IF 2.5 3区医学

Fitoterapia Pub Date : 2024-11-17 DOI: 10.1016/j.fitote.2024.106298

Kavita Joshi, Vaishnavi Singh, Samit Chatterjee, Poonam Khandelwal, Rashmy Nair, Sameer Qureshi, Snigdha Siddh, Vandana Nunia

{"title":"Assessment of lapachol's anti-inflammatory effectiveness in mitigating sepsis-induced acute lung injury.","authors":"Kavita Joshi, Vaishnavi Singh, Samit Chatterjee, Poonam Khandelwal, Rashmy Nair, Sameer Qureshi, Snigdha Siddh, Vandana Nunia","doi":"10.1016/j.fitote.2024.106298","DOIUrl":"https://doi.org/10.1016/j.fitote.2024.106298","url":null,"abstract":"<p><p>Sepsis-induced Acute Lung Injury (ALI) and Acute Respiratory Distress Syndrome (ARDS) pose life-threatening risks due to an excessive activation of proinflammatory cytokines via the JAK pathway. Currently, no confirmed drug treatment exists for ALI. In this study, we explored JAK1 as a potential therapeutic target to address this issue. This study evaluates lapachol, a bioactive secondary metabolite, for its potential in treating sepsis-induced Acute Lung Injury (ALI). Lapachol was selected based on in-silico analyses such as binding energy, RMSD, RMSF, H-bond graphs, and lig plots supported the hypothesis that Lapachol binds to JAK1 in a manner similar to Tofacitinib JAK1/3 inhibitor (Positive control). Lapachol, derived from the heartwood of Tecomella undulata, was used in this investigation. Swiss albino mice were categorized into control, LPS treated, positive control (Tofacitinib), and experimental groups (Lapachol at 20 and 40 mg/kg doses). Throughout the experiment, mice behaviour was monitored, and euthanasia was performed at 12 and 24-h intervals. Various analyses, including body weight, W/D ratio, lung weight/body weight ratio, flow cytometry of BAL fluid (at 12 and 24 h), histology, myeloperoxidase assays were performed. Results indicated that both Tofacitinib and Lapachol significantly reduced ALI markers, including lung weight/body weight ratio, cell counts, and granulocytes in bronchoalveolar lavage fluid. Moreover, histopathology and MPO analysis suggested that Lapachol, particularly at 40 mg/kg, exhibited anti-inflammatory effects comparable to Tofacitinib. Conclusively, the findings suggest that Lapachol possesses the potential to inhibit JAK1 kinase domains and mitigate ALI associated with sepsis similar to Tofacitinib.</p>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":" ","pages":"106298"},"PeriodicalIF":2.5,"publicationDate":"2024-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142675441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phytochemical characterization, toxicity and pharmacological profile of the central effects of the fixed fruit pulp oil of Mauritia flexuosa L.F. (buriti). Mauritia flexuosa L.F.（buriti）固定果肉油的植物化学特征、毒性和中枢效应药理学概况。

IF 2.5 3区医学

Fitoterapia Pub Date : 2024-11-17 DOI: 10.1016/j.fitote.2024.106303

Isaac Moura Araújo, Andressa de Alencar Silva, Luís Pereira-de-Morais, Debora de Menezes Dantas, Maysa de Oliveira Barbosa, Giovana Mendes Lacerda Leite, Carla de Fátima Alves Nonato, José Galberto Martins da Costa, Raimundo Luiz Silva Pereira, Marta Regina Kerntopf Mendonça, Henrique Douglas Melo Coutinho, Gyllyandeson de Araújo Delmondes

{"title":"Phytochemical characterization, toxicity and pharmacological profile of the central effects of the fixed fruit pulp oil of Mauritia flexuosa L.F. (buriti).","authors":"Isaac Moura Araújo, Andressa de Alencar Silva, Luís Pereira-de-Morais, Debora de Menezes Dantas, Maysa de Oliveira Barbosa, Giovana Mendes Lacerda Leite, Carla de Fátima Alves Nonato, José Galberto Martins da Costa, Raimundo Luiz Silva Pereira, Marta Regina Kerntopf Mendonça, Henrique Douglas Melo Coutinho, Gyllyandeson de Araújo Delmondes","doi":"10.1016/j.fitote.2024.106303","DOIUrl":"https://doi.org/10.1016/j.fitote.2024.106303","url":null,"abstract":"<p><p>Anxiety and depression are mental disorders that have been exponentially increasing over the last decades. Psychopharmacology emerged to try to alleviate the symptoms of these disorders; however, the side effects and the time it takes to achieve the desired effect are factors that decrease the search for and adherence to treatment. To remedy this situation, new compounds capable of improving the performance of these medications and reducing their adverse effects have been sought. The use of medicinal plants has been widely employed for this purpose. Mauritia flexuosa F.L., a palm tree with high incidence in Brazil, has been heavily targeted as all its parts are usable. The objective of this study is to evaluate the effects of fixed oil from the fruit of the buriti palm in models of depression and anxiety. The phytochemical profile of this oil and its toxicity were also investigated. The experiments conducted included the open field, rotarod, forced swim, and elevated plus maze tests. As a result, it was observed that the fixed oil from buriti palm presented 18 compounds, with elaidic acid being the major one, and showed no signs of toxicity. However, it demonstrated a possible stimulating activity in the open field test and had no effect on the motor system in the rotarod test. Furthermore, it exhibited an antidepressant-like effect in the forced swim test but an anxiety-like effect in the elevated plus maze test. Therefore, buriti oil may potentially be used in new formulations to assist in the treatment of anxiety and depression.</p>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":" ","pages":"106303"},"PeriodicalIF":2.5,"publicationDate":"2024-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142675539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Integrated workflows using metabolomics, genome mining, and biological evaluation reveal oxepine‑sulfur-containing anti-cryptococcal diketopiperazine produced by the endophyte Penicillium setosum. 利用代谢组学、基因组挖掘和生物评估的综合工作流程揭示了内生青霉 setosum 产生的含氧硫抗隐球菌二酮哌嗪。

IF 2.5 3区医学

Fitoterapia Pub Date : 2024-11-16 DOI: 10.1016/j.fitote.2024.106301

Cláudia Maria da Silva Costa de Oliveira, Milena Costa Bassicheto, Renan Santini Barbosa, Kiandro de Oliveira Gomes Neves, Caroline Dos Santos Monteiro, Miriam Uemi, Renata Castiglioni Pascon, Gilvan Ferreira da Silva, Hector Henrique Ferreira Koolen, Lívia Soman de Medeiros

{"title":"Integrated workflows using metabolomics, genome mining, and biological evaluation reveal oxepine‑sulfur-containing anti-cryptococcal diketopiperazine produced by the endophyte Penicillium setosum.","authors":"Cláudia Maria da Silva Costa de Oliveira, Milena Costa Bassicheto, Renan Santini Barbosa, Kiandro de Oliveira Gomes Neves, Caroline Dos Santos Monteiro, Miriam Uemi, Renata Castiglioni Pascon, Gilvan Ferreira da Silva, Hector Henrique Ferreira Koolen, Lívia Soman de Medeiros","doi":"10.1016/j.fitote.2024.106301","DOIUrl":"10.1016/j.fitote.2024.106301","url":null,"abstract":"<p><p>Cryptococcosis is a fungal infection for which treatment relies on old antifungal agents usually leading to drawbacks such as high toxicity and mainly low efficiency since drug resistance of microorganisms is strongly widespread. The discovery of new antifungal agents is urgent and investigations about underexplored Natural Product (NP) can yield the necessary outcomes to guide the discovery of new prototypes to anti-cryptococcal molecules development. In this scenario, an integrated strategy involving metabolomic data analysis, biological assessement and genome mining of P. setosum CMLD 18, revealed the biosynthesis of bis(methyl-sulfanyl) oxepine-containing diketopiperazine derivative, the bisdethiobis(methylthio)acetylaranotine (1) by the endophyte. The molecule showed a minimum inhibitory concentration (MIC) value of 0.125 mM when tested against C. neoformans. Evidence about the corresponding biosynthetic gene cluster (BGC) responsible for the biosynthesis of (1) in P. setosum were found. Moreover, other putative analogues of (1) were also detected, suggesting this microorganism may represent an important source of likely anti-cryptococcal molecules to be further investigated.</p>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":" ","pages":"106301"},"PeriodicalIF":2.5,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142667300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Kakuol and asarinin protecting liver injury via HSP90AA1/CDK2/mTOR signaling pathway. Kakuol和asarinin通过HSP90AA1/CDK2/mTOR信号通路保护肝损伤。

IF 2.5 3区医学

Fitoterapia Pub Date : 2024-11-15 DOI: 10.1016/j.fitote.2024.106297

Ling Jiang, Cai-Bo Tian, Rui-Han Ye, Nian Shi, Xing-Chao He, Yun-Li Zhao, Xiao-Dong Luo

引用次数: 0

Antidiabetic and antioxidant profiling of 67 African trifoliate yam accessions by planar on-surface assays versus in vitro assays 通过平面表面试验和体外试验对 67 个非洲三叶山药品种进行抗糖尿病和抗氧化分析。

IF 2.5 3区医学

Fitoterapia Pub Date : 2024-11-14 DOI: 10.1016/j.fitote.2024.106299

Priscilla O. Aiyedun , Mubo A. Sonibare , Badara Gueye , Dirk C. Albach , Julia Heil , Gertrud E. Morlock

{"title":"Antidiabetic and antioxidant profiling of 67 African trifoliate yam accessions by planar on-surface assays versus in vitro assays","authors":"Priscilla O. Aiyedun , Mubo A. Sonibare , Badara Gueye , Dirk C. Albach , Julia Heil , Gertrud E. Morlock","doi":"10.1016/j.fitote.2024.106299","DOIUrl":"10.1016/j.fitote.2024.106299","url":null,"abstract":"<div><div>Trifoliate yam (<em>Dioscorea dumetorum</em>) is traditionally used to treat diabetics in Nigeria. However, almost no information is available on its antidiabetic constituents and their natural variance. Hence, the activity of methanolic tuber extracts of 67 trifoliate yam accessions from the largest collection in Africa was proven by four colorimetric antidiabetic and antioxidant <em>in vitro</em> assays, as diabetes is also linked with oxidative stress. For the first time, selected accessions were also analyzed by planar bioactivity profiling. It has a comparatively higher, more differentiated information content, is more sustainable in terms of material consumption, and enables straightforward compound prioritization and characterization. Up to a dozen individual antioxidant zones were revealed as well as one prominent zone inhibiting α-glucosidase and α-amylase. The latter inhibition zone was tentatively assigned to palmitic, linoleic, oleic, linolenic, oxo-nonanoic fatty acids by direct elution to heated electrospray ionization high-resolution mass spectrometry.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"180 ","pages":"Article 106299"},"PeriodicalIF":2.5,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142638273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis and pharmacological activity evaluation of 2-(2-Phenylethyl)chromone analogues: The principal components in agarwood 2-(2-苯基乙基)铬酮类似物的合成和药理活性评价：沉香中的主要成分。

IF 2.5 3区医学

Fitoterapia Pub Date : 2024-11-13 DOI: 10.1016/j.fitote.2024.106296

Mingliang Zhang , Mengrong Niu , Jiangping Fan , Zihan Lu , Zhixiang Zhu , Bowen Gao , She-Po Shi

{"title":"Synthesis and pharmacological activity evaluation of 2-(2-Phenylethyl)chromone analogues: The principal components in agarwood","authors":"Mingliang Zhang , Mengrong Niu , Jiangping Fan , Zihan Lu , Zhixiang Zhu , Bowen Gao , She-Po Shi","doi":"10.1016/j.fitote.2024.106296","DOIUrl":"10.1016/j.fitote.2024.106296","url":null,"abstract":"<div><div>2-(2-Phenylethyl)chromones (PECs), the pivotal constituents responsible for the distinctive aroma and pharmacological potential of agarwood, are primarily obtained through extraction from natural materials. The restricted availability of agarwood has, however, hindered a comprehensive and systematic evaluation of their biological properties. In this study, we have chemically synthesized a total of 38 PEC derivatives, including 23 new compounds that had not been previously isolated from agarwood. These compounds were then evaluated for their inhibitory effects on nitric oxide release, neutrophil superoxide production, as well as their activities against tyrosinase, acetylcholinesterase, and <em>α</em>-glucosidase. The preliminary screening resulted in the identification of promising leads with potential therapeutic activities, and the structure-activity relationship of the synthesized PECs have also been briefly discussed. The results provide a foundation for the synthesis and pharmacological exploration of PECs, which sheds light on the pharmacological potential of agarwood's secondary metabolites.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"180 ","pages":"Article 106296"},"PeriodicalIF":2.5,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142617525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chemical profiles and antibacterial actions of Zanthoxylum acanthopodium DC. Essential oil growing in Indonesia Zanthoxylum acanthopodium DC.精油生长在印度尼西亚。

IF 2.5 3区医学

Fitoterapia Pub Date : 2024-11-12 DOI: 10.1016/j.fitote.2024.106300

Abdi Wira Septama , Eldiza Puji Rahmi , Aprilia Nur Tasfiyati , Nur Aini Khairunnisa , Halimah Raina Nasution , Nilesh Nirmal , Sofna Dewita Sari Banjarnahor , Nurhadi , Dadang Priyatmojo

{"title":"Chemical profiles and antibacterial actions of Zanthoxylum acanthopodium DC. Essential oil growing in Indonesia","authors":"Abdi Wira Septama , Eldiza Puji Rahmi , Aprilia Nur Tasfiyati , Nur Aini Khairunnisa , Halimah Raina Nasution , Nilesh Nirmal , Sofna Dewita Sari Banjarnahor , Nurhadi , Dadang Priyatmojo","doi":"10.1016/j.fitote.2024.106300","DOIUrl":"10.1016/j.fitote.2024.106300","url":null,"abstract":"<div><div>Foodborne illness caused by pathogens has been a major health problem. Antibacterial resistance renders therapeutic options for treating the condition more limited, hence there is a growing interest in finding novel antibacterial alternatives. <em>Zanthoxylum acanthopodium</em> (Rutaceae) essential oil (ZAEO) has a substantial potential to suppress the growth of bacterial infections. This study was conducted to evaluate antibacterial activity of ZAEO against four species of foodborne pathogens that cause potential infections. The checkerboard assay was used to identify synergistic effect of ZAEO and tetracycline, while bacteriolysis test was applied to evaluate the ability of ZAEO releasing material genetics of bacteria, inhibiting biofilm formation, and suppressing efflux pump. The oils of <em>Z. acanthopodium</em> was evaluated and showed that the highest constituents were limonene and geranyl acetate at 47.13 % and 23.84 %, respectively. These oils have the strongest ability to inhibit <em>Escherichia coli</em> compared to other pathogens with MIC value of 62.5 μg/mL. ZAEO and tetracycline also presented a synergistic effect against <em>E. coli</em> with FICI value of 0.37. Moreover, this combination of ZAEO and antibiotic shown as potential antibacterial agent by several mechanisms such as, decreasing biofilm formation, releasing ions, rupturing membrane cells, and suppressing the efflux pump of <em>E. coli.</em> It can be concluded that ZAEO and tetracycline presented a promising antibacterial activity, which can be explored further to develops antibacterial agents against foodborne pathogens.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"180 ","pages":"Article 106300"},"PeriodicalIF":2.5,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142617537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis, biological evaluation and mechanism study based on network pharmacology of amino acids esters of 20(S)-protopanaxadiol as novel anticancer agents. 基于网络药理学的 20(S)-protopanaxadiol 氨基酸酯类新型抗癌剂的合成、生物学评价和机理研究。

IF 2.5 3区医学

Fitoterapia Pub Date : 2024-11-11 DOI: 10.1016/j.fitote.2024.106274

Hongliu Xie, Fang Lin, Fei Shi, Elaine Johnstone, Yaqi Wang, Yang An, Jun Su, Jiayin Liu, Qinghai Dong, Jihua Liu

{"title":"Synthesis, biological evaluation and mechanism study based on network pharmacology of amino acids esters of 20(S)-protopanaxadiol as novel anticancer agents.","authors":"Hongliu Xie, Fang Lin, Fei Shi, Elaine Johnstone, Yaqi Wang, Yang An, Jun Su, Jiayin Liu, Qinghai Dong, Jihua Liu","doi":"10.1016/j.fitote.2024.106274","DOIUrl":"https://doi.org/10.1016/j.fitote.2024.106274","url":null,"abstract":"<p><p>As one of the metabolites of ginseng, 20(S)-protopanaxadiol (PPD) is a compound with dammarane-type tetracyclic triterpene, which performs a wide range of anticancer activities. In this study, PPD was used as a lead. A series of compounds were synthesized respectively with 11 amino acids through esterification and were evaluated for their cytotoxicity against several cancer cell lines. One of the synthetic products (PL) exhibited potent inhibitory effect on Huh-7 cells relative to that of PPD in vitro. Subsequently, the Annexin V-FITC /PI staining assay was used to verify that PL induced apoptosis of Huh-7 cells in a dose-dependent manner. A UPLC-Q/TOF-MS analysis method was established and validated for assessing pharmacokinetic properties after the administration of PPD and PL in rats. The results showed that compared with PPD, T<sub>1/2</sub>of PL in rats was prolonged, and the peak time was delayed, resulting in broader tissue distribution of the compound in the body. In addition, the targets of PL against several cancers were predicted and analyzed via network pharmacology. Molecular docking simulations demonstrated that PL interacted with the active sites of the above targets. In conclusion, this study provided a theoretical basis for the development and clinical application of anti-tumor activity of PPD.</p>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":" ","pages":"106274"},"PeriodicalIF":2.5,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142617531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of therapeutic and cosmetic cream based on flavonoids 开发基于黄酮类化合物的药用和美容膏霜。

IF 2.5 3区医学

Fitoterapia Pub Date : 2024-11-01 DOI: 10.1016/j.fitote.2024.106283

S.M. Adekenov, D.L. Savchenko, A.O. Kenzhebekov, A.N. Zhabaeva, A.S. Adekenova, V.V. Polyakov

{"title":"Development of therapeutic and cosmetic cream based on flavonoids","authors":"S.M. Adekenov, D.L. Savchenko, A.O. Kenzhebekov, A.N. Zhabaeva, A.S. Adekenova, V.V. Polyakov","doi":"10.1016/j.fitote.2024.106283","DOIUrl":"10.1016/j.fitote.2024.106283","url":null,"abstract":"<div><div>The article discusses the results of the development of a cream based on <em>Populus balsamifera</em> L. bud flavonoids, which have anti-inflammatory, skin-regenerating effects.</div><div>A cream's anti-inflammatory and wound-healing activity based on a flavonoid substance has been studied. In an experiment on a model of an cut skin wound, it was determined that a cream based on the sum of flavonoids of <em>Populus balsamifera</em> L. buds, containing pinostrobin, pinocembrin, tectochrysin, exhibits anti-inflammatory and wound-healing activity. Considering that the effectiveness of local wound treatment mainly depends on the rational treatment of the first phase of the wound process, we have developed a 1 % flavonoid cream and its production technology.</div><div>The technology for the production of flavonoid cream includes extraction and isolation of the sum of flavonoids from the raw material of <em>Populus balsamifera</em> L. buds, preparation of flavonoid substance and excipients, preparation of the cream base and cream, packaging and labelling of cream. Based on the results of our experiments, a pilot industrial regulation for the production of a new cream based on the sum of flavonoids of <em>Populus balsamifera</em> L. buds has been developed, and pilot production of an original therapeutic and cosmetic cream was organised.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"180 ","pages":"Article 106283"},"PeriodicalIF":2.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142568279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Garcinia flavonoids for healthy aging: Anti-senescence mechanisms and cosmeceutical applications in skin care 促进健康老龄化的藤黄类化合物：抗衰老机制和药用护肤品的应用。

IF 2.5 3区医学

Fitoterapia Pub Date : 2024-11-01 DOI: 10.1016/j.fitote.2024.106282

Idris Adewale Ahmed , Nor Hisam Zamakshshari , Maryam Abimbola Mikail , Ibrahim Bello , Md. Sanower Hossain

{"title":"Garcinia flavonoids for healthy aging: Anti-senescence mechanisms and cosmeceutical applications in skin care","authors":"Idris Adewale Ahmed , Nor Hisam Zamakshshari , Maryam Abimbola Mikail , Ibrahim Bello , Md. Sanower Hossain","doi":"10.1016/j.fitote.2024.106282","DOIUrl":"10.1016/j.fitote.2024.106282","url":null,"abstract":"<div><div>Cellular senescence, the irreversible arrest of cell division, is a hallmark of aging and a key contributor to age-related disorders. Targeting senescent cells represents a promising therapeutic approach to combat these ailments. This review explores the potential of <em>Garcinia</em> species, a genus rich in flavonoids with established antioxidant and anti-inflammatory properties, as a source of natural anti-senescence agents. We investigate the intricate connections between aging, cellular senescence, and oxidative stress, highlighting the detrimental effects of free radicals on cellular health. Furthermore, we analyze the diverse array of flavonoids identified within <em>Garcinia</em> and their established cellular mechanisms. We critically evaluate the emerging evidence for the anti-senescence potential of flavonoids in general and the limited research on <em>Garcinia</em> flavonoids in this context. By identifying existing knowledge gaps and paving the way for future research, this review underscores the exciting potential of <em>Garcinia</em> flavonoids as natural anti-senescence agents. These agents hold promise for not only promoting healthy aging but also for the development of cosmeceutical products that combat the visible signs of aging.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"180 ","pages":"Article 106282"},"PeriodicalIF":2.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142568281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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