Fitoterapia最新文献

{"title":"Concoctive principles of detoxification and retention of the main toxic hepatotoxicity of Tripterygium wilfordii and its anti-inflammatory efficacy by concocting with the medicinal excipient Spatholobi Caulis juice.","authors":"Lijie Ji, Yueyue Zhang, Yamin Li, Lingling Song, Tianzhu Zhang, Chenjie Du, Wanying Li, Xiaohui Wu, Qingwen He, Yanmei Wang, Qian Wang, Junming Wang","doi":"10.1016/j.fitote.2025.106400","DOIUrl":"https://doi.org/10.1016/j.fitote.2025.106400","url":null,"abstract":"<p><p>Tripterygium wilfordii (TW), which has severe hepatotoxicity, is commonly used as anti-rheumatism. Using the juice of auxiliary herbs in concocting poisonous herbs is a conventional method for toxicity reduction or efficacy enhancement. Traditional Chinese Pharmacy textbooks record that Spatholobi Caulis (SC) can alleviate the side effects caused by TW and also possesses excellent hepatoprotective effect. However, it is still unclear how the concoctive principles of hepatotoxicity reduction and anti-inflammatory efficacy retention of TW after being concocted with the medicinal excipient SC juice. Therefore, this study aimed to evaluate the hepatotoxicity and anti-inflammatory efficacy of concoction with SC juice on TW and preliminarily explored its detoxification mechanism. The attenuation effect of TW concocted with SC juice was determined by triptolide (TP) content, hepatic histological and serum biochemical indexes. The detoxification mechanism was predicted by network pharmacology and molecular docking, and confirmed by quantitative real-time PCR (qRT-PCR) and Western blot. Moreover, the anti-inflammatory efficacy was evaluated by paw edema test, and the major active ingredients in the SC juice introduced to TW concoction were detected. Concoction with SC juice significantly reduced TP content and serum biochemical indicator levels, alleviated liver pathological damage, introduced the main active ingredients, and inhibited the expression of hypoxia inducible factor-1α (HIF-1α) and vascular endothelial growth factor (VEGF). Furthermore, the anti-inflammatory efficacy was retained. In summary, this study elucidated that concoction with SC juice alleviated the hepatotoxicity of TW by inhibiting HIF-1α/VEGFA signaling, decreasing TP content, and introducing the main active components. Moreover, the anti-inflammatory efficacy was retained.</p>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":" ","pages":"106400"},"PeriodicalIF":2.5,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143037709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bletilla ochracea Schltr. protects against ethanol-induced acute gastric ulcers by alleviating oxidative stress and inflammation and modulating gut microbiota.","authors":"Xiaofen Li, Sili Liu, Yongmei Zhang, Chunhua Huang, Didong Lou","doi":"10.1016/j.fitote.2025.106397","DOIUrl":"https://doi.org/10.1016/j.fitote.2025.106397","url":null,"abstract":"<p><p>Gastric ulcers (GUs) are superficial diffuse lesions of the gastric mucosa that are characterised by being vulnerable to infection, difficult to cure and liable to recur. Bletilla ochracea Schltr. (BO) has the effects of astringent hemostasis, muscle growth and pain relief. We examined the effects of BO on acute GUs and their potential mechanisms from the perspectives of inflammation, oxidative stress and gut microbiota. Results indicated that BO alleviated pathological injury to the gastric mucosa and markedly alleviated oxidative stress and inflammation. In addition, BO significantly upregulated the levels of Nrf2, HO-1, NQO1 protein, and downregulated the levels of NF-κB p65, TLR4 protein. Moreover, BO significantly increased promoting the nuclear transfer of Nrf2 and markedly reduced the nuclear translocation of NF-κB p65. Furthermore, BO effectively modulated gut microbiota by increasing the diversity of species and relative abundance. Our study provided evidence that BO alleviated ethanol-induced acute GUs by activating the Nrf2/HO-1 and inhibiting the NF-κB p65/TLR4 signalling pathway, regulating dysbiosis of gut microbiota.</p>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":" ","pages":"106397"},"PeriodicalIF":2.5,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143028309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Five new triterpenoids isolated from mastic: Structural identification and their anti-inflammatory activity.","authors":"Wentian Xiang, Yangkai Luo, Xuerui An, Ting He, Ping Cai, Minawar Kurban, Wei Liu, Tao Yuan","doi":"10.1016/j.fitote.2025.106395","DOIUrl":"10.1016/j.fitote.2025.106395","url":null,"abstract":"<p><p>Five new oleanane-type triterpenoids were isolated from mastic. Their structures including absolute configurations were determined by extensive spectroscopic methods and single-crystal X-ray crystallographic experiments. Compound 1 is distinguished by its rare furan ring. Compounds 3-5 are formed by the oxidative ring-opening reaction of the A ring in oleanane-type triterpenes, while compounds 3 and 4 are nor-triterpenes with a carbon atom missing at the C-28 position. The anti-inflammatory potential of the compounds was anticipated through network pharmacology, followed by a detailed molecular docking analysis. Finally, the anti-inflammatory effects were verified through the establishment of an in vitro model. Notably, compounds 3 and 4 exhibited significant inhibitory effects on NO production in RAW264.7 cells induced by lipopolysaccharide, with IC₅₀ values of 8.68 ± 2.58 and 5.00 ± 3.06 μM, respectively. These values are lower than that of the positive control drug, dexamethasone, which has an IC₅₀ of 9.93 ± 1.17 μM. The significant anti-inflammatory activity of these compounds suggests their potential as treatment candidates for inflammatory diseases.</p>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":" ","pages":"106395"},"PeriodicalIF":2.5,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143022696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential of Glycyrrhiza in the prevention of colitis-associated colon cancer.","authors":"Fang Liu, Zhili Gu, Feiyang Yi, Xue Liu, Wenxuan Zou, Qingxia Xu, Yun Yuan, Nianzhi Chen, Jianyuan Tang","doi":"10.1016/j.fitote.2025.106398","DOIUrl":"https://doi.org/10.1016/j.fitote.2025.106398","url":null,"abstract":"<p><strong>Ethnopharmacological relevance: </strong>Glycyrrhiza, a legume native to the Mediterranean region, has a long history of ethnomedicinal use in China. Due to its antiviral, antibacterial, anti-inflammatory, antioxidant, antitumor, anti-ulcer, and hepatoprotective properties, Glycyrrhiza is widely utilized in the treatment of gastrointestinal disorders.</p><p><strong>The aim of the review: </strong>The specific mechanisms of the main active constituents of glycyrrhiza in the treatment of inflammatory bowel disease, precancerous lesions and colorectal cancer at all stages of the colitis-associated colon cancer \"Inflammation-Dysplasia-Cancer\" sequence, as well as its pharmacokinetics, toxicology, formulation improvements, and application studies, are reviewed to provide new insights and perspectives on glycyrrhiza as a dietary supplement to treat and prevent colitis-associated colon cancer.</p><p><strong>Materials and methods: </strong>Information on Glycyrrhiza was retrieved from electronic databases, including PubMed and Web of Science.</p><p><strong>Results: </strong>Glycyrrhiza is a well-established medicinal plant with significant potential for applications in both the food and pharmaceutical industries. Over 400 active constituents have been identified in Glycyrrhiza, including terpenoids, flavonoids, isoflavones, coumarins, and polyphenols. Numerous studies have demonstrated that Glycyrrhiza and its active compounds can inhibit the \"Inflammation-Dysplasia-Cancer\" progression of colitis-associated colon cancer by mitigating inflammatory bowel disease, reducing the number of intestinal precancerous lesions, and counteracting colorectal cancer. Furthermore, derivatives and nanocarriers are crucial for the effective treatment of colitis-associated colon cancer using Glycyrrhiza and its active constituents.</p><p><strong>Conclusion: </strong>In conclusion, Glycyrrhiza is a plant with both medicinal and nutritional value, making it a potential food ingredient and dietary supplement for the treatment of colitis-associated colon cancer.</p>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":" ","pages":"106398"},"PeriodicalIF":2.5,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143022697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antidiabetic effects of two naphthoquinones from the branches and leaves of Tectona grandis and possible mechanism.","authors":"Xuelin Chen, Jiyan Ni, Kun Zhang, Xia Zhao, Yumei Zhang","doi":"10.1016/j.fitote.2025.106396","DOIUrl":"10.1016/j.fitote.2025.106396","url":null,"abstract":"<p><p>Tectona grandis is a Dai medicine that plays an important role in traditional medicine in India, Myanmar, West Africa, and Yunnan Province in China. T. grandis was recorded as an anti-diabetic herb in the Ayurvedic Pharmacopoeia; however, its potential antidiabetic components and possible mechanisms of action have almostly not been described to far. To completely comprehend the pharmacological components and therapeutic potential of T. grandis, we isolated chemical components from the plant's leaves and branches, evaluated their antidiabetic activities, and explored the possible mechanisms of active compounds using molecular docking and network pharmacology. In this study, two new quinones (1-2) and eighteen known compounds (3-20) were isolated and identified from T. grandis. Except for the new quinones 1 and 2, compounds 4, 11-12, 14-15, 18-20 were separated from T. grandis for the first time. The naphthoquinones 1 and 3 showed significant antidiabetic activities in α-glucosidase inhibition assay (IC₅₀: 92.52 ± 5.05 and 45.37 ± 1.50 μM, respectively), glucose uptake assay (Inhibition rate: 63.90 ± 1.04 % and 65.41 ± 1.96 %, respectively) and preadipocyte differentiation inhibition assay (Lipid droplet content decreased by 8.49 ± 0.71 % and 13.89 ± 0.29 %, respectively, compared to the model group). Our study also revealed that T. grandis might treat diabetes by targeting CASP3, ESR1, and PTGS2. This study provided important support for the traditional usage of T. grandis as an antidiabetic herb by identifying its antidiabetic components and possible mechanism.</p>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":" ","pages":"106396"},"PeriodicalIF":2.5,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143002794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Five new bisabolane-type sesquiterpenoids with oxygen-containing heterocyclic systems from Curcuma longa.","authors":"Ou Dai, Guang-Xu Wu, Hong-Zhen Shu, Cheng Peng, Fei Liu, Liang Xiong","doi":"10.1016/j.fitote.2025.106399","DOIUrl":"10.1016/j.fitote.2025.106399","url":null,"abstract":"<p><p>Five new bisabolane-type sesquiterpenoids (1-5) were isolated from the rhizomes of Curcuma longa, and all of them were oxygen-containing heterocyclic compounds. The structures of the compounds were elucidated using comprehensive spectroscopic techniques, and their absolute configurations were confirmed through electronic circular dichroism (ECD) calculations. All of the compounds were evaluated for their vasorelaxant and anti-inflammatory activities. The results showed that only compound 4 exhibited a vasorelaxant effect against KCl-induced contraction of rat aortic rings, and it achieved a diastolic ratio that exceeded 25 % at a concentration of 25 μM.</p>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":" ","pages":"106399"},"PeriodicalIF":2.5,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143002804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The protective effect and potential mechanism of Zanthoxylum bungeanum Maxim. on atherosclerosis.","authors":"Zongchao Li, Ruoxuan Xu, Can Li, Chenglin Chi, Xiaoli Yang, Shufang Yang, Rongxia Liu","doi":"10.1016/j.fitote.2025.106394","DOIUrl":"10.1016/j.fitote.2025.106394","url":null,"abstract":"<p><p>The pericarp of Zanthoxylum bungeanum Maxim. (ZBM) is an edible spice with medicinal value, and it has anti-obesity, anti-inflammatory, and cardiovascular protective effects. This study investigated the therapeutic effect of ZBM on atherosclerosis (AS) and its potential mechanisms. An in vivo experimental model of AS was established on apolipoprotein-E deficient (ApoE^-/-) mice to evaluate the efficacy of ZBM. Serum metabolomics combined with the vascular smooth muscle cell (VSMC) proliferation model were subsequently conducted to analyze the mechanisms. Results showed that ZBM effectively alleviated blood lipid disorders, aortic lipid accumulation, and intimal thickness in mice. Metabolomics indicated that ZBM mainly regulated 5 major metabolic pathways, including TCA cycle, steroid hormone biosynthesis, sphingolipid metabolism, glyoxylate and dicarboxylate metabolism, glycerophospholipid metabolism, which affected lipid metabolism and cell proliferation. Further experiments showed that ZBM inhibited VSMC proliferation likely because it blocked the signal transducer activator of transcription 3 (STAT3) phosphorylation and activated nuclear factor E2-related factor-2 (Nrf2)/heme oxygenase-1 (HO-1) pathway, resulting in G0/G1 phase arrest and reactive oxygen species (ROS) clearance.</p>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":" ","pages":"106394"},"PeriodicalIF":2.5,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143002813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study on chemical composition, anti-inflammatory activity and quality control of the branch bark of Morus alba L.","authors":"Wenyuan Li, Lin Chen, Minpeng Li, Kaiye Peng, Xuemei Lin, Yifan Feng, Yun Zou, Xia Wu","doi":"10.1016/j.fitote.2025.106383","DOIUrl":"https://doi.org/10.1016/j.fitote.2025.106383","url":null,"abstract":"<p><p>In this study, the chemical constituents of branch bark and root bark of Morus alba L. were first qualitatively analyzed by UPLC-Q/TOF-MS. A total of 40 compounds were identified, including 20 flavonoids, 3 stilbenes, 1 phenolic acid, 1 alkaloid, 5 arylbenzofurans and 10 Diels-Alder adducts. Of these, 19 compounds were specific to the root bark, 10 to the branch bark, and 11 were common to both. Total phenolic and flavonoid contents were determined, and anti-inflammatory activities were evaluated. Ethyl acetate extracts of both significantly inhibited NO secretion, with the root bark showing a stronger effect than the branch bark. Chemical components of branch bark were further separated, and the anti-inflammatory activities of these isolated compounds were investigated. Eight compounds were isolated from the ethyl acetate extract of the branch bark of Morus alba L.. These compounds were able to inhibit the release of inflammatory factors, including NO, IL-6, and IL-1β, in a concentration-dependent manner. Among them, compounds SZP-1, SZP-6 and SZP-8 exhibited superior in vitro anti-inflammatory activity, comparable to the positive drug meloxicam at high concentrations. In addition, the quality standard of the branch bark of Morus alba L. was established for the first time according to the 2020 edition of the Chinese Pharmacopoeia. This study provides valuable insights into the medicinal value of the branch bark of Morus alba L. and promotes the comprehensive utilization of mulberry branch resources.</p>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"181 ","pages":"106383"},"PeriodicalIF":2.5,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143002777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chemical profile, biological potential, molecular docking, molecular dynamics, and ADMET approaches of essential oils from extracted endemic Prangos aricakensis leaf and stem.","authors":"Serbay Safak Gokcimen, Tevfik Ozen, Ibrahim Demirtas, Sarmad Marah, Fatih Gul, Lutfi Behcet","doi":"10.1016/j.fitote.2025.106391","DOIUrl":"https://doi.org/10.1016/j.fitote.2025.106391","url":null,"abstract":"<p><p>This paper investigated essential oils (EOs) of the endemic Prangos aricakensis (PA) used as spice and aroma by the Turkish people. Using a Clevenger-type device, EOs were obtained for the first time by hydro-distillation from dried parts of PA (L:leaf, S:stem). The EOs of the PALEO and PASEO were analyzed by GC-MS/MS. The main components of both parts were limonene, bornyl acetate, cinnamic acid ethyl ester, and methyl trans-cinnamate. In this work, enzyme inhibition, antioxidant, antimicrobial, antifungal, and DNA protection activities were applied for PASEO and PALEO. The PALEO in DPPH^• and PASEO in ABTS^•+ scavenging activities were better than standard. In BChE inhibition activity, PALEO (6.69 ± 0.01 μg/mL) was more effective than galantamine (9.88 ± 2.42 μg/mL). It was active against pathogen bacteria and fungus, ranging between 32 and 128 μg/mL in terms of MIC, respectively. The results of molecular docking and ADMET of the four major components of EOs supported the effectiveness of the biological activity. Also, molecular dynamics (MD) simulations were performed for 100 ns, and MM-PBSA energies were calculated for the best-scored molecules in docking. In particular, radical scavenger, anti-BChE potential, and usability to develop different formulations against the disease were supported by in vitro, ADMET, and MD studies.</p>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":" ","pages":"106391"},"PeriodicalIF":2.5,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143002801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New alkaloids from Melodinus fusiformis and their cytotoxic activities.","authors":"Peng-Fei Li, Hai-Min Cai, Jun-Yan Ran, Jie Xue, Sha Yin, Jiao Yin, Jie Luo, Huan-Yu Guan","doi":"10.1016/j.fitote.2025.106381","DOIUrl":"10.1016/j.fitote.2025.106381","url":null,"abstract":"<p><p>Four new alkaloids, meloformisine A (1), meloformine B (2), meloformine F (3), meloformine G (4), along with five known alkaloids (5-9) were isolated from the leaves and twigs of Melodinus fusiformis. Their structures were elucidated on the basis of detailed spectroscopic evidence, including 1D and 2D NMR, MS, and single-crystal X-ray diffraction analysis. The structure of 1 was a novel indole alkaloid with an unprecedented 6/5/5/5/5 pentacyclic skeleton. The evaluation of inhibition activity against human A-549, MCF-7, and K-562 cell lines showed that compounds 1, 2, 6 and 8 exhibited different levels of cytotoxic activities, with IC₅₀ values ranging from 8.72 to 47.32 μM, respectively.</p>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":" ","pages":"106381"},"PeriodicalIF":2.5,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143002808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}