Fitoterapia最新文献_第7页

Bioassay-guided evaluation of a potent dual inhibitor of host and gut microbial α-glucosidases from Galla chinensis: mechanism insights and in silico studies. 五倍子宿主和肠道微生物α-葡萄糖苷酶的有效双重抑制剂的生物测定指导评价：机制见解和硅片研究。

IF 2.6 3区医学

Fitoterapia Pub Date : 2025-09-01 Epub Date: 2025-08-05 DOI: 10.1016/j.fitote.2025.106790

Hao-Fan Sun, Tong Yang, Yu-Tong Liu, Dong-Ning Kang, Guang-Hao Zhu, Qi Zhou, Yu-Ling Yin, Xu-Dong Hou, Hui Tang, Jie Hou

{"title":"Bioassay-guided evaluation of a potent dual inhibitor of host and gut microbial α-glucosidases from Galla chinensis: mechanism insights and in silico studies.","authors":"Hao-Fan Sun, Tong Yang, Yu-Tong Liu, Dong-Ning Kang, Guang-Hao Zhu, Qi Zhou, Yu-Ling Yin, Xu-Dong Hou, Hui Tang, Jie Hou","doi":"10.1016/j.fitote.2025.106790","DOIUrl":"10.1016/j.fitote.2025.106790","url":null,"abstract":"<p><p>Type 2 diabetes mellitus (T2DM) is characterized by high blood glucose levels and has emerged as an increasing public health burden worldwide. α-Glucosidases from both host and gut microbiota played important roles in digestion of carbohydrate to monosaccharides. Dual inhibition against host and gut microbial α-glucosidases hold great potentials in regulating glucose absorption of T2DM patients. This study aimed to discover a dual inhibitor of both host α-glucosidase (α-Glu) and gut microbial glucosidase (SusB) derived from Bacteroides based on bioassay-guided screening. The results demonstrated that the ethanol extract of Galla chinensis exhibited superior dual inhibition on both α-glucosidases and its major constituent 1,2,3,4,6-O-pentagalloylglucose (PGG) could remarkably inhibit α-Glu and SusB with IC<sub>50</sub> values of 0.21 ± 0.01 μM and 13.23 ± 1.00 μM, respectively, while the IC<sub>50</sub> values of the positive control (acarbose) on α-Glu and SusB were 430.40 ± 19.56 μM and 0.68 ± 0.05 μM, respectively. Inhibition kinetic analysis revealed that PGG functioned as a non-competitive inhibitor against α-Glu with K<sub>i</sub> values of 0.27 ± 0.13 μM, and it acted as competitive inhibitor towards SusB with K<sub>i</sub> values of 4.50 ± 0.64 μM. Docking simulations demonstrated that PGG could generate hydrogen bonds with allosteric sites in α-Glu and catalytic residues in SusB, respectively. The binding energies of PGG with α-Glu and SusB were - 7.5 kcal/mol and - 9.3 kcal/mol, while them for acarbose were - 8.2 kcal/mol and - 7.3 kcal/mol, respectively. These findings revealed the potential mechanism of PGG for diabetic therapy through retarding the absorption of carbohydrates.</p>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":" ","pages":"106790"},"PeriodicalIF":2.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144798578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Limonin: Advances in extraction, synthesis, pharmacological mechanisms, and structural optimization for therapeutic potential 柠檬苦素：提取、合成、药理机制和结构优化的研究进展

IF 2.6 3区医学

Fitoterapia Pub Date : 2025-09-01 DOI: 10.1016/j.fitote.2025.106861

Xianghui Meng , Zhichao Xi , Xinwei Chen , Donovan Green , Yunhao Zhou , Yao Xian , Hongmei Zhang

{"title":"Limonin: Advances in extraction, synthesis, pharmacological mechanisms, and structural optimization for therapeutic potential","authors":"Xianghui Meng , Zhichao Xi , Xinwei Chen , Donovan Green , Yunhao Zhou , Yao Xian , Hongmei Zhang","doi":"10.1016/j.fitote.2025.106861","DOIUrl":"10.1016/j.fitote.2025.106861","url":null,"abstract":"<div><div>Limonin, a highly oxygenated nor-triterpenoid phytochemical abundant in <em>Citrus</em> plants, has attracted considerable attention because of its diverse pharmacological properties. Its significant anti-inflammatory, antioxidant, anticancer, antifungal, and antiviral activities have been demonstrated in recent studies and are associated with the modulation of multiple signaling pathways, highlighting its potential as a valuable lead compound for therapeutic development. However, poor solubility and limited bioavailability constrain its practical application, prompting interest in chemical synthesis and structural modification strategies to enhance therapeutic potential. This review systematically summarizes recent advances in the extraction, synthesis, pharmacological mechanisms, and structural optimization of limonin, including comparisons of extraction processes and analyses of structure–activity relationships. It further aims to encourage additional research on limonin and its derivatives and to support their clinical translation.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"186 ","pages":"Article 106861"},"PeriodicalIF":2.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144988405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to "Resin from ant nest (Formica rufa) used in Austrian folk medicine provides a new antimicrobial compound" [Fitoterapia 184 (2025) 106654]. “奥地利民间医药中使用的蚁巢树脂（Formica rufa）提供了一种新的抗菌化合物”[Fitoterapia 184(2025) 106654]的更正。

IF 2.6 3区医学

Fitoterapia Pub Date : 2025-09-01 Epub Date: 2025-06-19 DOI: 10.1016/j.fitote.2025.106682

Johannes-Paul Fladerer-Grollitsch, Anna Quehenberger, Selina Fladerer-Grollitsch, Olaf Kunert, Robert Weis, Andreas Leitner, Franz Bucar

引用次数: 0

Five new clerodane diterpenoids from Callicarpa integerrima and their anti-inflammatory activity 五种新甾烷二萜类化合物及其抗炎活性。

IF 2.6 3区医学

Fitoterapia Pub Date : 2025-09-01 DOI: 10.1016/j.fitote.2025.106857

Muhammad Aurang Zeb , Jian-Lin Lai , Xing-Jie Zhang , Lu-Yu Wang , Meng-Ru Wang , Yuan-Lin Kong , Xiao-Li Li , Kai Jiang , Wei-Lie Xiao

{"title":"Five new clerodane diterpenoids from Callicarpa integerrima and their anti-inflammatory activity","authors":"Muhammad Aurang Zeb , Jian-Lin Lai , Xing-Jie Zhang , Lu-Yu Wang , Meng-Ru Wang , Yuan-Lin Kong , Xiao-Li Li , Kai Jiang , Wei-Lie Xiao","doi":"10.1016/j.fitote.2025.106857","DOIUrl":"10.1016/j.fitote.2025.106857","url":null,"abstract":"<div><div>Five previously undescribed clerodane diterpenoids named calintegerinoids A<strong>–</strong>E (<strong>1–5</strong>), featuring 5/6 and 6/6 fused ring systems, were isolated from <em>Callicarpa integerrima</em>. Their structures were determined using modern spectroscopic techniques, including NMR, HR-ESI-MS, IR, UV, specific rotations, and ECD, supplemented by quantum chemical calculations and DP4+ analysis. Compared with the standard drug Andrographolide (IC<sub>50</sub> 8.01 ± 0.46 μM), compound <strong>3</strong> demonstrated potent inhibition of LDH release with an IC<sub>50</sub> value of 1.27 ± 0.05 μM. It also dose-dependently suppressed IL-1β release and potently blocked NLRP3 inflammasome activation triggered by LPS and Nigericin, leading to decreased pyroptosis. In addition, compound <strong>3</strong> decreased ASC speck formation in a dose-dependent manner, suggesting its significant anti-inflammatory potential by inhibiting NLRP3 inflammasome assembly.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"186 ","pages":"Article 106857"},"PeriodicalIF":2.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144991345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synergistic effects of Coptis rhizome and rhubarb in inhibiting MDA-MB-231 triple-negative breast cancer metastasis: Potential involvement of coptisine and resveratroloside. 黄连和大黄抑制MDA-MB-231三阴性乳腺癌转移的协同作用：黄连碱和白藜芦醇苷的潜在参与。

IF 2.6 3区医学

Fitoterapia Pub Date : 2025-09-01 Epub Date: 2025-07-29 DOI: 10.1016/j.fitote.2025.106774

Yun-Hao Dai, Pei-Yi Chu, Ying-Chun Yu, Wei-Yu Hsu, Juan-Cheng Yang, Ye Gu, Hong-Zin Lee, Yang-Chang Wu

{"title":"Synergistic effects of Coptis rhizome and rhubarb in inhibiting MDA-MB-231 triple-negative breast cancer metastasis: Potential involvement of coptisine and resveratroloside.","authors":"Yun-Hao Dai, Pei-Yi Chu, Ying-Chun Yu, Wei-Yu Hsu, Juan-Cheng Yang, Ye Gu, Hong-Zin Lee, Yang-Chang Wu","doi":"10.1016/j.fitote.2025.106774","DOIUrl":"10.1016/j.fitote.2025.106774","url":null,"abstract":"<p><p>Metastasis, particularly in aggressive triple-negative breast cancer (TNBC), is the leading cause of breast cancer-related mortality. San-Huang-Xie-Xin-Tang (SHXXT), a heat-clearing herbal formula, is commonly prescribed by Chinese medicine physicians to treat breast cancer patients, and our previous study found that its treatment was associated with reduced mortality in these patients. To further explore its therapeutic potential, we investigated the combined effect of its key ingredients, Coptis rhizome and rhubarb, on the metastasis of TNBC by using MDA-MB-231 cell line. Data showed that the water extract of SHXXT reduced cell migration without inducing cell death, and oral administration of Coptis rhizome and rhubarb extracts significantly suppressed metastasis in vivo. Notably, this combination exhibited a potent synergistic inhibitory effect on cell migration and invasion, with a combination index of 0.2. Further analysis identified coptisine and resveratroloside as key active compounds that synergistically inhibit cell mobility. They modulate divergent epithelial-to-mesenchymal transition-related protein expressions, and this complementary regulation may underlie their synergistic effect. Taken together, our findings demonstrate that the water extracts of Coptis rhizome and rhubarb synergistically inhibit metastatic property of TNBC cells, with coptisine and resveratroloside contributing to this effect at least partly, suggesting their potential for the development of new adjuvant therapies for TNBC treatment.</p>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":" ","pages":"106774"},"PeriodicalIF":2.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144759507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to "Unusual ingenoids from Euphorbia erythradenia Bioss. with pro-apoptotic effects" [Fitoterapia 91 (2013) 87-94]. “来自Euphorbia erythradenia Bioss的不寻常的ingenoids”的更正。具有促凋亡作用”[Fitoterapia 91(2013) 87-94]。

IF 2.6 3区医学

Fitoterapia Pub Date : 2025-09-01 Epub Date: 2025-08-07 DOI: 10.1016/j.fitote.2025.106777

Seyed Mohammad Zarei, Abdul Majid Ayatollahi, Mustafa Ghanadian, Farzad Kobarfard, Mahmoud Aghaei, M Iqbal Choudhary, Faranak Fallahian

引用次数: 0

Mechanistic insights into Shengxian Sanren granules' effects on chronic heart failure: A synergistic study of UPLC-Q-TOF-MS/MS and network pharmacology 生仙散仁颗粒治疗慢性心力衰竭的机制研究：UPLC-Q-TOF-MS/MS和网络药理学的协同研究

IF 2.6 3区医学

Fitoterapia Pub Date : 2025-08-31 DOI: 10.1016/j.fitote.2025.106859

Sisi Dai , Min Wang , Zheqin Zhu , Shenghua Lu , Rongzhen Liu , Hongping Long , Qiuyan Zhang , Jianhe Liu

{"title":"Mechanistic insights into Shengxian Sanren granules' effects on chronic heart failure: A synergistic study of UPLC-Q-TOF-MS/MS and network pharmacology","authors":"Sisi Dai , Min Wang , Zheqin Zhu , Shenghua Lu , Rongzhen Liu , Hongping Long , Qiuyan Zhang , Jianhe Liu","doi":"10.1016/j.fitote.2025.106859","DOIUrl":"10.1016/j.fitote.2025.106859","url":null,"abstract":"<div><h3>Objective</h3><div>This study aims to elucidate the pharmacological mechanisms and therapeutic targets of Shengxian Sanren Granules in the treatment of Chronic heart failure (CHF), with particular emphasis on the regulation of the PI3K/AKT/mTOR-mediated autophagy signaling pathway.</div></div><div><h3>Methods</h3><div>The major blood-absorbed components of Shengxian Sanren Granules were identified using ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS/MS). Network analysis was applied to predict potential targets and signaling pathways, revealing 37 core targets predominantly enriched in the PI3K-Akt and mTOR pathways. CHF rat models were established and treated with varying doses of Shengxian Sanren Granules. Cardiac function was evaluated by echocardiography, and myocardial remodeling and autophagy were assessed using histological (HE and MASSON staining) and molecular (ELISA, Western blot, and PCR) methods.</div></div><div><h3>Results</h3><div>A total of 21 blood-absorbed components were identified. Network analysis revealed 37 core targets, mainly involving the PI3K-Akt and mTOR pathways. In vivo experiments demonstrated that Shengxian Sanren Granules significantly improved cardiac function (increased EF and FS), reduced serum NT-proBNP levels, and downregulated phosphorylated PI3K, AKT, and mTOR. Additionally, Shengxian Sanren Granules inhibited excessive autophagy, as evidenced by decreased LC3II/I and Beclin-1 expression and increased P62 levels.</div></div><div><h3>Conclusion</h3><div>Shengxian Sanren Granules exert therapeutic effects against CHF through a multi-component, multi-target mechanism, primarily by modulating the PI3K/AKT/mTOR signaling pathway and suppressing excessive autophagy in cardiomyocytes.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"186 ","pages":"Article 106859"},"PeriodicalIF":2.6,"publicationDate":"2025-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144921525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ethnobotanical and alkaloid composition with their cytotoxicity of Tabernaemontana polyneura: A review with in silico ADMET analysis 多神经塔纳蒙塔的民族植物学和生物碱组成及其细胞毒性：硅ADMET分析综述。

IF 2.6 3区医学

Fitoterapia Pub Date : 2025-08-31 DOI: 10.1016/j.fitote.2025.106851

Wen Xin Toh , Sin Yee Tang , Kae Shin Sim , Siew Huah Lim , Chun Hoe Tan

{"title":"Ethnobotanical and alkaloid composition with their cytotoxicity of Tabernaemontana polyneura: A review with in silico ADMET analysis","authors":"Wen Xin Toh , Sin Yee Tang , Kae Shin Sim , Siew Huah Lim , Chun Hoe Tan","doi":"10.1016/j.fitote.2025.106851","DOIUrl":"10.1016/j.fitote.2025.106851","url":null,"abstract":"<div><h3>Introduction</h3><div><em>Tabernaemontana</em> is a genus of plants traditionally used to treat various diseases, such as syphilis. Many cytotoxic indole alkaloids were isolated and characterized from plants of this genus, suggesting their potential applications as chemotherapeutical drugs or drug leads. Nonetheless, the Malaysian native species <em>Tabernaemontana</em> <em>polyneura</em> was relatively unknown. This study provides an overview of the botany, ethnobotany, phytochemistry, and <em>in silico</em> ADMET analysis of cytotoxic alkaloids isolated from <em>T. polyneura</em>.</div></div><div><h3>Methods</h3><div>A comprehensive literature search was conducted using the SciFinder, Google Scholar, Science Direct, and PubMed databases. Relevant articles were screened based on predefined inclusion and exclusion criteria to summarize the botany, ethnobotany, and alkaloid composition of <em>T. polyneura</em>. Additionally, the pharmacokinetic properties of the cytotoxic alkaloids were computationally assessed using SwissADME and OSIRIS Data Warrior.</div></div><div><h3>Results</h3><div><em>T. polyneura,</em> a species primarily found in Malaysia, has 79 alkaloids isolated over the past 35 years, with 16 newly identified in 2023. Among them, 26 alkaloids had undergone cytotoxic assessment. <em>In silico</em> analyses suggest that most cytotoxic alkaloids comply with Lipinski's rule of five and Veber's rule and do not cause organ and systemic toxicity.</div></div><div><h3>Conclusion</h3><div>The cytotoxicity and good bioavailability of the alkaloids and <em>in silico</em> data highlight their potential for further pharmacological investigation and drug development. Future research should focus on <em>in vitro</em> and <em>in vivo</em> validation to explore their therapeutic viability.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"186 ","pages":"Article 106851"},"PeriodicalIF":2.6,"publicationDate":"2025-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144948004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New tetrahydrobenzocyclooctabenzofuranone and dibenzocyclooctadiene lignans from Kadsura jaonica 新的四氢苯并环二苯并呋喃酮和二苯并环二烯木脂素

IF 2.6 3区医学

Fitoterapia Pub Date : 2025-08-31 DOI: 10.1016/j.fitote.2025.106858

Yu Su , Jingjing Shen , Shuang Yao , Lei Miao , Yu Zhang , Chuan-Rui Zhang

{"title":"New tetrahydrobenzocyclooctabenzofuranone and dibenzocyclooctadiene lignans from Kadsura jaonica","authors":"Yu Su , Jingjing Shen , Shuang Yao , Lei Miao , Yu Zhang , Chuan-Rui Zhang","doi":"10.1016/j.fitote.2025.106858","DOIUrl":"10.1016/j.fitote.2025.106858","url":null,"abstract":"<div><div>Phytochemical investigation of <em>Kadsura japonica</em> led to the isolation and characterization of six new lignans, including four tetrahydrobenzocyclooctabenzofuranone ones designated as kadjaponins A–D (<strong>1</strong>–<strong>4</strong>), and two dibenzocyclooctadiene ones named kadjaponins E and F (<strong>5</strong> and <strong>6</strong>), along with eighteen known analogues (<strong>7</strong>–<strong>24</strong>). The structural elucidation of these compounds was achieved through comprehensive spectroscopic analyses, including NMR, MS, and electronic circular dichroism (ECD). Notably, compounds <strong>1</strong> and <strong>2</strong> were found to feature an unprecedented epoxy moiety, prompting the expected structural revisions of three previously reported compounds, heteroclitin J, longipedlignan O, and longipedlignan P. In biological evaluations, compound <strong>20</strong> demonstrated marginal cytotoxicity against HCT-116 human cancer cells (IC<sub>50</sub> = 46.6 ± 2.5 μM), while compounds <strong>5</strong> and <strong>19</strong>–<strong>23</strong> exhibited significant ABTS radical scavenging activity, comparable to that of vitamin C used as a positive control.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"186 ","pages":"Article 106858"},"PeriodicalIF":2.6,"publicationDate":"2025-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144925464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

HSQC−TOCSY fingerprinting-guided isolation of undescribed glycosides and scalemic pentaketides with neuroprotective activity from a mesophotic zone Ircinia sponge-associated fungus, Acremonium sp. NBUF233 hhsc - tocsy指纹图谱引导下从一株叶灰菌海绵相关真菌Acremonium sp. NBUF233中分离出具有神经保护活性的未描述的苷类和鳞片五肽。

IF 2.6 3区医学

Fitoterapia Pub Date : 2025-08-31 DOI: 10.1016/j.fitote.2025.106856

Tingting Wei , Jinchang Li , Qianjing Zheng , Yuying Liu , Guangjun Ran , Haomiao Ding , Shaohua Huang , Salman Khan , Bin Wu , Shan He , Tingting Wang

引用次数: 0