Fitoterapia最新文献_第2页

New diterpenoids from Callicarpa dichotoma and their anti-inflammatory activity 新二萜类化合物及其抗炎活性研究

IF 2.5 3区医学

Fitoterapia Pub Date : 2025-06-07 DOI: 10.1016/j.fitote.2025.106666

Qiaomiao Fang , Xueer Zhang , Minhua Feng, Weiqun Yang, Guangtian Peng, Zhongxiang Zhao, Chaozhan Lin, Chenchen Zhu, Aizhi Wu

{"title":"New diterpenoids from Callicarpa dichotoma and their anti-inflammatory activity","authors":"Qiaomiao Fang , Xueer Zhang , Minhua Feng, Weiqun Yang, Guangtian Peng, Zhongxiang Zhao, Chaozhan Lin, Chenchen Zhu, Aizhi Wu","doi":"10.1016/j.fitote.2025.106666","DOIUrl":"10.1016/j.fitote.2025.106666","url":null,"abstract":"<div><div>Callicarpa dichotoma is a distinctive herbal plant of the genus Callicarpa. However, research on the phytochemical and pharmacological properties of C. dichotoma is very limited. Presently, three new diterpenoids, named dichotomapene A − C(1–3), along with fourteen known analogues (4–17), were isolated from C. dichotoma. Their structures were elucidated by spectroscopy, quantum chemical electronic circular dichroism (ECD) calculations, and single-crystal X-ray diffraction analysis. Compound 1 was an unusual abietane-type diterpenoid with a five-membered lactone ring formed between C-6 and C-18. The undescribed crystal structures of compounds 4, 6, and 13 were obtained for the first time. The anti-inflammatory activity of six diterpenoids on RAW 264.7 murine macrophages induced by LPS was further investigated by measuring the secretion of nitric oxide (NO). Cytotoxic experiments manifested that compound 14 had significant toxicity on RAW 264.7 cells. Griess assay results indicated that compound 7 displayed the best anti-inflammatory activity among five diterpenoids. Furthermore, molecular docking analysis was conducted to interpret the anti-inflammatory mechanism of 7 interacted with inducible nitric oxide synthase(iNOS). This study is the first investigation of diterpenoids within C. dichotoma.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"184 ","pages":"Article 106666"},"PeriodicalIF":2.5,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144242700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diacytochalasin A:A rearranged cytochalasin from endophytic fungus Diaporthe hongkongensis Diacytochalasin A：一种来自内生真菌Diaporthe hongkonggensis的重排细胞松弛素。

IF 2.5 3区医学

Fitoterapia Pub Date : 2025-06-07 DOI: 10.1016/j.fitote.2025.106664

Cheng Yi , Xiulan Liu , Keliang Chen , Haiyan Cao , Chenyu Yang , Yang Liu , Yunbao Liu

引用次数: 0

Oleanane-type triterpenes from Salvia rosmarinus and their inhibitory activity on NO production 迷迭鼠尾草中齐墩烷型三萜及其对NO生成的抑制作用。

IF 2.5 3区医学

Fitoterapia Pub Date : 2025-06-07 DOI: 10.1016/j.fitote.2025.106670

Qing-Jiang Xu , Jia-Chen Liu , Jia Xu , Xin Wang , Xiao-Ya Shang , Jia-Chen Zi

{"title":"Oleanane-type triterpenes from Salvia rosmarinus and their inhibitory activity on NO production","authors":"Qing-Jiang Xu , Jia-Chen Liu , Jia Xu , Xin Wang , Xiao-Ya Shang , Jia-Chen Zi","doi":"10.1016/j.fitote.2025.106670","DOIUrl":"10.1016/j.fitote.2025.106670","url":null,"abstract":"<div><div>Three new oleanane-type triterpenes, 2α,3β-dihydroxy-12-oxooleana-9(11)-en-28-13β,28-lactone (1), 2α,3α-dihydroxy-11-oxooleana-12-en-28-oic acid (2), and 3β-hydroxy-11-oxo-28-norolean-12,17-diene (3), one new natural product 2-hydroxy-3-oxooleana-1,12-dien-28-oic acid (4), as well as three known compounds 3β,12α-dihydroxyoleanan-28,13β-olide (5), 3β-hydroxyolean-11α,12α-epoxy-13β,28-lactone (6) and 2α,3β-digydroxy-9(11),12-dien-28-oic acid (7) were isolated and elucidated from the anti-inflammatory activity fraction of the ethanol extract of Salvia rosmarinus. The structures of the compounds were identified by spectral analysis and comparison with compounds reported in the literature. The inhibitory activity of all compounds on NO production in RAW 264.7 cells stimulated by lipopolysaccharide was tested. The results showed that compounds 2, 4 and 7 had significant anti-inflammatory activity.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"184 ","pages":"Article 106670"},"PeriodicalIF":2.5,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144257671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects and mechanisms of dietary polyphenols in ameliorating glycolipid metabolic disorders: Inhibition of advanced glycation end products 膳食多酚在改善糖脂代谢紊乱中的作用和机制：抑制晚期糖基化终产物。

IF 2.5 3区医学

Fitoterapia Pub Date : 2025-06-06 DOI: 10.1016/j.fitote.2025.106668

Shuo Wang , Yanqing Zhang , Wei Li , Xiaotong Zhao , Mengyu Zhang , Min Wang , Junbo Xie

{"title":"Effects and mechanisms of dietary polyphenols in ameliorating glycolipid metabolic disorders: Inhibition of advanced glycation end products","authors":"Shuo Wang , Yanqing Zhang , Wei Li , Xiaotong Zhao , Mengyu Zhang , Min Wang , Junbo Xie","doi":"10.1016/j.fitote.2025.106668","DOIUrl":"10.1016/j.fitote.2025.106668","url":null,"abstract":"<div><div>In recent years, the incidence of glycolipid metabolic disorders such as nonalcoholic fatty liver disease (NAFLD), obesity, and diabetic nephropathy (DN) has increased sharply, posing a significant threat to global public health and economic stability. Advanced glycation end products (AGEs), formed via the Maillard reaction (MR) between the carbonyl groups of reducing sugars and the free amino groups of proteins, play a critical role in the pathogenesis of these conditions. As such, inhibiting AGEs formation has emerged as a promising strategy for the prevention and treatment of glycolipid metabolic diseases. Recent studies have demonstrated that dietary polyphenols can inhibit AGEs formation through multiple mechanisms. These compounds are characterized by their safety, low toxicity, wide availability, and ease of access. This review first discusses the effects of AGEs formation, digestion, and absorption on human health, as well as the mechanisms by which AGEs contribute to disturbances in glucose and lipid metabolism and the progression of related metabolic diseases. It then provides a comprehensive overview of the mechanisms by which dietary polyphenols inhibit both endogenous and exogenous AGEs, and summarizes recent findings on their ability to ameliorate glycolipid metabolic disorders through AGEs suppression. Finally, this review highlights the potential of dietary polyphenols as modulators of glycolipid metabolism and outlines future research directions and challenges in this field. It is anticipated that this review will enhance scientific understanding of dietary polyphenols and promote their practical application in the development of novel functional foods.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"184 ","pages":"Article 106668"},"PeriodicalIF":2.5,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144247179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ethnopharmacology and antidiabetic potential of flavonoid-rich Krambe kotschayana: Integrative preclinical and in silico profiling. 民族药理学和抗糖尿病潜力富含黄酮类化合物的山楂：综合临床前和计算机分析。

IF 2.5 3区医学

Fitoterapia Pub Date : 2025-06-06 DOI: 10.1016/j.fitote.2025.106652

Geeta Devi, Varun Gorki, Richa Puri, Sudheer Kumar Dokuparthi, Lingaraju Aipuri

{"title":"Ethnopharmacology and antidiabetic potential of flavonoid-rich Krambe kotschayana: Integrative preclinical and in silico profiling.","authors":"Geeta Devi, Varun Gorki, Richa Puri, Sudheer Kumar Dokuparthi, Lingaraju Aipuri","doi":"10.1016/j.fitote.2025.106652","DOIUrl":"https://doi.org/10.1016/j.fitote.2025.106652","url":null,"abstract":"The Kinnaur tribe has traditionally employed CrambekotschayanaBoiss. for treating jaundice and fever, yet itspotential as an antidiabetic agent has not been examined. This research assesses the antioxidant properties, carbohydrate enzyme blocking, and antidiabetic impacts of its methanol extract (CKME) in alloxan-induced diabetic Wistar rats, as well as liver histopathological changes. Ethnobotanical studies found 17 medicinal plants utilized for managing diabetes. CKME, abundant in phenolics and flavonoids, featured rutin and isorhamnetin-3,7-diglucoside(LCMS/MS) along with vital minerals (WDXRF). It effectively inhibited α-glycosidase (IC50: 110.03 ± 0.615 μg/ml) and markedly lowered blood glucose (p < 0.001), improved lipid profiles, and boosted liver function at 400 mg/kg over 21 days. CKME reduced serum urea, uric acid, creatinine, ALT, and ALP, suggesting protective benefits for the liver and kidneys. Results endorse the traditional application of C. kotschayana in managing diabetes and promoting liver health, necessitating additional research to clarify its bioactive mechanisms.","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":" ","pages":"106652"},"PeriodicalIF":2.5,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144247180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring metabolite diversification via OSMAC strategy and UPLC-QTOF-MS in Aspergillus sp. Y-WS27 利用OSMAC策略和UPLC-QTOF-MS研究曲霉Y-WS27的代谢物多样性。

IF 2.5 3区医学

Fitoterapia Pub Date : 2025-06-05 DOI: 10.1016/j.fitote.2025.106665

Ming Chen , Yuting Wu , Peixi Zhang , Zhenxiong Lin , Jiaqi Shi , Jing Li , Bonan Yan , Li Guo , Wenxi Zhang , Qi Shi , Jieqing Liu

{"title":"Exploring metabolite diversification via OSMAC strategy and UPLC-QTOF-MS in Aspergillus sp. Y-WS27","authors":"Ming Chen , Yuting Wu , Peixi Zhang , Zhenxiong Lin , Jiaqi Shi , Jing Li , Bonan Yan , Li Guo , Wenxi Zhang , Qi Shi , Jieqing Liu","doi":"10.1016/j.fitote.2025.106665","DOIUrl":"10.1016/j.fitote.2025.106665","url":null,"abstract":"<div><div>This study investigated the efficacy of the One Strain Multiple Compounds (OSMAC) strategy in enhancing the anti-cancer potential of metabolites derived from the marine fungus Aspergillus sp. Y-WS27. Twenty-five culture conditions were employed to assess the inhibitory effects of crude extracts on cancer cell proliferation. Among them, the extract obtained from rice solid culture (R-0) demonstrated significantly enhanced inhibitory activity, as revealed by base peak chromatograms (BPC). The metabolite profile of R-0 showed a marked increase in the diversity and abundance of secondary metabolites compared to the control group (P-0). Ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC-QTOF-MS), along with ACD/MS Structure ID Suite, identified eight distinct compounds (1–8). These included butyrolactones, terretonins, and monacolin derivatives. Further purification yielded 17 compounds (1–17), with compounds 7 and 9 exhibiting significant anti-proliferative effects against MCF-7, A549, and HeLa cancer cells (IC50 values ranging from 9.88 to 30.28 μg/mL). Compound 7 displayed superior efficacy with IC50 values of 12.12, 10.21, and 9.88 μg/mL, respectively, while compound 9 showed moderate activity with reduced cytotoxicity to normal HK-2 cells. These findings demonstrated the utility of the OSMAC strategy in modulating secondary metabolite production and revealing previously undetected compounds. This research provided a robust framework for the discovery of novel natural products with therapeutic potential against cancer.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"185 ","pages":"Article 106665"},"PeriodicalIF":2.5,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144247181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Botany, applications, phytochemistry, and biological activities of Allium mongolicum regel: An update review 蒙古葱的植物学、应用、植物化学及生物活性研究进展

IF 2.5 3区医学

Fitoterapia Pub Date : 2025-06-03 DOI: 10.1016/j.fitote.2025.106661

Xu Wu , Xiao-Hui Bian , Zi-Han Ma , Xin-Yi Zhang , Shi-Yuan Tang , Zhang-Li Jiang , Hui Zhang , He-Shui Yu , Zhi-Ying Dou

{"title":"Botany, applications, phytochemistry, and biological activities of Allium mongolicum regel: An update review","authors":"Xu Wu , Xiao-Hui Bian , Zi-Han Ma , Xin-Yi Zhang , Shi-Yuan Tang , Zhang-Li Jiang , Hui Zhang , He-Shui Yu , Zhi-Ying Dou","doi":"10.1016/j.fitote.2025.106661","DOIUrl":"10.1016/j.fitote.2025.106661","url":null,"abstract":"<div><div>Allium mongolicum, also known as Allium mongolicum Regel or Shā Cōng, is a perennial xerophytic herb that grows in high-altitude desert areas. It is commonly used as a vegetable in daily life with nutritional value beneficially, and it can be made into delicious food with various ingredients, so it is increasingly popular among people of different ages. Interestingly, it is also a traditional Chinese medicine (TCM) of Chinese particularly in Inner Mongolia, and records of its use as a medicine can be found in ancient Chinese books in Ming dynasty. Additionally, there was a significant influence in improving the quality and local flavor of meat (mutton and beef) by using A. mongolicum. To date, as a plant of medicine food homology, over 200 constituents, including flavonoid and phenolic acids, essential oil, amino acids, microelements, and polysaccharide that were isolated and identified from A mongolicum. Increasing numbers of evidence have been revealed the possess a range of biological activities abroad, especially effects on bacteriostasis, antioxidant, anti-tumor, regulating immune, digestive-protective. Furthermore, the flavonoids were indicated for gastrointestinal-protective, such as flavonosides A3, mongo flavonosides A4, kaempferol-3-O-β-D-glucopyranoside, and kaempferol-3-O-β-D-glucopyranosyl (1 → 4)-β-D-glucopyranoside. We hope this review provides a new understanding for the future development in food exploitation, functional food innovation, and medical resource of A. mongolicum and its active ingredients as scientific evidence for health care products.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"184 ","pages":"Article 106661"},"PeriodicalIF":2.5,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144233649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trichodermanols A−C, three new metabolites from the Ganoderma lucidum-derived endophytic Trichoderma sp. GLQ02 and their anti-inflammatory activity 木霉醇A - C：三种来自灵芝内生真菌木霉sp. GLQ02的新代谢产物及其抗炎活性。

IF 2.5 3区医学

Fitoterapia Pub Date : 2025-06-03 DOI: 10.1016/j.fitote.2025.106657

Ping-Ping Wu , Xin-Huan Qiu , Hua-Jin Yu , Long-Jun Li , Xia Cheng , Yi-Ping Chen , Qi Luo

引用次数: 0

Eutymeroterpenoids A–G with cytotoxic and anti-inflammatory activity from the fungus Eutypella scoparia GZU-4-19Y 具有细胞毒和抗炎活性的茯苓真蝶萜类A-G

IF 2.5 3区医学

Fitoterapia Pub Date : 2025-06-03 DOI: 10.1016/j.fitote.2025.106660

Jingxin He , Binglin Chang , Shiting He , Die Yan , Yuwei Zhou , Jingnan Li , Zhongqiu Liu , Hui Cui , Yena Liu

{"title":"Eutymeroterpenoids A–G with cytotoxic and anti-inflammatory activity from the fungus Eutypella scoparia GZU-4-19Y","authors":"Jingxin He , Binglin Chang , Shiting He , Die Yan , Yuwei Zhou , Jingnan Li , Zhongqiu Liu , Hui Cui , Yena Liu","doi":"10.1016/j.fitote.2025.106660","DOIUrl":"10.1016/j.fitote.2025.106660","url":null,"abstract":"<div><div>Eutymeroterpenoids A–G (1–7), seven new eremophilane-type sesquiterpenoids, together with one known compound cryptosphaerolide (8), were isolated from marine-derived Eutypella scoparia GZU-4-19Y. Their structures were established by analysis of their NMR data and electronic circular dichroism calculations. All of them featured the unique 11‑carbon alkyl chain were rarely found in natural sesquiterpenoids. The isolates were evaluated for their anti-cancer and anti-inflammatory activities in vitro. Compounds 4, 5, 7 and 8 exhibited moderate cytotoxic activities against two human cancer cell lines (HT29 and HepG2). In addition, compounds 5 and 8 displayed good inhibitory activities against lipopolysaccharide-induced NO production in RAW264.7 cells with IC50 values of 26.9 and 13.7 μM, respectively, comparable to that of the positive control indomethacin (IC50 value = 24.2 μM). Western blot analysis further indicated that compounds 5 and 8 decreased the level of pro-inflammatory enzymes iNOS and COX-2.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"184 ","pages":"Article 106660"},"PeriodicalIF":2.5,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144223379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In vitro activity, structural characterization and modulation of DSS-induced intestinal inflammation in zebrafish by Pseudognaphalium affine (D.Don) Anderb polysaccharides 伪gnaphalium affine (d.d an) Anderb多糖对dss诱导的斑马鱼肠道炎症的体外活性、结构表征和调节作用

IF 2.5 3区医学

Fitoterapia Pub Date : 2025-06-03 DOI: 10.1016/j.fitote.2025.106658

Yan Zhang , Yazi Wang , Jing Shi, Hui Wang, Shan Xu, Qin Ge, Huiying Zhang

{"title":"In vitro activity, structural characterization and modulation of DSS-induced intestinal inflammation in zebrafish by Pseudognaphalium affine (D.Don) Anderb polysaccharides","authors":"Yan Zhang , Yazi Wang , Jing Shi, Hui Wang, Shan Xu, Qin Ge, Huiying Zhang","doi":"10.1016/j.fitote.2025.106658","DOIUrl":"10.1016/j.fitote.2025.106658","url":null,"abstract":"<div><div>A wide range of medicinal values and good health effects characterizes pseudognaphalium affine (D.Don) Anderb. PHP, as a polysaccharide fraction, was isolated and purified from Pseudognaphalium affine (D.Don) Anderb. This study evaluated PHP's structural characteristics in terms of its molecular weight, functional groups, and monosaccharide content. After dextrose sodium sulfate (DSS)-induced ulcerative colitis (UC) in zebrafish, the anti-inflammatory efficacy of PHP against macrophage RAW264.7 in vitro was assessed, as well as its impact on pathological alterations, oxidative stress state, and expression of inflammation-related genes. According to the data, PHP is a neutral heteropolysaccharide comprising nine monosaccharides. It markedly decreased the secretion of pro-inflammatory cytokines (TNF-α, IL-6) and altered the oxidative stress status of RAW264.7 cells. It increased oxidative stress markers and decreased the clinical signs of zebrafish colitis (CAT, SOD). PHP concurrently controlled the expression of genes linked to the NF-κB and MyD88 signaling pathways. Overall, PHP showed striking alleviation of ulcerative colitis in zebrafish, which can effectively facilitate the development of adjuvants and medicinal and edible plants to treat ulcerative colitis.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"184 ","pages":"Article 106658"},"PeriodicalIF":2.5,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144231706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0