Fitoterapia最新文献

{"title":"Napifera A-F, six previously undescribed sesquiterpenoid derivatives from the roots of Crepis napifera.","authors":"Xupeng Yang, Yixin Zhang, Cuibin Kong, Zheng Wang, Fanfan Cao, Lianyu Tang, Jingming Jia, Anhua Wang","doi":"10.1016/j.fitote.2026.107513","DOIUrl":"https://doi.org/10.1016/j.fitote.2026.107513","url":null,"abstract":"<p><p>Phytochemical investigation of the roots of Crepis napifera yielded six previously undescribed sesquiterpenoid derivatives, napifera A-F (1-5 and 16), together with 23 known compounds. The new compounds comprised five non-glycosylated sesquiterpenoid-derived acids (1-5) and one acylated sesquiterpene lactone glucoside (16). Their structures were elucidated through spectroscopic and computational analyses. All isolates were evaluated for cytotoxicity against five tumor cell lines and antibacterial activity against Staphylococcus aureus. Compound 11 showed an IC₅₀ of 14.38 ± 0.57 μM against HeLa cells and an MIC of 12.5 μg/mL against S. aureus. These findings expand the known structural diversity of sesquiterpenoids from C. napifera.</p>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":" ","pages":"107513"},"PeriodicalIF":2.9,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149223638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tryptamine-triggered chemodiversity expansion of polyketides produced by Daldinia eschscholzii.","authors":"Xiao Jing Lv, Xue Yang, Jing Wang, Fei Ding, Ren Xiang Tan","doi":"10.1016/j.fitote.2026.107520","DOIUrl":"https://doi.org/10.1016/j.fitote.2026.107520","url":null,"abstract":"<p><p>To expand the chemical space of small-molecule metabolites, we cultured the prolific fungal polyketide producer Daldinia eschscholzii in the presence of tryptamine-a substrate bearing an indole moiety widely found in marketed drugs and bioactive compounds. Six unprecedented indole-polyketides, named (±)-dalestrymanes A-F (1-6), were isolated and structurally characterized using chromatographic and spectroscopic methods. Each indole-polyketide underwent chiral resolution to yield pairs of enantiomers (1a/1b-6a/6b). The absolute configurations of separated enantiomers were determined by electronic circular dichroism (ECD) calculations. (±)-Dalestrymanes DF (4-6) are the first heterotrimers of tryptophol with two molecules of a fungal polyketide-1-(2,6-dihydroxyphenyl)butan-1-one, which can dimerize into nodulisporin F. Compounds 4b and 6a showed cytotoxicity against A549 cells (IC₅₀: 2.2 μM and 2.9 μM, respectively), while 5a was active against A375 cells (IC₅₀: 1.6 μM).</p>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":" ","pages":"107520"},"PeriodicalIF":2.9,"publicationDate":"2026-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149220173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioactive compounds and therapeutic potential of the Brazilian genus Kielmeyera (Calophyllaceae): a comprehensive review.","authors":"Carla de Moura Martins, Sérgio Antônio Lemos de Morais, Francisco José Tôrres de Aquino","doi":"10.1016/j.fitote.2026.107515","DOIUrl":"https://doi.org/10.1016/j.fitote.2026.107515","url":null,"abstract":"<p><p>The genus Kielmeyera Mart. (Calophyllaceae) comprises dozens of species, most of which are endemic to South American biomes, particularly the Cerrado, coastal ecosystem, and rupestrian grasslands. Several species have long been used in Brazilian traditional medicine for the treatment of inflammation, wound healing, gastrointestinal disorders, ulcers, leishmaniasis, fevers, and diverse infectious diseases. Despite the ecological and medicinal relevance of the genus, phytochemical and pharmacological investigations remain relatively limited. Available studies indicate that Kielmeyera species possess a specialized secondary metabolism rich in phenolic polyketide-derived compounds, especially xanthones and benzophenones, together with flavonoids and triterpenes. Based on the taxonomic treatment adopted in this review, we identified 55 accepted species of Kielmeyera. Of these, 22 species have been investigated phytochemically, whereas biological or pharmacological activities have been reported for only 13 species. Thus, 33 species had no phytochemical or pharmacological studies identified in the literature surveyed. Experimental studies have reported antimicrobial, antiparasitic, anti-inflammatory, antioxidant, cytotoxic, and other bioactivities that partially support their traditional medicinal uses. However, no published clinical evidence, including randomized controlled trials, observational studies, or well-documented case series-currently supports the therapeutic efficacy of Kielmeyera preparations in humans. This review provides the first comprehensive and critical synthesis of more than six decades of published research on the taxonomy, ethnobotany, phytochemistry, and pharmacological properties of Kielmeyera species, while highlighting current knowledge gaps and future research priorities.</p>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":" ","pages":"107515"},"PeriodicalIF":2.9,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149206756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Qingre Chushi decoction ameliorates MC903-induced atopic dermatitis in association with reduced JAK-STAT6 activation and decreased CD206⁺IL-31⁺ macrophage abundance.","authors":"Yujiao Meng, Yueyue Ma, Wenbo Liu, Lijiaming Zhou, Huike Ma, Haoyue Zhu, Xiaohan Yu, Tingting Di, Yan Wang, Jingxia Zhao, Ping Li","doi":"10.1016/j.fitote.2026.107516","DOIUrl":"https://doi.org/10.1016/j.fitote.2026.107516","url":null,"abstract":"<p><p>Qingre Chushi Decoction (QRCSD) is a traditional Chinese medicine formula used clinically for atopic dermatitis (AD), whereas its immunological basis remains poorly understood. This study investigated the therapeutic effects and associated immune changes of QRCSD in an MC903-induced murine AD model. The chemical profile of QRCSD was characterized by UPLC-Q-TOF-MS/MS, and four representative marker compounds, including chlorogenic acid, gentiopicroside, baicalin, and glycyrrhizic acid, were quantitatively determined by targeted UPLC-MS/MS in MRM mode for quality control. AD-like lesions were induced in male C57BL/6 J mice by topical MC903 application. Dermatitis severity, scratching behavior, and transepidermal water loss were assessed, while epidermal barrier proteins, pruritogenic mediators, circulating cytokines, and immune-cell profiles were evaluated by histological analysis, immunofluorscence, ELISA, and flow cytometry. QRCSD markedly reduced dermatitis severity, epidermal thickness, TEWL, scratching behavior, and mast-cell infiltration, while restoring filaggrin and involucrin expression and reducing TSLP and IL-31 levels. Circulating IL-4, IL-13, IL-17 A, IL-6, TNF-α, IFN-γ, and total IgE were also decreased. Flow cytometry revealed altered T-cell profiles following QRCSD treatment. In the QRCSD-H group, reduced eosinophil and macrophage proportions and decreased CD206⁺IL-31⁺ macrophages were observed in lesional skin. Transcriptomic and protein analyses further demonstrated JAK-STAT-associated immune changes, including decreased phosphorylation of JAK1, JAK3, and STAT6, accompanied by reduced Arg1 and CD206 expression. Collectively, QRCSD ameliorated MC903-induced AD and was associated with restored epidermal barrier function, altered systemic and cutaneous immune responses, reduced CD206⁺IL-31⁺ macrophage abundance, and decreased JAK-STAT6 pathway activation. These findings provide a biological basis for the immunoregulatory effects of QRCSD in AD.</p>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":" ","pages":"107516"},"PeriodicalIF":2.9,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149192282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Investigating potential quality markers of Stellariae Radix on correlations among absorbed blood components, signature metabolites and pharmacodynamic indicators\" [Fitoterapia 195 (2026) 107478].","authors":"Yangkun Zhou, Meng Zhan, Ying Zhang, Tingting Li, Hongfeng Quan, Lin Dong","doi":"10.1016/j.fitote.2026.107502","DOIUrl":"https://doi.org/10.1016/j.fitote.2026.107502","url":null,"abstract":"","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":" ","pages":"107502"},"PeriodicalIF":2.9,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149127090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Suppression of inflammatory response by chrysin, a flavone isolated from Potentilla evestita Th. Wolf. In silico predictive study on its mechanistic effect” [FITOTE 103 (2015) 129–135]","authors":"Abdur Rauf,&nbsp;Rehan Khan,&nbsp;Muslim Raza,&nbsp;Haroon Khan,&nbsp;Samreen Pervez,&nbsp;Vincenzo De Fe,&nbsp;Francesco Maione,&nbsp;Nicola Mascolo","doi":"10.1016/j.fitote.2026.107458","DOIUrl":"10.1016/j.fitote.2026.107458","url":null,"abstract":"","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"194 ","pages":"Article 107458"},"PeriodicalIF":2.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148873133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ginseng-Schisandra ameliorates D-galactose-induced cognitive impairment in mice: Evidence from gut microbiota and metabolomic analyses.","authors":"Yaran Teng, Qiumin Huang, Shuqi Zhang, Xintong Du, Hui Li, Wei Wu","doi":"10.1016/j.fitote.2026.107493","DOIUrl":"https://doi.org/10.1016/j.fitote.2026.107493","url":null,"abstract":"<p><p>Age-related cognitive decline is associated with oxidative stress, systemic inflammation, gut microbial dysbiosis, and metabolic disturbance. This study characterized the chemical profile of a Panax ginseng-Schisandra chinensis co-decoction (TG) and evaluated its effects in a D-galactose-treated mouse model. Chemical constituents were analyzed by liquid chromatography-mass spectrometry. Behavioral performance, serum and brain oxidative-stress markers, serum cytokines, fecal microbiota, short-chain fatty acids (SCFAs), and serum, fecal, and brain metabolites were assessed. Compared with separately prepared extracts, the co-decoction showed a distinctive profile enriched in ginsenoside Rk1. TG-treated mice showed improved performance in behavioral tests, higher superoxide dismutase, glutathione peroxidase, and reduced glutathione values, and lower malondialdehyde values than model mice. TG treatment was also associated with shifts in gut microbial composition, increased fecal acetate, propionate, and butyrate, and changes in tryptophan-, catecholamine-, glycerophospholipid-, and pterin-related metabolites. Targeted liquid chromatography-tandem mass spectrometry (LC-MS/MS) supported group differences in key tryptophan-pathway metabolites. Correlation analyses were exploratory because no association remained significant after false-discovery-rate correction. These findings show that TG administration co-occurred with behavioral, redox, microbial, and metabolic changes in this model; however, the study design does not establish that microbiota or metabolite changes caused the behavioral effects.</p>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":" ","pages":"107493"},"PeriodicalIF":2.9,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149074166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Nagarudine, a new C₁₉-diterpenoid alkaloid from Aconitum nagarum Stapf: Isolation, structure elucidation, synthesis of nagarudine analogue, and apoptotic activity\" [Fitoterapia 189 (2026) 107089].","authors":"Mei-Zhen Ye, Yang Yang, Cheng Yuan, Yu-Qi Yang, Ning Ding, Qin He, Shuai Huang, Lin Chen, Xian-Li Zhou","doi":"10.1016/j.fitote.2026.107473","DOIUrl":"https://doi.org/10.1016/j.fitote.2026.107473","url":null,"abstract":"","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":" ","pages":"107473"},"PeriodicalIF":2.9,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149030339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nitrogen-containing dihydro-β-agarofuran derivatives and macrocyclic spermidine alkaloids with anti-tumor activity from the stems of Tripterygium wilfordii","authors":"Liang Zhang,&nbsp;Jiayi Chen,&nbsp;Guangyan Luo,&nbsp;Xiaoming Huang,&nbsp;Jianqun Liu","doi":"10.1016/j.fitote.2026.107332","DOIUrl":"10.1016/j.fitote.2026.107332","url":null,"abstract":"<div><div>A total of eight nitrogen-containing dihydro-<em>β</em>-agarofuran derivatives (<strong>1–8</strong>), seven of which (<strong>2–8</strong>) are new compounds, together with four known 13-membered macrocyclic spermidine alkaloids (<strong>9–12</strong>), were isolated from aqueous ethanol extracts of the dried stems of <em>Tripterygium wilfordii</em>. These compounds were evaluated for their <em>in vitro</em> inhibitory activities against several cancer cell lines. Nitrogen-containing dihydro-<em>β</em>-agarofuran derivatives exhibited very weak inhibitory activities, while 13-membered macrocyclic spermidine alkaloids displayed differential effects. Notably, the IC₅₀ values of celacarfurine in 72 h on MCF-7, AFC, AGS, RL95–2 and AN3 CA cell lines were 14.33, 8.36, 9.40, 11.97 and 21.92 μM, respectively. In addition, celacarfurine and celafurine exhibited synergistic effects on 5-fluorouracil-resistant HCT116 cell model. The calculate combination indexes of 40 μM celacarfurine and 200 μM celafurine against this model were 0.50 and 0.66, respectively. The potent anti-tumor activity of celacarfurine is likely to be attributed to hydrogen-bonding interactions formed by the three amide moieties within its 13-membered macrocyclic scaffold.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"192 ","pages":"Article 107332"},"PeriodicalIF":2.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148257715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New dibenzofurans from Phellinus ribis and their anti-inflammatory activity","authors":"Ying Wang,&nbsp;Xiangyun Guo,&nbsp;Xinya Wang,&nbsp;Yuan Lu,&nbsp;Yiqun Li,&nbsp;Yongqing Zhang,&nbsp;Zhongying Fang,&nbsp;Ran Yang","doi":"10.1016/j.fitote.2026.107333","DOIUrl":"10.1016/j.fitote.2026.107333","url":null,"abstract":"<div><div>Four previously undescribed dibenzofurans and derivatives, named ribisin G–J (<strong>1</strong>–<strong>4</strong>), along with seven known compounds (<strong>5</strong>–<strong>11</strong>) were isolated from <em>Phellinus ribis</em>. Among them, compounds <strong>1</strong>–<strong>3</strong> were identified as fully aromatic dibenzofurans, whereas compound <strong>4</strong> was a dibenzofuran derivative. Their structures were elucidated by comprehensive spectroscopic analysis. The absolute configuration of compound <strong>4</strong> was further confirmed by ECD calculation. The anti-inflammatory activity of all compounds was assessed in lipopolysaccharide (LPS)-induced RAW 264.7 macrophages. Notably, compound <strong>4</strong> exhibited inhibitory activity against nitric oxide (NO) production, with an IC₅₀ value of 12.23 ± 0.81 <em>μ</em>mol·L⁻¹. Further studies revealed that compound <strong>4</strong> significantly inhibited the expression of IL-6, IL-1<em>β</em> and TNF-<em>α</em>.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"192 ","pages":"Article 107333"},"PeriodicalIF":2.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148257769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}