Frontiers in Bioengineering and Biotechnology最新文献

{"title":"Effects of single-session perturbation-based balance training with progressive intensities on resilience and dynamic gait stability in healthy older adults.","authors":"Ringo Tang-Long Zhu, Friederike A Schulte, Navrag B Singh, Christina Zong-Hao Ma, Chris Awai Easthope, Deepak K Ravi","doi":"10.3389/fbioe.2025.1642158","DOIUrl":"10.3389/fbioe.2025.1642158","url":null,"abstract":"<p><strong>Introduction: </strong>Single-session perturbation-based balance training (PBT) has demonstrated improvements in dynamic stability during the initial step following perturbation in older adults. However, its broader effects on comprehensive balance recovery remain inconclusive. This pilot laboratory-based randomized controlled study investigated the impact of personalized single-session PBT on reactive balance control during walking, employing advanced stability analysis techniques.</p><p><strong>Methods: </strong>Ten participants in the training group (67.1 ± 2.8 years; 5 males & 5 females) underwent a single session consisting of 32 unpredictable treadmill-induced slips and trips of progressively increasing intensity, while ten participants in the control group (72.8 ± 5.2 years; 5 males & 5 females) engaged in unperturbed treadmill walking. Key outcome measures included margin of stability (MoS) parameters: minimum MoS and the number of recovery steps, and resilience parameters: peak instability and recovery time, assessed at baseline, immediately post-intervention, and 3 months post-intervention following an unexpected treadmill slip.</p><p><strong>Results: </strong>In the training group, participants exhibited significant increases in minimum MoS values immediately post-intervention (-33 ± 84 mm; <i>p</i> < 0.001) and 3 months post-intervention (-71 ± 70 mm; <i>p</i> < 0.01) as compared to pre-intervention (-140 ± 87 mm); they also showed a significant reduction in peak instability immediately post-intervention (34 ± 14 mm; <i>p =</i> 0.019) as compared to pre-intervention (57 ± 25 mm). These changes were not observed in the control group. However, neither group demonstrated significant alterations in the number of recovery steps or recovery time across the different assessment periods.</p><p><strong>Discussion and conclusion: </strong>In conclusion, single-session PBT enhanced reactive balance control by improving the magnitude of post-perturbation responses, but it did not significantly influence the speed of recovery to baseline conditions.</p>","PeriodicalId":12444,"journal":{"name":"Frontiers in Bioengineering and Biotechnology","volume":"13 ","pages":"1642158"},"PeriodicalIF":4.8,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12426064/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145063793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrating rhythmic auditory stimulation in intelligent rehabilitation technologies for enhanced post-stroke recovery.","authors":"Yanyan Zhao, Han Xu, Jianming Fu","doi":"10.3389/fbioe.2025.1649011","DOIUrl":"10.3389/fbioe.2025.1649011","url":null,"abstract":"<p><p>Stroke remains the leading cause of adult disability worldwide, resulting in long-term motor and cognitive impairments and imposing substantial socioeconomic burdens. Despite the widespread use of rehabilitation therapies, clinical outcomes remain suboptimal, underscoring the urgent need for more effective interventions to enhance neuroplasticity. This review explores the potential of integrating rhythmic auditory stimulation (RAS)-a music-based neurorehabilitation technique that leverages auditory-motor synchronization-with intelligent rehabilitation technologies such as robotics and virtual reality (VR). While various music-based interventions have shown promise in neurological recovery, this review focuses specifically on RAS due to its precise temporal structure, well-established neurophysiological mechanisms, and strong compatibility with technology-assisted platforms. We systematically examine the clinical evidence supporting RAS, evaluate the strengths and limitations of current intelligent rehabilitation systems, and discuss future directions for creating closed-loop, adaptive therapy paradigms. By combining RAS with robotic and VR-based interventions, we propose a novel framework for enhancing motor and cognitive recovery after stroke. This integrated approach offers new opportunities for personalized, engaging, and scalable neurorehabilitation strategies grounded in neuroscience, engineering, and clinical practice.</p>","PeriodicalId":12444,"journal":{"name":"Frontiers in Bioengineering and Biotechnology","volume":"13 ","pages":"1649011"},"PeriodicalIF":4.8,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12426047/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145063537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Time-of-flight camera achieves high diagnostic accuracy in adolescent idiopathic scoliosis: a promising radiation-free alternative to radiography.","authors":"André Boché, Anne Tabard-Fougère, Ludmilla Bazin, Mathieu Severyns, Romain Dayer, Tanguy Vendeuvre","doi":"10.3389/fbioe.2025.1629872","DOIUrl":"10.3389/fbioe.2025.1629872","url":null,"abstract":"<p><strong>Background: </strong>The close monitoring of the adolescent idiopathic scoliosis (AIS) population during the growing years is necessary and requires repetitive X-rays. This study aimed to evaluate the validity and test characteristics of the time-of-flight (TOF) camera, a novel radiation-free tool, for assessing trunk asymmetry in patients with AIS.</p><p><strong>Methods: </strong>In this prospective diagnostic accuracy study, 94 AIS patients (10-18 years) underwent standardized TOF camera imaging (seated position). Among them, 81 also received an angle of trunk rotation (ATR) assessment using a scoliometer (forward-bending position). The average major Cobb angle (CA) in the cohort was 21.4°. The global trunk asymmetry (GTA) provided by the TOF camera and the scoliometer-based ATR were compared with the gold-standard major Cobb angle from 2D radiography (standing position) using Pearson correlation. Receiver operating characteristic (ROC) analysis evaluated the diagnostic accuracy of GTA for AIS diagnosis (CA > 10°) and brace indication (CA > 20°). Sensitivity (Se), specificity (Sp), and area under the curve (AUC) values were reported and compared for GTA and ATR.</p><p><strong>Results: </strong>GTA was significantly correlated with the radiographic CA (p < 0.001). For scoliosis diagnosis (CA ≥ 10°), the AUC was 0.87 (0.79-0.96) for GTA (threshold = 7°, Se = 80%, and Sp = 80%) and 0.95 (0.9-1.0) for ATR. The AUC values of GTA and ATR were not significantly different (<i>p</i> = 0.129), but sensitivity was significantly lower for GTA (76%) than for ATR (91%). For brace indication (CA ≥ 20°), the AUC was 0.92 (0.86-0.97) for GTA (threshold = 7.87, Se = 93%, and Sp = 76%).</p><p><strong>Conclusion: </strong>The TOF camera appears to offer promising test characteristics for AIS diagnosis, with a high correlation to radiographic CA and competitive diagnostic accuracy using a scoliometer. Although the seated positioning differs from standard radiographs, this approach enhances reproducibility and patient compliance. The high sensitivity and specificity of the TOF camera for scoliosis diagnosis highlight its potential as a safe, fast, and reliable alternative to X-ray imaging in routine clinical settings. Further investigations (assessing solid screening characteristics and inter- and intra-individual repeatability and validity) are needed before it can replace repetitive radiographs for monitoring AIS progression in growing patients.</p>","PeriodicalId":12444,"journal":{"name":"Frontiers in Bioengineering and Biotechnology","volume":"13 ","pages":"1629872"},"PeriodicalIF":4.8,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12426477/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145063695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Synergistic advances in gene technology, nanobiotechnology, and photonic innovations for next-generation diagnostics and therapeutics.","authors":"Zhi Chen","doi":"10.3389/fbioe.2025.1685142","DOIUrl":"10.3389/fbioe.2025.1685142","url":null,"abstract":"","PeriodicalId":12444,"journal":{"name":"Frontiers in Bioengineering and Biotechnology","volume":"13 ","pages":"1685142"},"PeriodicalIF":4.8,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12423038/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145063801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimization of braided stent design for cerebral aneurysms: the role of wire cross-sectional geometry.","authors":"Aohua Zhang, Xinru Li, Zhengbiao Yang, Yutang Xie, Tao Wu, Yanru Xue, Yanqin Wang, Yongwang Zhao, Weiyi Chen, Chenming Sun, Jinzhu Yin, Meng Zhang, Xiaogang Wu, Xuesong Li, Yonghong Wang","doi":"10.3389/fbioe.2025.1643750","DOIUrl":"10.3389/fbioe.2025.1643750","url":null,"abstract":"<p><p>Flow-diverting stents are crucial for aneurysm treatment, with their structural design significantly impacting post-implantation hemodynamics. While clinically effective, opportunities remain to enhance their flexibility, flow diversion capability, and long-term safety through ongoing structural optimization. In this study, with Pipeline Embolization Device (PED) as a reference, four kinds of flow-diverting stents with different braided cross-section shapes (quadrilateral, hexagon, octagon, and decagon) were designed under the condition of keeping the amount of material constant. Firstly, pure bending loads are applied to each stent through finite element analysis, and its flexibility is evaluated by analyzing the torque-angle curve. Secondly, the computational fluid dynamics method was utilized to simulate the hemodynamic characteristics after the implantation of each stent. The results show that: (1) Under the condition of bending 60°, the decagonal stent has the best flexibility, followed by the quadrilateral one. (2) The overall blood flow distribution of stents with different cross-sections is similar, but there are differences in the local average flow velocity of the tumor cavity: the circular one is the highest, and the quadrilateral one is the lowest. (3) The wall pressure gradient change of the polygonal stent is gentler than that of the circular one. Among them, the wall pressure of the hexagonal and decagonal stents is the maximum and the average pressure in the cavity is the lowest. (4) The area of the low WSS region on the aneurysm wall is the largest in quadrilaterals and the smallest in circles. On the maternal artery segment, the hexagon is the largest and the quadrilateral is the smallest. Comprehensive comparison shows that quadrilateral and decagonal cross-section stents exhibit better comprehensive performance. Through the above research, theoretical support can be provided for the optimal design of flow-diverting stents structures.</p>","PeriodicalId":12444,"journal":{"name":"Frontiers in Bioengineering and Biotechnology","volume":"13 ","pages":"1643750"},"PeriodicalIF":4.8,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12423101/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145063679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of hip manipulation on muscle strength, proprioception and motor tests of basketball players during training.","authors":"Rafał Studnicki, Zuzanna Patrzykąt, Adam Kawczyński","doi":"10.3389/fbioe.2025.1632262","DOIUrl":"10.3389/fbioe.2025.1632262","url":null,"abstract":"<p><strong>Introduction: </strong>This study aimed to (i) investigate the effects of diagonal manual therapy on gluteus medius activation and (ii) examine its impact on quadriceps femoris activation, both critical for lower limb stability.</p><p><strong>Methods: </strong>Nine male basketball players (mean age 23.8 ± 4.1 years) participated in a randomized crossover trial, with measurements taken before the intervention, immediately after, and following a training session. Muscle activation of the gluteus medius, tensor fascia lata, and quadriceps was assessed via EMG, alongside evaluations of proprioception, the Y-Balance Test, and Standing Broad Jump. Repeated-measures ANOVA revealed significant time effects for all Y-Balance Test directions (anterior, posteromedial, and posterolateral) with large effect sizes (partial η² > 0.70).</p><p><strong>Results: </strong>A significant interaction between intervention and assessment was also observed for proprioception at 90° hip flexion (p = 0.073), with a very large effect size (partial η²= 0.835). Main effects of the intervention were significant for maximal and mean activation of the gluteus medius, maximal activation of the tensor fascia lata, and maximal and mean activation of the vastus medialis, with the vastus lateralis showing especially notable maximal activation (partial η² > 0.65). Furthermore, significant interactions with very large effect sizes (partial η² often > 0.80) emerged for maximal activation of the gluteus medius, vastus lateralis (maximal, mean, and median values), rectus femoris maximal activation, and vastus medialis mean activation.</p><p><strong>Discussion: </strong>These findings provide preliminary evidence that diagonal manual therapy effectively enhances neuromuscular activation of the gluteus medius, a key muscle for lower limb stability. Moreover, the intervention influenced activation of other critical muscles such as the vastus lateralis and quadriceps femoris, suggesting a broader neuromuscular facilitation that may benefit dynamic postural control. Improvements in dynamic balance and proprioception further indicate potential functional gains.</p>","PeriodicalId":12444,"journal":{"name":"Frontiers in Bioengineering and Biotechnology","volume":"13 ","pages":"1632262"},"PeriodicalIF":4.8,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12423034/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145063724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"User-centered development of a personalized adaptive mirror therapy for upper-limb post-stroke rehabilitation using virtual reality and myoelectric control.","authors":"Paolo De Pasquale, Daniela De Bartolo, Marta Russo, Denise J Berger, Antonella Maselli, Daniele Borzelli, Emma Colamarino, Donatella Mattia, Christian Nissler, Markus Nowak, Elena Falomo, Javier Soto Morras, Moco Raffael Schiller, Claudio Castellini, Giovanni Morone, Andrea d'Avella","doi":"10.3389/fbioe.2025.1655416","DOIUrl":"10.3389/fbioe.2025.1655416","url":null,"abstract":"<p><strong>Introduction: </strong>Cerebral stroke often results in significant motor deficits, including contralateral hemiparesis of the upper limb. Rehabilitation protocols with high-intensity and task-specific exercises can improve these deficits. Recent technological advancements in virtual reality (VR), myoelectric control, and exergames may be exploited to enhance rehabilitation effectiveness. However, novel rehabilitation approaches combining these novel methodologies have rarely been developed with the active involvement of both therapists and patients.</p><p><strong>Methods: </strong>An interdisciplinary team developed a novel system, Validation of the Virtual Therapy Arm (VVITA), for post-stroke upper-limb rehabilitation combining VR, myoelectric control, and exergames using a user-centered design (UCD) approach. The VVITA hardware includes a head-mounted VR display, motion tracking devices integrated in the VR system, and wireless armbands to record electromyographic (EMG) signals, providing an interactive virtual environment for immersive rehabilitation exercises implementing a virtual mirror therapy. Assistance and task difficulty are adjusted dynamically based on patient performance, promoting active participation and motor learning.</p><p><strong>Results: </strong>The development process involved iterative phases, involving focus groups with stroke patients, therapists, and researchers. A pilot study with four stroke survivors assessed the system's feasibility, demonstrating its potential for personalized and adaptive rehabilitation.</p><p><strong>Conclusion: </strong>The VVITA system enhances mirror therapy by integrating VR and myoelectric control, providing a tailored approach to upper-limb post-stroke rehabilitation. The UCD approach ensured the system met patient and therapist needs, showing promise for improving motor recovery and rehabilitation outcomes.</p>","PeriodicalId":12444,"journal":{"name":"Frontiers in Bioengineering and Biotechnology","volume":"13 ","pages":"1655416"},"PeriodicalIF":4.8,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12423055/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145063735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Insights in biosensors and biomolecular electronics 2024: novel developments, current challenges, and future perspectives.","authors":"Guozhen Liu, Zhugen Yang","doi":"10.3389/fbioe.2025.1668411","DOIUrl":"10.3389/fbioe.2025.1668411","url":null,"abstract":"","PeriodicalId":12444,"journal":{"name":"Frontiers in Bioengineering and Biotechnology","volume":"13 ","pages":"1668411"},"PeriodicalIF":4.8,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12423070/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145063833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Yarrowia lipolytica</i> as a promising cell factory for microbial production of value-added nutraceuticals.","authors":"Soseon Lee, Ju Hyeon Lee, Hyun June Park, Seung-Ho Baek","doi":"10.3389/fbioe.2025.1673169","DOIUrl":"10.3389/fbioe.2025.1673169","url":null,"abstract":"<p><p>The oleaginous yeast <i>Yarrowia lipolytica</i> has emerged as a powerful chassis for the sustainable production of high-value nutraceuticals. Its innate metabolism, characterized by a high flux towards the key precursor acetyl-CoA, makes it an ideal host for synthesizing complex molecules like carotenoids, flavonoids, and specialty lipids. This review summarizes recent progress in engineering <i>Y. lipolytica</i> cell factories, focusing on the synergistic application of metabolic engineering and synthetic biology. Key strategies discussed include enhancing precursor supply, redirecting metabolic flux away from competing pathways, and optimizing heterologous gene expression. We highlight the use of advanced tools like organelle compartmentalization to improve reaction efficiency and biosensor-driven screening to accelerate strain development. Furthermore, systems biology approaches utilizing multi-omics data are proving crucial for identifying novel engineering targets and overcoming metabolic bottlenecks. This review consolidates these advancements and discusses future perspectives for creating robust, industrially-relevant <i>Y. lipolytica</i> platforms for the bio-based economy.</p>","PeriodicalId":12444,"journal":{"name":"Frontiers in Bioengineering and Biotechnology","volume":"13 ","pages":"1673169"},"PeriodicalIF":4.8,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12423049/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145063856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"N-acetyl cysteine as an additive to bone cement against pathogens involved in periprosthetic joint infections.","authors":"Maja Charlotte Bohn, Hilke Oltmanns, Heidi Harting, Jessica Meißner","doi":"10.3389/fbioe.2025.1595821","DOIUrl":"10.3389/fbioe.2025.1595821","url":null,"abstract":"<p><p>Periprosthetic joint infections (PJIs) and septic loosening of implants are common complications following surgical replacement of destructive joints in both human and veterinary medicine. Increasing occurrence of multi-resistant bacteria and failure to manage periprosthetic joint infections make it necessary to identify new antibacterial substances for the treatment and prevention of these infections. N-acetyl cysteine (NAC), a derivative of the amino acid cysteine, has been chosen as a candidate substance due to its shown antibacterial activity. The aim of the study was to evaluate the suitability of NAC for the use together with polymethylmethacrylate bone cement in the context of PJIs. Antibacterial activity of pure NAC and NAC-containing bone cement against clinical isolates of <i>Staphylococcus (S.) pseudintermedius</i> was tested by determining minimal inhibitory concentrations, analyzing growth of bacteria on bone cement, and examining the influence on infection of human osteosarcoma (HOS) cells. Cytotoxicity of pure NAC and bone cement with NAC against HOS cells was analyzed with viability and proliferation assays, Live/Dead staining of cells on bone cement, measurement of Interleukin-6 (IL-6) release, and visualizing activation of p38 MAP kinase with Western blotting. NAC inhibited growth of <i>Staphylococcus pseudintermedius</i> at 2.5 mg/mL and reduced bacterial growth on bone cement but could not inhibit infection of cells at 1.5 mg/mL. The IC₅₀ of pure NAC for viability was 3.6 mg/mL. Bone cement with NAC reduced viability and proliferation at some concentrations but did not provoke IL-6 release. Western blots indicated that p38 could be activated following treatment with NAC. Taken together, antibacterial effectiveness could be shown but cytocompatibility of NAC in bone cement was limited, so that NAC cannot currently be used as a bone cement additive. Further research is necessary to balance antibacterial activity and cytotoxicity.</p>","PeriodicalId":12444,"journal":{"name":"Frontiers in Bioengineering and Biotechnology","volume":"13 ","pages":"1595821"},"PeriodicalIF":4.8,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12423035/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145063652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}