Frontiers in Bioengineering and Biotechnology最新文献

{"title":"Low-temperature cold plasma promotes wound healing by inhibiting skin inflammation and improving skin microbiome.","authors":"Jie Zhou, Zengkun Sun, Xiaoru Wang, Shouguo Wang, Wen Jiang, Dongqi Tang, Tao Xia, Fang Xiao","doi":"10.3389/fbioe.2025.1511259","DOIUrl":"10.3389/fbioe.2025.1511259","url":null,"abstract":"<p><p>Wound healing includes four consecutive and overlapping stages of hemostasis, inflammation, proliferation, and remodeling. Factors such as aging, infection, and chronic diseases can lead to chronic wounds and delayed healing. Low-temperature cold plasma (LTCP) is an emerging physical therapy for wound healing, characterized by its safety, environmental friendliness, and ease of operation. This study utilized a self-developed LTCP device to investigate its biological effects and mechanisms on wound healing in adult and elderly mice. Histopathological studies found that LTCP significantly accelerated the healing rate of skin wounds in mice, with particularly pronounced effects in elderly mice. LTCP can markedly inhibit the expression of pro-inflammatory cytokines (<i>TNF-α</i>, <i>IL-6</i>, <i>IL-1β</i>) and senescence-associated secretory phenotype factors (<i>MMP-3</i>, <i>MMP-9</i>), while significantly increasing the expression of tissue repair-related factors, such as <i>VEGF</i>, <i>bFGF</i>, <i>TGF-β</i>, <i>COL-I</i>, and <i>α-SMA</i>. It also regulated the expression of genes related to cell proliferation and migration (<i>Aqp5</i>, <i>Spint1</i>), inflammation response (<i>Nlrp3</i>, <i>Icam1</i>), and angiogenesis (<i>Ptx3</i>, <i>Thbs1</i>), promoting cell proliferation and inhibit apoptosis. Furthermore, LTCP treatment reduced the relative abundance of harmful bacteria such as <i>Delftia</i>, <i>Stenotrophomonas</i>, <i>Enterococcus</i>, and <i>Enterobacter</i> in skin wounds, while increasing the relative abundance of beneficial bacteria such as <i>Muribaculaceae</i>, <i>Acinetobacter</i>, <i>Lachnospiraceae NK4A136_group</i>, and <i>un_f__Lachnospiraceae</i>, thereby improving the microbial community structure of skin wounds. These research findings are of significant implications for understanding the mechanism of skin wound healing, as well as for the treatment and clinical applications of skin wounds, especially aging skin.</p>","PeriodicalId":12444,"journal":{"name":"Frontiers in Bioengineering and Biotechnology","volume":"13 ","pages":"1511259"},"PeriodicalIF":4.3,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11882593/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143572690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Orthopedic surgical robotic systems in knee arthroplasty: a comprehensive review.","authors":"Xuanze Fan, Yan Wang, Shouwei Zhang, Yuan Xing, Jinhua Li, Xinlong Ma, Jianxiong Ma","doi":"10.3389/fbioe.2025.1523631","DOIUrl":"10.3389/fbioe.2025.1523631","url":null,"abstract":"<p><p>In conjunction with the accelerated evolution of robotics, the advancement of robot-assisted minimally invasive surgical systems is occurring at a similarly accelerated pace, and is becoming increasingly accepted. It is employed in numerous surgical specialties, including orthopedics, and has significantly transformed traditional surgical techniques. Among these applications, knee arthroplasty represents one of the most prevalent and efficacious procedures within the domain of robot-assisted orthopedic surgery. The implementation of surgical robotic systems has the potential to enhance the precision and accuracy of surgical outcomes, facilitate reproducibility, reduce technical variability, mitigate patient discomfort, and accelerate recovery. In this paper, a literature review of the Web of Science and PubMed databases was conducted to search for all articles on orthopedic surgical robotics through November 2024. It mainly summarizes the most commonly used and widely accepted robotic systems in the field of orthopedic surgery, with a particular focus on their application in knee arthroplasty procedures. Orthopedic robotic systems can be classified into three principal categories: autonomous robotic systems, semi-autonomous robotic systems, and teleoperated robotic systems. In the context of knee arthroplasty, the characteristics of different robotic systems are examined in relation to three types of Total Knee Arthroplasty (TKA), Unicompartmental Knee Arthroplasty (UKA) and Patellofemoral Arthroplasty (PFA). In conclusion, the current state of orthopedic surgical robotics is reviewed, and future development prospects and challenges are proposed.</p>","PeriodicalId":12444,"journal":{"name":"Frontiers in Bioengineering and Biotechnology","volume":"13 ","pages":"1523631"},"PeriodicalIF":4.3,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11882601/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143572056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of phage surface display for the identification of Eu³⁺-binding peptides.","authors":"Gerda Techert, Björn Drobot, Robert Braun, Christoph Bloss, Nora Schönberger, Sabine Matys, Katrin Pollmann, Franziska L Lederer","doi":"10.3389/fbioe.2025.1508018","DOIUrl":"10.3389/fbioe.2025.1508018","url":null,"abstract":"<p><p>Europium as one of the rare earth elements (REE) has outstanding properties in terms of its application for high-tech and renewable energy products. The high supply risk of REE, coupled with their low recovery rates from secondary sources, necessitates innovative recycling approaches. We introduce a phage display-based peptide biosorbent recycling technology that offers a cost-effective and environmentally friendly solution for recovering metal ions, supporting circular economy goals. In this study, we used phage surface display to screen for peptides with high affinity for europium (III) ions (Eu³⁺). Performing several independent biopanning experiments with the Ph.D.-12 Phage Display Peptide Library and different elution methods as well as combining them with next-generation sequencing, we identified eight peptides with moderate to good affinities for Eu³⁺ ions, verified by time-resolved laser fluorescence spectroscopy. The peptides EALTVNIKREME as well as DVHHVDGNDLQPFEGGGS and DSIHSDVTKDGRYPVEGGGS, the latter are variants of enriched dodecamers, proved to be the best candidates for future biosorption and selectivity studies. This study underscores the potential of phage surface display for peptide-based REE recovery, laying the foundation for selective recycling technologies from secondary raw materials.</p>","PeriodicalId":12444,"journal":{"name":"Frontiers in Bioengineering and Biotechnology","volume":"13 ","pages":"1508018"},"PeriodicalIF":4.3,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11882594/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143572672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AI-based biplane X-ray image-guided method for distal radius fracture reduction.","authors":"Qing Zha, Sizhou Shen, Ziyang Ma, Manqiu Yu, Hongzheng Bi, Hongbo Yang","doi":"10.3389/fbioe.2025.1502669","DOIUrl":"10.3389/fbioe.2025.1502669","url":null,"abstract":"<p><strong>Background: </strong>In the course of manual reduction of distal radius fractures, many doctors rely on tactile perception to assess the displacement of the fracture. However, a more accurate determination of the severity of the fracture and the success of the reduction requires measurement software to annotate the fracture images, which is difficult to achieve real-timely in actual procedure of reduction. Which may lead to misdiagnosis when experienced doctors rely on their intuition. Therefore, it is necessary to develop an AI-based method for calculating fracture parameters to provide real-time display, particularly in fracture reduction machines.</p><p><strong>Methods: </strong>An AI-based method for automatically calculating of radiographic parameters in distal radius fractures (DRF) was developed. Initially, anteroposterior (AP) and lateral (LAT) X-ray images of patients with distal radius fractures were collected from three hospitals and preprocessed. Subsequently, several neural network structures, UNet, DeeplabV3+, PSPNet, and TransUNet, are compared in terms of utility and accuracy, and finally, the models obtained from the UNet image segmentation algorithm are used for semantic segmentation of the radius and ulna. Following this, the contours of the radius and ulna were extracted using OpenCV, key points were detected, and the principal axes were calculated. Finally, the computed parameters including radial angle (RA), radial length (RL), ulnar variance (UV), and palmar tilt (PT) were calculated and displayed on the image.</p><p><strong>Results: </strong>The advantages and disadvantages of several models were considered, and finally the UNet neural network model was used as the core algorithm of the image segmentation model in this study. The segmentation accuracy for the radius and ulna in the AP and LAT X-ray images reached 91.31% and 88.63%, respectively. The average errors between the automated calculations of parameters RA, RL, UV, and PT and the manually annotated results by physicians were -1.36°, -1.7 mm, 0.66 mm, and -1.06°, respectively. The system has been initially deployed on the same computer that operates the radial fracture fracture repositioning robot.</p><p><strong>Conclusion: </strong>The automated parameter calculation method developed in this study accurately computes diagnostic parameters for assessing distal radius fractures and can be utilized in the image-guided reduction process of fracture rehabilitation robots. This method has the potential to evolve into an intelligent diagnostic tool for physicians, thereby enhancing the accuracy of distal radius fracture diagnosis.</p>","PeriodicalId":12444,"journal":{"name":"Frontiers in Bioengineering and Biotechnology","volume":"13 ","pages":"1502669"},"PeriodicalIF":4.3,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11880290/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143565835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomechanical analysis of spinal range of motion and intervertebral disc loadings in normal and adolescent idiopathic scoliosis models.","authors":"Haikuan Wang, Zhengwei Ma, Zhihua Wu, Yuanfang Lin, Jie Yu, Xin Qian, Sili Jian, Yueli Sun, Wei Wei, Xiang Yu, Ziyang Liang","doi":"10.3389/fbioe.2025.1473776","DOIUrl":"10.3389/fbioe.2025.1473776","url":null,"abstract":"<p><strong>Objective: </strong>While the Lenke classification enhances our structural understanding of adolescent idiopathic scoliosis (AIS), the biomechanical implications for spinal range of motion (ROM) and intervertebral disc (IVD) loadings remain unclear. This study aims to quantitatively explore and compare these biomechanical responses in normal thoracolumbar spines and those with various curvatures of Lenke types under pure bending conditions.</p><p><strong>Methods: </strong>The baseline thoracolumbar finite element (FE) model was derived from a comprehensive human body FE model, validated, and calibrated against spinal responses under dynamic compression and quasi-static bending conditions. Using mesh morphing, AIS models of Lenke 1, Lenke 2, Lenke 3, and Lenke 5 were established to represent their respective spinal curvatures. Pure bending moments of ±7.5 Nm in flexion-extension, lateral bending, and axial rotation were applied to both normal and AIS models. Global spinal ROM and ROM of spinal segments T1-T6, T7-T12, and L1-Sacrum were measured under each loading condition. IVD mechanical loadings, including force, moment, and VonMises stress, were also evaluated and compared across all models.</p><p><strong>Results: </strong>AIS models showed higher principal ROM compared to the normal model, with Lenke 2 having the highest ROM from T1-Sacrum and Lenke 3 the highest ROM from T6-12. AIS models exhibited more asymmetry in segmental ROM, particularly in the lumbar spine during lateral bending and axial rotation. IVD mechanical loadings varied significantly between normal and AIS models, influenced by spinal curvature types. AIS models had higher secondary moments and shear forces, especially under flexion-extension. The highest stress was mostly observed in the frontal IVD regions under flexion which was greatly reduced under extension. Lateral bending caused the highest stress predominantly on the same side as the loading direction in the IVD regions. The IVDs of T6-T7 and T12-L1 showed even stress distribution under axial rotation, while the right IVD regions of L5-Sacrum sustained the highest stress under right axial rotation, and the left regions under left axial rotation. In Lenke 3 and Lenke 5 models, the right (concave) regions of the T12-L1 IVD consistently sustained higher stress levels, regardless of the loading conditions applied.</p><p><strong>Conclusion: </strong>This study underscores significant biomechanical differences between normal and AIS models, revealing intricate interactions within scoliotic spines and enhancing our understanding of AIS biomechanics. These insights can aid in better diagnosis, treatment planning, and prognosis. Extension-focused therapeutic exercises may reduce stress on anterior IVDs, potentially lowering the risk of low back pain or disc herniation, while careful management of rotational exercises can help minimize stress in the lower lumbar regions.</p>","PeriodicalId":12444,"journal":{"name":"Frontiers in Bioengineering and Biotechnology","volume":"13 ","pages":"1473776"},"PeriodicalIF":4.3,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11880291/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143565977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing sparse inertial sensor setups for sagittal-plane walking and running reconstructions.","authors":"Eva Dorschky, Marlies Nitschke, Matthias Mayer, Ive Weygers, Heiko Gassner, Thomas Seel, Bjoern M Eskofier, Anne D Koelewijn","doi":"10.3389/fbioe.2025.1507162","DOIUrl":"10.3389/fbioe.2025.1507162","url":null,"abstract":"<p><p>Estimating spatiotemporal, kinematic, and kinetic movement variables with little obtrusion to the user is critical for clinical and sports applications. One possible approach is using a sparse inertial sensor setup, where sensors are not placed on all relevant body segments. Here, we investigated if movement variables can be estimated similarly accurate from sparse sensor setups as from a full lower-body sensor setup. We estimated the variables by solving optimal control problems with sagittal plane lower-body musculoskeletal models, in which we minimized an objective that combined tracking of accelerometer and gyroscope data with minimizing muscular effort. We created simulations for 10 participants at three walking and three running speeds, using seven sensor setups with between two and seven sensors located at the feet, shank, thighs, and/or pelvis. We found that differences between variables estimated from inertial sensors and those from optical motion capture were small for all sensor setups. Including all sensors did not necessarily lead to the smallest root mean square deviations (RMSDs) and highest coefficients of determination ( <math> <mrow> <msup><mrow><mtext>R</mtext></mrow> <mrow><mn>2</mn></mrow> </msup> </mrow> </math> ). Setups without a pelvis sensor led to too much forward trunk lean and inaccurate spatiotemporal variables. Mean RMSDs were highest for the setup with two foot-worn inertial sensors (largest error in knee angle during running: 18 deg vs. 11 deg for the full lower-body setup), and ranged between 4.8-18 deg for the joint angles, between 1.0-5.4 BW BH% for the joint moments, and between 0.03 BW-0.49 BW for the ground reaction forces. We found strong or moderate relationships ( <math> <mrow> <msup><mrow><mtext>R</mtext></mrow> <mrow><mn>2</mn></mrow> </msup> <mo>></mo> <mn>0.5</mn></mrow> </math> ) on average for all kinematic and kinetic variables, except for the hip and knee moment for five out of the seven setups. The large range of the coefficient of determination for most kinetic variables indicated individual differences in simulation quality. Therefore, we conclude that we can perform a comprehensive sagittal-plane motion analysis with sparse sensor setups as accurately as with a full sensor setup with sensors on the feet and on either the pelvis or the thighs. Such a sparse sensor setup enables comprehensive movement analysis outside the laboratory, by increasing usability of inertial sensors.</p>","PeriodicalId":12444,"journal":{"name":"Frontiers in Bioengineering and Biotechnology","volume":"13 ","pages":"1507162"},"PeriodicalIF":4.3,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11879983/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143566403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancements in extracellular vesicles biomanufacturing: a comprehensive overview of large-scale production and clinical research.","authors":"Ziqian Li, Junyu Yan, Xiang Li, Hui Chen, Chen Lin, Yuhang Zhang, Tian Gao, Yabo Zhang, Yue Shu, Shuyuan Pan, Yuntao Zhang","doi":"10.3389/fbioe.2025.1487627","DOIUrl":"10.3389/fbioe.2025.1487627","url":null,"abstract":"<p><p>Extracellular vesicles (EVs) are nano-sized, membranous structures secreted by cells into the extracellular space, have attracted considerable attention in the field of biosciences for their role in intercellular communication in various physiological and pathological processes. Their ubiquitous presence in bodily fluids and cell-specific characteristics make them promising candidates as biomarkers. Additionally, their ability to transport biological therapeutics across different biological barriers to specific target cells underscores their significant translational potential for diagnostic and therapeutic purposes. Significant progress has been achieved in the translation of EVs research to clinical applications, however, challenges persist in the large-scale production of EVs, particularly in the areas of scalable manufacturing, efficient isolation methods, drug loading techniques, and advanced characterization technology. This review critically examines the complex processes involved in EVs biogenesis and explores recent developments in large-scale EVs production. By synthesizing knowledge from these fields, this review aims to provide a holistic perspective on the evolving landscape of EVs research and its applications, underscoring both the accomplishments and the obstacles that lie ahead in fully realizing the potential of EVs in biomedicine.</p>","PeriodicalId":12444,"journal":{"name":"Frontiers in Bioengineering and Biotechnology","volume":"13 ","pages":"1487627"},"PeriodicalIF":4.3,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11879961/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143566662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum: Recent advances in gold nanostructure-based biosensors in detecting diabetes biomarkers.","authors":"Tahereh Jamshidnejad-Tosaramandani, Soheila Kashanian, Kobra Omidfar, Helgi B Schiöth","doi":"10.3389/fbioe.2025.1526911","DOIUrl":"https://doi.org/10.3389/fbioe.2025.1526911","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.3389/fbioe.2024.1446355.].</p>","PeriodicalId":12444,"journal":{"name":"Frontiers in Bioengineering and Biotechnology","volume":"13 ","pages":"1526911"},"PeriodicalIF":4.3,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11881186/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143566404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomechanical impact of cortical bone vs. traditional pedicle screw trajectories: a finite element study on lumbar spinal instrumentation.","authors":"Xishan Li, Khaled H A Abdel-Latif, Jefrem Schwab, Xiang Zhou, Jie Yang, Zully M Ritter, Arndt F Schilling, Maximilian Reinhold","doi":"10.3389/fbioe.2025.1541114","DOIUrl":"10.3389/fbioe.2025.1541114","url":null,"abstract":"<p><strong>Background: </strong>Pedicle screw fixation using the cortical bone trajectory (CBT) enhances stability by engaging cortical bone, offering a valuable alternative to the traditional pedicle screw trajectory (TT). This study used finite element analysis to compare L4-5 instrumentation with CBT and TT screws, investigating whether the increased cortical bone engagement in CBT improves stability but makes it more susceptible to fatigue failure.</p><p><strong>Methods: </strong>A L3-sacrum model was generated using anonymized CT patient data, validated against existing studies, showing consistent ROM (range of motion) values. A mono-segmental L4-5 instrumentation with an interbody fusion cage was configured with both TT and CBT models, differentiated for healthy and osteoporotic bone (reduced Young's modulus). Both models were exposed to simulated biomechanical loading conditions (compression, flexion, extension, lateral bending, and rotation) to calculate screw loosening and breakage risk. Screw loosening was assessed by measuring micro-movements within the screw hole, while screw breakage was evaluated based on maximum stress values and their frequency at the same locations.</p><p><strong>Results: </strong>In both healthy and osteoporotic bone, the CBT model exhibited smaller micro-movements compared to the TT model across all motions. For maximum stress in healthy bone, CBT showed lower stress during right rotation but higher stress in the other six motions. In osteoporotic bone, CBT stress exceeded TT stress in all conditions. The TT model in healthy bone showed stress concentrations at three locations, while CBT distributed stress across five sites. In osteoporotic bone, CBT showed stress at three locations, while TT distributed stress at four. Notably, in the TT model, maximum stress occurred at the screw head in six of seven movements, whereas in the CBT model, three movements showed maximum stress at the screw head and three at the screw tail.</p><p><strong>Conclusion: </strong>CBT screws, by traversing three cortical layers, achieve greater integration with the vertebral bone compared to TT screws, thus reducing the risk of screw loosening. Although this increases the maximum stress on the screws, the stress is more evenly distributed, with the screw tail helping to reduce the risk of breakage.</p>","PeriodicalId":12444,"journal":{"name":"Frontiers in Bioengineering and Biotechnology","volume":"13 ","pages":"1541114"},"PeriodicalIF":4.3,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11876142/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143556430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent applications of stimulus-responsive smart hydrogels for osteoarthritis therapy.","authors":"Zhuoming Xu, Jintao Liu, Hanyin Hu, Jun Ma, Haiyang Yang, Jiayi Chen, Hongwei Xu, Haodong Hu, Huanhuan Luo, Gang Chen","doi":"10.3389/fbioe.2025.1539566","DOIUrl":"10.3389/fbioe.2025.1539566","url":null,"abstract":"<p><p>Osteoarthritis is one of the most common degenerative joint diseases, which seriously affects the life of middle-aged and elderly people. Traditional treatments such as surgical treatment and systemic medication, often do not achieve the expected or optimal results, which leads to severe trauma and a variety of side effects. Therefore, there is an urgent need to develop novel therapeutic options to overcome these problems. Hydrogels are widely used in biomedical tissue repairing as a platform for loading drugs, proteins and stem cells. In recent years, smart-responsive hydrogels have achieved excellent results as novel drug delivery systems in the treatment of osteoarthritis. This review focuses on the recent advances of endogenous stimuli (including enzymes, pH, reactive oxygen species and temperature, etc.) responsive hydrogels and exogenous stimuli (including light, shear, ultrasound and magnetism, etc.) responsive hydrogels in osteoarthritis treatment. Finally, the current limitations of application and future prospects of smart responsive hydrogels are summarized.</p>","PeriodicalId":12444,"journal":{"name":"Frontiers in Bioengineering and Biotechnology","volume":"13 ","pages":"1539566"},"PeriodicalIF":4.3,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11872905/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143540778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}