Changes in volumetric bone mineral density after ACL reconstruction with single-bundle and double-bundle: a 1-year follow-up study using peripheral quantitative computed tomography.

IF 4.3 3区工程技术 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Frontiers in Bioengineering and Biotechnology Pub Date : 2025-05-22 eCollection Date: 2025-01-01 DOI:10.3389/fbioe.2025.1606404

Binbin Yin, Chaohua Fang, Ren Hai Feng, Jian Min Wu

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引用次数: 0

Abstract

Background: The purpose of this study is to quantify changes in volumetric bone mineral density (vBMD) in different regions of the tibial plateau after single-bundle (SB) and double-bundle (DB) anterior cruciate ligament reconstruction (ACLR).

Methods: Twenty-six patients with diagnosed anterior cruciate ligament (ACL) rupture were allocated into SB (10) or DB group (16) and completed the last follow-up at 12 months. Peripheral quantitative computed tomography (pQCT) was performed before surgery and at 1, 3, 6, and 12 months after surgery. Four regions of interest (ROI) were identified 2 mm below the medial and lateral subchondral plate of the knee joint, namely, the anteromedial (AM), posteromedial (PM), anterolateral (AL) and posterolateral (PL) regions. The vBMD of each ROI was measured and compared between the groups at different timepoints.

Results: For the vBMD, a significant change in all ROIs can be found over time, with the values at all ROIs decreased until 6 months postoperatively and then steadily increased, but the values did not reach preoperative levels. The AM region had the highest vBMD, followed by the PL region, and the vBMD was lowest in the AL region. For the change percent, the decrease magnitude was comparable between AM and PM region at postoperative 1 and 12 months, but it was greater at PM region at postoperative 3 and 6 months. Comparing DB ACLR and SB ACLR, there was no significant difference in the change percent of vBMD in all ROIs, except for in the AL region at 1 month postoperatively.

Conclusion: A partially reversible decline in vBMD was found in the proximal tibia at 12 months after ACLR. But the change percent varied among the different regions, which may indicate inadequate restoration of knee kinematics after ACLR. DB and SB ACLR methods may have a similar effect on knee kinematics.

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单束和双束ACL重建后体积骨密度的变化：周围定量计算机断层扫描1年随访研究。

背景：本研究的目的是量化单束（SB）和双束（DB）前交叉韧带重建（ACLR）后胫骨平台不同区域的体积骨矿物质密度（vBMD）的变化。方法：将诊断为前交叉韧带（ACL）破裂的患者26例分为SB组（10例）和DB组（16例），最后一次随访时间为12个月。术前及术后1、3、6、12个月行外周定量计算机断层扫描（pQCT）。在膝关节内侧和外侧软骨下板下方2mm处确定四个感兴趣区域（ROI），即前内侧（AM），后内侧（PM），前外侧（AL）和后外侧（PL）区域。测量各组在不同时间点ROI的vBMD，并进行比较。结果：对于vBMD，随着时间的推移，所有roi都有明显的变化，直到术后6个月，所有roi的值都有所下降，然后稳步上升，但没有达到术前水平。AM区vBMD最高，PL区次之，AL区vBMD最低。对于变化百分比，术后1和12个月AM区和PM区下降幅度相当，但术后3和6个月PM区下降幅度更大。比较DB ACLR和SB ACLR，除术后1个月AL区域外，所有roi的vBMD变化百分比无显著差异。结论：ACLR术后12个月胫骨近端vBMD出现部分可逆性下降。但不同区域的变化百分比不同，这可能表明ACLR后膝关节运动学恢复不足。DB和SB ACLR方法可能对膝关节运动学有相似的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Bioengineering and Biotechnology Chemical Engineering-Bioengineering

CiteScore

8.30

自引率

5.30%

发文量

2270

审稿时长

12 weeks

期刊介绍： The translation of new discoveries in medicine to clinical routine has never been easy. During the second half of the last century, thanks to the progress in chemistry, biochemistry and pharmacology, we have seen the development and the application of a large number of drugs and devices aimed at the treatment of symptoms, blocking unwanted pathways and, in the case of infectious diseases, fighting the micro-organisms responsible. However, we are facing, today, a dramatic change in the therapeutic approach to pathologies and diseases. Indeed, the challenge of the present and the next decade is to fully restore the physiological status of the diseased organism and to completely regenerate tissue and organs when they are so seriously affected that treatments cannot be limited to the repression of symptoms or to the repair of damage. This is being made possible thanks to the major developments made in basic cell and molecular biology, including stem cell science, growth factor delivery, gene isolation and transfection, the advances in bioengineering and nanotechnology, including development of new biomaterials, biofabrication technologies and use of bioreactors, and the big improvements in diagnostic tools and imaging of cells, tissues and organs. In today`s world, an enhancement of communication between multidisciplinary experts, together with the promotion of joint projects and close collaborations among scientists, engineers, industry people, regulatory agencies and physicians are absolute requirements for the success of any attempt to develop and clinically apply a new biological therapy or an innovative device involving the collective use of biomaterials, cells and/or bioactive molecules. “Frontiers in Bioengineering and Biotechnology” aspires to be a forum for all people involved in the process by bridging the gap too often existing between a discovery in the basic sciences and its clinical application.