Fitoterapia最新文献_第7页

Antioxidant potential, enzyme inhibitory activity and HPLC-MS/MS phenolics profiles in Salvia aegyptiaca L. (Lamiaceae, Nepetoideae, Mentheae) growing in Tunisia

IF 2.5 3区医学

Fitoterapia Pub Date : 2025-03-11 DOI: 10.1016/j.fitote.2025.106473

Ons Jendoubi , Siwar Majdoub , Hekmat B. AL-Hmadi , Ridha El Mokni , Simone Angeloni , Ahmed M. Mustafa , Giovanni Caprioli , Gokhan Zengin , Filippo Maggi , Saoussen Hammami

{"title":"Antioxidant potential, enzyme inhibitory activity and HPLC-MS/MS phenolics profiles in Salvia aegyptiaca L. (Lamiaceae, Nepetoideae, Mentheae) growing in Tunisia","authors":"Ons Jendoubi , Siwar Majdoub , Hekmat B. AL-Hmadi , Ridha El Mokni , Simone Angeloni , Ahmed M. Mustafa , Giovanni Caprioli , Gokhan Zengin , Filippo Maggi , Saoussen Hammami","doi":"10.1016/j.fitote.2025.106473","DOIUrl":"10.1016/j.fitote.2025.106473","url":null,"abstract":"<div><div>The present study aimed to assess for the first time the antioxidant and enzyme inhibition activities of phenolic secondary metabolites of Tunisian <em>Salvia aegyptiaca</em> extracted using different solvents (methanol, ethyl acetate, chloroform and hexane). The phytochemical composition was examined via HPLC-MS/MS. The evaluation of the antioxidant effects involved the utilization of multiple techniques including phosphomolybdenum, antiradical (DPPH and ABTS), reducing power (FRAP and CUPRAC), and ferrous chelating assays. Additionally, the inhibitory activity was tested on different enzymes: <em>α</em>-amylase, <em>α</em>-glucosidase, acetylcholinesterase, butyrylcholinesterase, and tyrosinase.</div><div>The HPLC examination of various extracts revealed the quantification of 11 phenolic acids, 11 flavonoids, along with ellagic and <em>trans</em>-cinnamic acids. The chloroform extract was predominated by the presence of syringic acid (4665.38 mg/Kg) while the highest accumulation of caffeic acid (3058.47 and 2593.19 mg/Kg), kaempferol (4675.33 and 4025.04 mg/Kg) and hesperidin (8449.26 and 3705.82 mg/Kg) were recorded in methanol and ethyl acetate, respectively. Our findings demonstrated that the Tunisian <em>S. aegyptiaca</em> extracts exhibited a notable <em>α</em>-amylase and <em>α</em>-glycosidase inhibitory capabilities. It is worthy to note that the crude methanolic extract demonstrated the strongest antioxidant properties, and it was the richest source of total phenolic constituents.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"182 ","pages":"Article 106473"},"PeriodicalIF":2.5,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143621244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anti-breast cancer effect of Phellinus pini and its chemical composition characterization

IF 2.5 3区医学

Fitoterapia Pub Date : 2025-03-11 DOI: 10.1016/j.fitote.2025.106480

Jiajia Hu , Jiyuan Cao , Huixin Cheng , Xiaojin Liu , Guoying Zhang , Jianya Ling

引用次数: 0

Discovery of a lignan alkaloid, vitedoamine A, as an IKKβ inhibitor for suppressing NF-κB mediated inflammatory responses and osteoclastogenesis in rheumatoid arthritis

IF 2.5 3区医学

Fitoterapia Pub Date : 2025-03-11 DOI: 10.1016/j.fitote.2025.106482

Bingke Bai , Shuting Zhou , Yaoli Guo , Hongrui Wang , Xuhui He , Baokang Huang , Chengjian Zheng

{"title":"Discovery of a lignan alkaloid, vitedoamine A, as an IKKβ inhibitor for suppressing NF-κB mediated inflammatory responses and osteoclastogenesis in rheumatoid arthritis","authors":"Bingke Bai , Shuting Zhou , Yaoli Guo , Hongrui Wang , Xuhui He , Baokang Huang , Chengjian Zheng","doi":"10.1016/j.fitote.2025.106482","DOIUrl":"10.1016/j.fitote.2025.106482","url":null,"abstract":"<div><div>Phenylnaphthalene-type lignans have been recognized as the major anti-inflammatory constituents in <em>V. negundo</em> seeds, among which vitedoamine A (VA) was the first discovered lignan alkaloid bearing a γ-lactam. However, the protective effects and specific target of VA against rheumatoid arthritis (RA) have not been explored yet. Herein, our study revealed that VA could inhibit the transcriptional activity of NF-κB, and suppress the production of NO and reduce the expressions of inflammatory cytokines (IL-1β, IL-6, and TNF-α) in several inflammatory cell models, mainly via inhibiting the phosphorylation of IKKα/β and p65, and prevented the degradation of IκBα, thus restraining NF-κB activation. Meanwhile, VA considerably down-regulated the phosphorylation of IKKα/β and p65, and inhibited the degradation of IκBα in RANKL-induced osteoclasts formation and differentiation, suggesting that VA may impede osteoclastogenesis and relieve joint damage in RA. Furthermore, VA interfered IKK/IκBα/NF-κB pathway and decreased the expressions of inflammatory cytokines in IL-1β stimulated fibroblast-like synoviocytes (FLSs), suggesting that VA possessed promising in vitro anti-RA capacity, probably by direct targeting IKKβ and inhibiting its activity (IC<sub>50</sub> value: 39 μM). In addition, molecular docking displayed that VA could bind with residues Cys99 and Asp103 in IKKβ via hydrogen bonds, thus preventing ATP from binding with IKKβ to inhibit the activity of IKKβ. Taken together, VA directly targets IKKβ and significantly inhibits the IKK/IκBα/NF-κB pathway, thus inhibiting inflammatory responses in FLSs and mitigating joint damage related to osteoclastogenesis, displaying great potential in treating RA.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"182 ","pages":"Article 106482"},"PeriodicalIF":2.5,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143609735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bioassay-guided and DeepSAT + SMART-driven identification of hepatoprotective phenolics from the fruits of Phyllanthus emblica

IF 2.5 3区医学

Fitoterapia Pub Date : 2025-03-11 DOI: 10.1016/j.fitote.2025.106475

Zhenzhen Liang , Sheng Li , Hui Wang , Ziyi Tang , Bodou Zhang , Yinling Wei , Yun Huang , Ning Li , Yu Zhang

{"title":"Bioassay-guided and DeepSAT + SMART-driven identification of hepatoprotective phenolics from the fruits of Phyllanthus emblica","authors":"Zhenzhen Liang , Sheng Li , Hui Wang , Ziyi Tang , Bodou Zhang , Yinling Wei , Yun Huang , Ning Li , Yu Zhang","doi":"10.1016/j.fitote.2025.106475","DOIUrl":"10.1016/j.fitote.2025.106475","url":null,"abstract":"<div><div>To explore potential protective effects of natural products against alcohol-induced liver disease, a bioactivity-driven approach and HSQC-based DeepSAT and SMART were employed. Twelve phenolics, including four previously uncharacterized compounds (<strong>1</strong>–<strong>4</strong>), were identified from the fruits of <em>Phyllanthus emblica</em>. Their structures were elucidated as gallic acid analogs through comprehensive spectroscopic analysis, including HRESIMS and NMR methods. Network pharmacology predicted that compounds <strong>1</strong>–<strong>12</strong> may target on AKT1, TNF, and NFKB1, with potential to improve alcohol-induced liver injury, as suggested by Swiss Target Prediction. Compounds <strong>1</strong>–<strong>4</strong>, <strong>6</strong>, <strong>8</strong>, and <strong>9</strong> exhibited significant protective effects against alcohol-induced liver damage in NCTC-1469 cells at a concentration of 20 <em>μ</em>g/mL. Notably, compound <strong>4</strong> was found to exert its anti-alcoholic liver injury effect via the TLR4/NF-<em>κ</em>B signaling pathway.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"182 ","pages":"Article 106475"},"PeriodicalIF":2.5,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143621246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis, cytotoxicity and HQSAR study of amides-fused isosteviol derivatives as potential anti-colorectal cancer agents

IF 2.5 3区医学

Fitoterapia Pub Date : 2025-03-10 DOI: 10.1016/j.fitote.2025.106471

Cong-Jun Liu , Ling-Yan Guo , Tian-Ci Li , Yong Wang , Wei Wang , Bing-Chao Duan , Yan-Fei Zhang , Xing-Jie Dai , Yu-Ling Li , Yu-Fei Wang

引用次数: 0

Discovery of antioxidants and α-glycosidase inhibitors from an endophytic fungus Penicillium brefeldianum F4a 从一种内生真菌青霉菌（Penicillium brefeldianum F4a）中发现抗氧化剂和 α-糖苷酶抑制剂

IF 2.5 3区医学

Fitoterapia Pub Date : 2025-03-10 DOI: 10.1016/j.fitote.2025.106479

Yan Bai , Feng Guo , Jiangchun Hu , Huaqi Pan

{"title":"Discovery of antioxidants and α-glycosidase inhibitors from an endophytic fungus Penicillium brefeldianum F4a","authors":"Yan Bai , Feng Guo , Jiangchun Hu , Huaqi Pan","doi":"10.1016/j.fitote.2025.106479","DOIUrl":"10.1016/j.fitote.2025.106479","url":null,"abstract":"<div><div>Oxidative stress significantly contributes to the progression of diabetes. The use of antioxidants or <em>α</em>-glycosidase inhibitors would be an effective therapeutic strategy for diabetes. To discover natural antioxidants or <em>α</em>-glycosidase inhibitors, two new compounds, penidione A (<strong>1</strong>) and peniorcinol D (<strong>2</strong>), were obtained from the endophytic fungus <em>Penicillium brefeldianum</em> F4a isolated from the roots of <em>Houttuynia cordata</em> Thunb. (Saururaceae). The structures were identified through a comprehensive analysis of spectroscopic data, including HR-ESI-MS, UV, IR, 1D and 2D NMR, together with quantum chemical calculations. Biological tests indicated that penidione A displayed weaker <em>α</em>-glycosidase inhibition activity than that of acarbose and peniorcinol D showed significant ABTS<sup>•+</sup> scavenging activity, comparable to that of <em><span>l</span></em>-ascorbic acid. Moreover, molecular docking analyses showed that penidione A had a good binding affinity with <em>α</em>-glycosidase, and the binding mode included hydrogen bonding and hydrophobic interaction. This work could provide valuable information for developing antioxidants or <em>α</em>-glycosidase inhibitors as lead compounds to treat diabetes.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"182 ","pages":"Article 106479"},"PeriodicalIF":2.5,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143609833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis and evaluation of demethylzeylasteral derivatives as potential anticancer therapies for colon cancer: In vitro antiproliferation, cell cycle arrest analyses, network pharmacology investigations, and molecular docking studies.

IF 2.5 3区医学

Fitoterapia Pub Date : 2025-03-10 DOI: 10.1016/j.fitote.2025.106481

Lin Xing, Jieying Yuan, Yuxin Ding, Enxiao Wang, Ruilong Sheng, Junting Fan, Xiuwei H Yang, Ruihua Guo

{"title":"Synthesis and evaluation of demethylzeylasteral derivatives as potential anticancer therapies for colon cancer: In vitro antiproliferation, cell cycle arrest analyses, network pharmacology investigations, and molecular docking studies.","authors":"Lin Xing, Jieying Yuan, Yuxin Ding, Enxiao Wang, Ruilong Sheng, Junting Fan, Xiuwei H Yang, Ruihua Guo","doi":"10.1016/j.fitote.2025.106481","DOIUrl":"https://doi.org/10.1016/j.fitote.2025.106481","url":null,"abstract":"<p><p>A series of novel demethylzeylasteral derivatives 1-3 was synthesized by performing modifications on the aldehyde groups at the C-4 positions. Subsequently, the anti - proliferative activities of derivatives 1-3 was evaluated using three human cancer cell line models (HCT116, SKOV3, and HepG2) and the CCK - 8 assay. Compared with demethylzeylasteral, derivative 2 exhibited a remarkable inhibitory effect on HCT116 (4.17 ± 0.07 μM), SKOV3 (24.15 ± 1.65 μM), and HepG2 (36.66 ± 0.42 μM), DOX using as a positive control. Treatment with derivative 2 alone led to moderate cell cycle arrest at the S-phase in a concentration- dependent manner. However, when derivative 2 was combined with PTX, it influenced cell cycle arrest at the G1 phase. Meanwhile, treatment with derivative 2 markedly induced apoptosis in tumor cells. When derivative 2 was combined with PTX, it increased the rate of late apoptosis in HCT116 cells. Consistent with this observation, our subsequent network pharmacology analysis showed that TP53 was the most deeply colored and had the most connections with other targets. Then, the docking analysis indicated that derivative 2 could activate TP53 by interacting with the Pro-1537 residues of the protein. Overall, a new series of demethylzeylasteral derivatives with enhanced anti - tumor efficacy compared to their parent compound were developed, indicating derivative 2 has great potential to be used as a candidate anticancer agent in natural - product - based cancer chemotherapy.</p>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":" ","pages":"106481"},"PeriodicalIF":2.5,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143614060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Black raspberry seed oil – Chemical composition, antioxidant/antimicrobial activities and in vitro wound-healing potential

IF 2.5 3区医学

Fitoterapia Pub Date : 2025-03-10 DOI: 10.1016/j.fitote.2025.106477

Nemanja Krgović , Dejan Stojković , Marija Ivanov , Milena Dimitrijević , Nebojša Menković , Milan Ilić , Miloš S. Jovanović , Katarina Šavikin , Jelena Živković

{"title":"Black raspberry seed oil – Chemical composition, antioxidant/antimicrobial activities and in vitro wound-healing potential","authors":"Nemanja Krgović , Dejan Stojković , Marija Ivanov , Milena Dimitrijević , Nebojša Menković , Milan Ilić , Miloš S. Jovanović , Katarina Šavikin , Jelena Živković","doi":"10.1016/j.fitote.2025.106477","DOIUrl":"10.1016/j.fitote.2025.106477","url":null,"abstract":"<div><div>This study aimed to perform chemical characterization of black raspberry seed oil (<em>Rubus occidentalis</em> L., Rosaceae) from Serbia in terms of fatty acids and tocols composition, total carotenoid content, as well as to investigate its antioxidant/antimicrobial activities and <em>in vitro</em> wound-healing potential. GC/MS analysis revealed that linoleic (39.30 %), <em>α</em>-linolenic (30.49 %) and oleic (18.94 %) acid were dominant fatty acids. HPLC analysis highlighted <em>γ</em>-tocopherol as the prevailing tocopherol isomer (166.80 mg/100 g). Spectrophotometric method determined a total carotenoid content of 1.20 mg/100 g. Appreciable antiradical activity (DPPH – IC<sub>50</sub> 3.02 mg/mL; ABTS – IC<sub>50</sub> 1.33 mg/mL) and a high level of reducing ability (FRAP value of 393.74 μmol Fe<sup>2+</sup>/100 g) were observed. Significant antibacterial activity against <em>Salmonella</em> Typhimurium, <em>Escherichia coli</em> and <em>Bacillus cereus</em>, in addition to antifungal activity against strains from <em>Aspergillus</em> and <em>Trichoderma</em> genera, was demonstrated. By cell viability assay, no cytotoxicity (IC<sub>50</sub> > 401 μg/mL) was established on human keratinocytes (HaCaT cells). The wound-healing activity, evaluated by scratch assay, was found to be 2.41-fold higher in HaCaT cells treated with 100 μg/mL of black raspberry seed oil (41.77 %) than in non-treated cells (17.34 %). Taken together, black raspberry seed oil holds promising health potential.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"182 ","pages":"Article 106477"},"PeriodicalIF":2.5,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143614058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unlocking the biological potential of crebanine, oxocrebanine and dehydrocrebanine: Pharmacological activity and related molecular mechanisms

IF 2.5 3区医学

Fitoterapia Pub Date : 2025-03-07 DOI: 10.1016/j.fitote.2025.106467

Dinesh Kumar Patel

{"title":"Unlocking the biological potential of crebanine, oxocrebanine and dehydrocrebanine: Pharmacological activity and related molecular mechanisms","authors":"Dinesh Kumar Patel","doi":"10.1016/j.fitote.2025.106467","DOIUrl":"10.1016/j.fitote.2025.106467","url":null,"abstract":"<div><div>The aim of this review is to highlight the biological potential of the aporphine class of alkaloids, crebanine, oxocrebanine and dehydrocrebanine and their molecular mechanisms, in order to understand their therapeutic potential in medicine. Using the phrases herbal medicine, aporphine, crebanine, oxocrebanine, dehydrocrebanine, and phytochemical, all of the scientific data on crebanine, oxocrebanine, and dehydrocrebanine used in this review was gathered from Google, Google Scholar, PubMed, Scopus, and Science Direct. Nevertheless, analytical techniques for the isolation, separation, and identification of crebanine, oxocrebanine, and dehydrocrebanine are also covered in this study. Present review describes the biological potential of crebanine against cerebral ischemia, human cancer, hepatocellular carcinoma, human lung adenocarcinoma, memory and cognition, and cardiac tissues with their anti-inflammatory, anti-bacterial, cytotoxic potential and anti-invasion effect. Additionally, oxocrebanine biological potential against breast cancer, inflammatory disorders, and acute lung injury is explained by scientific research. Nonetheless, the biological effects of dehydrocrebanine on malaria, cancer, and ulcerative colitis are also discussed in this article. In order to understand the potential for health promotion in human illnesses, this review also discussed the molecular mechanisms behind the pharmacological effects of crebanine, oxocrebanine, and dehydrocrebanine. For the isolation, separation, and identification of crebanine, oxocrebanine, and dehydrocrebanine in biological and non-biological substances, the analytical data showed the significance of various analytical techniques. The biological potential of crebanine, oxocrebanine, and dehydrocrebanine is discussed in the current review along with its various molecular mechanisms, pharmacokinetics, and analytical features. To claim their therapeutic applicability in human illnesses, however, the scientific community needs clinical data.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"182 ","pages":"Article 106467"},"PeriodicalIF":2.5,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143584892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inhaled turmerone can attenuate nicotine-induced degeneration of the aorta

IF 2.5 3区医学

Fitoterapia Pub Date : 2025-03-07 DOI: 10.1016/j.fitote.2025.106465

Mayo Higashihara , Daisuke Shimizu , Chihiro Kishi , Tomoko Sumi , Shuto Kakihara , Yuri Yoshioka , Shinichi Matsumura , Tatsuya Moriyama , Nobuhiro Zaima

{"title":"Inhaled turmerone can attenuate nicotine-induced degeneration of the aorta","authors":"Mayo Higashihara , Daisuke Shimizu , Chihiro Kishi , Tomoko Sumi , Shuto Kakihara , Yuri Yoshioka , Shinichi Matsumura , Tatsuya Moriyama , Nobuhiro Zaima","doi":"10.1016/j.fitote.2025.106465","DOIUrl":"10.1016/j.fitote.2025.106465","url":null,"abstract":"<div><div>Nicotine in secondhand smoke can increase the risk of development of cardiovascular disease in passive smokers through degeneration of the aorta which is one of main pathologies of cardiovascular disease. We speculated that the adverse effect of nicotine can be attenuated by volatile active molecules. As the potential molecule having vasoprotective effect, we focused on turmerone which is major volatile compound in turmeric (<em>Curcuma longa</em>). Oral administration of turmerone reportedly shows biological activities such as anti-inflammation, anti-oxidation, and anti-depression effects. We previously reported that turmerone was detected in the blood and organs of mice that inhaled turmeric essential oil. In addition, high fat-induced weight gain was suppressed in the group of mice that inhaled turmeric essential oil, suggesting the existence of biological activity of inhaled turmerone. However, the effects of inhaled turmerone on the aorta remain unclear. The aim of this study is to investigate the effects of inhaled turmerone on nicotine-induced aortic degeneration. Nicotine-induced degradation of elastic fiber and increased matrix metalloproteinase (MMP)-2 was attenuated by inhalation of the turmeric essential oil. In the serum of mice that inhaled the turmeric essential oil, all turmerone species, α-turmerone, β-turmerone, and ar-turmerone, were detected. In ex vivo cultured aorta, ar-turmerone showed the strongest protective effects on nicotine-induced degeneration of the aorta compared to α-turmerone and β-turmerone. These data indicate that inhaled turmerone attenuate nicotine-induced aortic degeneration after incorporated into the body.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"182 ","pages":"Article 106465"},"PeriodicalIF":2.5,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143585431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0