Fitoterapia最新文献_第7页

Terpenoids from the whole plants of Chloranthus holostegius 全株青兰的萜类化合物

IF 2.6 3区医学

Fitoterapia Pub Date : 2026-03-01 Epub Date: 2025-12-24 DOI: 10.1016/j.fitote.2025.107065

Huan Yan , Yong-Sheng Zhou , Long-Gao Xiao , Wei Ni , Yupeng Geng , Hai-Yang Liu

{"title":"Terpenoids from the whole plants of Chloranthus holostegius","authors":"Huan Yan , Yong-Sheng Zhou , Long-Gao Xiao , Wei Ni , Yupeng Geng , Hai-Yang Liu","doi":"10.1016/j.fitote.2025.107065","DOIUrl":"10.1016/j.fitote.2025.107065","url":null,"abstract":"<div><div>The phytochemical reinvestigation on the whole plants of <em>Chloranthus holostegius</em> led to the isolation of five undescribed sesquiterpenes (named chloranholosins U-Y, <strong>1</strong>–<strong>5</strong>), including two lindenane-type sesquiterpenes, two acorane-type sesquiterpenes, and one elemane-type sesquiterpene, together with 30 known compounds. Their structures and absolute configurations were elucidated by a comprehensive method including the spectroscopic data, and electronic circular dichroism (ECD) calculations. Chloranholosin U (<strong>1</strong>) was elucidated as a rare lindenane–dinormonotepenoid hybrid with an oxa-difuranofurone moiety. Furthermore, all new isolates and 18 known compounds were evaluated for their inhibitory activity against LPS-induced nitric oxide (NO) production in RAW 264.7 macrophage cells, while their cytotoxic activities were also assessed against five human tumor cell lines. Though these compounds did not show inhibitory activity for NO production, compounds <strong>16</strong>, <strong>34</strong>, and <strong>35</strong> displayed moderate cytotoxicity. Compound <strong>16</strong> showed cytotoxicity against HL-60, HepG2, MDA-MB-231, and SW480 (IC<sub>50</sub> 10.98–36.48 μM), compounds <strong>34</strong> and <strong>35</strong> were active on HL-60 (IC<sub>50</sub> 18.98 and 14.89 μM), and <strong>34</strong> also inhibited A549 (IC<sub>50</sub> 24.32 μM).</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"189 ","pages":"Article 107065"},"PeriodicalIF":2.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145838639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Botrychium ternatum, the Hmong medicinal flora, improves acetaminophen-induced hepatic injury by inhibiting the abnormal activation of the B cell receptor signaling pathway Botrychium ternatum是一种苗族药用植物，通过抑制B细胞受体信号通路的异常激活来改善对乙酰氨基酚诱导的肝损伤。

IF 2.6 3区医学

Fitoterapia Pub Date : 2026-03-01 Epub Date: 2026-01-23 DOI: 10.1016/j.fitote.2026.107096

Tao Chen , Ya-Ru Yang , Ming-Hui He , Xu Zhang , Shang-Gao Liao , Zhu Zeng , Yun-Guang Long , Yan Lin , Bo Tu

{"title":"Botrychium ternatum, the Hmong medicinal flora, improves acetaminophen-induced hepatic injury by inhibiting the abnormal activation of the B cell receptor signaling pathway","authors":"Tao Chen , Ya-Ru Yang , Ming-Hui He , Xu Zhang , Shang-Gao Liao , Zhu Zeng , Yun-Guang Long , Yan Lin , Bo Tu","doi":"10.1016/j.fitote.2026.107096","DOIUrl":"10.1016/j.fitote.2026.107096","url":null,"abstract":"<div><h3>Aim of study</h3><div>This study investigated the hepatoprotective effects of BT, its chemical composition, correlations with target components, and mechanisms underlying acetaminophen (APAP)-induced liver injury.</div></div><div><h3>Materials and methods</h3><div>APAP-induced injury models were established using HepG2 cells and C57BL/6 mice. Cell viability, cytotoxicity, levels of pro-inflammatory cytokines (IL-1β, TNF-α), apoptosis, and proliferation were evaluated through CCK-8, ELISA, flow cytometry, and EDU staining. In C57BL/6 mice model, measurements included body weight, liver index, serum levels of transaminases (ALT, AST) and ALP, and hepatic histopathology via H&E staining. Key signaling pathways were identified through RNA sequencing, KEGG/GO enrichment analyses, RT-qPCR, and Western blotting (WB). Chemical components of BT were analyzed using UHPLC-QE-Orbitrap HRMS, with subsequent molecular docking and dynamics simulations for studying component-target interactions.</div></div><div><h3>Results</h3><div>The findings indicated that BT (25/100 μg/mL in cells; 50/100/200 mg/kg in C57BL/6 mice model) significantly enhanced cell viability, reduced inflammatory cytokine levels and apoptosis, mitigated liver damage, and lowered serum enzyme levels in a dose-dependent manner. The B-cell receptor (BCR) signaling pathway emerged as crucial based on RNA sequencing, which was confirmed by WB and RT-qPCR. Analysis revealed forty-five compounds in BT, with kaempferitrin demonstrating consistent binding to LYN kinase (a key BCR pathway target) throughout 100 ns simulations.</div></div><div><h3>Conclusions</h3><div>In summary, BT demonstrates substantial hepatoprotective effects, potentially by suppressing the BCR signaling pathway, with kaempferitrin identified as a critical bioactive component targeting LYN kinase.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"189 ","pages":"Article 107096"},"PeriodicalIF":2.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146045913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Involvement of the NO-sGC/cGMP signaling pathway in the vasodilator and hypotensive effects of the ethanol-soluble fraction from Citrullus lanatus (Thunb.) Matsum. & Nakai seeds in rats NO-sGC/cGMP信号通路参与甜瓜醇溶部分的血管扩张和降压作用（Thunb.）Matsum。& Nakai种子在老鼠体内。

IF 2.6 3区医学

Fitoterapia Pub Date : 2026-03-01 Epub Date: 2025-12-23 DOI: 10.1016/j.fitote.2025.107041

Aline Aparecida Macedo Marques , Karyne Garcia Tafarelo Moreno , Luciane Barbosa Pessoa , Luana Ale Bertoncello Pael , Katiana Simões Kittelson , Ariany Carvalho dos Santos , Gabriela Pereira da Silva , Bianca Viana Silva , Maria Luiza Fidelis da Silva , Luana Bonifácio Sanches , Denise Brentan da Silva , Arquimedes Gasparotto Junior

{"title":"Involvement of the NO-sGC/cGMP signaling pathway in the vasodilator and hypotensive effects of the ethanol-soluble fraction from Citrullus lanatus (Thunb.) Matsum. & Nakai seeds in rats","authors":"Aline Aparecida Macedo Marques , Karyne Garcia Tafarelo Moreno , Luciane Barbosa Pessoa , Luana Ale Bertoncello Pael , Katiana Simões Kittelson , Ariany Carvalho dos Santos , Gabriela Pereira da Silva , Bianca Viana Silva , Maria Luiza Fidelis da Silva , Luana Bonifácio Sanches , Denise Brentan da Silva , Arquimedes Gasparotto Junior","doi":"10.1016/j.fitote.2025.107041","DOIUrl":"10.1016/j.fitote.2025.107041","url":null,"abstract":"<div><div>The therapeutic management of hypertension involves both pharmacological and non-pharmacological interventions. However, control remains inadequate despite effective treatments, often due to poor adherence. In this context, herbal medicines offer a complementary approach to conventional therapy. <em>Citrullus lanatus</em> (watermelon) seeds, frequently discarded as agricultural byproducts, represent a promising source of bioactive compounds. This study evaluated the cardiorenal properties of three extracts obtained from dried <em>C. lanatus</em> seeds, including an ethanol-soluble fraction from an aqueous extract (ESCL), a hydroethanolic extract, and an aqueous extract obtained by turbolysis. These extracts were chemically characterized using liquid chromatography coupled with diode array detection and mass spectrometry. Diuretic and hypotensive activities were assessed in vivo in normotensive female Wistar rats, while vasodilatory mechanisms were investigated ex vivo in isolated mesenteric vascular beds. Among the preparations screened, only the ESCL fraction displayed significant cardiorenal activity, reducing blood pressure and peripheral vascular resistance. Mechanistic investigation revealed that this vascular response is mediated via the nitric oxide/soluble guanylate cyclase/cyclic guanosine monophosphate signaling cascade. These findings highlight the pharmacological potential of ESCL as a candidate for the development of novel hypotensive agents.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"189 ","pages":"Article 107041"},"PeriodicalIF":2.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145833318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quinones from Rubia manjith and their antitumor activity 芒草中醌类成分及其抗肿瘤活性研究。

IF 2.6 3区医学

Fitoterapia Pub Date : 2026-03-01 Epub Date: 2026-01-19 DOI: 10.1016/j.fitote.2026.107097

Yan-Fei Xu , Yun-Jie Wang , Zhuo-Tao Li , Li-Yuan Shi , Qia Wang , Ning-Hua Tan , Xue-Jia Zhang , Li Feng , Zhe Wang

{"title":"Quinones from Rubia manjith and their antitumor activity","authors":"Yan-Fei Xu , Yun-Jie Wang , Zhuo-Tao Li , Li-Yuan Shi , Qia Wang , Ning-Hua Tan , Xue-Jia Zhang , Li Feng , Zhe Wang","doi":"10.1016/j.fitote.2026.107097","DOIUrl":"10.1016/j.fitote.2026.107097","url":null,"abstract":"<div><div><em>Rubia</em> plants, well-recognized as medicinal resources, are characterized by diverse phytoconstituents and a broad spectrum of biological activities, and have traditionally been employed in managing various diseases. <em>R. manjith</em>, a representative species of the genus <em>Rubia</em> enriched with quinone derivatives, has long been used in traditional Chinese medicine for the treatment of hematemesis, hematuria, inflammation, ulcers, and dermatological disorders. However, up to now, no research on the chemical components of this plant has been carried out. The present study focuses on the quinone constituents of <em>R. manjith</em> with the aim of identifying potential anti-tumor agents. From the roots and rhizomes of <em>R. manjith</em>, four previously undescribed anthraquinones (<strong>1</strong>–<strong>4</strong>), together with thirty-one known quinones (<strong>5</strong>–<strong>35</strong>), were successfully isolated and identified. Their cytotoxic activities were assessed against several colorectal cancer cell lines, among which <strong>6</strong> exhibited pronounced antiproliferative effects. Furthermore, network pharmacology analysis in combined with molecular docking was employed to elucidate the potential mechanisms underlying the anti-tumor activity of <strong>6</strong>.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"189 ","pages":"Article 107097"},"PeriodicalIF":2.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146017995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A novel compound mixture mitigates hyperglycemia, insulin resistance, dyslipidemia, and oxidative stress in streptozotocin induced diabetic rats: A therapeutic drug lead for metabolic syndrome 一种新型化合物混合物可减轻链脲佐菌素诱导的糖尿病大鼠的高血糖、胰岛素抵抗、血脂异常和氧化应激：一种代谢综合征的治疗药物。

IF 2.6 3区医学

Fitoterapia Pub Date : 2026-03-01 Epub Date: 2026-01-11 DOI: 10.1016/j.fitote.2026.107091

Thushara Indika Sampath , Susanthi Jayasinghe , Anoja Priyadarshani Attanayake , Veranja Karunaratne

{"title":"A novel compound mixture mitigates hyperglycemia, insulin resistance, dyslipidemia, and oxidative stress in streptozotocin induced diabetic rats: A therapeutic drug lead for metabolic syndrome","authors":"Thushara Indika Sampath , Susanthi Jayasinghe , Anoja Priyadarshani Attanayake , Veranja Karunaratne","doi":"10.1016/j.fitote.2026.107091","DOIUrl":"10.1016/j.fitote.2026.107091","url":null,"abstract":"<div><div>Plant-derived bioactive compounds play a crucial role in managing metabolic syndrome (MetS) components such as hyperglycemia, insulin resistance, and atherogenic dyslipidemia. The present study investigates the glucose and lipid lowering potential of a novel compound mixture composed of garcinol, piperine, butyl oleate, pipnoohine, and bismurrayanimbine (molar ratio of 9:33:1:4:1) and its effects on insulin resistance and atherogenic indices in streptozotocin induced (60 mgkg<sup>−1</sup>, ip) diabetic rats. The oral administration of the compound mixture at low (10 mgkg<sup>−1</sup>), therapeutic (25 mgkg<sup>−1</sup>), and high (50 mgkg<sup>−1</sup>) doses resulted in dose-dependent improvement in oral glucose tolerance with an increase of 6%, 9%, and 12%, respectively. There was a corresponding elevation in serum insulin (4%, 66%, 66%) and C-peptide (18%, 152%, 153%), along with reduction in serum fasting glucose (8%, 29%, 30%) and percentage of HbA<sub>1C</sub> (18%, 27%, 31%) compared to diabetic untreated rats (<em>p</em> < 0.05). Histopathological assessment of H and <em>E</em>-stained sections of the pancreatic tissue confirmed islet cell restoration. At the therapeutic dose, the mixture reduced homeostatic model assessment of insulin resistance (HOMA-IR) and increased homeostatic model assessment of β-cell functions (HOMA-β), aligning with pancreatic functions. Furthermore, all doses improved the antioxidant status and reversed atherogenic dyslipidemia in diabetic rats. Biochemical analysis revealed significant improvement in hepatic hexokinase activity at 25 and 50 mgkg<sup>−1</sup> doses (<em>p</em> < 0.05). Overall, the compound mixture showed promising results as an adjunct therapy for managing hyperglycemia and atherogenic dyslipidemia associated with MetS, highlighting its potential to be developed as a therapeutic agent.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"189 ","pages":"Article 107091"},"PeriodicalIF":2.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145965010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Astracondensatols F–L, cycloartane triterpenoids from Astragalus condensatus with their anti-inflammatory potential astracondensatol F-L：从黄芪中提取的环artane三萜，具有抗炎作用。

IF 2.6 3区医学

Fitoterapia Pub Date : 2026-03-01 Epub Date: 2025-12-25 DOI: 10.1016/j.fitote.2025.107071

Fadime Aydoğan , Merve Inci Camci , Jin Zhang , Jianping Zhao , Nirmal D. Pugh , Ikhlas A. Khan , Zulfıqar Ali

{"title":"Astracondensatols F–L, cycloartane triterpenoids from Astragalus condensatus with their anti-inflammatory potential","authors":"Fadime Aydoğan , Merve Inci Camci , Jin Zhang , Jianping Zhao , Nirmal D. Pugh , Ikhlas A. Khan , Zulfıqar Ali","doi":"10.1016/j.fitote.2025.107071","DOIUrl":"10.1016/j.fitote.2025.107071","url":null,"abstract":"<div><div>Phytochemical investigation on the roots of <em>Astragalus condensatus</em> (Fabaceae) led to the isolation of seven previously undescribed cycloartane-type triterpenoids, named astracondensatols F–L (<strong>1–7</strong>), alongside twelve known cycloartane derivatives (<strong>8–19</strong>) and fifteen other known secondary metabolites (<strong>20–34</strong>)<em>.</em> The structures of these compounds were elucidated through comprehensive spectroscopic analysis, including 1D and 2D NMR, as well as high-resolution electrospray ionization mass spectrometry (HRESIMS). The isolated triterpenoids were evaluated for their effect on nuclear factor kappa B (NF-<em>κ</em>B)-driven luciferase expression in THP-1 monocytes stimulated with <em>Escherichia coli</em> lipopolysaccharide (LPS). Five compounds (<strong>3</strong>, <strong>4</strong>, <strong>8</strong>, <strong>10</strong>, and cyclocephagenol) demonstrated a dose-dependent suppression of NF-<em>κ</em>B activation. Notably, these effects were non-selective, as they also inhibited Sp-1 control activity similarly.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"189 ","pages":"Article 107071"},"PeriodicalIF":2.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145846187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Alstotriamine A, a triamino monoterpene indole alkaloid with an unprecedented pentacyclic caged skeleton and anti-inflammatory alkaloids from Alstonia mairei Alstotriamine A，一种具有前所未有的五环笼状骨架的三氨基单萜吲哚生物碱和抗炎生物碱，来自Alstonia marei。

IF 2.6 3区医学

Fitoterapia Pub Date : 2026-03-01 Epub Date: 2026-01-18 DOI: 10.1016/j.fitote.2026.107099

Pengfei Jin , Guijuan Zheng , Yimiao Chen , Xinqiao Liu , Song Hu

{"title":"Alstotriamine A, a triamino monoterpene indole alkaloid with an unprecedented pentacyclic caged skeleton and anti-inflammatory alkaloids from Alstonia mairei","authors":"Pengfei Jin , Guijuan Zheng , Yimiao Chen , Xinqiao Liu , Song Hu","doi":"10.1016/j.fitote.2026.107099","DOIUrl":"10.1016/j.fitote.2026.107099","url":null,"abstract":"<div><div>A novel triamino monoterpene indole alkaloid, alstotriamine A (<strong>1</strong>), a new monoterpene indole alkaloid (<strong>2</strong>), and five known analogues (<strong>3</strong>–<strong>7</strong>) were isolated from the branches and leaves of <em>Alstonia mairei</em>. Their structures were elucidated <em>via</em> extensive spectroscopic methods and quantum chemical calculations including the <sup>13</sup>C NMR-DP4+ analysis and electronic circular dichroism (ECD) calculations. Alstotriamine A (<strong>1</strong>), possessing an unprecedented pentacyclic caged skeleton incorporating with a third nitrogen atom, represents the first example of C-3 and C-17 cyclic corynanthe alkaloid, and a plausible biosynthetic pathway was proposed. Furthermore, compounds <strong>1</strong>, <strong>2</strong>, <strong>5</strong>, and <strong>7</strong> displayed significant inhibitory effects on the LPS-induced NO production in RAW264.7 mouse macrophages with IC<sub>50</sub> values ranging from 4.6 to 16.2 μM, and the active compounds <strong>2</strong> and <strong>5</strong> dose-dependently decreased the levels of the pro-inflammatory cytokines TNF-<em>α</em> and IL-6.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"189 ","pages":"Article 107099"},"PeriodicalIF":2.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146009450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gardenia jasminoides Ellis polysaccharides improve gut microbiota disorder and glucose homeostasis in type 2 diabetic mice 栀子多糖改善2型糖尿病小鼠肠道菌群紊乱和葡萄糖稳态。

IF 2.6 3区医学

Fitoterapia Pub Date : 2026-03-01 Epub Date: 2026-01-01 DOI: 10.1016/j.fitote.2025.107080

Wenye Lu , Wanjun Ju , Ningning Niu , Yuanyuan Li , Tianming Wang , Yu Feng , Yueming Ma , Jiasheng Wu

{"title":"Gardenia jasminoides Ellis polysaccharides improve gut microbiota disorder and glucose homeostasis in type 2 diabetic mice","authors":"Wenye Lu , Wanjun Ju , Ningning Niu , Yuanyuan Li , Tianming Wang , Yu Feng , Yueming Ma , Jiasheng Wu","doi":"10.1016/j.fitote.2025.107080","DOIUrl":"10.1016/j.fitote.2025.107080","url":null,"abstract":"<div><div>Type 2 diabetes mellitus (T2DM) is the most prevalent metabolic disorder. <em>Gardenia jasminoides</em> Ellis is a traditional herbal medicine used in metabolic disease treatment; however, the effects of <em>Gardenia jasminoides</em> Ellis polysaccharides (GPS) on T2DM remain unknown. This study aimed to investigate the antidiabetic effect of GPS in a T2DM mouse model induced by high-fat diet (HFD) and streptozotocin administration, and to elucidate the potential molecular mechanism. Treatment with low and high doses (200 and 400 mg/kg) of GPS significantly reduced the fasting blood glucose level of T2DM mice by 44.8 % and 33.0 %, respectively. In T2DM mice, oral glucose tolerance test outcomes and insulin tolerance were significantly improved by GPS intervention (<em>p</em> < 0.05), and the pancreatic tissue damage was ameliorated compared with control mice. Moreover, GPS intervention upregulated the liver expression of peroxisome proliferator-activated receptor gamma (PPARγ) by 1.7 fold, improved insulin resistance, and increased glycogen synthesis in T2DM mice compared with in untreated control mice (<em>p</em> < 0.05). More importantly, GPS intervention significantly improved gut microbiota dysbiosis, increased the abundance of short chain fatty acids producing <em>Lactobacillus</em> and <em>Dubosiella</em> by 6.6- and 16.5-fold, respectively, and elevated the serum level of butyric acid in T2DM mice. Furthermore, in vitro experiments confirmed that butyric acid can induce PPARγ expression. In conclusion, these findings suggest that GPS may alleviate T2DM by reshaping the gut microbiota and regulating intestinal metabolites. Therefore, GPS may be a potential prebiotic for modulating T2DM-associated metabolic disorders.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"189 ","pages":"Article 107080"},"PeriodicalIF":2.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145896384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antioxidant active ingredients from the seeds of Dimocarpus longan Lour 龙眼种子抗氧化活性成分的研究。

IF 2.6 3区医学

Fitoterapia Pub Date : 2026-03-01 Epub Date: 2025-12-23 DOI: 10.1016/j.fitote.2025.107043

Bin Liu , Yang Xu , Lingxiao Ren , Xiaofen Liu , Lixia Chen , Hua Li

引用次数: 0

Nagarudine, a new C19-diterpenoid alkaloid from Aconitum nagarum Stapf: Isolation, structure elucidation, synthesis of nagarudine analogue, and apoptotic activity 纳加鲁定：一种新的c19 -二萜类生物碱的分离、结构鉴定、纳加鲁定类似物的合成及细胞凋亡活性研究。

IF 2.6 3区医学

Fitoterapia Pub Date : 2026-03-01 Epub Date: 2026-01-03 DOI: 10.1016/j.fitote.2026.107089

Mei-Zhen Ye , Yang Yang , Cheng Yuan , Yu-Qi Yang , Ning Ding , Qin He , Shuai Huang , Lin Chen , Xian-Li Zhou

引用次数: 0