Zonghan Wang, Ze Wang, Lingchuan Gu, Ying Zhang, Tiao Su, Jiangming Luo, Chengjun Huang, Xiaoyuan Gong, Yang Peng, Guangxing Chen
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引用次数: 0
Abstract
Introduction: In cases of hip joint damage, such as osteoarthritis (OA), rheumatoid arthritis (RA), avascular necrosis, or hip fractures, total hip arthroplasty (THA) is a critical surgical intervention. For individuals whose hip abnormalities stem from congenital issues, injuries, or previous operations, this procedure can encounter considerable obstacles, including complex bone defects, soft tissue deficiencies, and an increased risk of infections, which may result in poor alignment, joint instability, and higher need for revisions. This study explored the application of personalized, three-dimensional (3D)-printed porous tantalum buttresses designed specifically for acetabular reconstruction. Renowned for its compatibility with human biology, tantalum facilitates superior integration with natural bone.
Methods: The development process started with the generation of meticulous computer-aided design (CAD) models, derived from preoperative imaging techniques such as computed tomography (CT) scans and (magnetic resonance imaging) MRIs, which allowed for the creation of components precisely matching each patient's unique anatomical structure. The 3D-printed porous tantalum buttresses were made by cutting-edge additive manufacturing methods. The porosity of the tantalum structure promoted the growth of new bone tissue into the implant, improving its stability and durability. During surgeries, the buttress was positioned to reconstruct the acetabulum, laying a solid foundation for the artificial hip joint.
Results: The results of our study showed that all surgeries were successfully completed with no significant vascular or nerve damage. Postoperative evaluations showed that the buttress had excellent biomechanical function and firm fixation, with a large amount of bone ingrowth, improving the fitness and performance of the implant while reducing the possibility of subsequent problems such as loosening or dislocation.
Discussion: This innovative technique has great potential in clinical practice for better outcomes and quality of life for patients with complex hip deformities.
期刊介绍：
The translation of new discoveries in medicine to clinical routine has never been easy. During the second half of the last century, thanks to the progress in chemistry, biochemistry and pharmacology, we have seen the development and the application of a large number of drugs and devices aimed at the treatment of symptoms, blocking unwanted pathways and, in the case of infectious diseases, fighting the micro-organisms responsible. However, we are facing, today, a dramatic change in the therapeutic approach to pathologies and diseases. Indeed, the challenge of the present and the next decade is to fully restore the physiological status of the diseased organism and to completely regenerate tissue and organs when they are so seriously affected that treatments cannot be limited to the repression of symptoms or to the repair of damage. This is being made possible thanks to the major developments made in basic cell and molecular biology, including stem cell science, growth factor delivery, gene isolation and transfection, the advances in bioengineering and nanotechnology, including development of new biomaterials, biofabrication technologies and use of bioreactors, and the big improvements in diagnostic tools and imaging of cells, tissues and organs.
In today`s world, an enhancement of communication between multidisciplinary experts, together with the promotion of joint projects and close collaborations among scientists, engineers, industry people, regulatory agencies and physicians are absolute requirements for the success of any attempt to develop and clinically apply a new biological therapy or an innovative device involving the collective use of biomaterials, cells and/or bioactive molecules. “Frontiers in Bioengineering and Biotechnology” aspires to be a forum for all people involved in the process by bridging the gap too often existing between a discovery in the basic sciences and its clinical application.
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