Fitoterapia最新文献_第7页

Chemical constituents and anti-inflammatory investigation of Elsholtzia rugulosa Hemsl 黑草的化学成分及抗炎研究

IF 2.5 3区医学

Fitoterapia Pub Date : 2025-04-17 DOI: 10.1016/j.fitote.2025.106550

Xue-Ying Xu , Qiong Jin , Jia-Mei Geng, Pei-Feng Zhu, Zhu-Ya Yang, Xin Duan, Lu Liu

引用次数: 0

Chemical composition and anti-osteoarthritis potential of Lolium perenne L. assisted with computational studies 利用计算机辅助研究了黑麦草的化学成分和抗骨关节炎的潜力

IF 2.5 3区医学

Fitoterapia Pub Date : 2025-04-17 DOI: 10.1016/j.fitote.2025.106551

Mahmoud Nagaty Mahrous , Eman Zekry Attia , Mohamed S.A. Abdelkader , Deiaa E. Elsayed Abouzed , Sahar M. Gebril , Radwan Alnajjar , Ahmed A. Al-Karmalawy , Ashraf Nageeb Elsayed Hamed

{"title":"Chemical composition and anti-osteoarthritis potential of Lolium perenne L. assisted with computational studies","authors":"Mahmoud Nagaty Mahrous , Eman Zekry Attia , Mohamed S.A. Abdelkader , Deiaa E. Elsayed Abouzed , Sahar M. Gebril , Radwan Alnajjar , Ahmed A. Al-Karmalawy , Ashraf Nageeb Elsayed Hamed","doi":"10.1016/j.fitote.2025.106551","DOIUrl":"10.1016/j.fitote.2025.106551","url":null,"abstract":"<div><div>Osteoarthritis (OA) is a serious health issue that lacks a totally effective treatment. In light of the critical need for alternative therapies to halt osteoarthritis and its progress, This study explores the potential of <em>Lolium perenne</em> as a treatment for osteoarthritis for the first time. The research evaluates the plant's protective effects against monosodium iodoacetate (MIA)-induced OA in rats. 24 rats were assigned into 4 groups, group I (sham control), group II (OA), group III (dichloromethane fraction (FrII) + OA), and group IV (ethyl acetate fraction (FrIII) + OA). For 21 days, the samples were given orally at a dose of 40 mg/kg. The obtained results indicated all treatment groups showed a significant decrease in the severity of articular cartilage degradation and in the concentration of Interleukin-1 beta (IL-1β) and Tumor necrosis factor alpha (TNF-α) cytokines compared to the OA-induced group Moreover, eight structurally varied metabolites were isolated and identified from the FrII and FrIII fractions derived from the methanol extract of the aerial part of <em>L. perenne</em>, which were linked with pro-inflammatory cytokines in the computational docking investigation. Interestingly, salcolin B (<strong>2b</strong>) and calquiquelignan E (<strong>4</strong>) isolated from FrII fraction, showed prevalent activity for the two tested receptors [salcolin B, IL-1β (−6.7354 kcal/mol) and calquiquelignan E, TNF-α (−6.2038 kcal/mol)] compared to the reference flurbiprofen drug. Finally, the frontier candidates against IL-1β and TNF-α receptors simulated at 100 ns and the MM-GBSA calculations confirming the docking results. These findings highlight L. <em>perenne</em>'s potential as a natural therapeutic for OA.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"183 ","pages":"Article 106551"},"PeriodicalIF":2.5,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143874674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Isocoumarin and pyranone derivatives isolated from the mangrove-associated fungus Exserohilum rostratum NS-KS-3 as α-glucosidase inhibitors 从红树林相关真菌rostratum exserhilum NS-KS-3中分离的异香豆素和吡喃酮衍生物作为α-葡萄糖苷酶抑制剂

IF 2.5 3区医学

Fitoterapia Pub Date : 2025-04-17 DOI: 10.1016/j.fitote.2025.106555

Hongyan Bian , Bo Ding , Jie Huang, Rongchun Huang, Juntao Liu, Huaxin Peng, Kailing Wu, Qiushu Chen, Jingru Wang, Yiwen Tao, Hongbo Huang

引用次数: 0

Transdermal anti-inflammatory effects and mechanisms of hydrogel patches containing seco-iridoids from Gentiana macrophylla Pall 含巨叶龙胆次生环烯醚萜的水凝胶贴剂的透皮抗炎作用及其机制

IF 2.5 3区医学

Fitoterapia Pub Date : 2025-04-15 DOI: 10.1016/j.fitote.2025.106544

Huan Liu , Yao Zhong , Rong Huang , Shian Meng , Guang Chen

{"title":"Transdermal anti-inflammatory effects and mechanisms of hydrogel patches containing seco-iridoids from Gentiana macrophylla Pall","authors":"Huan Liu , Yao Zhong , Rong Huang , Shian Meng , Guang Chen","doi":"10.1016/j.fitote.2025.106544","DOIUrl":"10.1016/j.fitote.2025.106544","url":null,"abstract":"<div><div><em>Gentiana macrophylla</em> Pall. (GMP), known as “Qinjiao” in the Chinese Pharmacopeia, has a long history of clinical application in treating rheumatoid arthritis, primarily due to its iridoid components. However, the transdermal anti-inflammatory efficacy, active ingredients, and underlying mechanisms of these components remain under-investigated. This study aimed to clarify the transdermal anti-inflammatory effects and mechanisms of seco-iridoids from GMP by establishing a hydrogel patch transdermal drug delivery system. Using crude and refined GMP iridoid extracts as active components, the hydrogel patch system was established based on physicochemical properties, skin irritation tests, <em>in vitro</em> drug release, and skin permeation. The anti-inflammatory efficacy of these iridoid hydrogel patches was assessed using a carrageenan-induced paw edema model in mice. Content analysis and skin permeation studies identified gentiopicroside (GPS) and swertiamarin (SWE) as the key bioactive constituents. The hydrogel patch system demonstrated superior skin permeation and sustained drug release profiles compared to oral administration, addressing issues of poor bioavailability and rapid metabolism. Mechanistic studies revealed that these seco-iridoids exert their anti-inflammatory effects primarily through modulation of the iNOS/COX-2/NF-κB signaling cascade. Pharmacokinetic evaluations showed significant improvements in bioavailability and prolonged drug release, highlighting the clinical advantages of the transdermal approach. This work lays a solid foundation for the further optimization and clinical translation of GMP-based transdermal formulations, providing a framework for the investigation of iridoid transdermal systems and their therapeutic applications in inflammatory conditions.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"183 ","pages":"Article 106544"},"PeriodicalIF":2.5,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143839749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Alkaloids from the medicinal plant Incarvillea sinensis: Molecular diversity, synthesis, pharmacological properties and mechanism of action 药用植物马齿苋生物碱的分子多样性、合成、药理性质和作用机制

IF 2.5 3区医学

Fitoterapia Pub Date : 2025-04-15 DOI: 10.1016/j.fitote.2025.106548

Christian Bailly

{"title":"Alkaloids from the medicinal plant Incarvillea sinensis: Molecular diversity, synthesis, pharmacological properties and mechanism of action","authors":"Christian Bailly","doi":"10.1016/j.fitote.2025.106548","DOIUrl":"10.1016/j.fitote.2025.106548","url":null,"abstract":"<div><div>The plant genus <em>Incarvillea</em> includes several species used in traditional medicine for the treatment of inflammatory diseases and neurodegenerative pathologies in Central Asia. This is the case for the species <em>Incarvillea sinensis</em> Lam. (jiao-hao) used in Chinese medicine for the treatment of rheumatism and various ailments. A variety of alkaloids has been isolated from the plant, including molecules with analgesic properties but also natural products endowed with antitumor activities. The present review provides a survey of the alkaloids isolated from <em>I. sinensis</em>, with a focus on incarvilline-type compounds including incarvillateine, incarvine and incasine derivatives. Bioactive compounds have been identified and used as template for the design of antinociceptive agents or antitumor agents, in the incarvillateine and incarvine series, respectively. The incarvillateine series is difficult to exploit because of the compound has been suspected to trigger neuroinflammation. However, incarvillateine derivatives incorporating a truxillic acid-like moiety are studied as antinociceptive agents. The incarvine series looks more promising with the discovery of antimetastatic products, like incarvine C targeting the GTPase Rac1, frequently overexpressed or mutated in solid tumors. Incarvines C and G represent interesting scaffold to design compounds interfering with the cytoskeleton dynamic via Rac1 inhibition. Altogether, the review shed light on the medicinal interest of <em>Incarvillea sinensis</em> and its bioactive phytoconstituents. The goal is to encourage further studies into the discovery of new <em>Incarvillea</em> natural products and the elucidation of their mechanism of action, while promoting the responsible use of the natural resources.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"183 ","pages":"Article 106548"},"PeriodicalIF":2.5,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143839746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fritaipaines A − J, isosteroidal alkaloids with anti-neuroinflammatory activity from the bulbs of Fritillaria taipaiensis 从太白贝母球茎中提取具有抗神经炎活性的等甾体类生物碱

IF 2.5 3区医学

Fitoterapia Pub Date : 2025-04-15 DOI: 10.1016/j.fitote.2025.106546

En-Ke Qu , Mei-Li Yang , Shi-Jun Liu , Hang-Ying Li , Zai-Long Huang , Lan-Run Yang , Rui Luo , Yan-Ni Liang , Dong-Bo Zhang

{"title":"Fritaipaines A − J, isosteroidal alkaloids with anti-neuroinflammatory activity from the bulbs of Fritillaria taipaiensis","authors":"En-Ke Qu , Mei-Li Yang , Shi-Jun Liu , Hang-Ying Li , Zai-Long Huang , Lan-Run Yang , Rui Luo , Yan-Ni Liang , Dong-Bo Zhang","doi":"10.1016/j.fitote.2025.106546","DOIUrl":"10.1016/j.fitote.2025.106546","url":null,"abstract":"<div><div>Ten new isosteroidal alkaloids, fritaipaines A − J (<strong>1</strong>−<strong>10</strong>), and six known congeners (<strong>11</strong>–<strong>16</strong>) were isolated from the bulbs of <em>Fritillaria taipaiensis</em>. The planar structure of these compounds as well as the absolute configuration, were fully elucidated based on spectroscopic and single-crystal X-ray diffraction data analysis and electronic circular dichroism (ECD) methods. Fritaipaines A (<strong>1</strong>) and B (<strong>2</strong>) are rare C<sub>26</sub> cevanine-type alkaloids having C-18 nor carbon skeleton. Fritaipaines C − F (<strong>3</strong>–<strong>6</strong>) are the first examples of jervine-type alkaloids featuring an inversed E/F ring moiety. The characteristic <sup>13</sup>C NMR data for judging E/F rings-inversion of jervine-type alkaloids were summarized. Compounds <strong>5</strong>, <strong>9</strong>, and <strong>16</strong> exhibited potent nitric oxide (NO) inhibitory activity in lipopolysaccharide (LPS) stimulated BV-2 cells with IC<sub>50</sub> values of 3.7 ± 0.4, 10.3 ± 1.1, and 6.9 ± 0.7 μM, respectively. All compounds showed weak or no acetylcholinesterase (AChE) inhibition as determined by the Ellman's method. The results of network pharmacology experiments predicted that the anti-Alzheimer<em>'</em>s disease (AD) effect of fritaipaine E (<strong>5</strong>) was related to 9 signaling pathways and 5 core targets, including SRC, PIK3CA, AKT1, EGFR, and IGF1R. Molecular docking simulations highlighted interactions between <strong>5</strong> and core targets, showing inhibitory effects on AD.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"183 ","pages":"Article 106546"},"PeriodicalIF":2.5,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143855982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Triterpenoids from Ganoderma cochlear against inflammation and renal fibrosis 灵芝三萜抗炎症及肾纤维化作用

IF 2.5 3区医学

Fitoterapia Pub Date : 2025-04-14 DOI: 10.1016/j.fitote.2025.106543

Jian-Biao Zhang , Sheng-Hong Li , Zhi-Yuan Li , Yong-Ming Yan , Yong-Xian Cheng

引用次数: 0

Brunodelphinone and Brunodelphinine a, two novel C20-diterpenoid alkaloids isolated from Delphinium brunonianum Royle 从 Delphinium brunonianum Royle 分离出的两种新型 C20-二萜生物碱 Brunodelphinone 和 Brunodelphinine a

IF 2.5 3区医学

Fitoterapia Pub Date : 2025-04-14 DOI: 10.1016/j.fitote.2025.106532

Yuan-sheng Zou , Ze-ren Dawa , Fang-le Liu , Mei-qi Wang , Chen-chen Zhu , Chao-zhan Lin

引用次数: 0

Bisabolane-type sesquiterpenoids and cyclic tetrapeptide from the marine fungus Aspergillus sp. WHUF05242 海洋真菌曲霉（Aspergillus sp. WHUF05242）的双abolane型倍半萜类和环四肽

IF 2.5 3区医学

Fitoterapia Pub Date : 2025-04-14 DOI: 10.1016/j.fitote.2025.106547

Yu-Ting Zhong , Zi-Fang Zhao , Wei-Chen Chen , Philomina Panin Edjah , Kong-Kai Zhu , Cong-Kui Tian , Kui Hong , Wei-Xin Tao , Ke-Yong Zhang , Meng-Ke Zhang , Fu-Qian Wang , You-Sheng Cai

{"title":"Bisabolane-type sesquiterpenoids and cyclic tetrapeptide from the marine fungus Aspergillus sp. WHUF05242","authors":"Yu-Ting Zhong , Zi-Fang Zhao , Wei-Chen Chen , Philomina Panin Edjah , Kong-Kai Zhu , Cong-Kui Tian , Kui Hong , Wei-Xin Tao , Ke-Yong Zhang , Meng-Ke Zhang , Fu-Qian Wang , You-Sheng Cai","doi":"10.1016/j.fitote.2025.106547","DOIUrl":"10.1016/j.fitote.2025.106547","url":null,"abstract":"<div><div>Two new bisabolane-type sesquiterpenoids, aspergillolanoids A and B (<strong>1</strong> and <strong>2</strong>), along with a previously unreported cyclic tetrapeptide, aspergitertide A (<strong>5</strong>), and four known compounds (<strong>3</strong>, <strong>4</strong>, <strong>6</strong> and <strong>7</strong>), have been isolated from the deep-sea-derived fungus <em>Aspergillus</em> sp. WHUF05242. Structural elucidation of these compounds was accomplished through comprehensive spectroscopic analysis, including HR-ESIMS and 1D/2D NMR spectroscopic data. The absolute stereochemistry of <strong>1</strong> was unambiguously determined by single-crystal X-ray crystallographic analysis, while the chiral center configurations of <strong>5</strong> were resolved through time-dependent density functional theory (TDDFT)-based ECD calculations. Antimicrobial evaluation revealed that compound <strong>7</strong> demonstrated moderate antibacterial activity against <em>Staphylococcus aureus</em> with MIC value of 16 μg/mL.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"183 ","pages":"Article 106547"},"PeriodicalIF":2.5,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143839750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tigliane and premyrsinane diterpenoids from Euphorbia monostyla and their cytotoxic activity 大戟科植物中的 Tigliane 和 premyrsinane 二萜及其细胞毒性活性

IF 2.5 3区医学

Fitoterapia Pub Date : 2025-04-14 DOI: 10.1016/j.fitote.2025.106525

Atabay Kokanov , Hequn Yang , Dan Tang , Artyk Kokanov , Jiangyu Zhao , Haji Akber Aisa

引用次数: 0