Fitoterapia最新文献_第8页

Pentacyclic triterpenoids with cytotoxic activity from the stems of Syzygium jambos (L.) Alston 具有细胞毒性活性的五环三萜类化合物，来自茜草茎（L. Alston）。

IF 2.5 3区医学

Fitoterapia Pub Date : 2024-12-12 DOI: 10.1016/j.fitote.2024.106346

Zhilong Liu , Yuepei Huang , Jieting Chen , Lihua Peng , Weilin Qiao , Wei Li , De-an Guo

引用次数: 0

Synergistic antitumor effects of Phlorizin and Temozolomide in glioblastoma: Mechanistic insights and molecular targeting 苯丙嗪和替莫唑胺在胶质母细胞瘤中的协同抗肿瘤作用：机制和分子靶向

IF 2.5 3区医学

Fitoterapia Pub Date : 2024-11-29 DOI: 10.1016/j.fitote.2024.106313

Junzhi Hou , Zhaobin Xing , Ang Li , Hongjiao Wu , Ye Jin , Qinqin Song , Shanshan Ji , Zhi Zhang , Xuemei Zhang

{"title":"Synergistic antitumor effects of Phlorizin and Temozolomide in glioblastoma: Mechanistic insights and molecular targeting","authors":"Junzhi Hou , Zhaobin Xing , Ang Li , Hongjiao Wu , Ye Jin , Qinqin Song , Shanshan Ji , Zhi Zhang , Xuemei Zhang","doi":"10.1016/j.fitote.2024.106313","DOIUrl":"10.1016/j.fitote.2024.106313","url":null,"abstract":"<div><div>Glioblastoma (GBM), one of the most aggressive brain cancers, presents significant treatment challenges due to its complex biology and resistance to conventional therapies, necessitating the development of new, low-toxicity, and effective treatments. This study explores the antitumor potential of phlorizin, a naturally occurring dihydrochalcone, as a standalone agent and in combination with temozolomide (TMZ), the standard chemotherapeutic for GBM. Phlorizin was found to significantly inhibit cell viability and migration in vitro, with synergistic effects observed when combined with TMZ. Comprehensive analyses, including protein-protein interaction network construction, enrichment analysis, and molecular docking with AKT1, identified the PI3K/AKT/mTOR signaling pathway as a critical mediator of glioblastoma cell survival and proliferation targeted by phlorizin. Pathway enrichment analysis of 88 intersection targets further highlighted this pathway's role in phlorizin's activity. Western blot validation confirmed that phlorizin inhibits the expression of key proteins within the PI3K/AKT/mTOR pathway, providing a mechanistic basis for its antitumor effects. These findings suggest that phlorizin, particularly in combination with TMZ, holds significant potential as a therapeutic strategy for glioblastoma by targeting molecular pathways critical for cancer cell survival and proliferation.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"180 ","pages":"Article 106313"},"PeriodicalIF":2.5,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142759479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Danggui Buxue decoction alleviates primary dysmenorrhea in rats by regulating the MEK1/2/ERK1/2/NF-κB pathway 当归补血汤通过调节MEK1/2/ erk1 /NF-κB通路减轻大鼠原发性痛经

IF 2.5 3区医学

Fitoterapia Pub Date : 2024-11-29 DOI: 10.1016/j.fitote.2024.106315

Shi-Jia Gao , Xiao-Li Li , Rui Gao , Wen-Hong Tan , Wen Li , Lu Liu

引用次数: 0

New diketopiperazine dimers and 4-hydroxyphenylacetates from an endolichenic fungus Aspergillus sp. 内生真菌曲霉的新二酮哌嗪二聚体和4-羟基苯乙酸酯。

IF 2.5 3区医学

Fitoterapia Pub Date : 2024-11-27 DOI: 10.1016/j.fitote.2024.106318

Bingjie Su , Tao Zhang , Mengjia Mao , Renzhong Wang , Baoqing You , Jing Zhang , Liyan Yu , Shuyi Si , Jingshuai Wu , Minghua Chen

引用次数: 0

N6-(2-hydroxyethyl)-adenosine (HEA) exhibits antitumor activity for osteosarcoma progression by regulating IGF1 signaling N6-（2-羟乙基）-腺苷（HEA）通过调节IGF1信号传导，在骨肉瘤进展中表现出抗肿瘤活性

IF 2.5 3区医学

Fitoterapia Pub Date : 2024-11-27 DOI: 10.1016/j.fitote.2024.106319

Yu Dai , Guan Huang , Xiao Zhong , Yihua Yang , Junqiang Ye

{"title":"N6-(2-hydroxyethyl)-adenosine (HEA) exhibits antitumor activity for osteosarcoma progression by regulating IGF1 signaling","authors":"Yu Dai , Guan Huang , Xiao Zhong , Yihua Yang , Junqiang Ye","doi":"10.1016/j.fitote.2024.106319","DOIUrl":"10.1016/j.fitote.2024.106319","url":null,"abstract":"<div><h3>Background</h3><div>Osteosarcoma is a highly malignant bone tumor with poor prognosis and limited treatment options due to resistance and side effects.</div></div><div><h3>Objectives</h3><div>This study investigates the effects of N6-(2-hydroxyethyl)-adenosine (HEA) on osteosarcoma cells and its impact on the IGF1 signaling pathway.</div></div><div><h3>Methods</h3><div>Saos2 and MG63 cell lines were treated with HEA. Cell viability, apoptosis, migration, invasion, and EMT markers were assessed. IGF1 expression was analyzed using Western blot, qPCR, and ELISA. IGF1 silencing and recombinant IGF1 treatments were used to explore HEA's mechanisms.</div></div><div><h3>Results</h3><div>HEA significantly decreased osteosarcoma cell viability and induced apoptosis in a dose- and time-dependent manner. It also inhibited cell migration and invasion, and modulated EMT markers by upregulating E-cadherin and downregulating N-cadherin and vimentin. HEA downregulated IGF1 at both the mRNA and protein levels, and reduced IGF1 secretion. Furthermore, HEA inhibited the PI3K-AKT signaling pathway, which is activated by IGF1. IGF1 silencing mimicked HEA's effects, whereas recombinant IGF1 pre-treatment partially reversed HEA's effects on cell viability, apoptosis, and EMT markers.</div></div><div><h3>Conclusions</h3><div>HEA exerts potent anti-cancer effects on osteosarcoma cells both <em>in vitro</em> and <em>in vivo</em> by targeting the IGF1 pathway and inhibiting downstream PI3K-AKT signaling. These results suggest that HEA holds promise as a novel therapeutic agent for osteosarcoma.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"180 ","pages":"Article 106319"},"PeriodicalIF":2.5,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142744324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Structurally diverse coumarin derivatives from the buds of Edgeworthia gardneri and their cytotoxic activities 栀子花蕾香豆素衍生物的结构多样性及其细胞毒活性。

IF 2.5 3区医学

Fitoterapia Pub Date : 2024-11-26 DOI: 10.1016/j.fitote.2024.106314

Yan-Long Li , Yu Sun , Zhan Chai , Yan-Jun Sun , Wei Gao , Hui Chen , Meng Li , Jun-Min Wang , Wei-Sheng Feng

{"title":"Structurally diverse coumarin derivatives from the buds of Edgeworthia gardneri and their cytotoxic activities","authors":"Yan-Long Li , Yu Sun , Zhan Chai , Yan-Jun Sun , Wei Gao , Hui Chen , Meng Li , Jun-Min Wang , Wei-Sheng Feng","doi":"10.1016/j.fitote.2024.106314","DOIUrl":"10.1016/j.fitote.2024.106314","url":null,"abstract":"<div><div>Five new coumarins, including three phenypropaninized coumarins edgegardnerols A–C (<strong>1</strong>–<strong>3</strong>), two bicoumarins edgegardnerols D and E (<strong>4</strong> and <strong>5</strong>), along with eight known analogues, were isolated and identified from the dried buds of <em>E. gardneri</em>. Their structures were elucidated by comprehensive analysis of their NMR, IR, UV, HR-ESI-MS, and ECD data. Furthermore, the absolute configurations of the glucose moiety were confirmed by HPLC analysis after acidic hydrolysis and chemical derivatization. The cytotoxic activities of all isolated compounds were evaluated against A549 and SMMC-7721 cell lines. Among the tested isolates, compound <strong>12</strong> showed the most potent cytotoxicity with IC<sub>50</sub> values of 22.65 μM and 25.83 μM in these two cell lines, respectively. Compared with cisplatin (29.78 μM), compound <strong>12</strong> exhibited stronger cytotoxic activity in A549 cell line. The preliminary structure-activity relationship showed that 7-hydroxy group on coumarin skeleton was structurally required for the cytotoxity against the A-549 and SMMC-7721 cell lines.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"180 ","pages":"Article 106314"},"PeriodicalIF":2.5,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142750164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bioactive phenolics from the bulbs of Hymenocallis littoralis 鳞茎中的生物活性酚。

IF 2.5 3区医学

Fitoterapia Pub Date : 2024-11-26 DOI: 10.1016/j.fitote.2024.106309

Ruyang Guan , Wenxin Zhang , Ziqi Deng , Jingwen Xu , Hui Hu , Ying Li , Xiangjiu He , Yihai Wang

{"title":"Bioactive phenolics from the bulbs of Hymenocallis littoralis","authors":"Ruyang Guan , Wenxin Zhang , Ziqi Deng , Jingwen Xu , Hui Hu , Ying Li , Xiangjiu He , Yihai Wang","doi":"10.1016/j.fitote.2024.106309","DOIUrl":"10.1016/j.fitote.2024.106309","url":null,"abstract":"<div><div><em>Hymenocallis littoralis</em>, commonly known as Coastal Spider lily, is a perennial herbaceous plant in the Amaryllidaceae family. It is native to tropical and subtropical regions of the Americas, celebrated for its remarkably beautiful flowers. In this study, five previously undescribed chromones, one new benzopyran, along with five known chromones and fourteen known flavonoids, were identified. Among these, compounds <strong>6</strong>, <strong>9</strong>, <strong>12</strong>, <strong>18</strong>, <strong>19</strong>, <strong>20</strong>, and <strong>22</strong> were natural products isolated from <em>H. littoralis</em> for the first time. Their structures were determined using spectroscopic techniques (NMR and MS). Anti-inflammatory activities of the isolated chromone and benzopyran were evaluated in lipopolysaccharide (LPS) stimulated RAW 264.7 macrophage cells. Compound <strong>11</strong> exhibited significant inhibitory effects on nitric oxide (NO) production with an IC<sub>50</sub> value of 38.24 <em>μ</em>M. Further investigations revealed that compound <strong>11</strong> exerted its anti-inflammatory activity by preventing the nuclear translocation of NF-<em>κ</em>B and down-regulating the expression of pro-inflammatory factors, including iNOS, COX-2, IL-1<em>β</em>, and IL-6, in a concentration-dependent manner. This study provides evidence that benzopyran from <em>H. littoralis</em> may serve as a potential source of an anti-inflammatory agent.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"180 ","pages":"Article 106309"},"PeriodicalIF":2.5,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142738884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anti-inflammatory 5,6,7,8-tetrahydro-2-(2-phenylethyl) chromone derivatives from the stems of Aquilaria sinensis 从旱莲草茎中提取的 5,6,7,8-四氢-2-（2-苯基乙基）铬酮衍生物具有抗炎作用。

IF 2.5 3区医学

Fitoterapia Pub Date : 2024-11-26 DOI: 10.1016/j.fitote.2024.106312

Xia Liu , Min Yu , Jie Chen , Bin Hu , Jia-Bo Huang , Wei-Qun Yang , Zhong-Xiang Zhao

{"title":"Anti-inflammatory 5,6,7,8-tetrahydro-2-(2-phenylethyl) chromone derivatives from the stems of Aquilaria sinensis","authors":"Xia Liu , Min Yu , Jie Chen , Bin Hu , Jia-Bo Huang , Wei-Qun Yang , Zhong-Xiang Zhao","doi":"10.1016/j.fitote.2024.106312","DOIUrl":"10.1016/j.fitote.2024.106312","url":null,"abstract":"<div><div>Three previously undescribed 5,6,7,8-tetrahydro-2-(2-phenylethyl)chromones, (5<em>S</em>,6<em>R</em>,7<em>S</em>,8<em>S</em>)-8-chloro-5-ethoxy-6,7-dihydroxy-2-[2-(4′-methoxyphenyl)ethyl]-5,6,7,8-tetrahydrochromone (<strong>1</strong>), (5<em>R</em>,6<em>S</em>,7<em>R</em>,8<em>R</em>)-8-chloro-5-ethoxy-6,7-dihydroxy-2-(2- phenylethyl)-5,6,7,8-tetrahydrochromone (<strong>2</strong>), (5<em>S</em>,6<em>R</em>,7<em>S</em>,8<em>R</em>)-5,8-dichloro-6,7- dihydroxy-2-[2-(4′-methoxyphenyl)ethyl]-5,6,7,8-tetrahydrochromone (<strong>3</strong>), and 28 known analogues (<strong>4</strong>–<strong>31</strong>) were isolated from the stems of <em>Aquilaria sinensis</em>. Their structures were characterized by the spectroscopic methods, and the absolute configuration was resolved by circular dichroism (CD) spectroscopy. Bioactivity evaluation indicated that compounds <strong>3</strong>–<strong>8</strong> had significant inhibition effect in the production of NO in an inflammatory cell model with relatively lower IC<sub>50</sub> values of 5.54, 11.44, 3.68, 7.15, 10.26 and 13.04 μM, respectively, compared to the positive control indomethacin (IC<sub>50</sub> = 23.03 μM).</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"180 ","pages":"Article 106312"},"PeriodicalIF":2.5,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142738881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tracheloside, the main constituent of the total lignan extract from Trachelospermi Caulis, inhibited rheumatoid arthritis via IL-17/MAPK signaling pathway 通过 IL-17/MAPK 信号通路抑制类风湿性关节炎的主要成分--Trachelospermi Caulis 木酚素总提取物中的 Tracheloside

IF 2.5 3区医学

Fitoterapia Pub Date : 2024-11-26 DOI: 10.1016/j.fitote.2024.106311

He-Fei Wang , Zi-Hong Huang , Wei Zou , Chun-Hua Lai , Qin-Gang Tan

{"title":"Tracheloside, the main constituent of the total lignan extract from Trachelospermi Caulis, inhibited rheumatoid arthritis via IL-17/MAPK signaling pathway","authors":"He-Fei Wang , Zi-Hong Huang , Wei Zou , Chun-Hua Lai , Qin-Gang Tan","doi":"10.1016/j.fitote.2024.106311","DOIUrl":"10.1016/j.fitote.2024.106311","url":null,"abstract":"<div><div>A quantitative analysis method was established using high-performance liquid chromatography (HPLC) to simultaneously determine five lignans in the total lignan extract (TLE) from Trachelospermi Caulis at 280 nm, including nortracheloside, tracheloside, nortrachelogenin, trachelogenin, and arctigenin. The method demonstrated good linearity for each lignan within their respective ranges, with precision, stability, and repeatability meeting the criteria for quantitative analysis. Tracheloside, the most abundant compound in the TLE, effectively inhibited the release of inflammatory factors IL-6 and IL-17, and suppressed the migration MH7A cells <em>in vitro</em>. Furthermore, tracheloside reduced the production of key inflammatory factors, including COX-2, IL-6, IL-17, MMP2, MMP3, MMP9, JNK, p-JNK, p38, and p-p38 in TNF-α induced MH7A cells, thereby inhibiting the IL-17/MAPK signaling pathway, and thus contributing to its anti-rheumatoid arthritis effects. This study represents the first report on the simultaneous quantification of five major lignans from Trachelospermi Caulis and the anti-inflammatory properties of tracheloside.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"180 ","pages":"Article 106311"},"PeriodicalIF":2.5,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142720707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Iridoid glycosides from the flowers of Gardenia jasminoides: Isolation, characterization, and antioxidant potential 栀子花环烯醚萜苷的分离、表征及抗氧化活性研究。

IF 2.5 3区医学

Fitoterapia Pub Date : 2024-11-26 DOI: 10.1016/j.fitote.2024.106316

Wei Li , Huiyu Li , Qingsen Shao , Xueci Liang , Qiugui Zhou , Yun Tang

引用次数: 0