Fitoterapia最新文献

{"title":"Alkaloids in Cancer therapy: Targeting the tumor microenvironment and metastasis signaling pathways","authors":"Raoufeh Koochaki ,&nbsp;Elaheh Amini ,&nbsp;Sara Zarehossini ,&nbsp;Danial Zareh ,&nbsp;Saeed Mohammadian Haftcheshmeh ,&nbsp;Saurav Kumar Jha ,&nbsp;Prashant Kesharwani ,&nbsp;Abolfazl Shakeri ,&nbsp;Amirhossein Sahebkar","doi":"10.1016/j.fitote.2024.106222","DOIUrl":"10.1016/j.fitote.2024.106222","url":null,"abstract":"<div><div>The use of phytomedicine in cancer therapy is a growing field of research that takes use of the medicinal properties of plant-derived compounds. Under the domain of cancer therapy and management, alkaloids, a prominent group of natural compounds, have showed significant potential. Alkaloids often affect a wide range of essential cellular mechanisms involved in cancer progression. These multi-targeting capabilities, can give significant advantages to alkaloids in overcoming resistance mechanisms. For example, berberine, an alkaloid found in Berberis species, is widely reported to induce apoptosis by activating caspases and regulating apoptotic pathways. Notably, alkaloids like as quinine have showed promise in inhibiting the formation of new blood vessels required for tumor growth. In addition, alkaloids have shown anti-proliferative and anticancer properties mostly <em>via</em> modulating key signaling pathways involved in metastasis, including those regulating epithelial-mesenchymal transition. This work provides a comprehensive overview of naturally occurring alkaloids that exhibit anticancer properties, with a specific emphasis on their underlying molecular mechanisms of action. Furthermore, many methods to modify previously reported difficult physicochemical properties using nanocarriers in order to enhance its systemic bioavailability have been discussed as well. This study also includes information on newly discovered alkaloids that are now being studied in clinical trials for their potential use in cancer treatment. Further, we have also briefly mentioned on the application of high-throughput screening and molecular dynamics simulation for acceleration on the identification of potent alkaloids based compounds to target and treat cancer.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"179 ","pages":"Article 106222"},"PeriodicalIF":2.5,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142344325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chemical composition and antifungal efficacy of Tunisian Prunus armeniaca L. kernels with formulation of an antidermatophyte cream based on kernel powder","authors":"Soukaina Hrichi ,&nbsp;Raja Chaâbane-Banaoues ,&nbsp;Haikel Hrichi ,&nbsp;Sameh Belgacem ,&nbsp;Oussama Babba ,&nbsp;Guido Flamini ,&nbsp;Hamouda Babba","doi":"10.1016/j.fitote.2024.106223","DOIUrl":"10.1016/j.fitote.2024.106223","url":null,"abstract":"<div><div>The biological activities of plant products are extremely correlated to the constituents present in each derivate. The present research aims to obtain by gas chromatography, the chemical profile of <em>Prunus armeniaca</em> L. kernel volatile fractions. The evaluation of the in vitro antifungal activities of the sterilized powder and volatile fractions of the plant <em>P. armeniaca</em> L. kernels was performed. Diffusion in a solid medium and broth microdilution methods were applied on fungi with medical importance (dermatophytes, yeasts and <em>Aspergillus</em> spp.). <em>P. armeniaca</em> L. powder based antidermatphyte cream has been formulated. Hydro-distillation generated two volatile fractions (VF1 and VF2) and chromatographic analysis showed the presence of three compounds for VF1 (98.7 % benzaldehyde, 1.0 % benzyl alcohol and 0.3 % 1,8-cineole) and two compounds for VF2 (90.3 % benzaldehyde and 9.3 % benzyl alcohol). The 2.5 % to 5 % concentrations in powder showed antifungal activities against dermatophytic strains. 1.25 to 2 mg/mL concentrations in volatile fractions were efficient against yeast strains, with a better efficiency for the VF1. The creams formulated were stable, cosmetically attractive with satisfactory pH, viscosity and spread ability. <em>Prunus armeniaca</em> L. kernel powders and the cream derived from them exhibit potent antifungal activities. This work presents a simple, ecological and economical means of formulating antifungal active substances and valorizing natural products.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"179 ","pages":"Article 106223"},"PeriodicalIF":2.5,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142344327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meroterpenoids with anti-triple negative breast cancer and antimicrobial activities from Arnebia euchroma","authors":"Ping Hai ,&nbsp;Haiyan Jia ,&nbsp;Zhiqiang Luo ,&nbsp;Huixia Fan ,&nbsp;Yunqing He ,&nbsp;Xianyan Li ,&nbsp;Peng Lin ,&nbsp;Qin Zhang ,&nbsp;Yuan Gao ,&nbsp;Jian Yang","doi":"10.1016/j.fitote.2024.106234","DOIUrl":"10.1016/j.fitote.2024.106234","url":null,"abstract":"<div><div>Two new meroterpenoids, arneuchrols A and B (<strong>1</strong> and <strong>2</strong>), together with twelve known analogs (<strong>3</strong>–<strong>14</strong>) were isolated from the root of <em>Arnebia euchroma</em>. The structures of <strong>1</strong> and <strong>2</strong> including their absolute configurations were elucidated by NMR, HRESIMS, and DFT calculation of their NMR and ECD data. The structure of pseudoshikonin I, firstly isolated from <em>Lithospermi radix</em> was revised as shikonofuran E (<strong>4</strong>). Anti-triple negative breast cancer (anti-TNBC) and antimicrobial activities of the isolated compounds were tested. Compounds <strong>3</strong>, <strong>4</strong>, <strong>6</strong>, <strong>7</strong>, <strong>9</strong>, <strong>10</strong>, and <strong>13</strong> exhibited potent inhibitory activity against TNBC (MDA-MB-231 cells) with IC₅₀ values in the range of 0.18–4.58 μM. Compound <strong>10</strong> displayed antifungal activity against five plant pathogenic fungi with MIC values in the range of 6.25–25 μg/mL. Compound <strong>9</strong> exhibited antibacterial activity against <em>Micrococcus lysodeikticus</em> with MIC value of 12.5 μg/mL.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"179 ","pages":"Article 106234"},"PeriodicalIF":2.5,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142344335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The structure elucidation, anti-aging and hypoglycemic effects of an O-acetyl mannoglucan from the bulbs of Lanzhou lily","authors":"Heping Hui ,&nbsp;Hui Jin ,&nbsp;Xiaoyan Yang ,&nbsp;Xuejun Wang ,&nbsp;Bo Qin","doi":"10.1016/j.fitote.2024.106240","DOIUrl":"10.1016/j.fitote.2024.106240","url":null,"abstract":"<div><div>An <em>O</em>-acetyl mannoglucan (BHP-1) from Lanzhou lily bulbs was structurally elucidated using partial acid hydrolysis, GC–MS, and 2D NMR techniques (COSY, NOESY, HSQC and HMBC) built on prior research, revealing a backbone of -<em>α</em>-D-(1 → 4)-Glc<em>p</em>-<em>β</em>-D-(1 → 4)-Man<em>p</em>- with the most potential side chains -<em>α</em>-D-(1 → 4)-Glc<em>p-β</em>-D-(1 → 4)-Man<em>p-α</em>-D-(1 → 4)-Glc<em>p</em>-<em>α</em>-D-(1 → Glc<em>p</em>- and -<em>α</em>-D-(1 → 4)-Glc<em>p</em>-<em>β</em>-D-(1 → 4)-Man<em>p-α-</em>D-(1 → Glc<em>p</em>-, attached to <em>O</em>-2 and <em>O</em>-3 of glucose and mannose residues, and featuring <em>O</em>-acetyl groups at <em>O</em>-2 or <em>O</em>-3 position of mannose. The terminal residue was <em>α</em>-D-(1 → Glc<em>p</em>. BHP-1 demonstrated anti-aging and hypoglycemic effects, as assessed by <em>C. elegans</em> model and glycolytic enzyme effect in vitro, respectively. The results showed that BHP-1 dose-dependently prolonged lifespan of <em>C. elegans</em> by 33 % at 4 mg/mL under normal conditions, with greater extensions under thermal and oxidative stress (50 % and 80 % increases, respectively, <em>p</em> &lt; 0.05), which were attributed to enhanced antioxidant enzymes (SOD and CAT) and lowered MDA levels of <em>C. elegans</em>. Additionally, BHP-1 exhibited remarkable inhibition on <em>α</em>-glucosidase (93 %) and moderate inhibition on <em>α</em>-amylase (53 %) at 4 mg/mL, with competitive inhibition of <em>α</em>-glucosidase and mixed non-competitive inhibition of <em>α</em>-amylase, respectively. These potential effects might be linked to BHP-1's diverse sugar linkages, higher content of Glc, and certain <em>O</em>-acetyl contents.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"179 ","pages":"Article 106240"},"PeriodicalIF":2.5,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142344336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The synthesis and bioactivity of apigenin derivatives","authors":"Shun Liu ,&nbsp;Xing Zheng ,&nbsp;Zhongqin Luo ,&nbsp;Caihong Tang ,&nbsp;Yufei Hu ,&nbsp;Qingying Peng ,&nbsp;Pengbing Mi ,&nbsp;Hongfei Chen ,&nbsp;Xu Yao","doi":"10.1016/j.fitote.2024.106228","DOIUrl":"10.1016/j.fitote.2024.106228","url":null,"abstract":"<div><h3>Background</h3><div>Apigenin, a naturally occurring compound with a flavone core structure, is known for its diverse bioactivities, including anti-inflammation, anti-toxicant, anti-cancer and so on. There has been significant interest in the medicinal chemistry community. To address these challenges, researchers have developed various derivatives of apigenin to address challenges such as poor water-solubility and low intestinal absorption, aiming to enhance the pharmacological activities and pharmacokinetic properties of this compound.</div></div><div><h3>Objective</h3><div>In recent years, there has been a proliferation of apigenin derivatives with enhanced bioactivity. However, there is a lack of comprehensive reviews on the function-based modification of these derivatives. In this paper, we provide an overview of the apigenin derivatives with varying bioactivities and explored their structure activity relationships. And the functions of different groups of apigenin derivatives were also analyzed.</div></div><div><h3>Conclusion</h3><div>This review summarized the current achievements that could provide some clues for further study of apigenin-based drugs.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"179 ","pages":"Article 106228"},"PeriodicalIF":2.5,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142344333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modification of natural compounds through biotransformation process by microorganisms and their pharmacological properties","authors":"Nigora Rustamova ,&nbsp;Guozheng Huang ,&nbsp;Maksud Isokov ,&nbsp;Jakhongir Movlanov ,&nbsp;Ruziev Farid ,&nbsp;Islamov Buston ,&nbsp;Hua Xiang ,&nbsp;Kahramon Davranov ,&nbsp;Abulimiti Yili","doi":"10.1016/j.fitote.2024.106227","DOIUrl":"10.1016/j.fitote.2024.106227","url":null,"abstract":"<div><div>The biotransformation of natural compounds by fungal microorganisms is a complex biochemical process. Tandem whole-cell biotransformation offers a promising, alternative, and cost-effective method for modifying of bioactive novel compounds. This approach is particularly beneficial for structurally complex natural products that are difficult to be synthesized through traditional synthetic methods. Biotransformation also provides significant regio- and stereoselectivity, making it a valuable tool for the chemical modification of natural compounds. By utilizing microbial conversion reactions, the biological activity and structural diversity of natural products can be enhanced. In this review, we have summarized 282 novel metabolites resulting from microbial transformation by various microorganisms. We discussed the chemical structures and pharmacological properties of these novel biotransformation products. The review would assist scientists working in the fields of biotechnology, organic chemistry, medicinal chemistry, and pharmacology.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"179 ","pages":"Article 106227"},"PeriodicalIF":2.5,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142344330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An updated overview of Gypsophila species: Phytochemical and pharmacological investigations","authors":"Marzie Kamali ,&nbsp;Marjan Talebi ,&nbsp;Javad Mottaghipisheh ,&nbsp;Elahe Sasani ,&nbsp;Bahram Moradi Mirshekari","doi":"10.1016/j.fitote.2024.106230","DOIUrl":"10.1016/j.fitote.2024.106230","url":null,"abstract":"<div><div>Medicinal plants and their consituents play a crucial role in disease prevention and treatment. The genus <em>Gypsophila</em> (Caryophyllaceae family), comprising approximately 150 species of flowering plants, holds significant value in both ornamental and therapeutic fields. Traditional uses in various cultures highlight their potential in treating a range of conditions, such as liver disorders, diabetes, and kidney stones. These resilient plants, known for their delicate blooms and adaptability to diverse environments, are rich in chemical compounds, including non-volatile constituents such as phenolic compounds (e.g., flavonoids), terpenoids, saponins, cyclopeptides, and alkaloids. Additionally, monoterpenes and sesquiterpenes, the primary volatile constituents, exhibit significant insecticidal properties. <em>Gypsophila</em> species show a broad spectrum of pharmacological effects, including hepatoprotective, cytotoxic, anti-diabetic, antioxidant, cytotoxic, anti-inflammatory, diuretic, neuroprotective, and anti-obesity properties. This review underscores the promising therapeutic potential of <em>Gypsophila</em> and advocates for further research, particularly clinical trials, to thoroughly assess their efficacy and safety. By consolidating existing knowledge, it sheds light on the potential of <em>Gypsophila</em> species as valuable resources for human health and underscores the need for continued exploration to uncover novel treatments and interventions.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"179 ","pages":"Article 106230"},"PeriodicalIF":2.5,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142327293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioactive polyketides and tryptophol alkaloids from the endophytic fungus Botryosphaeria dothidea LE-07 of Chinese tulip tree","authors":"Xiao-Rui Liu ,&nbsp;Ke-Xin Li ,&nbsp;Hao-Wei Chen ,&nbsp;Yu-Hang He ,&nbsp;Hai-Yan Wang ,&nbsp;Yi-Cheng Mao ,&nbsp;Ji-Yang Li ,&nbsp;Jin-Feng Hu ,&nbsp;Juan Xiong","doi":"10.1016/j.fitote.2024.106229","DOIUrl":"10.1016/j.fitote.2024.106229","url":null,"abstract":"<div><div>Two new tetraketide-derived phenol rhamnosides [botryrhamnosides A (<strong>1</strong>) and B (<strong>2</strong>)] and a new rhamnosylated tryptophol alkaloid (botryrhamnoside C, <strong>3</strong>), along with seven related known compounds (<strong>4</strong>–<strong>10</strong>) were isolated from the solid culture of <em>Botryosphaeria dothidea</em> LE-07, an endophytic fungus residing in the leaves of the rare medicinal plant Chinese tulip tree (<em>Liriodendron chinense</em>). Their structures with the absolute configurations were determined by a combination of spectroscopy methods, comparing specific rotations, electronic circular dichroism (ECD) calculations, and single-crystal X-ray diffraction analysis. Compounds <strong>1</strong> and <strong>2</strong> are rare tetraketide-derived resorcinols incorporating a <span>l</span>-rhamnose moiety, while <strong>3</strong> represents the first example of rhamnose-bound tryptophol derivatives produced by microorganisms. These metabolites were evaluated in vitro for their antimicrobial and anti-neuroinflammation activities. The rhamnosylated derivatives <strong>1</strong>–<strong>5</strong> displayed potent antibacterial activity against <em>Escherichia coli</em>, with MIC values in the range of 8–16 μg/mL. Compound <strong>2</strong> attenuated neuroinflammation in lipopolysaccharide (LPS)-induced BV-2 microglial cells, by decreasing the level of pro-inflammatory mediators [nitric oxide (NO), tumor necrosis factor-<em>α</em> (TNF-<em>α</em>), and interleukin 6 (IL-6)] and down-regulating the mRNA expression of inducible nitric oxide synthase (iNOS). In addition, compound <strong>8</strong> exhibited remarkable inhibitory effect against the ATP-citrate lyase (ACL), an emerging drug target for hyperlipidemia and related glycolipid metabolic disorders, with an IC₅₀ value of 5.32 μM.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"179 ","pages":"Article 106229"},"PeriodicalIF":2.5,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142327295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antileishmanial, antitrypanosomal and anti-coronavirus activities of benzophenanthridine alkaloids and other specialized metabolites isolated from the root bark of Zanthoxylum zanthoxyloides (Lam.) B.Zepernick & Timler","authors":"Abda Ba ,&nbsp;Vincent Roumy ,&nbsp;Malak Al Ibrahim ,&nbsp;Kristelle Hughes ,&nbsp;Thierry Hennebelle ,&nbsp;Jennifer Samaillie ,&nbsp;Sevser Sahpaz ,&nbsp;Mehdi A. Beniddir ,&nbsp;Marie-France Hérent ,&nbsp;Karin Séron ,&nbsp;Joëlle Quetin Leclercq ,&nbsp;Matar Seck ,&nbsp;Céline Rivière","doi":"10.1016/j.fitote.2024.106232","DOIUrl":"10.1016/j.fitote.2024.106232","url":null,"abstract":"<div><div>Strong antileishmanial and antitrypanosomal activities were highlighted for the crude methanolic extract (IC₅₀ = 0.61 and 2.15 μg/mL, respectively) of <em>Zanthoxylum zanthoxyloides</em> (Lam.) B.Zepernick &amp; Timler root bark, as well as for its apolar partitions (cyclohexane: IC₅₀ = 0.66 and 5.17 μg/mL, respectively and dichloromethane: IC₅₀ = 0.07 and 0.22 μg/mL, respectively), with a good selectivity index (SI) towards WI-38 cells. In addition, cyclohexane and dichloromethane extracts exhibited a dose-dependent inhibition of human coronavirus HCoV-229E infection in hepatoma Huh-7 cells expressing or not the cellular protease TMPRSS2 (IC₅₀ values of 5.29 μg/mL and 4.87 μg/mL, respectively). Fractionation of these active extracts led to the isolation of a new racemic benzophenanthridine alkaloid named zanthoxyloithrine (<strong>1</strong>), together with 13 known compounds. Their structures were elucidated by spectroscopic techniques including IR, UV, HR-MS, 1D and 2D NMR and electronic circular dichroism. In parallel, HR-ESI-MS/MS based dereplication and molecular networking analysis were performed to identify unpurified compounds in cyclohexane and dichloromethane extracts. Zanthoxyloithrine (<strong>1</strong>) showed strong antileishmanial (IC₅₀ = 0.14 μM, SI = 52.0) and antitrypanosomal (IC₅₀ = 0.36 μM, SI = 20.8) activities. In addition, compound (<strong>1</strong>) demonstrated a high antiviral activity against HCoV-229E with IC₅₀ value of 6.70 μM in presence of TMPRRS2 and without significant toxicity on Huh-7 cells. Other purified benzo[<em>c</em>]phenanthridine alkaloids also showed anti-coronavirus and antiparasitic activities.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"179 ","pages":"Article 106232"},"PeriodicalIF":2.5,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142344326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sesquiterpenes from the seeds of Cichorium glandulosum and their anti- neuroinflammation activities","authors":"Zheyang Wei ,&nbsp;Bo Li ,&nbsp;Ablajan Turak ,&nbsp;Haji Akber Aisa","doi":"10.1016/j.fitote.2024.106239","DOIUrl":"10.1016/j.fitote.2024.106239","url":null,"abstract":"<div><div>Three previously undescribed sesquiterpenes, along with three known ones were isolated from the seeds of <em>Cichorium glandulosum</em>. The structures of them were elucidated by the analysis of spectroscopic data. The isolated compounds were tested for their neuroprotective effects against LPS-induced neuroinflammation in BV-2 cells. Santamarine (<strong>5</strong>) exhibited inhibitory activity on LPS-induced NO production in BV-2 cells with IC₅₀ of 0.89 ± 0.12 μM. The mechanism of the compound <strong>5</strong> was related to activating the NF-<em>κ</em>B, MAPK and cGAS/STING pathways.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"179 ","pages":"Article 106239"},"PeriodicalIF":2.5,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142344332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}