Fitoterapia最新文献

{"title":"Yinqiao antipruritic formula attenuates atopic dermatitis-like skin lesions through modulating the cytokine-cytokine receptor interaction pathway","authors":"Hua-qi Hu ,&nbsp;Fang Liu ,&nbsp;Wen-da Wang ,&nbsp;Shuai-bing He ,&nbsp;Yu-die Lu ,&nbsp;Jie Guo ,&nbsp;Dian-dong Hou ,&nbsp;Huan-yu Zhao","doi":"10.1016/j.fitote.2025.106529","DOIUrl":"10.1016/j.fitote.2025.106529","url":null,"abstract":"<div><div>Yinqiao Antipruritic Formula (YQAF) is a traditional Chinese medicine (TCM) formula for treating atopic dermatitis (AD) that has been used by the Huzhou Traditional Chinese Medicine Hospital in long-term clinical practice. It has definite therapeutic effects and minimal toxic side effects. However, the specific mechanism underlying the therapeutic effects of YQAF on AD remains ambiguous. We demonstrated the therapeutic effect of YQAF on Th2 type inflammation in a 2,4-dinitrochlorobenzene (DNCB)-induced AD mice model and elucidated the underlying mechanism. Results showed that YQAF effectively ameliorated the AD-like skin damage. YQAF suppressed the abnormal thickening of the epidermal hyperplasia induced by DNCB, decreased the mast cells infiltration, the collagen fibres number in the skin lesions, and reduced the expression of tumor necrosis factor-α (TNF-α), thymic stromal lymphopoietin (TSLP), interleukin (IL)-6 and nuclear factor kappa B (NF-κB). YQAF inhibited the Th2-type immune response, decreased the percentages of Th2 cells in dLNs, reduced the infiltration of group 2 innate lymphoid cells (ILC2), and suppressed the expression of IL-4 and IL-13 in skin lesions. According to the transcriptome sequencing results, YQAF inhibited the cytokine-cytokine interaction pathways. Our findings indicated that YQAF improved the symptoms of DNCB-induced AD-like lesions, which may be related to the inhibition of cytokine-cytokine interaction pathways. This indicated the potential of YQAF as a traditional Chinese Medicine formula for the treatment of AD.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"183 ","pages":"Article 106529"},"PeriodicalIF":2.5,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143817222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The key active ingredients identification and pharmacological mechanism investigation of extract of ethyl acetate from Er Miao San aganist rheumatoid arthritis","authors":"Jia-Yu Wang ,&nbsp;Ran Tang ,&nbsp;Si-Meng Chen ,&nbsp;Wen-Rui Su ,&nbsp;Jin Wang ,&nbsp;Zhi-Fang Qin ,&nbsp;Jia-Hua Yin ,&nbsp;Zi-Hua Xuan ,&nbsp;Hong-Su Zhao ,&nbsp;Min Zhang ,&nbsp;Wei Zhang ,&nbsp;Xiao-Yi Jia","doi":"10.1016/j.fitote.2025.106534","DOIUrl":"10.1016/j.fitote.2025.106534","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Background&lt;/h3&gt;&lt;div&gt;Er Miao San (EMS) is a basic formula for clearing heat and drying dampness in traditional Chinese medicine (TCM), which is mainly used in the treatment of rheumatoid arthritis (RA). Previous studies have found that the ethyl acetate extract of EMS (EMS-EA) has the best anti-inflammatory effect, but its specific pharmacological material basis is still unclear.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Purpose&lt;/h3&gt;&lt;div&gt;The aim of the study was to investigate the active components of the EMS-EA against RA and its mechanism of action using a combination of serum pharmacochemistry and network pharmacology.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;The anti-RA efficacy of EMS-EA was evaluated by establishing a rat model of adjuvant arthritis (AA). The chemical constituents of the EMS-EA and the blood components in the serum of rats after the administration of EMS-EA were detected by the ultra-high liquid chromatography-quadrupole Extractive Orbitrap Mass spectrometry (UPLC-QE-Orbitrap-MS). Network pharmacological analysis was utilized to predict the potential mechanism of action of key blood-entry components against RA, molecular docking, molecular dynamics simulations and &lt;em&gt;in vitro&lt;/em&gt; experiments were performed to preliminarily validate the results of network drug prediction. The anti-proliferative activity and pro-apoptotic ability of the key blood-entry components against TNF-α (10 ng/mL)-induced inflammatory injury model of MH7A were detected by MTT assay and TUNEL staining, the levels of IL-6 and IL-1β in the supernatant of the cells were detected by ELISA, and pathway proteins by WB assay.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;Compared with the model group, EMS-EA treatment significantly attenuated the ankle joint injury condition in AA rats, reduced foot volume, arthritis index, organ index and serum levels of TNF-α, IL-6 and IL-1β in rats, and alleviated the pathologies such as formation of vascular opacities and synovial hyperplasia of knee joints to different degrees. In positive and negative ion mode, 51 compounds including 19 alkaloids, 8 terpenoids, Subsequently, berberine (BER) and atractylenolide I (AT-I) were detected in the serum collected from rats after EMS-EA administration. Phellodendrine (PHE) found in rat abdominal aorta serum. Network pharmacology,molecular docking and molecular dynamics simulations results revealed that BER、AT-I and PHE may exert anti-RA effects by modulating the MAPK signaling pathway, whose core targets are mainly CASP3, MAPK1 and MAPK8. Finally, we performed &lt;em&gt;in vitro&lt;/em&gt; experiments to investigate the anti-RA activity of the three blood entry components mentioned above. The results showed that all three compounds were able to significantly reduce the TNF-α-induced proliferation level of MH7A cells and increase their apoptotic ability, while inhibiting the release of IL-1β and IL-6. WB experiments showed that all three compounds significantly elevated the level of Cleaved-caspase 3 in TNF-α-induced","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"183 ","pages":"Article 106534"},"PeriodicalIF":2.5,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143817217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytochemical and pharmacological properties of the genus Pseudotsuga","authors":"Jia-Wen Zhu ,&nbsp;Jin-Biao Xu ,&nbsp;Zhe-Yun Shao","doi":"10.1016/j.fitote.2025.106528","DOIUrl":"10.1016/j.fitote.2025.106528","url":null,"abstract":"<div><div><em>Pseudotsuga</em> is a crucial genus of timber trees in the Pinaceae family, comprising approximately 18 species that are predominantly found in western North America and East Asia. Over the past several decades, scholarly attention has primarily focused on the phytochemical study of <em>Pseudotsuga menziesii</em>, revealing a diverse range of compounds, including monoterpenes, sesquiterpenes, and flavonoids. Notably, recent advancements have also identified rare triterpene-monoterpene and triterpene-diterpene adducts, as well as triterpenoid dimers, from the <em>Pseudotsuga</em> genus. In this review, we comprehensively cover studies on <em>Pseudotsuga</em> species, comprising isolated compounds and their potential biological activities. The present review demonstrates that <em>Pseudotsuga</em> species exhibit a wide spectrum of pharmacological activities, largely attributed to the activities of terpenoids, flavonoids, and phenolics. These discoveries not only enrich our understanding of the chemical diversity of the <em>Pseudotsuga</em> genus but also highlight its potential in pharmaceutical and therapeutic applications.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"183 ","pages":"Article 106528"},"PeriodicalIF":2.5,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143825412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Propolis: A comprehensive review on the nature's polyphenolic wonder","authors":"Arun Kumar Balasubramaniam ,&nbsp;Ashmitha Elangovan ,&nbsp;Maheen Abdul Rahman ,&nbsp;Subhendu Nayak ,&nbsp;Durga Swain ,&nbsp;Harathi Parasur Babu ,&nbsp;Aarthi Narasimhan ,&nbsp;Vikramdeep Monga","doi":"10.1016/j.fitote.2025.106526","DOIUrl":"10.1016/j.fitote.2025.106526","url":null,"abstract":"<div><div>Propolis, a resinous substance produced by honeybees, has been utilized in traditional medicine for centuries due to its diverse biological activities. This review explores the phytochemical composition, therapeutic applications, and potential health benefits of propolis. Comprising a complex mixture of resins, waxes, essential oils, and pollen, propolis exhibits significant antimicrobial, antioxidant, anti-inflammatory, immunomodulatory, and anticancer properties. The phytochemical content of propolis varies with its botanical and geographical origins, influencing its bioactivity. Propolis has shown promise in wound healing, oral health, cardiovascular protection, neuroprotection, hepatoprotection, and gastrointestinal health. Despite its therapeutic potential, challenges such as standardization, quality control, and regulatory issues need to be addressed. Future research should focus on elucidating the mechanisms of action, optimizing extraction methods, and conducting extensive clinical trials to validate its efficacy and safety. Sustainable production and conservation efforts are essential to ensure the continuous supply of high- quality propolis. This review highlights the need for interdisciplinary research to fully harness the potential of propolis in modern medicine.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"183 ","pages":"Article 106526"},"PeriodicalIF":2.5,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143817327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-inflammatory glycoside withanolides from leaves of Athenaea velutina","authors":"Lavosyer da Silva Mendonça ,&nbsp;Késya Amanda Dantas Rocha ,&nbsp;Francisco das Chagas Lima Pinto ,&nbsp;Lidiana Rabelo da Silva ,&nbsp;Flavia Almeida Santos ,&nbsp;Josean Fechine Tavares ,&nbsp;Edilberto Rocha Silveira ,&nbsp;Otília Deusdenia Loiola Pessoa","doi":"10.1016/j.fitote.2025.106522","DOIUrl":"10.1016/j.fitote.2025.106522","url":null,"abstract":"<div><div>The phytochemical study of the CH₂Cl₂ and EtOAc soluble fractions from the leaf ethanol extract of <em>Athenaea velutina</em> resulted in the isolation of the new withanolides <strong>1</strong>–<strong>3</strong>, two of which substituted at the C-3 by a disaccharide 3<em>β</em>-<em>O</em>-[<em>α</em>-L-rhamnopyranosyl-(1 → 4)-<em>β</em>-<span>d</span>-glucopyranosyl], and four others previously reported (<strong>4–7</strong>). The structures of the new withanolides were elucidated by detailed interpretation of their 1D- and 2D-NMR spectra and the HRESIMS analysis. An anti-inflammatory screening was performed using the two major withanolides (<strong>1</strong> and <strong>2</strong>), analyzing their effects on the viability of RAW 264.7 cells and their ability to inhibit cellular nitric oxide production. While withanolide <strong>1</strong> exhibited pro-inflammatory activity by increasing nitrite production in LPS-stimulated macrophages, compound <strong>2</strong>, in opposition, demonstrated anti-inflammatory action by reducing those levels.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"183 ","pages":"Article 106522"},"PeriodicalIF":2.5,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143817218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extraction technology, component analysis, and the immunomodulatory effects in immunosuppressed broilers of total flavonoids extract from the thorns of Gleditsia sinensis Lam","authors":"Jingyi Xu,&nbsp;Aohua Zhou,&nbsp;Shaoyang Yue,&nbsp;Hanyu Zhao,&nbsp;Yilin Xiao,&nbsp;Yuru Guo,&nbsp;Fei Mo,&nbsp;Mingchun Liu,&nbsp;Chunlian Tian","doi":"10.1016/j.fitote.2025.106524","DOIUrl":"10.1016/j.fitote.2025.106524","url":null,"abstract":"<div><div>Spina Gleditsiae is the dry thorns from <em>Gleditsia sinensis</em> Lam. (<em>G. sinensis</em>), exhibits the effect of reducing swelling and toxins, and draining pus. Flavonoids are the primary active constituents of Spina Gleditsiae, but their extraction technology has not been studied systematically. Relevant studies revealed that Spina Gleditsiae shown certain immunomodulatory effects, but its mechanism was still unclear. This research was carried out about the extraction process, chemical composition, and the effects on the immune function of total flavonoids extract (TFE). The extraction conditions of TFE were investigated by response surface methodology, and the major components were preliminarily analyzed and inferred by ultra performance liquid chromatography- quadrupole-time-of-flight-mass spectrum method. The immunomodulatory effect of TFE was evaluated by cyclophosphamide induced immunosuppressed broilers. The yield of TFE was 1.80 % under the following optimized conditions: ethanol concentration 50 %, extraction time 20 min, and the ratio of solvent to material 50:1 ml/g. In addition, the main chemical components in the TFE have been preliminarily identified based on related literature and mass spectrometry information. Meanwhile, the TFE could mitigate the immunosuppressive state caused by cyclophosphamide in broilers by improving the histomorphology of immune organs, increasing the index of immune organ, elevating the serum levels of IL-2, IFN-β, and IFN-γ, and raising the titer of Newcastle disease antibodies in the serum. Furthermore, the immunoregulatory effects of these flavonoids were found to be closely related to the enhancement of the relative expression level of key genes and proteins in the TLR4-MyD88/TICAM-NF-κB signaling pathway. The findings of the study suggest that TFE derived from the thorns of <em>G. sinensis</em> holds promise as an enhanced traditional Chinese medicine with the capability to potentially bolster immune function.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"183 ","pages":"Article 106524"},"PeriodicalIF":2.5,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143829363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aloe Vera flowers extracts inhibit melanogenesis via activating PI3K/Akt signaling pathway: Network pharmacology and experimental validation","authors":"Jiaxin Li ,&nbsp;Wei Zou ,&nbsp;MingKun Li ,&nbsp;Yongtao Yan ,&nbsp;Yue Yu ,&nbsp;Xiaomin Li ,&nbsp;Yan-Long Ma","doi":"10.1016/j.fitote.2025.106530","DOIUrl":"10.1016/j.fitote.2025.106530","url":null,"abstract":"<div><div><em>Aloe vera</em> is a traditional herbal medicine that has been used for thousands of years. However, its flowers are commonly considered useless and discarded. Although, a few recent studies find <em>Aloe vera</em> flowers extracts (AVFE) with ability to inhibit tyrosinase (TYR) activity <em>in vitro</em>, systematic research on AVFE as skin whitening agent against melanogenesis <em>in vitro</em> and <em>in vivo</em> is yet lack. Therefore, the anti-TYR activity and anti-melanogenic effects of AVFEs <em>in vitro</em> B16F10 cell model and <em>in vivo</em> zebrafish embryo model, analysis of all-components of AVFE, network pharmacology and protein expression of melanogenesis-related signaling pathways were well conducted in this study. The results demonstrated that AVFE could significantly reduce cellular TYR activity and melanin content <em>via</em> activating the phosphorylation of p-Akt and p-GSK-3β in PI3K/Akt signaling pathway, followed by reducing the phosphorylation of MITF and then downregulation of TYR, TRP1 and TRP2 expression levels, and finally decreasing TYR, TRP1, TRP2 and melanin syntheses. In addition, 24 components of AVFE were most likely responsible for its skin depigmentation. In conclusion, this study provides a basis for understanding the mechanism of AVFE on skin depigmentation, as well as a potential for applying AVFE as skin whitening agent in cosmetics.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"183 ","pages":"Article 106530"},"PeriodicalIF":2.5,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143817216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The hepatoprotective effect of Lonicera japonica Flos on rats with high-fat diet-induced non-alcoholic fatty liver disease","authors":"Xue Ma,&nbsp;Chun-Yong Sun,&nbsp;Yan Zhang,&nbsp;Jia Li,&nbsp;Dong-Sheng Zhao","doi":"10.1016/j.fitote.2025.106516","DOIUrl":"10.1016/j.fitote.2025.106516","url":null,"abstract":"<div><div><em>Lonicerae Japonica</em> Flos (LJF) is an edible-medicinal herb, rich in phenolic acids, flavonoids, iridoids and other bioactive ingredients, that has anti-inflammatory, antioxidant, antilipemic, and hepatoprotective effects. However, its effect on non-alcoholic fatty liver disease (NAFLD) remains to be elucidated. The aim of this study was to determine the effect of LJF on liver injury in rats with high-fat diet (HFD)-induced NAFLD. The administration of LJF extract to rats with HFD-induced NAFLD significantly improved their body weight and daily food intake, liver tissue steatosis, lipid droplet vacuolization, and inflammatory cell infiltration. In addition, the LJF extract also improved to varying degrees the serum biochemical parameters, liver lipid content, levels of inflammatory factors, and oxidative stress markers. Among the treatment groups, the LJF high-dose group (LJF-H) showed the most significant improvement effect. Additionally, the correlation matrix heatmap visualization indicated that LJF may ameliorate NAFLD mainly by lowering liver lipid content and improving serum biochemical parameters.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"183 ","pages":"Article 106516"},"PeriodicalIF":2.5,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Absorption, distribution, metabolism, and excretion (ADME) of R,S-Goitrin in Radix Isatidis in rats by LC-MS/MS determination","authors":"Jia Tang ,&nbsp;Lisha Ye ,&nbsp;Baolian Wang","doi":"10.1016/j.fitote.2025.106514","DOIUrl":"10.1016/j.fitote.2025.106514","url":null,"abstract":"<div><div><em>Radix Isatidis</em> (syn. Isatis indigotica Fort.) is employed in the treatment of fever, influenza, acute tonsillitis, viral hepatitis, and COVID-19, demonstrating diverse pharmacological activities, including antibacterial, antiviral, antioxidant, anticancer, and immune-regulatory effects. Furthermore, there is significant potential for the development of new clinical applications. In order to investigate the pharmacokinetic characteristics, a quantitative method for determining R,S-goitrin in rat plasma using liquid chromatography-tandem mass spectrometry (LC-MS/MS) was developed and validated. The established LC-MS/MS method was employed to investigate the pharmacokinetics, tissue distribution, plasma protein binding, excretion, and metabolic characteristics of <em>Radix Isatidis</em> extract following oral administration in rats. Meanwhile, by comparing with the oral monomer group, the absorption profile of the extract in rats was assessed. After oral administration of different doses of <em>Radix Isatidis</em> extract (0.1,0.3,1 g/kg) to male rats, showed dose-dependent increases in R,S-goitrin's C_max and AUC, with bioavailability at 56.33 %. No gender differences in pharmacokinetics (PK) were observed. Compared with the monomer R,S-goitrin (0.03 mg/kg), it was observed higher <em>in vivo</em> exposure AUC_(0-t) and peak concentration C_max of R,S-goitrin after dosing of the Radix Isatidis extract with equal dosage of R,S-goitrin. R,S-goitrin was widely distributed in immune organs (adrenal glands, thymus, lymph nodes), liver, spleen, and gastrointestinal tract after oral administration of <em>Radix Isatidis</em> extract (0.1 g/kg) in rats. R,S-goitrin was primarily excreted <em>via</em> urine, accounting for 56 % of the administered dose, with plasma protein binding ranging from 13 % to 16.4 % across different species. These findings provide data to support <em>Radix Isatidis</em> clinical use in antibacterial, anti-inflammatory, anticancer therapies, and formulation development.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"183 ","pages":"Article 106514"},"PeriodicalIF":2.5,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phenoxybiphenyl derivatives from an endophyte, Neohendersonia kickxii","authors":"Reo Takahashi ,&nbsp;Zulfikar ,&nbsp;Mayuka Hakozaki ,&nbsp;Yuko Kanno ,&nbsp;Shota Uesugi ,&nbsp;Takuya Koseki ,&nbsp;Yoshihito Shiono","doi":"10.1016/j.fitote.2025.106518","DOIUrl":"10.1016/j.fitote.2025.106518","url":null,"abstract":"<div><div>Three undescribed phenoxybiphenyl, neohenbiphenylols A (<strong>1</strong>), B (<strong>2</strong>) and C (<strong>3</strong>) along with known of diphenyl ethers <strong>4</strong>, and <strong>5</strong>, and dibenzofuran <strong>6</strong> were isolated from the endophyte <em>Neohendersonia kickxii</em> RT-749. The structures of these undescribed compounds, including their absolute configurations, were elucidated by analyses of NMR, UV, IR, HRESITOFMS, and ECD data. Compounds <strong>1</strong>–<strong>3</strong> showed cytotoxicity against human promyelocytic leukemia (HL60) cells with IC₅₀ values of 3.7, 4.3 and 7.3 μM, respectively, and antimicrobial activity against <em>Bacillus subtilis</em> with an MIC value of 25 <em>μ</em>gmL^-1.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"183 ","pages":"Article 106518"},"PeriodicalIF":2.5,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143788233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}