: </strong>The AO/OTA 31-A3.3 is the most unstable type with a lesser trochanteric fragment and a broken lateral femoral wall (LFW), which constitute a four-part unstable intertrochanteric fracture. Implant failure remains one of the catastrophic consequences after surgical treatment. A novel nail-plate construct, called proximal femoral universal nail system (PFUN), is proposed by our team to fix comminuted LFW fracture fragment and lesser trochanteric fragment. The aim of this study is to evaluate the biomechanical properties of PFUN compared with proximal femoral nails anti-rotation (PFNA) for the treatment of AO/OTA 31-A3.3 intertrochanteric fractures.</p><p><strong>Methods: </strong>An AO/OTA 31-A3.3 intertrochanteric fracture model was established by computed tomography images. The models of implant (PFUN and PFNA) were created and virtually inserted into the A3.3 fracture model. The von Mises stress on the proximal femur, fracture end, implant and the total displacement of the device components were evaluated and compared for both PFUN and PFNA models.</p><p><strong>Results: </strong>The maximum von Mises stress in the proximal femur of the PFNA model increased by 85.81% when compared with the PFUN model in A 3.3 intertrochanteric fractures. The peak von Mises stress was located at the medial-inferior part of the fracture ends in the PFUN and PFNA models and the maximum von Mises stress in the PFUN model and PFNA model was 27.27 MPa and 49.95MPa, respectively. The PFUN model and PFNA model had similar peak von Mises stress in the implant. Furthermore, the maximum displacement in the PFUN model was much smaller than that in the PFNA model.</p><p><strong>Conclusion: </strong>The PFUN exhibited a lower peak von Mises stress in the proximal femur and fracture end, and a smaller maximum model displacement than PFNA in A3.3 intertrochanteric fractures. Our findings might provide valuable references for clinical decision making in surgical treatment of complex intertrochanteric fractures.</p>","PeriodicalId":12444,"journal":{"name":"Frontiers in Bioengineering and Biotechnology","volume":"13 ","pages":"1559765"},"PeriodicalIF":4.3,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12133827/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144224863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum: Advanced surface modification techniques for titanium implants: a review of osteogenic and antibacterial strategies.","authors":"Handong Zhang, Zidong Wu, Zemin Wang, Xinfeng Yan, Xudong Duan, Huaqiang Sun","doi":"10.3389/fbioe.2025.1629360","DOIUrl":"https://doi.org/10.3389/fbioe.2025.1629360","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.3389/fbioe.2025.1549439.].</p>","PeriodicalId":12444,"journal":{"name":"Frontiers in Bioengineering and Biotechnology","volume":"13 ","pages":"1629360"},"PeriodicalIF":4.3,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12130630/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144215417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bottom-up Biomaterial strategies for creating tailored stem cells in regenerative medicine.","authors":"Brenda Cruz-Gonzalez, Ellie Johandes, Dominique Gramm, Donny Hanjaya-Putra","doi":"10.3389/fbioe.2025.1581292","DOIUrl":"10.3389/fbioe.2025.1581292","url":null,"abstract":"<p><p>Biomaterial-assisted stem cell therapies hold immense promise for regenerative medicine, yet clinical translation remains challenging. This review focuses on recent advances and persistent limitations in applying induced pluripotent stem cells (iPSCs), endothelial colony-forming cells (ECFCs), multipotent mesenchymal stromal cells (MSCs), and embryonic stem cells (ESCs) within engineered microenvironments. We introduce a novel \"bottom-up\" approach to biomaterial design. This approach focuses first on understanding the fundamental biological properties and microenvironmental needs of stem cells, then engineering cell-instructive biomaterials to support them. Unlike conventional methods that adapt cells to pre-existing materials, this strategy prioritizes designing biomaterials from the molecular level upward to address key challenges, including differentiation variability, incomplete matching of iPSCs to somatic counterparts, functional maturity of derived cells, and survival of ECFCs/MSCs in therapeutic niches. By replicating lineage-specific mechanical, chemical, and spatial cues, these tailored biomaterials enhance differentiation fidelity, reprogramming efficiency, and functional integration. This paradigm shift from passive scaffolds to dynamic, cell-instructive platforms bridges critical gaps between laboratory success and clinical translation, offering a transformative roadmap for regenerative medicine and tissue engineering.</p>","PeriodicalId":12444,"journal":{"name":"Frontiers in Bioengineering and Biotechnology","volume":"13 ","pages":"1581292"},"PeriodicalIF":4.3,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12129962/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144215416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of knee sleeves on joint angle variability during gait in older adults: a principal component analysis.","authors":"Wakako Tsuchida, Takuma Inai, Shoma Kudo, Yoshiyuki Kobayashi, Masahiro Fujimoto","doi":"10.3389/fbioe.2025.1525174","DOIUrl":"10.3389/fbioe.2025.1525174","url":null,"abstract":"<p><strong>Introduction: </strong>As the global elderly population increases, maintaining walking ability and minimizing fall risk among older adults is crucial for their health and wellbeing. Knee sleeves are commonly utilized in geriatric sports and rehabilitation to stabilize knee joint movement and enhance gait stability. However, their effects on joint kinematics during walking in healthy older adults, particularly on joint angle variability-a factor associated with fall risk-remain inadequately explored. This study aimed to investigate the influence of knee sleeves on joint angle variability during gait in healthy older adults.</p><p><strong>Methods: </strong>Principal component analysis was performed on 16 healthy older adults residing in the community, utilizing 3D spatiotemporal data of the participants' time-normalized lower limb joint angles throughout the complete gait cycle. The analysis involved a 64 × 1818 input matrix, accounting for 16 participants, two conditions (control and knee sleeves), two walking speeds (normal and fast), three angles, three axes, 101 time points, and two parameters (average and variability). Kinematic waveforms were reconstructed based on the statistical findings to identify notable differences in joint angle variabilities between the conditions.</p><p><strong>Results and discussion: </strong>The outcomes revealed reduced variability in knee and ankle joint angles on the sagittal plane when walking with knee sleeves compared to walking without them. Conversely, an increased variability in hip, knee, and ankle joint angles was observed on the sagittal plane when walking at a fast speed compared to a normal speed. These results suggest that knee sleeves may reduce variability in knee and ankle joint angles during walking in older adults, potentially lowering the risk of falls. This effect appears particularly beneficial during fast-paced walking, where joint angle fluctuations are more pronounced than during normal-speed walking. These findings offer quantitative evidence for the effectiveness of knee sleeves in enhancing walking performance in healthy older adults.</p>","PeriodicalId":12444,"journal":{"name":"Frontiers in Bioengineering and Biotechnology","volume":"13 ","pages":"1525174"},"PeriodicalIF":4.3,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12129960/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144215420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"pH-triggered CS@ZnO₂ nanocomposites: Self-activated ROS generation for efficient bacterial eradication.","authors":"Yu Zhang, Jun Liu, Sha Li, Jinhua Zhou, Jiushan Liu, Yan Huang","doi":"10.3389/fbioe.2025.1608188","DOIUrl":"10.3389/fbioe.2025.1608188","url":null,"abstract":"<p><p>Functional nanomaterials based on reactive oxygen species (ROS) have attracted considerable attention in the treatment of bacterial infections, owing to their high sterilization efficiency and low tendency to induce drug resistance. Natural polymers, known for their excellent biocompatibility, have been widely used in the development of antibacterial dressings. In this study, chitosan-zinc peroxide composite dressing (CS@ZnO₂) was synthesized using zinc acetate and chitosan as primary raw materials, and comprehensive characterizations were performed. Under the slightly acidic conditions of bacterial infections, CS@ZnO₂ could self-decompose to release H₂O₂ and produce large amount of ROS, which would cause damage to bacteria. The <i>in vitro</i> antibacterial properties of CS@ZnO₂ were investigated using <i>Escherichia coli</i> (<i>E</i>. <i>coli</i>) and <i>Staphylococcus aureus</i> (<i>S</i>. <i>aureus</i>) as representative pathogens. The results demonstrated that CS@ZnO₂ exhibited potent antibacterial efficacy against both <i>S</i>. <i>aureus</i> and <i>E</i>. <i>coli</i>. This research provides an important theoretical foundation and technical support for the development of novel antibacterial materials, and has the potential to improve the efficacy of treatments for bacterial infections in the future.</p>","PeriodicalId":12444,"journal":{"name":"Frontiers in Bioengineering and Biotechnology","volume":"13 ","pages":"1608188"},"PeriodicalIF":4.3,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12129926/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144215422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-modal remote sensory learning for multi-objects over autonomous devices.","authors":"Aysha Naseer, Naif Almudawi, Hanan Aljuaid, Abdulwahab Alazeb, Yahay AlQahtani, Asaad Algarni, Ahmad Jalal, Hui Liu","doi":"10.3389/fbioe.2025.1430222","DOIUrl":"10.3389/fbioe.2025.1430222","url":null,"abstract":"<p><strong>Introduction: </strong>There has been an increasing focus on object segmentation within remote sensing images in recent years due to advancements in remote sensing technology and the growing significance of these images in both military and civilian realms. In these situations, it is critical to accurately and quickly identify a wide variety of objects. In many computer vision applications, scene recognition in aerial-based remote sensing imagery presents a common issue.</p><p><strong>Method: </strong>However, several challenging elements make this work especially difficult: (i) Different objects have different pixel densities; (ii) objects are not evenly distributed in remote sensing images; (iii) objects can appear differently depending on viewing angle and lighting conditions; and (iv) there are fluctuations in the number of objects, even the same type, in remote sensing images. Using a synergistic combination of Markov Random Field (MRF) for accurate labeling and Alex Net model for robust scene recognition, this work presents a novel method for the identification of remote sensing objects. During the labeling step, the use of MRF guarantees precise spatial contextual modeling, which improves comprehension of intricate interactions between nearby aerial objects. By simultaneously using deep learning model, the incorporation of Alex Net in the following classification phase enhances the model's capacity to identify complex patterns in aerial images and adapt to a variety of object attributes.</p><p><strong>Results: </strong>Experiments show that our method performs better than others in terms of classification accuracy and generalization, indicating its efficacy analysis on benchmark datasets such as UC Merced Land Use and AID.</p><p><strong>Discussion: </strong>Several performance measures were calculated to assess the efficacy of the suggested technique, including accuracy, precision, recall, error, and F1-Score. The assessment findings show a remarkable recognition rate of around 97.90% and 98.90%, on the AID and the UC Merced Land datasets, respectively.</p>","PeriodicalId":12444,"journal":{"name":"Frontiers in Bioengineering and Biotechnology","volume":"13 ","pages":"1430222"},"PeriodicalIF":4.3,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12130010/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144215421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum: Computational modeling of superparamagnetic nanoparticle-based (affinity) diagnostics.","authors":"Loï Van Dieren, Antoine A Ruzette, Vlad Tereshenko, Haïzam Oubari, Yanis Berkane, Jonathan Cornacchini, Filip Thiessen Ef, Curtis L Cetrulo, Korkut Uygun, Alexandre G Lellouch","doi":"10.3389/fbioe.2025.1610782","DOIUrl":"https://doi.org/10.3389/fbioe.2025.1610782","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.3389/fbioe.2024.1500756.].</p>","PeriodicalId":12444,"journal":{"name":"Frontiers in Bioengineering and Biotechnology","volume":"13 ","pages":"1610782"},"PeriodicalIF":4.3,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12132079/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144215418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}