IF 2.5 3区医学

Fitoterapia Pub Date : 2025-06-13 DOI: 10.1016/j.fitote.2025.106681

Wen-Hui Du, Ling Leng, Wei Chen, Long-Fei He, Gang Li, Zhu Qiu, Shu-Jun Fang, Yi-Ling Yang, Chao-Jiang Xiao, Bei Jiang

引用次数: 0

Chemical structure and antifouling activity of yoshioaplysins A-C isolated from red alga genus Laurencia. 红藻赤藻素A-C的化学结构及防污活性研究。

IF 2.5 3区医学

Fitoterapia Pub Date : 2025-06-13 DOI: 10.1016/j.fitote.2025.106683

Ryosuke Fukada, Keisuke Nishikawa, Misaki Nagasaka, Masayuki Kirihara, Shinobu Takizawa, Yoshiki Morimoto, Kazumi Nimura, Norio Kikuchi, Yukimasa Yamagishi, Takahiro Ishii, Takashi Kamada

引用次数: 0

Clerodane furanoditerpenoids from the tuberous roots of Tinospora sagittata (Oliv.) Gagnep. and their α-glucosidase inhibitory activity 从矢状木的块根中提取的氯烷呋喃二萜Gagnep。及其α-葡萄糖苷酶抑制活性

IF 2.5 3区医学

Fitoterapia Pub Date : 2025-06-12 DOI: 10.1016/j.fitote.2025.106680

Zhang-Juan Li , Ming Hu , Rong-Qing Yuan, Ling Jia, Ya-Xuan Ma, Zhou Liu, Meng-Xia Shen, Gui-Fa Zhu, Gan-peng Li, Xing-De Wu

引用次数: 0

Forsyditerpenes A–O, CC-type clerodane and aromatic abietane diterpenoids with anti-inflammatory activities from the seeds of Forsythia suspensa 连翘种子中具有抗炎活性的连翘二萜A-O、cc型氯烷和芳香枞烷二萜。

IF 2.5 3区医学

Fitoterapia Pub Date : 2025-06-12 DOI: 10.1016/j.fitote.2025.106675

Hui-Ying Li , Meng-Yu Bao , Hao-Ming Xiong , Can-Can Wang , Li-Ping Bai , Wei Zhang , Cheng-Yu Chen , Zhi-Hong Jiang , Guo-Yuan Zhu

{"title":"Forsyditerpenes A–O, CC-type clerodane and aromatic abietane diterpenoids with anti-inflammatory activities from the seeds of Forsythia suspensa","authors":"Hui-Ying Li , Meng-Yu Bao , Hao-Ming Xiong , Can-Can Wang , Li-Ping Bai , Wei Zhang , Cheng-Yu Chen , Zhi-Hong Jiang , Guo-Yuan Zhu","doi":"10.1016/j.fitote.2025.106675","DOIUrl":"10.1016/j.fitote.2025.106675","url":null,"abstract":"<div><div>Diterpenoids, the bioactive terpenoids of many medicinal plants, have not been reported in the seeds of <em>Forsythia suspensa.</em> In this study, twelve undescribed clerodane (<strong>1</strong>−<strong>12</strong>) and three new aromatic abietane (<strong>13</strong>–<strong>15</strong>) diterpenoids, named forsyditerpenes A–O, were isolated from the seeds of <em>Forsythia suspensa</em>. Among them, forsyditerpenes A–L (<strong>1</strong>–<strong>12</strong>) have rear CC-type clerodane skeleton, which possess the <em>cis</em> configuration of the A/B ring junction and the α-oriented C-17 and C-20. Furthermore, forsyditerpenes N (<strong>14</strong>) and O (<strong>15</strong>) are rearranged <em>ent</em>-abietane diterpenoids. Structural characterization was achieved by a combination of NMR, HR-ESI-MS, and X-ray diffraction. Forsyditerpenes C (<strong>3</strong>) and D (<strong>4</strong>) showed inhibitory effects of LPS-induced NO release with IC<sub>50</sub> values of 26.2 and 12.8 μM, respectively, which should be partly achieved through inhibiting iNOS protein expression in RAW264.7 cells.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"185 ","pages":"Article 106675"},"PeriodicalIF":2.5,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144293599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antiviral properties of the natural product eugenol: A review 天然产物丁香酚抗病毒特性研究进展

IF 2.5 3区医学

Fitoterapia Pub Date : 2025-06-11 DOI: 10.1016/j.fitote.2025.106674

Mei Chen , Yun-Ke Nie , Xin-Yu Liu , Yang Liu , Dao-Yu Guo

{"title":"Antiviral properties of the natural product eugenol: A review","authors":"Mei Chen , Yun-Ke Nie , Xin-Yu Liu , Yang Liu , Dao-Yu Guo","doi":"10.1016/j.fitote.2025.106674","DOIUrl":"10.1016/j.fitote.2025.106674","url":null,"abstract":"<div><div>Natural small molecule compounds have become the alternative options for developing antiviral reagent due to their broad-spectrum antiviral properties and low toxicity. Eugenol is a natural volatile phenolic aromatic compound primarily derived from clove oil. The small compound is well-recognized for its local anesthetic, anti-inflammatory, and preservative properties, making it a common choice for oral disinfection and as an adjunctive treatment for periodontitis. Clinical and experimental evidence shows that eugenol exhibits significant inhibitory effects against a variety of pathogenic microorganisms, including bacteria, fungi, and the viruses. In viral infectious diseases, eugenol can directly interact with pathogenic antigens in viral structures to prevent viral invasion. Additionally, it offers anti-inflammatory and antioxidant benefits by inhibiting multiple inflammatory mediators, thereby reducing organ damage. To the best of our knowledge, recent advancements in the antiviral properties of eugenol have not been solely addressed. This review aims to offer a new insight into the antiviral activity of eugenol and its potential mechanisms of action. Based on the literature review, we suggest that the antiviral mechanisms of eugenol are associated with cellular autophagy, and that the nuclear factor kappa-B (NF-κB) signaling pathway is the primary inflammatory pathway regulated by eugenol. These findings highlight the need for further investigation through rigorously designed experimental studies focused on specific viruses.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"185 ","pages":"Article 106674"},"PeriodicalIF":2.5,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144281043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Five new 14-oxygenated taxanes from the cell cultures of Taxus × media 从红豆杉×培养基细胞培养中获得5个新的14-氧合紫杉烷

IF 2.5 3区医学

Fitoterapia Pub Date : 2025-06-11 DOI: 10.1016/j.fitote.2025.106676

Yuxin Wang , Changkang Li , Songyang Sui, Jimei Liu, Jungui Dai

引用次数: 0

Identification of the anti-epileptic effect of speciogynine through molecular network-aided metabolite profiling of M. speciosa alkaloids using zebrafish 以斑马鱼为研究对象，利用分子网络辅助对斑蝶生物碱的代谢物谱分析鉴定斑蝶碱的抗癫痫作用

IF 2.5 3区医学

Fitoterapia Pub Date : 2025-06-09 DOI: 10.1016/j.fitote.2025.106667

Suleiman Abubakar Garba , Puspanjali Swain , Khozirah Shaari , Adlin Afzan , Soo Yee Lee , Cheol-Hee Kim , Siti Munirah Mohd Faudzi

{"title":"Identification of the anti-epileptic effect of speciogynine through molecular network-aided metabolite profiling of M. speciosa alkaloids using zebrafish","authors":"Suleiman Abubakar Garba , Puspanjali Swain , Khozirah Shaari , Adlin Afzan , Soo Yee Lee , Cheol-Hee Kim , Siti Munirah Mohd Faudzi","doi":"10.1016/j.fitote.2025.106667","DOIUrl":"10.1016/j.fitote.2025.106667","url":null,"abstract":"<div><div><em>Mitragyna speciosa</em> is a native plant to Southeast Asian countries, known its medicinal use as an analgesic and stimulant. Apart from the indole-type alkaloids, which have been shown to be responsible for its pharmacological properties, there is still limited information on other classes of compounds present in various parts of the plant. In an effort to fill this knowledge gap, the present study applied tandem liquid chromatography-mass spectrometry (LC-MS/MS)-based molecular networking to obtain more information on the chemodiversity of <em>M. speciosa</em>. Analysis of the generated molecular map obtained from methanol extracts of leaves (green- and red-veined), stem bark, stem tissue and fruits, revealed the putative presence of not only the characteristic indole-type alkaloids, but also flavoalkaloids, iridoids, triterpenoid saponins, glycoside derivatives, phenolic acids, flavonoids, and polyphenols, pervading all different parts of the plant. The class of flavoalkaloids is reported herein as new for <em>M. speciosa</em>. Continuing our interest in the biological properties of the chemical constituents of the plant, two minor indole alkaloids, speciogynine and isopaynantheine, purified from the leaf extract were evaluated for their toxicity and antiepileptic potential in zebrafish animal model. Interestingly, speciogynine exhibited a significant dose-dependent effect in reducing hyperactive movements in a zebrafish epilepsy model with mild toxic effects, indicating that it could be a promising anti-epileptic lead compound for further exploration.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"184 ","pages":"Article 106667"},"PeriodicalIF":2.5,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144262643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Highly oxygenated acorane sesquiterpenes from the marine-sourced Trichoderma harzianum CS-152. 海源哈兹木霉CS-152的高氧合子果烷倍半萜。

IF 2.5 3区医学

Fitoterapia Pub Date : 2025-06-09 DOI: 10.1016/j.fitote.2025.106672

Yan-He Li, Xiao-Ming Li, Xin Li, Xiao-Shan Shi, Sui-Qun Yang, Hong-Lei Li, Bin-Gui Wang

引用次数: 0

A heteropolysaccharide from Hypsizygus ulmarius fruit bodies attenuates D-galactose-induced cognitive decline by enhancing mitochondrial function and improving antioxidant activity in mice 一种来自黑果子实体的杂多糖通过增强线粒体功能和提高抗氧化活性来减轻d -半乳糖引起的小鼠认知能力下降

IF 2.5 3区医学

Fitoterapia Pub Date : 2025-06-09 DOI: 10.1016/j.fitote.2025.106669

Sudha Govindan , Jayasakthi Shanmugam , Devaki Unni , Amritha Sukumaran , Prasanna Ramani

{"title":"A heteropolysaccharide from Hypsizygus ulmarius fruit bodies attenuates D-galactose-induced cognitive decline by enhancing mitochondrial function and improving antioxidant activity in mice","authors":"Sudha Govindan , Jayasakthi Shanmugam , Devaki Unni , Amritha Sukumaran , Prasanna Ramani","doi":"10.1016/j.fitote.2025.106669","DOIUrl":"10.1016/j.fitote.2025.106669","url":null,"abstract":"<div><div>The study aimed to examine the antioxidant properties <em>in vitro</em> and the <em>in vivo</em> D-galactose-induced oxidative damage model from the fruiting bodies of <em>Hypsizygus ulmarius</em> Polysaccharide (HUP), which have an average molecular weight of 2.076 × 10<sup>3</sup> Da and are primarily composed of glucose and galactose, with minor sugars including xylose, rhamnose, fucose, and mannose. Through <em>in vitro</em> antioxidant tests, HUP exhibited iron-reducing ability, β-carotene bleaching inhibition, and hydroxyl radical scavenging action. Additionally, <em>in vivo</em> antioxidant assays demonstrated that HUP at 200 or 400 mg/kg BW and α-tocopherol as positive control could significantly increase the activities of enzymic antioxidants (CAT, SOD, GSH-Px, GST, and GR), non-enzymic antioxidants (TAOC, GSH, Vit C), in the serum and brain of D-Gal aging-induced mice. The levels of LPO, HPO, PCO, and AOPP levels were decreased on treatment with HUP and boosted the brain, spleen, and thymus indices, improved learning and memory, and stimulated the immune system in older mice. Treatment with HUP also reduced an increase in acetylcholinesterase activity. The decreased activities of NADH dehydrogenase, malate dehydrogenase (MDH), and isocitrate dehydrogenase (ICDH) in the brain mitochondria were restored to normal levels. In all biochemical parameters, the HUP had a dose-dependent positive effect, with 400 mg/kg being the most beneficial According to the current findings, HUP may offer a new source of natural antioxidants for use in functional foods and nutritional supplements.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"185 ","pages":"Article 106669"},"PeriodicalIF":2.5,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144271979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification of anti-inflammatory and antimicrobial compounds from leaves and rhizome of Iris pseudacorus collected in Ireland bogland using chemical profiling techniques 用化学分析技术鉴定爱尔兰假鸢尾叶和根茎中的抗炎和抗菌化合物。

IF 2.5 3区医学

Fitoterapia Pub Date : 2025-06-08 DOI: 10.1016/j.fitote.2025.106671

Özlem Erol , Shipra Nagar , Mohammed Ali Selo , Ismael Obaidi , John J. Walsh , Helen Sheridan , Young Hae Choi

{"title":"Identification of anti-inflammatory and antimicrobial compounds from leaves and rhizome of Iris pseudacorus collected in Ireland bogland using chemical profiling techniques","authors":"Özlem Erol , Shipra Nagar , Mohammed Ali Selo , Ismael Obaidi , John J. Walsh , Helen Sheridan , Young Hae Choi","doi":"10.1016/j.fitote.2025.106671","DOIUrl":"10.1016/j.fitote.2025.106671","url":null,"abstract":"<div><div><em>Iris pseudacorus</em>, a species native to Irish wetlands, was investigated for its antimicrobial and anti-inflammatory potential as part of a broader study on bogland medicinal plants. Methanol extracts from leaves and rhizomes were chemically profiled using NMR, LC-MS, and HPTLC, leading to the identification of three bioactive compounds: syringic acid, luteolin 7-<em>O</em>-β-D-glucoside, and liquiritigenin. HPTLC bioautography revealed that these compounds exhibited moderate antimicrobial activity against <em>Staphylococcus aureus</em> ATCC 29213, with MIC values ranging from 128 to 256 μg/mL. In vitro anti-inflammatory assays using THP-1 macrophages further demonstrated significant inhibition of interleukin-6 (IL-6) production, particularly by liquiritigenin, which showed the strongest bioactivity in both assays. These findings highlight the therapeutic potential of <em>I. pseudacorus</em> and support its traditional use in Irish ethnobotany, offering a promising example of bioactive compound discovery from underexplored wetland flora.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"185 ","pages":"Article 106671"},"PeriodicalIF":2.5,"publicationDate":"2025-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144265785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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