Fitoterapia最新文献_第3页

Hyperwightianols A–H, monoterpenoid demethylated acylphloroglucinol derivatives from Hypericum wightianum

IF 2.5 3区医学

Fitoterapia Pub Date : 2025-02-13 DOI: 10.1016/j.fitote.2025.106437

Chuan-Lu Fu , Ping Ying , Zi-Wei Jia , Tian-Jie Cao , Qiang Zheng , You-Jun Wu , Wei-Ming Huang , Ze Liu , Ling-Yi Kong , Wen-Jun Xu

{"title":"Hyperwightianols A–H, monoterpenoid demethylated acylphloroglucinol derivatives from Hypericum wightianum","authors":"Chuan-Lu Fu , Ping Ying , Zi-Wei Jia , Tian-Jie Cao , Qiang Zheng , You-Jun Wu , Wei-Ming Huang , Ze Liu , Ling-Yi Kong , Wen-Jun Xu","doi":"10.1016/j.fitote.2025.106437","DOIUrl":"10.1016/j.fitote.2025.106437","url":null,"abstract":"<div><div>Twelve undescribed optically pure monoterpenoid demethylated acylphloroglucinol derivatives, named hyperwightianols A–H (1–8), were isolated from the dried whole herb of Hypericum wightianum, along with ten structurally related known compounds (9–18). The structures of the new compounds were elucidated using UV spectroscopy, HRMS, and extensive 1D & 2D NMR experiments. Absolute configurations of the new compounds were determined via chiral HPLC resolution and electronic circular dichroism (ECD) calculations. Brewster's rule, experimental and computed NMR chemical shift analyses, and conformational studies were collectively employed to validate the configuration of the C-1 2-methylbutanoyl moiety. Compounds 4 and (±)-14 exhibited potent inhibitory activity against NO release in LPS-induced RAW264.7 cells, with IC50 values of 9.56 ± 0.47 and 8.55 ± 1.10 μM, respectively.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"182 ","pages":"Article 106437"},"PeriodicalIF":2.5,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143425321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anti-inflammatory lignans from peeled stems of Syringa pinnatifolia

IF 2.5 3区医学

Fitoterapia Pub Date : 2025-02-13 DOI: 10.1016/j.fitote.2025.106445

Hongying Chen , Jiatong Wang , Jingjing Sun , Qiuyuan Ding , Yiru Shen , Tao Wang , Changxin Liu , Xiaoli Gao , Xingyun Chai

{"title":"Anti-inflammatory lignans from peeled stems of Syringa pinnatifolia","authors":"Hongying Chen , Jiatong Wang , Jingjing Sun , Qiuyuan Ding , Yiru Shen , Tao Wang , Changxin Liu , Xiaoli Gao , Xingyun Chai","doi":"10.1016/j.fitote.2025.106445","DOIUrl":"10.1016/j.fitote.2025.106445","url":null,"abstract":"<div><div>Three new lignans namely alashanenols H1–J1 (1–3) and one dimeric lignan namely bisyringol A (4) together with 15 known analogues (5–19) were isolated from the peeled stems of Syringa pinnatifolia Hemsl. with the aid of an in vitro anti-inflammation guided fractionation. The structures were elucidated by analysis of spectroscopic data, including IR, UV, MS, and NMR, and their absolute configurations were resolved by X-ray single crystal diffraction analysis and comparison of experimental and calculated 13C NMR and ECD data. Compound 2 possesses a cage-like motif in lignan family and 4 owns a rare framework composed of one lignan and one norlignan fragments. The bioassay results showed that 4, 13, and 18 significantly inhibit the NO production in LPS-induced RAW264.7 cells with IC50 values of 5.90 ± 0.28, 53.26 ± 9.96 and 53.25 ± 6.84 μM, compared with the positive control indomethacin (IC50 33.6).</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"182 ","pages":"Article 106445"},"PeriodicalIF":2.5,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143425316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Polyphenols from the husk of T. acornis suppresses MDA-MB-231 cells growth via Fanconi Anemia pathway

IF 2.5 3区医学

Fitoterapia Pub Date : 2025-02-13 DOI: 10.1016/j.fitote.2025.106443

Guangchun Gao , Jun Li , Xin Lu , Xiaomin Wang , Dongfeng Yang , Jiming Wu

{"title":"Polyphenols from the husk of T. acornis suppresses MDA-MB-231 cells growth via Fanconi Anemia pathway","authors":"Guangchun Gao , Jun Li , Xin Lu , Xiaomin Wang , Dongfeng Yang , Jiming Wu","doi":"10.1016/j.fitote.2025.106443","DOIUrl":"10.1016/j.fitote.2025.106443","url":null,"abstract":"<div><div>Triple-negative breast cancer (TNBC) is an aggressive subtype with poor prognosis. Recently, polyphenols derived from the husk of T. acornis (HTA) have shown promise as potential cancer treatment agents. This study aimed to explore the anti-TNBC effects and mechanisms of HTA polyphenols in vitro using MDA-MB-231 TNBC cells, a representative cell line of this type. Initially, we assessed the impact of HTA polyphenols on cell proliferation, invasion, migration, cell cycle, and apoptosis. Key active compounds, 1,2,3,6-tetra-O-galloyl-beta-d-glucose (TGG) and gallic acid (GA), were identified for their anti-TNBC properties. Transcriptome data analysis, GO annotation, KEGG enrichment, and protein-protein interaction (PPI) analysis revealed significant pathways in HTA polyphenol-treated MDA-MB-231 cells. A total of 3312 differentially expressed genes (DEGs) were identified, including 19 related to the Fanconi anemia (FA) pathway. Many of these DEGs are primarily involved in processes such as DNA replication, cell cycle regulation, and extracellular matrix (ECM)-receptor interactions. Consistent with these changes, FANCD2 and FANCG, among the 19 DEGs, were found to be downregulated in cells treated with HTA polyphenols, TGG, and GA. This was confirmed by western blotting and immunofluorescence assays. In conclusion, HTA has a significant anti-TNBC effect by inhibiting cancer occurrence and development. The underlying molecular mechanism may be associated with its modulation of the FA pathway. Overall, these findings underscore the potential of HTA polyphenols as a therapeutic agent or functional food for TNBC patients.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"182 ","pages":"Article 106443"},"PeriodicalIF":2.5,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143419732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phenolic compounds from the aerial parts of Artemisia vachanica Krasch. ex Poljakov

IF 2.5 3区医学

Fitoterapia Pub Date : 2025-02-12 DOI: 10.1016/j.fitote.2025.106438

Parviz Sukhrobov , Jun Li , Dan Tang , Sodik Numonov , Haji Akber Aisa

{"title":"Phenolic compounds from the aerial parts of Artemisia vachanica Krasch. ex Poljakov","authors":"Parviz Sukhrobov , Jun Li , Dan Tang , Sodik Numonov , Haji Akber Aisa","doi":"10.1016/j.fitote.2025.106438","DOIUrl":"10.1016/j.fitote.2025.106438","url":null,"abstract":"<div><div>A pair of undescribed enantiomers of phenolic compound bearing a rare oxetane moiety, (±)-vachanin L [(±)-1], and an undescribed monoterpene, vachanin M (2), along with fifteen known compounds including a monoterpene (3), a diterpene (4), seven flavonoids (5–11) and six lignan analogs (12–17) were isolated from the aerial parts of Artemisia vachanica Krasch. ex Poljakov. Their structures were identified based on HR-ESI-MS and NMR spectroscopy techniques. Relative configuration of vachanin L (1) was established by 13C NMR calculations and DP4+ probability analysis, and absolute configurations of (±)-vachanin L [(±)-1] and vachanin M (2) were successfully confirmed by ECD calculations and X-ray diffraction analysis. Compound 4 exhibited significant cytotoxic activity against MCF7, HT29 and Hela cell lines with IC50 values of 23.20 μM, 27.69 μM and 36.93 μM, respectively.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"182 ","pages":"Article 106438"},"PeriodicalIF":2.5,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143425331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New steroid and meroterpenoids from a sewage fungus Eurotium sp

IF 2.5 3区医学

Fitoterapia Pub Date : 2025-02-11 DOI: 10.1016/j.fitote.2025.106434

Xueqiong Liu , Zediao Huang , Junguo Huang , Tao Zhu , Qingpei Liu , Wenjing Wang , Xiaolong Yang

引用次数: 0

Novel monoterpene indole alkaloids from the fruits of Bousigonia mekongensis and their antiproliferative effects on HepG2 cells

IF 2.5 3区医学

Fitoterapia Pub Date : 2025-02-11 DOI: 10.1016/j.fitote.2025.106430

De-Dong Zhou , Yuan-Yuan Bai , Yuan-Yi Lin , Xiao-Dong Zhao , Zhi-Yuan Lu , Zhi-Wei Wang , Xiao-Jing Wang

引用次数: 0

The anti-aging and anti-Alzheimer's disease potential of kinsenoside prepared from Anoectochilus roxburghii

IF 2.5 3区医学

Fitoterapia Pub Date : 2025-02-11 DOI: 10.1016/j.fitote.2025.106441

Xin Yuan , He Ni , Fan Shi , Yan-bo Huang , Yi Hou , Song-Qing Hu

{"title":"The anti-aging and anti-Alzheimer's disease potential of kinsenoside prepared from Anoectochilus roxburghii","authors":"Xin Yuan , He Ni , Fan Shi , Yan-bo Huang , Yi Hou , Song-Qing Hu","doi":"10.1016/j.fitote.2025.106441","DOIUrl":"10.1016/j.fitote.2025.106441","url":null,"abstract":"<div><div>Anoectochilus roxburghii is a high-value plant resource for nutraceutical efficacy and medicinal applications, among which kinsenoside is recognized as the main bioactive glycoside. However, the anti-aging and anti-Alzheimer's disease (AD) activities of kinsenoside have long been neglected. The objective of this study was to investigate the influences of kinsenoside on aging and amyloid-β (Aβ) proteotoxicity and underlying molecular mechanisms in Caenorhabditis elegans (C. elegans). Kinsenoside (50 μM) could significantly prolong the mean lifespan of C. elegans by 26.3 %. Moreover, it improved the physiological functions, stress resistance and in vivo antioxidant activities of C. elegans. Further studies indicated that kinsenoside upregulated the mRNA expression levels of aging-associated genes including sir-2.1, hsp-16.2, sek-1, skn-1, sod-3, hsf-1, gst-4. The genetic studies and molecular docking studies supported that SKN-1 and HSF-1 transcription factors were requirements for the kinsenoside-mediated longevity. Furthermore, kinsenoside could exert a protective effect on Aβ-induced proteotoxicity by regulating stress-responsive and autophagy-related genes in C. elegans CL4176. The results sheds light on the bioactive properties and pharmaceutical potential of kinsenoside including anti-aging and anti-AD, broadening the prospects of kinsenoside for industrial applications.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"182 ","pages":"Article 106441"},"PeriodicalIF":2.5,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143394558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Study on the transformation law of anthraquinones in rhubarb combined with licorice based on biopharmaceutics

IF 2.5 3区医学

Fitoterapia Pub Date : 2025-02-11 DOI: 10.1016/j.fitote.2025.106429

Yu Yin , Jue Zhuang , Xuerou Wei , Wei Chen , Bingyu Hao , Yanru Deng , Yi Liu , Meng Wang , Xiaoliang Ren

{"title":"Study on the transformation law of anthraquinones in rhubarb combined with licorice based on biopharmaceutics","authors":"Yu Yin , Jue Zhuang , Xuerou Wei , Wei Chen , Bingyu Hao , Yanru Deng , Yi Liu , Meng Wang , Xiaoliang Ren","doi":"10.1016/j.fitote.2025.106429","DOIUrl":"10.1016/j.fitote.2025.106429","url":null,"abstract":"<div><div>The core of Chinese medicine compound prescription is the synergistic effect between the components and the effect of the interaction between the components on the dissolution and absorption of the drug. As a classic Chinese herbal formula, the laxative effect of Dahuang-Gancao decoction (DGD) is mainly derived from the anthraquinones in rhubarb. However, these components may also trigger adverse reactions due to their potency. Licorice, as a moderating herb, can alleviate the harshness of rhubarb. In this study, ultra performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS/MS) technique was used to identify 28 constituents in DGD, mainly including anthraquinones, licorice flavonoids, licorice saponins and other constituents. Moreover, the effect of licorice on the in vivo bioavailability of rhubarb after compatibility was investigated based on biopharmaceutics approach. The results showed that licorice and its fractions (licorice polysaccharides, licorice total saponins and licorice total flavonoids) promoted the stability and solubility of the active ingredients in rhubarb (Aloe-emodin-8-O-β-D-glucoside, Sennoside B, Sennoside A, Aloe-emodin, Rhein, Emodin, Chrysophanol and Physcion) in varying degrees and thereby improved their bioavailability in vivo. In addition, although there was no change in the biopharmaceutics classification of anthraquinone components, their pairing mainly resulted in increased solubility and decreased permeability. These findings provide a theoretical basis for elucidating the compatibility mechanism of the two.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"182 ","pages":"Article 106429"},"PeriodicalIF":2.5,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143413921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chemical constituents from the stems of Ephedra intermedia and their α-glucosidase and AChE inhibitory effects 中间麻黄茎中的化学成分及其α-葡萄糖苷酶和 AChE 抑制作用

IF 2.5 3区医学

Fitoterapia Pub Date : 2025-02-10 DOI: 10.1016/j.fitote.2025.106433

Ying Niu , Yan-Ling Liu , Yan-Gang Cao , Yi-Xin Zhao , Xu Chen , Di Lu , Bing-Xian Zhao , Xiao-Ke Zheng , Wei-Sheng Feng

引用次数: 0

Five new C19-diterpenoid alkaloids from Delphinium pachycentrum Hemsl. and Delphinium majus Ulbr. as potential acetylcholinesterase inhibitors

IF 2.5 3区医学

Fitoterapia Pub Date : 2025-02-10 DOI: 10.1016/j.fitote.2025.106431

Jing-Chuan Wu , Gui-Fang Li , Hong-Yu Ruan , Rui-Jie Lu , Shuai Huang , Lin Chen , Xian-Li Zhou

{"title":"Five new C19-diterpenoid alkaloids from Delphinium pachycentrum Hemsl. and Delphinium majus Ulbr. as potential acetylcholinesterase inhibitors","authors":"Jing-Chuan Wu , Gui-Fang Li , Hong-Yu Ruan , Rui-Jie Lu , Shuai Huang , Lin Chen , Xian-Li Zhou","doi":"10.1016/j.fitote.2025.106431","DOIUrl":"10.1016/j.fitote.2025.106431","url":null,"abstract":"<div><div>Two new C19-diterpenoid alkaloids, named pachycenines F–G (1–2), along with three known diterpenoid alkaloids (3–5), were extracted from the whole plant of Delphinium pachycentrum Hemsl. Additionally, three new C19-diterpenoid alkaloids, majuszine A–C (6–8), along with twenty-four known compounds (9–32) were isolated from the whole plant of Delphinium majus Ulbr. The structures of all these compounds were identified using IR, HR-ESI-MS, 1D and 2D NMR. Notably, compounds 1–2 are rare diterpenoid alkaloids that are characterized by the absence of an oxygenated substituent at the C-16 position. Compounds 6–8, on the other hand, all possess a special cyclic ketone structure, which is known to play a crucial role in various pharmacological activities. Furthermore, majuszine A (6) exhibited significant acetylcholinesterase inhibitory activity with an IC50 value of 5.74 μM. Finally, molecular docking simulations revealed the binding mechanism and interaction mode between majuszine A (6) and acetylcholinesterase.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"182 ","pages":"Article 106431"},"PeriodicalIF":2.5,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143406469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0