IF 2.5 3区医学

Fitoterapia Pub Date : 2025-04-04 DOI: 10.1016/j.fitote.2025.106516

Xue Ma, Chun-Yong Sun, Yan Zhang, Jia Li, Dong-Sheng Zhao

{"title":"The hepatoprotective effect of Lonicera japonica Flos on rats with high-fat diet-induced non-alcoholic fatty liver disease.","authors":"Xue Ma, Chun-Yong Sun, Yan Zhang, Jia Li, Dong-Sheng Zhao","doi":"10.1016/j.fitote.2025.106516","DOIUrl":"https://doi.org/10.1016/j.fitote.2025.106516","url":null,"abstract":"Lonicerae Japonica Flos (LJF) is an edible-medicinal herb, rich in phenolic acids, flavonoids, iridoids and other bioactive ingredients, that has anti-inflammatory, antioxidant, antilipemic, and hepatoprotective effects. However, its effect on non-alcoholic fatty liver disease (NAFLD) remains to be elucidated. The aim of this study was to determine the effect of LJF on liver injury in rats with high-fat diet (HFD)-induced NAFLD. The administration of LJF extract to rats with HFD-induced NAFLD significantly improved their body weight and daily food intake, liver tissue steatosis, lipid droplet vacuolization, and inflammatory cell infiltration. In addition, the LJF extract also improved to varying degrees the serum biochemical parameters, liver lipid content, levels of inflammatory factors, and oxidative stress markers. Among the treatment groups, the LJF high-dose group (LJF-H) showed the most significant improvement effect. Additionally, the correlation matrix heatmap visualization indicated that LJF may ameliorate NAFLD mainly by lowering liver lipid content and improving serum biochemical parameters.","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":" ","pages":"106516"},"PeriodicalIF":2.5,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Absorption, distribution, metabolism, and excretion (ADME) of R,S-Goitrin in Radix Isatidis in rats by LC-MS/MS determination.

IF 2.5 3区医学

Fitoterapia Pub Date : 2025-04-04 DOI: 10.1016/j.fitote.2025.106514

Jia Tang, Lisha Ye, Baolian Wang

{"title":"Absorption, distribution, metabolism, and excretion (ADME) of R,S-Goitrin in Radix Isatidis in rats by LC-MS/MS determination.","authors":"Jia Tang, Lisha Ye, Baolian Wang","doi":"10.1016/j.fitote.2025.106514","DOIUrl":"https://doi.org/10.1016/j.fitote.2025.106514","url":null,"abstract":"Radix Isatidis (syn. Isatis indigotica Fort.) is employed in the treatment of fever, influenza, acute tonsillitis, viral hepatitis, and COVID-19, demonstrating diverse pharmacological activities, including antibacterial, antiviral, antioxidant, anticancer, and immune-regulatory effects. Furthermore, there is significant potential for the development of new clinical applications. In order to investigate the pharmacokinetic characteristics, a quantitative method for determining R,S-goitrin in rat plasma using liquid chromatography-tandem mass spectrometry (LC-MS/MS) was developed and validated. The established LC-MS/MS method was employed to investigate the pharmacokinetics, tissue distribution, plasma protein binding, excretion, and metabolic characteristics of Radix Isatidis extract following oral administration in rats. Meanwhile, by comparing with the oral monomer group, the absorption profile of the extract in rats was assessed. After oral administration of different doses of Radix Isatidis extract (0.1,0.3,1 g/kg) to male rats, showed dose-dependent increases in R,S-goitrin's Cmax and AUC, with bioavailability at 56.3 %. No gender differences in pharmacokinetics (PK) were observed. Compared with the monomer R,S-goitrin (0.03 mg/kg), it was observed higher in vivo exposure AUC(0-t) and peak concentration Cmax of R,S-goitrin after dosing of the Radix Isatidis extract with equal dosage of R,S-goitrin. R,S-goitrin was widely distributed in immune organs (adrenal glands, thymus, lymph nodes), liver, spleen, and gastrointestinal tract after oral administration of Radix Isatidis extract (0.1 g/kg) in rats. R,S-goitrin was primarily excreted via urine, accounting for 56 % of the administered dose, with plasma protein binding ranging from 13 % to 16.4 % across different species. These findings provide data to support Radix Isatidis clinical use in antibacterial, anti-inflammatory, anticancer therapies, and formulation development.","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":" ","pages":"106514"},"PeriodicalIF":2.5,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phenoxybiphenyl derivatives from an endophyte, Neohendersonia kickxii.

IF 2.5 3区医学

Fitoterapia Pub Date : 2025-04-03 DOI: 10.1016/j.fitote.2025.106518

Reo Takahashi, Zulfikar, Mayuka Hakozaki, Yuko Kanno, Shota Uesugi, Takuya Koseki, Yoshihito Shiono

引用次数: 0

Shuteria involucrata alleviates OVA-induced asthma through the TLR4/NF-κB pathway.

IF 2.5 3区医学

Fitoterapia Pub Date : 2025-04-01 DOI: 10.1016/j.fitote.2025.106520

Lue Bao, Lisha Wei, Xiaohong Li, Xiaoyun Jiang, Duan Rong, Lingrui Zhou, Lu Liu, Wenhong Tan, Feng Huang, Zhuya Yang

引用次数: 0

Evaluation of anti-arthritic and anti-inflammatory potential of Ajugarin-I from Ajuga Bracteosa wall ex. Benth against Freund's complete adjuvant induced arthritis.

IF 2.5 3区医学

Fitoterapia Pub Date : 2025-04-01 DOI: 10.1016/j.fitote.2025.106517

Fatima Zafar, Hammad Ismail, Ihsan-Ul Haq

{"title":"Evaluation of anti-arthritic and anti-inflammatory potential of Ajugarin-I from Ajuga Bracteosa wall ex. Benth against Freund's complete adjuvant induced arthritis.","authors":"Fatima Zafar, Hammad Ismail, Ihsan-Ul Haq","doi":"10.1016/j.fitote.2025.106517","DOIUrl":"https://doi.org/10.1016/j.fitote.2025.106517","url":null,"abstract":"Rheumatoid arthritis (RA) is a prolonged autoimmune disease that targets the lining of small joints, causing inflammation and destruction of bone and cartilage. Anti-inflammatory drugs are available but offer short-term relief with adverse side effects. The present research was planned to study the in-vivo antiarthritic potential of ajugarin-I, sequestered from the Ajuga bracteosa. In-vivo studies include anti-inflammatory, analgesic, antidepressant, hematology profile, histopathological, radiological, and antioxidant analysis. The in-vivo results revealed that a high dose (HD, 60 mg/kg) of ajugarin-I significantly decreased the inflammatory paw edema (40 ± 0.04 %). Ajugarin-I also showed excellent analgesic behavior with 89 ± 0.55 % and 85 ± 0.55 % increments in pain threshold induced by cold and hot stimuli. Whereas ajugarin-I showed 95.1 ± 0.04 % antidepressant activity. Moreover, it showed strong antioxidant potential by raising the level of catalase, glutathione-S-transferase, and reducing glutathione while decreasing MDA levels in the liver, kidney, brain, paw, and spleen. Reduced serum levels of alanine transaminase (ALT), aspartate transaminase (AST), and alkaline phosphatase (ALP) (with 67.5 ± 3.53 %, 83.5 ± 3.53 % and 85 ± 7.07 % respectively), were observed with HD of ajugarin-I. Furthermore, its 60 mg/kg dose restored hematological abnormalities by raising the Hb level (85 ± 0.7 %) RBCs (91 ± 0.5 %), MCV (83 ± 2 %), platelet count (83 ± 0.5 %) and lowered the WBC (68 ± 0.35 %) level. Abnormalities in histoarchitecture of paw, liver, and kidney were curtailed by HD of ajugarin-I demonstrating its regenerative properties. Radiological analysis of the left hind paw showed that ajugarin-I lessened the inflammation in articular areas. These findings will guide a novel area of research for exploiting ajugarin-I as novel anti-arthritic and anti-inflammatory agent.","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":" ","pages":"106517"},"PeriodicalIF":2.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143779431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Eight new C₂₁-steroidal glycosides from the roots of Cynanchum auriculatum.

IF 2.5 3区医学

Fitoterapia Pub Date : 2025-03-31 DOI: 10.1016/j.fitote.2025.106519

Ya-Yu Wu, Lan-Wen Gao, Yu-Jun Tang, Bo Hu, Ya-Lin Hu, Yu-Bo Zhang, Guang-Xiong Zhou

引用次数: 0

Anti-diabetic sesquiterpenoids from the heartwood of Entandrophragma cylindricum

IF 2.5 3区医学

Fitoterapia Pub Date : 2025-03-29 DOI: 10.1016/j.fitote.2025.106515

Hong-Yan Mu , Kai-Wen Kang , Yan Zhang , Ju-Cai Xu , Dong-Li Li , Jing-Wei Jin , Jia-Le Gan , Hong-Guang Li , Li-She Gan

{"title":"Anti-diabetic sesquiterpenoids from the heartwood of Entandrophragma cylindricum","authors":"Hong-Yan Mu , Kai-Wen Kang , Yan Zhang , Ju-Cai Xu , Dong-Li Li , Jing-Wei Jin , Jia-Le Gan , Hong-Guang Li , Li-She Gan","doi":"10.1016/j.fitote.2025.106515","DOIUrl":"10.1016/j.fitote.2025.106515","url":null,"abstract":"<div><div>(<img>)-(7S,8S)-10,11-dihydro-curcumene-3,8-diol (1) and one new cadinane-type sesquiterpenoid, (<img>)-(1R,4S,6S,7S,10R)-cadinan-1,4-diol (2), together with six known ones (3–8), were isolated from 95 % ethanol extract of the heartwood of Entandrophragma cylindricum. Structures of the new compounds were elucidated on the basis of detailed spectroscopic analysis and quantum chemical calculations, including GIAO calculation of NMR chemical shifts and TDDFT calculation of ECD spectrum, which verified the relative and absolute configurations on the flexible side chain of 1, respectively. All sesquiterpenoids were evaluated for their potential to enhance glucose uptake in C2C12 myotubes. Compound 2 (20 μM) significantly increased glucose uptake to the same level as that of metformin (2 mM). Western blot analysis on AMPKα, GLUT4, and ACC1 revealed that compound 2 activated the AMPK-GLUT4 signaling pathway in C2C12 myotubes.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"183 ","pages":"Article 106515"},"PeriodicalIF":2.5,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143748315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cassane butenolides from the fruits of Caesalpinia pulcherrima

IF 2.5 3区医学

Fitoterapia Pub Date : 2025-03-28 DOI: 10.1016/j.fitote.2025.106500

Huiping Xie , Ting Long , Yongchun Gao , Dan Huang , Liqin Wang

引用次数: 0

Ten-membered lactones with antifungal activity against the postharvest pathogens from Penicillium restrictum

IF 2.5 3区医学

Fitoterapia Pub Date : 2025-03-28 DOI: 10.1016/j.fitote.2025.106495

Jing Sun , Feng-Shuang Wei , Tong-De Zhao , Rong-Fei Ma , Xiao-Xiao Hu , Heng-Xiang Li , Chao Liu , Ju-Cheng Zhang , Xue-Qiong Yang , Ya-Bin Yang , Zhong-Tao Ding

{"title":"Ten-membered lactones with antifungal activity against the postharvest pathogens from Penicillium restrictum","authors":"Jing Sun , Feng-Shuang Wei , Tong-De Zhao , Rong-Fei Ma , Xiao-Xiao Hu , Heng-Xiang Li , Chao Liu , Ju-Cheng Zhang , Xue-Qiong Yang , Ya-Bin Yang , Zhong-Tao Ding","doi":"10.1016/j.fitote.2025.106495","DOIUrl":"10.1016/j.fitote.2025.106495","url":null,"abstract":"<div><div>Two undescribed ten-membered lactones, named penicirestricols A (1) and B (2), and two unprecedented ten-membered lactone-adenine hybrids, penicirestricols C (3) and D (4), along with four known compounds, decarestrictines B (5), A1 (6), F (7), and I (8) were isolated from the endophytic fungus Penicillium restrictum. The structures were determined by 1D, 2D NMR techniques, mass spectrometry, ECD, and NMR calculations. Compounds 3, 7, and 8 from P. restrictum showed significant antifungal activities against postharvest pathogens Fusarium asiaticum and Alternaria tenuissima with MICs ≤8 μg/mL. Thus, the compounds isolated from P. restrictum have the potentiality to be developed as the novel antifungal agents.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"183 ","pages":"Article 106495"},"PeriodicalIF":2.5,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143739315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Four new meroterpenoid derivatives with cytotoxicity from the mangrove-derived fungus Penicillium sp. HLLG-122

IF 2.5 3区医学

Fitoterapia Pub Date : 2025-03-27 DOI: 10.1016/j.fitote.2025.106494

Yu-Yue Qin , Xiao-Bo Liu , Tian-Tao Xiong , Hong Xiao , Xuan Zhang , Xin-Ming Song , Bin Gong , Wan-Shan Li , Guang-Ying Chen

{"title":"Four new meroterpenoid derivatives with cytotoxicity from the mangrove-derived fungus Penicillium sp. HLLG-122","authors":"Yu-Yue Qin , Xiao-Bo Liu , Tian-Tao Xiong , Hong Xiao , Xuan Zhang , Xin-Ming Song , Bin Gong , Wan-Shan Li , Guang-Ying Chen","doi":"10.1016/j.fitote.2025.106494","DOIUrl":"10.1016/j.fitote.2025.106494","url":null,"abstract":"<div><div>Four new meroterpenoids, including two seco isodhilarane-type meroterpenoids peniciacetals J-K (1 and 2), two austins-type meroterpenoids peniciacetals L-M (3 and 4), along with five known analogues (5–9) were isolated from the mangrove-derived fungus Penicillium sp. HLLG-122 based on the OSMAC approach. The structures, including absolute configurations of new compounds were elucidated by HRESIMS, 1D, 2D NMR spectroscopic data, X-ray diffraction analysis, and quantum chemical electronic circular dichroism (ECD) calculation. Peniciacetal J (1) was characterized with a unique 6/7/6/5/6/5 hexacyclic systems with a furan ring moiety. Compound 3 showed weak cytotoxicity against HepG2 and MCF-7 cell lines with IC50 values of 38.9 and 34.1 μM, respectively. Compound 8 showed moderate cytotoxicity against HepG2 and MCF-7 cell lines with IC50 values of 10.7 and 13.3 μM, respectively. Compound 9 exhibited good cytotoxicity against HepG2 cell line with the IC50 value of 4.8 μM.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"183 ","pages":"Article 106494"},"PeriodicalIF":2.5,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143739316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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