Hongjun Tao, Yang Wen, Rongfang Yu, Yining Xu, Fangliang Yu
{"title":"基于多种机器学习算法的小学学龄儿童头前姿势障碍预测模型建立","authors":"Hongjun Tao, Yang Wen, Rongfang Yu, Yining Xu, Fangliang Yu","doi":"10.3389/fbioe.2025.1607419","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Forward head posture frequently occurs among primary school children, potentially due to prolonged sedentary behavior associated with academic demands and reduced physical activity. However, existing prevention and screening methods fail to accurately and promptly predict the onset of forward head posture.</p><p><strong>Objective: </strong>This study aims to identify highly sensitive predictive indicators for forward head posture in primary school children using the Least Absolute Shrinkage and Selection Operator (LASSO) regression algorithm. Multiple machine learning algorithms are applied to construct distinct risk prediction models, with the most effective model selected through comparative analysis. The Shapley Additive Explanations (SHAP) method is used to quantify the influence of each feature on model outcomes, ensuring enhanced model interpretability.</p><p><strong>Methods: </strong>Employing a cross-sectional study design, this research recruited 520 primary school-aged children, gathering data on demographics, anthropometrics, and physical activity levels. Univariate logistic regression was utilized to identify high-risk factors for forward head posture. The LASSO algorithm was subsequently applied to select key predictors. Six machine learning models-K-nearest neighbor (KNN), light gradient boosting machine (LGBM), extreme gradient boosting (XGBoost), random forest (RF), linear model (LM), and support vector machine (SVM)-were developed to predict risk. The performance of each model was evaluated, and the best-performing model was further interpreted using the Shapley Additive Explanations (SHAP) algorithm.</p><p><strong>Results: </strong>A total of 514 children were ultimately included in the study, of whom 300 exhibited forward head posture. LASSO analysis identified age, bodyweight, BMI, sex, and weekly total homework time as prominent risk indicators. Among the 6 predictive models, the random forest algorithm demonstrated the highest performance (AUC = 0.865), significantly outperforming the others. SHAP analysis revealed that BMI, bodyweight, and age were the most influential predictors, with BMI contributing the most.</p><p><strong>Conclusion: </strong>The random forest-based prediction model achieved superior predictive accuracy for forward head posture among Chinese primary school children, emphasizing the importance of monitoring BMI, bodyweight, and age for early intervention and prevention efforts.</p>","PeriodicalId":12444,"journal":{"name":"Frontiers in Bioengineering and Biotechnology","volume":"13 ","pages":"1607419"},"PeriodicalIF":4.8000,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12162659/pdf/","citationCount":"0","resultStr":"{\"title\":\"Predictive model establishment for forward-head posture disorder in primary-school-aged children based on multiple machine learning algorithms.\",\"authors\":\"Hongjun Tao, Yang Wen, Rongfang Yu, Yining Xu, Fangliang Yu\",\"doi\":\"10.3389/fbioe.2025.1607419\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Forward head posture frequently occurs among primary school children, potentially due to prolonged sedentary behavior associated with academic demands and reduced physical activity. However, existing prevention and screening methods fail to accurately and promptly predict the onset of forward head posture.</p><p><strong>Objective: </strong>This study aims to identify highly sensitive predictive indicators for forward head posture in primary school children using the Least Absolute Shrinkage and Selection Operator (LASSO) regression algorithm. Multiple machine learning algorithms are applied to construct distinct risk prediction models, with the most effective model selected through comparative analysis. The Shapley Additive Explanations (SHAP) method is used to quantify the influence of each feature on model outcomes, ensuring enhanced model interpretability.</p><p><strong>Methods: </strong>Employing a cross-sectional study design, this research recruited 520 primary school-aged children, gathering data on demographics, anthropometrics, and physical activity levels. Univariate logistic regression was utilized to identify high-risk factors for forward head posture. The LASSO algorithm was subsequently applied to select key predictors. Six machine learning models-K-nearest neighbor (KNN), light gradient boosting machine (LGBM), extreme gradient boosting (XGBoost), random forest (RF), linear model (LM), and support vector machine (SVM)-were developed to predict risk. The performance of each model was evaluated, and the best-performing model was further interpreted using the Shapley Additive Explanations (SHAP) algorithm.</p><p><strong>Results: </strong>A total of 514 children were ultimately included in the study, of whom 300 exhibited forward head posture. LASSO analysis identified age, bodyweight, BMI, sex, and weekly total homework time as prominent risk indicators. Among the 6 predictive models, the random forest algorithm demonstrated the highest performance (AUC = 0.865), significantly outperforming the others. SHAP analysis revealed that BMI, bodyweight, and age were the most influential predictors, with BMI contributing the most.</p><p><strong>Conclusion: </strong>The random forest-based prediction model achieved superior predictive accuracy for forward head posture among Chinese primary school children, emphasizing the importance of monitoring BMI, bodyweight, and age for early intervention and prevention efforts.</p>\",\"PeriodicalId\":12444,\"journal\":{\"name\":\"Frontiers in Bioengineering and Biotechnology\",\"volume\":\"13 \",\"pages\":\"1607419\"},\"PeriodicalIF\":4.8000,\"publicationDate\":\"2025-05-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12162659/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Frontiers in Bioengineering and Biotechnology\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://doi.org/10.3389/fbioe.2025.1607419\",\"RegionNum\":3,\"RegionCategory\":\"工程技术\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q1\",\"JCRName\":\"BIOTECHNOLOGY & APPLIED MICROBIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Bioengineering and Biotechnology","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.3389/fbioe.2025.1607419","RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"BIOTECHNOLOGY & APPLIED MICROBIOLOGY","Score":null,"Total":0}
Predictive model establishment for forward-head posture disorder in primary-school-aged children based on multiple machine learning algorithms.
Background: Forward head posture frequently occurs among primary school children, potentially due to prolonged sedentary behavior associated with academic demands and reduced physical activity. However, existing prevention and screening methods fail to accurately and promptly predict the onset of forward head posture.
Objective: This study aims to identify highly sensitive predictive indicators for forward head posture in primary school children using the Least Absolute Shrinkage and Selection Operator (LASSO) regression algorithm. Multiple machine learning algorithms are applied to construct distinct risk prediction models, with the most effective model selected through comparative analysis. The Shapley Additive Explanations (SHAP) method is used to quantify the influence of each feature on model outcomes, ensuring enhanced model interpretability.
Methods: Employing a cross-sectional study design, this research recruited 520 primary school-aged children, gathering data on demographics, anthropometrics, and physical activity levels. Univariate logistic regression was utilized to identify high-risk factors for forward head posture. The LASSO algorithm was subsequently applied to select key predictors. Six machine learning models-K-nearest neighbor (KNN), light gradient boosting machine (LGBM), extreme gradient boosting (XGBoost), random forest (RF), linear model (LM), and support vector machine (SVM)-were developed to predict risk. The performance of each model was evaluated, and the best-performing model was further interpreted using the Shapley Additive Explanations (SHAP) algorithm.
Results: A total of 514 children were ultimately included in the study, of whom 300 exhibited forward head posture. LASSO analysis identified age, bodyweight, BMI, sex, and weekly total homework time as prominent risk indicators. Among the 6 predictive models, the random forest algorithm demonstrated the highest performance (AUC = 0.865), significantly outperforming the others. SHAP analysis revealed that BMI, bodyweight, and age were the most influential predictors, with BMI contributing the most.
Conclusion: The random forest-based prediction model achieved superior predictive accuracy for forward head posture among Chinese primary school children, emphasizing the importance of monitoring BMI, bodyweight, and age for early intervention and prevention efforts.
期刊介绍:
The translation of new discoveries in medicine to clinical routine has never been easy. During the second half of the last century, thanks to the progress in chemistry, biochemistry and pharmacology, we have seen the development and the application of a large number of drugs and devices aimed at the treatment of symptoms, blocking unwanted pathways and, in the case of infectious diseases, fighting the micro-organisms responsible. However, we are facing, today, a dramatic change in the therapeutic approach to pathologies and diseases. Indeed, the challenge of the present and the next decade is to fully restore the physiological status of the diseased organism and to completely regenerate tissue and organs when they are so seriously affected that treatments cannot be limited to the repression of symptoms or to the repair of damage. This is being made possible thanks to the major developments made in basic cell and molecular biology, including stem cell science, growth factor delivery, gene isolation and transfection, the advances in bioengineering and nanotechnology, including development of new biomaterials, biofabrication technologies and use of bioreactors, and the big improvements in diagnostic tools and imaging of cells, tissues and organs.
In today`s world, an enhancement of communication between multidisciplinary experts, together with the promotion of joint projects and close collaborations among scientists, engineers, industry people, regulatory agencies and physicians are absolute requirements for the success of any attempt to develop and clinically apply a new biological therapy or an innovative device involving the collective use of biomaterials, cells and/or bioactive molecules. “Frontiers in Bioengineering and Biotechnology” aspires to be a forum for all people involved in the process by bridging the gap too often existing between a discovery in the basic sciences and its clinical application.