IF 2.5 3区医学

Fitoterapia Pub Date : 2024-11-01 DOI: 10.1016/j.fitote.2024.106282

{"title":"Garcinia flavonoids for healthy aging: Anti-senescence mechanisms and cosmeceutical applications in skin care","authors":"","doi":"10.1016/j.fitote.2024.106282","DOIUrl":"10.1016/j.fitote.2024.106282","url":null,"abstract":"<div><div>Cellular senescence, the irreversible arrest of cell division, is a hallmark of aging and a key contributor to age-related disorders. Targeting senescent cells represents a promising therapeutic approach to combat these ailments. This review explores the potential of <em>Garcinia</em> species, a genus rich in flavonoids with established antioxidant and anti-inflammatory properties, as a source of natural anti-senescence agents. We investigate the intricate connections between aging, cellular senescence, and oxidative stress, highlighting the detrimental effects of free radicals on cellular health. Furthermore, we analyze the diverse array of flavonoids identified within <em>Garcinia</em> and their established cellular mechanisms. We critically evaluate the emerging evidence for the anti-senescence potential of flavonoids in general and the limited research on <em>Garcinia</em> flavonoids in this context. By identifying existing knowledge gaps and paving the way for future research, this review underscores the exciting potential of <em>Garcinia</em> flavonoids as natural anti-senescence agents. These agents hold promise for not only promoting healthy aging but also for the development of cosmeceutical products that combat the visible signs of aging.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142568281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of medicinal and cosmetic cream based on flavonoids. 开发基于黄酮类化合物的药用和美容膏霜。

IF 2.5 3区医学

Fitoterapia Pub Date : 2024-11-01 DOI: 10.1016/j.fitote.2024.106283

S M Adekenov, D L Savchenko, A O Kenzhebekov, A N Zhabaeva, A S Adekenova, V V Polyakov

{"title":"Development of medicinal and cosmetic cream based on flavonoids.","authors":"S M Adekenov, D L Savchenko, A O Kenzhebekov, A N Zhabaeva, A S Adekenova, V V Polyakov","doi":"10.1016/j.fitote.2024.106283","DOIUrl":"https://doi.org/10.1016/j.fitote.2024.106283","url":null,"abstract":"<p><p>The article discusses the results of the development of a cream based on Populus balsamifera L. bud flavonoids, which have anti-inflammatory, skin-regenerating effects. A cream's anti-inflammatory and wound-healing activity based on a flavonoid substance has been studied. In an experiment on a model of an incised skin wound, it was determined that a cream based on the sum of flavonoids from balsam poplar buds, containing pinostrobin, pinocembrin, tectochrysin, exhibits anti-inflammatory and wound-healing activities. Considering that the effectiveness of local wound treatment mainly depends on the rational treatment of the first phase of the wound process, we have developed a 1 % flavonoid cream and its production technology. The technology for the production of flavonoid cream includes extraction and isolation of the sum of flavonoids from the raw material of Populus balsamifera L. buds, preparation of flavonoid substance and excipients, preparation of the cream base and cream, packaging and labelling of cream. Based on the results of our experiments, a pilot industrial regulation for the production of a new cream based on the sum of flavonoids of Populus balsamifera L. buds has been developed, and pilot production of an original medicinal and cosmetic cream was organised.</p>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142568279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biochemometric-guided isolation of new Isosteroidal alkaloids from Fritillaria cirrhosa D.Don (Liliaceae, syn. Fritillaria roylei Hook) as acetylcholinesterase inhibitors. 从 Fritillaria cirrhosa D.Don (Liliaceae, syn. Fritillaria roylei Hook) 中以生物化学计量学为指导分离出新的异甾体生物碱作为乙酰胆碱酯酶抑制剂。

IF 2.5 3区医学

Fitoterapia Pub Date : 2024-10-29 DOI: 10.1016/j.fitote.2024.106279

Prateek Singh Bora, Shivani Puri, Prithvi Pal Singh, Upendra Sharma

{"title":"Biochemometric-guided isolation of new Isosteroidal alkaloids from Fritillaria cirrhosa D.Don (Liliaceae, syn. Fritillaria roylei Hook) as acetylcholinesterase inhibitors.","authors":"Prateek Singh Bora, Shivani Puri, Prithvi Pal Singh, Upendra Sharma","doi":"10.1016/j.fitote.2024.106279","DOIUrl":"https://doi.org/10.1016/j.fitote.2024.106279","url":null,"abstract":"<p><p>Globally, Alzheimer's disease is an urgent public health concern with the ageing population in developing nations. Recent studies have identified isosteroidal alkaloids as promising therapeutic agents for Alzheimer's treatment. Fritillaria species are well-known rich sources of steroidal and isosteroidal alkaloids. In this context, the current study focuses on the biochemometric-guided isolation of three previously undescribed and two known isosteroidal alkaloids as acetylcholinesterase (AChE) inhibitors from the bulbs of Fritillaria cirrhosa D.Don. The isolated molecules were characterized by NMR, HR-ESI-MS, FT-IR, and DP4+ analysis. Subsequently, all isolates were evaluated for AChE inhibitory activity using Ellman's method. Among the evaluated molecules, 1 (IC<sub>50</sub>: 33.0 ± 4.4 μM) and 5 (IC<sub>50</sub>: 24.7 ± 4.5 μM) showed promising AChE inhibition in vitro. Enzyme kinetic studies of isolated molecules revealed mixed inhibition kinetics with K<sub>i</sub> varying from 1.3 to 24.4 μM. Moreover, the in silico studies showed excellent binding affinities of isolated molecules with the target protein and good drug-like ADMET properties. The present study identified new isosteroidal alkaloids as promising AChE inhibitors from F. cirrhosa bulbs via a biochemometric approach and advocated their further exploration for treating neurodegenerative disorders.</p>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142557455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Isosativene and sativene sesquiterpene derivatives from Dendrobium nobile 来自金钗石斛的 Isosativene 和 sativene 倍半萜衍生物。

IF 2.5 3区医学

Fitoterapia Pub Date : 2024-10-28 DOI: 10.1016/j.fitote.2024.106281

{"title":"Isosativene and sativene sesquiterpene derivatives from Dendrobium nobile","authors":"","doi":"10.1016/j.fitote.2024.106281","DOIUrl":"10.1016/j.fitote.2024.106281","url":null,"abstract":"<div><div>Two unusual isosativene sesquiterpene derivatives, named dendronobilol A (<strong>1</strong>) and dendronobilside A (<strong>2</strong>), and two unusual sativene sesquiterpene derivatives, named dendronobilsides B (<strong>3</strong>) and C (<strong>4</strong>), had been isolated from the stems of <em>Dendrobium nobile</em>. The structures of all the compounds were established using spectroscopic methods and by comparison with literature data, and their absolute configurations were confirmed via single-crystal X-ray diffraction data and electronic circular dichroism (ECD) calculations. Dendronobilol A (<strong>1</strong>) and dendronobilside A (<strong>2</strong>) possessed a unique tricyclo[4.3.0.1<sup>2, 8</sup>]decan ring system, while dendronobilsides B (<strong>3</strong>) and C (<strong>4</strong>) presented a unique tricyclo[4.4.0.0<sup>2, 8</sup>]decan core carbon skeleton. The above two types of sesquiterpene derivatives had been isolated and purified from plants for the first time. Compounds <strong>1</strong> and <strong>2</strong> exhibited significant effects on glucose consumption with doses of 20 and 40 μmol/L in insulin-resistant HepG2 cells, and thus improve insulin resistance.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142544629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Polygala tenuifolia root extract attenuates ischemic stroke by inhibiting HMGB1 trigger neuroinflammation 远志根提取物通过抑制 HMGB1 引发的神经炎症减轻缺血性中风的症状

IF 2.5 3区医学

Fitoterapia Pub Date : 2024-10-28 DOI: 10.1016/j.fitote.2024.106280

{"title":"Polygala tenuifolia root extract attenuates ischemic stroke by inhibiting HMGB1 trigger neuroinflammation","authors":"","doi":"10.1016/j.fitote.2024.106280","DOIUrl":"10.1016/j.fitote.2024.106280","url":null,"abstract":"<div><div><em>Polygala tenuifolia</em> Willd., a famous traditional Chinese medicine, has been widely applied to treat central nervous system diseases. In this study, <em>P. tenuifolia</em> root extract exhibited a moderate anti-ischemic effect on <em>in-vitro</em> oxygen-glucose deprivation/reperfusion (OGD/R) model. In transient middle cerebral artery occlusion (tMCAO) rats, <em>P. tenuifolia</em> root extract significantly attenuated brain infarction and neurological deficits in a dose-dependent manner. Compared with the sham group, the release of damage-associated molecular patterns (DAMPs)-HMGB1 in the ischemic brain was significantly higher, which was inhibited by <em>P. tenuifolia</em> root extract. To further explore such neuroprotective effects whether associated with aseptic inflammation, HMGB1-activated BV2 microglial cells model was established. The extract of <em>P. tenuifolia</em> was found to inhibit the downstream inflammatory response driven by HMGB1, with an IC<sub>50</sub> value of 49.46 μg/mL. In addition, the extract was also found to be able to directly interact with HMGB1 in the surface plasmon resonance (SPR) experiment. Phytochemical studies showed that the extract of <em>P. tenuifolia</em> root contains a large number of terpenoids, oligosaccharides and phenolic compounds, which likely contribute to the above observed biological activities. Our results not only provide some data support for the clinical application of <em>P. tenuifolia</em> against cerebral ischemia, but also clarify the potential target of <em>P tenuifolia</em>'s anti-inflammatory properties.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142544630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Natural compounds for endometriosis and related chronic pelvic pain: A review 治疗子宫内膜异位症和相关慢性盆腔疼痛的天然化合物：综述

IF 2.5 3区医学

Fitoterapia Pub Date : 2024-10-28 DOI: 10.1016/j.fitote.2024.106277

{"title":"Natural compounds for endometriosis and related chronic pelvic pain: A review","authors":"","doi":"10.1016/j.fitote.2024.106277","DOIUrl":"10.1016/j.fitote.2024.106277","url":null,"abstract":"<div><div>Endometriosis is a chronic gynecological disorder characterized by significant chronic pelvic pain (CPP) and infertility, adversely affecting the quality of life for many women worldwide.</div><div>This review aims to synthesize recent findings on natural bioactive compounds derived from various plant sources that exhibit beneficial effects in the management of endometriosis and related CPP.</div><div>A thorough search of databases, including PubMed, Scopus, and Google Scholar, was conducted to identify studies evaluating the efficacy of natural compounds on endometriosis and related CPP. In alphabetical order, curcumins, ginsenosides, polyphenols and other secondary metabolites showed promising effects on oxidative stress, inflammation, and pain modulation associated with endometriosis acting on multiple pathways. Most of the selected articles were <em>in vitro</em> and <em>in vivo</em> studies in animal models, with a limited number of clinical trials.</div><div>The reported natural compounds according to the highlighted multiple bioactivities, might be valuable complementary alternatives as supplements, nutraceuticals, or in advanced personalized nutrition. Further clinical investigations are needed to comprehensively evaluate their therapeutic potential, safety, efficacy and to establish effective treatment protocols.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142554757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rare crocins ameliorate thrombus in zebrafish larvae by regulating lipid accumulation and clotting factors 稀有鳄鱼毒素通过调节脂质积累和凝血因子改善斑马鱼幼体的血栓形成。

IF 2.5 3区医学

Fitoterapia Pub Date : 2024-10-28 DOI: 10.1016/j.fitote.2024.106278

{"title":"Rare crocins ameliorate thrombus in zebrafish larvae by regulating lipid accumulation and clotting factors","authors":"","doi":"10.1016/j.fitote.2024.106278","DOIUrl":"10.1016/j.fitote.2024.106278","url":null,"abstract":"<div><div>Crocin-4 is a water-soluble carotenoid that exhibits cardiovascular protection effects through anti-inflammatory and antioxidant effects. However, the pharmacodynamic effects and mechanisms of its analogues crocin-1 and crocin-2′ have not been reported. In this study, we evaluated the protective effects of rare crocins on cardiovascular systems. In ox-LDL induced HUVECs model, 0.02, 0.1, 0.5, 1, 2, 3, 4, 5, 6 μg/mL crocin-1 and crocin-2′ can increase cell viability by up to 80 %. Meanwhile, rare crocins at concentrations between 25–100 μg/mL crocin-1 and crocin-2′ reduced the lipid accumulation by 30 % in cholesterol-induced zebrafish larvae. What's more, the therapeutic potential of rare crocins on thrombosis has also been explored. In vitro experiments, rare crocin-1 and crocin-2′ at concentrations of 0.02, 0.05, 0.2, 0.5, 1, 2, 5, 10 μg/mL protected Human Umbilical Vein Endothelial Cells (HUVECs) against lipopolysaccharides-induced oxidative stress and inflammation. In vivo studies revealed that rare crocins at concentrations of 25, 50, 100, 150, 200, and 300 μg/mL exerted significant antithrombotic effect on arachidonic acid (AA)-induced zebrafish and there was nearly no potential risk for the deformity of zebrafish at 300 μg/mL dosages. In brief, rare crocins was viewed as a potentially useful candidate for the treatment of cardiovascular diseases because of its anti-inflammatory, antioxidant, and anticoagulant properties.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142544631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploration of potential mechanism of Sanhua Jiangzhi granules for the treatment of hyperlipidemia based on network pharmacology and experimental verification 基于网络药理学和实验验证的三花姜枝颗粒治疗高脂血症的潜在机制探索

IF 2.5 3区医学

Fitoterapia Pub Date : 2024-10-24 DOI: 10.1016/j.fitote.2024.106271

{"title":"Exploration of potential mechanism of Sanhua Jiangzhi granules for the treatment of hyperlipidemia based on network pharmacology and experimental verification","authors":"","doi":"10.1016/j.fitote.2024.106271","DOIUrl":"10.1016/j.fitote.2024.106271","url":null,"abstract":"<div><div>Sanhua Jiangzhi Granules (SJG) is a traditional Chinese patent medicine known for regulating lipid metabolism. In this study, we utilized UPLC-TOF-MS to analyze the components of SJG and, in conjunction with network pharmacology, identified 125 core chemical constituents. These components were individually queried and intersected with targets related to hyperlipidemia, resulting in the identification of 312 core targets. KEGG and GO analyses suggested that the mechanism of SJG in treating hyperlipidemia may primarily involve the PPAR signaling pathway. To further validate the efficacy and underlying signaling mechanisms of SJG, we conducted experiments using 60 rats. The results indicated that SJG significantly reduced body weight, lowered serum levels of total cholesterol (TC), triglycerides (TG), and low-density lipoprotein cholesterol (LDL-C), while increasing high-density lipoprotein cholesterol (HDL<img>C) levels. Enzyme-linked immunosorbent assay (ELISA) results demonstrated that SJG decreased hepatic TC and TG levels and mitigated lipid accumulation in the liver. Hematoxylin and eosin (HE) staining indicated that SJG improved liver pathological morphology and reduced the risk of fatty liver disease. Western blot analyses showed that treatment with SJG down-regulated the expression of stearoyl-CoA desaturase (SCD), 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), phospholipid transfer protein (PLTP), and fatty acid-binding protein 1 (FABP1), while up-regulating the expression of cholesterol 7α-hydroxylase (CYP7A1), carnitine palmitoyltransferase 1 (CPT-1), and PPARα by activating the PPAR signaling pathway. In conclusion, this study demonstrated that SJG activates the PPAR signaling pathway, leading to decreased body weight, lowered blood lipid levels, reduced hepatic TC and TG, and improved liver pathology in rats.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142497674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Two new flavonoids from the leaves of Garcinia smeathmannii, in vitro and in silico anti-inflammatory potentials 辣木叶中的两种新黄酮类化合物的体外和体内抗炎潜力。

IF 2.5 3区医学

Fitoterapia Pub Date : 2024-10-24 DOI: 10.1016/j.fitote.2024.106273

{"title":"Two new flavonoids from the leaves of Garcinia smeathmannii, in vitro and in silico anti-inflammatory potentials","authors":"","doi":"10.1016/j.fitote.2024.106273","DOIUrl":"10.1016/j.fitote.2024.106273","url":null,"abstract":"<div><div><em>Garcinia smeathmannii</em> is a well-known plant for its uses in the effective treatment of intestinal parasites, skin eruptions and skin burns. The dichloromethane-methanol (2:3) crude extract of the leaves of <em>G. smeathmannii</em> led to the isolation and characterization of twenty compounds (<strong>1</strong>−<strong>20</strong>) using chromatographic and spectroscopic techniques. Extracts and compounds were screened <em>in vitro</em> for their anti-inflammatory (ROS), antiglycation and antileishmanial (<em>L. tropica</em>) activities. Compounds were also screened for their <em>in silico</em> anti-inflammatory activities using Maestro 4.2.1 software with the co-crystal complex structures of the ovine oCOX-1: meloxicam (PDB Id: <span><span>4O1Z</span><svg><path></path></svg></span>) and murine mCOX-2: meloxicam (PDB Id: <span><span>4M11</span><svg><path></path></svg></span>) proteins. An unprecedented flavonol (<strong>1</strong>) and a flavone dimer (<strong>2</strong>) together with eighteen known compounds (<strong>3</strong>−<strong>20</strong>) were characterized. All the tested samples <em>in vitro</em> revealed no antiglycation and antileishmanial activities. Beside, extracts revealed moderate anti-inflammatory activities (IC<sub>50</sub> ranging from 24.1 ± 2.0 to 34.7 ± 0.8 μg/mL). Only compound (<strong>13</strong>) revealed an anti-inflammatory activity which was 9.33 times more active than the reference (Ibuprofen, IC<sub>50</sub> = 11.2 ± 1.9 μg/mL) with IC<sub>50</sub> of 1.2 ± 0.0 μg/mL. Compounds (<strong>2</strong>–<strong>9</strong>, <strong>11</strong>–<strong>13</strong> and <strong>19</strong>–<strong>20</strong>) were docked and the docking scores were ranging from −10.178 to −6.119 (kcal/mol) which were in agreement with the experimental anti-inflammatory activity. These results are in agreement with the traditional uses of the leave of <em>G. smeathmannii</em> as cataplasm for skin eruption and as analgesic agent.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142497679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Solanapyrone analogues from endophytic Nigrospora sphaerica MZW-A associated with the endangered conifer Pinus wangii 与濒危针叶树 Pinus wangii 相关的 Nigrospora sphaerica MZW-A 内生菌中的茄碱类似物。

IF 2.5 3区医学

Fitoterapia Pub Date : 2024-10-23 DOI: 10.1016/j.fitote.2024.106275

{"title":"Solanapyrone analogues from endophytic Nigrospora sphaerica MZW-A associated with the endangered conifer Pinus wangii","authors":"","doi":"10.1016/j.fitote.2024.106275","DOIUrl":"10.1016/j.fitote.2024.106275","url":null,"abstract":"<div><div>Eight previously undescribed solanapyrone analogues, sphasolanapyrones A–H (<strong>1</strong>–<strong>8</strong>), together with four structurally related known compounds (<strong>9</strong>–<strong>12</strong>) were obtained from the solid fermentation of <em>Nigrospora sphaerica</em> MZW-A, an endophytic fungus isolated from the fresh branches of the endangered conifer <em>Pinus wangii</em>. This study represents the first investigation on the secondary metabolites of endophytic fungus associated with this precious plant. The structures and absolute configurations of compounds <strong>1</strong>–<strong>8</strong> were elucidated by extensive spectroscopic analysis and electronic circular dichroism (ECD) calculations. <strong>1</strong> and <strong>2</strong> are first examples of 3,4-<em>vic</em> diol solanapyrone analogues, whereas <strong>7</strong> and <strong>8</strong> are rare 17-<em>nor</em>-solanapyrones. Among these isolates, <strong>3</strong>, <strong>4</strong>, <strong>5</strong>, and <strong>11</strong> showed weak inhibitory against <em>Staphylococcus aureus.</em> In addition, compound <strong>5</strong> displayed weak cytotoxic effects against several tumor cell lines.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142497675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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