Fitoterapia最新文献

{"title":"Natural compounds for endometriosis and related chronic pelvic pain: A review","authors":"Agostino Zaurito ,&nbsp;Irsida Mehmeti ,&nbsp;Francesco Limongelli ,&nbsp;Roberta Zupo ,&nbsp;Alessandro Annunziato ,&nbsp;Sergio Fontana ,&nbsp;Roberta Tardugno","doi":"10.1016/j.fitote.2024.106277","DOIUrl":"10.1016/j.fitote.2024.106277","url":null,"abstract":"<div><div>Endometriosis is a chronic gynecological disorder characterized by significant chronic pelvic pain (CPP) and infertility, adversely affecting the quality of life for many women worldwide.</div><div>This review aims to synthesize recent findings on natural bioactive compounds derived from various plant sources that exhibit beneficial effects in the management of endometriosis and related CPP.</div><div>A thorough search of databases, including PubMed, Scopus, and Google Scholar, was conducted to identify studies evaluating the efficacy of natural compounds on endometriosis and related CPP. In alphabetical order, curcumins, ginsenosides, polyphenols and other secondary metabolites showed promising effects on oxidative stress, inflammation, and pain modulation associated with endometriosis acting on multiple pathways. Most of the selected articles were <em>in vitro</em> and <em>in vivo</em> studies in animal models, with a limited number of clinical trials.</div><div>The reported natural compounds according to the highlighted multiple bioactivities, might be valuable complementary alternatives as supplements, nutraceuticals, or in advanced personalized nutrition. Further clinical investigations are needed to comprehensively evaluate their therapeutic potential, safety, efficacy and to establish effective treatment protocols.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"179 ","pages":"Article 106277"},"PeriodicalIF":2.5,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142554757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Two new flavonoids from the leaves of Garcinia smeathmannii, in vitro and in silico anti-inflammatory potentials","authors":"Moïse Sirlam ,&nbsp;Peron Bosco Leutcha ,&nbsp;Guy Raphael Sado Nouemsi ,&nbsp;Humaira Zafar ,&nbsp;Hycienth Fung Tegha ,&nbsp;Denis Kehdinga Sema ,&nbsp;Virginie Flaure Tsague Tankeu ,&nbsp;Yves Oscar Nganso Ditchou ,&nbsp;Madan Poka ,&nbsp;Patrick Hulisani Demana ,&nbsp;Atia-tul-Wahab ,&nbsp;Muhammad Iqbal Choudhry ,&nbsp;Xavier Siwe Noundou ,&nbsp;Alain Meli Lannang","doi":"10.1016/j.fitote.2024.106273","DOIUrl":"10.1016/j.fitote.2024.106273","url":null,"abstract":"<div><div><em>Garcinia smeathmannii</em> is a well-known plant for its uses in the effective treatment of intestinal parasites, skin eruptions and skin burns. The dichloromethane-methanol (2:3) crude extract of the leaves of <em>G. smeathmannii</em> led to the isolation and characterization of twenty compounds (<strong>1</strong>−<strong>20</strong>) using chromatographic and spectroscopic techniques. Extracts and compounds were screened <em>in vitro</em> for their anti-inflammatory (ROS), antiglycation and antileishmanial (<em>L. tropica</em>) activities. Compounds were also screened for their <em>in silico</em> anti-inflammatory activities using Maestro 4.2.1 software with the co-crystal complex structures of the ovine oCOX-1: meloxicam (PDB Id: <span><span>4O1Z</span><svg><path></path></svg></span>) and murine mCOX-2: meloxicam (PDB Id: <span><span>4M11</span><svg><path></path></svg></span>) proteins. An unprecedented flavonol (<strong>1</strong>) and a flavone dimer (<strong>2</strong>) together with eighteen known compounds (<strong>3</strong>−<strong>20</strong>) were characterized. All the tested samples <em>in vitro</em> revealed no antiglycation and antileishmanial activities. Beside, extracts revealed moderate anti-inflammatory activities (IC₅₀ ranging from 24.1 ± 2.0 to 34.7 ± 0.8 μg/mL). Only compound (<strong>13</strong>) revealed an anti-inflammatory activity which was 9.33 times more active than the reference (Ibuprofen, IC₅₀ = 11.2 ± 1.9 μg/mL) with IC₅₀ of 1.2 ± 0.0 μg/mL. Compounds (<strong>2</strong>–<strong>9</strong>, <strong>11</strong>–<strong>13</strong> and <strong>19</strong>–<strong>20</strong>) were docked and the docking scores were ranging from −10.178 to −6.119 (kcal/mol) which were in agreement with the experimental anti-inflammatory activity. These results are in agreement with the traditional uses of the leave of <em>G. smeathmannii</em> as cataplasm for skin eruption and as analgesic agent.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"179 ","pages":"Article 106273"},"PeriodicalIF":2.5,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142497679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploration of potential mechanism of Sanhua Jiangzhi granules for the treatment of hyperlipidemia based on network pharmacology and experimental verification","authors":"Junfei Wei ,&nbsp;Qian Lv ,&nbsp;Fei Luan ,&nbsp;Xiaofei Zhang ,&nbsp;Dongyan Guo ,&nbsp;Bingtao Zhai ,&nbsp;Shucun Chen ,&nbsp;Junbo Zou ,&nbsp;Yajun Shi","doi":"10.1016/j.fitote.2024.106271","DOIUrl":"10.1016/j.fitote.2024.106271","url":null,"abstract":"<div><div>Sanhua Jiangzhi Granules (SJG) is a traditional Chinese patent medicine known for regulating lipid metabolism. In this study, we utilized UPLC-TOF-MS to analyze the components of SJG and, in conjunction with network pharmacology, identified 125 core chemical constituents. These components were individually queried and intersected with targets related to hyperlipidemia, resulting in the identification of 312 core targets. KEGG and GO analyses suggested that the mechanism of SJG in treating hyperlipidemia may primarily involve the PPAR signaling pathway. To further validate the efficacy and underlying signaling mechanisms of SJG, we conducted experiments using 60 rats. The results indicated that SJG significantly reduced body weight, lowered serum levels of total cholesterol (TC), triglycerides (TG), and low-density lipoprotein cholesterol (LDL-C), while increasing high-density lipoprotein cholesterol (HDL<img>C) levels. Enzyme-linked immunosorbent assay (ELISA) results demonstrated that SJG decreased hepatic TC and TG levels and mitigated lipid accumulation in the liver. Hematoxylin and eosin (HE) staining indicated that SJG improved liver pathological morphology and reduced the risk of fatty liver disease. Western blot analyses showed that treatment with SJG down-regulated the expression of stearoyl-CoA desaturase (SCD), 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), phospholipid transfer protein (PLTP), and fatty acid-binding protein 1 (FABP1), while up-regulating the expression of cholesterol 7α-hydroxylase (CYP7A1), carnitine palmitoyltransferase 1 (CPT-1), and PPARα by activating the PPAR signaling pathway. In conclusion, this study demonstrated that SJG activates the PPAR signaling pathway, leading to decreased body weight, lowered blood lipid levels, reduced hepatic TC and TG, and improved liver pathology in rats.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"179 ","pages":"Article 106271"},"PeriodicalIF":2.5,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142497674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Solanapyrone analogues from endophytic Nigrospora sphaerica MZW-A associated with the endangered conifer Pinus wangii","authors":"Mengran Wang ,&nbsp;Haowei Chen ,&nbsp;Lihong Yan ,&nbsp;Jingtao Chen ,&nbsp;Lu Gan ,&nbsp;Zhichun Shen ,&nbsp;Juan Xiong ,&nbsp;Jinfeng Hu ,&nbsp;Jiyang Li","doi":"10.1016/j.fitote.2024.106275","DOIUrl":"10.1016/j.fitote.2024.106275","url":null,"abstract":"<div><div>Eight previously undescribed solanapyrone analogues, sphasolanapyrones A–H (<strong>1</strong>–<strong>8</strong>), together with four structurally related known compounds (<strong>9</strong>–<strong>12</strong>) were obtained from the solid fermentation of <em>Nigrospora sphaerica</em> MZW-A, an endophytic fungus isolated from the fresh branches of the endangered conifer <em>Pinus wangii</em>. This study represents the first investigation on the secondary metabolites of endophytic fungus associated with this precious plant. The structures and absolute configurations of compounds <strong>1</strong>–<strong>8</strong> were elucidated by extensive spectroscopic analysis and electronic circular dichroism (ECD) calculations. <strong>1</strong> and <strong>2</strong> are first examples of 3,4-<em>vic</em> diol solanapyrone analogues, whereas <strong>7</strong> and <strong>8</strong> are rare 17-<em>nor</em>-solanapyrones. Among these isolates, <strong>3</strong>, <strong>4</strong>, <strong>5</strong>, and <strong>11</strong> showed weak inhibitory against <em>Staphylococcus aureus.</em> In addition, compound <strong>5</strong> displayed weak cytotoxic effects against several tumor cell lines.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"179 ","pages":"Article 106275"},"PeriodicalIF":2.5,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142497675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Two new abietane diterpenoids from Caryopteris trichosphaera","authors":"Qing-Yu Lu ,&nbsp;Zhao-Jie Wang ,&nbsp;Li-Yu Bai ,&nbsp;Wen-Biao Zu ,&nbsp;Zhong-Shun Zhou ,&nbsp;Yan-Yan Zhu ,&nbsp;Xing-Chao He ,&nbsp;Yun-Li Zhao ,&nbsp;Xiao-Dong Luo","doi":"10.1016/j.fitote.2024.106269","DOIUrl":"10.1016/j.fitote.2024.106269","url":null,"abstract":"<div><div>Two new abietane diterpenoids, cartrisine A (<strong>1</strong>) and cartrisine B (<strong>2</strong>) were isolated from <em>Caryopteris trichosphaera</em>. Their structures were elucidated based on HR-ESI-MS and NMR spectral data. Compound <strong>2</strong> exhibited moderate antibacterial bioactivity against MRSA and VRE, and showed a strong synergistic effect with market antibiotics against MRSA and VRE.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"179 ","pages":"Article 106269"},"PeriodicalIF":2.5,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142497678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel normonoterpene glycoside and a new benzophenone derivative from Hypericum cerastioides and their in vitro cytotoxic activities","authors":"Rima Konya Konuk ,&nbsp;Başak Aru ,&nbsp;Ceren Öztürk ,&nbsp;Hasan Kırmızıbekmez","doi":"10.1016/j.fitote.2024.106276","DOIUrl":"10.1016/j.fitote.2024.106276","url":null,"abstract":"<div><div>Phytochemical investigations on the aerial parts of <em>Hypericum cerastioides</em> led to the isolation and identification of a novel normonoterpene (<strong>1</strong>) and a previously undescribed benzophenone glycoside (<strong>3</strong>) along with eleven known secondary metabolites (<strong>2</strong>, <strong>4</strong>–<strong>13</strong>). Their structures were deduced based on extensive 1D and 2D NMR analyses as well as HRESIMS. Compound <strong>1</strong> is a rare type of normonoterpene derivative with eight carbon atoms. The chemotaxonomic significance of the isolates was also discussed. Compounds were evaluated for their <em>in vitro</em> cytotoxic activities against SW480, A375, DU145 and MCF7 cancer cell lines using doxorubicin as a reference drug. Compounds <strong>1</strong> and <strong>7</strong> demonstrated weak cytotoxicity.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"179 ","pages":"Article 106276"},"PeriodicalIF":2.5,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142497672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Talarmalnoids A–F: Fusicoccane diterpenoids from an arthropod-derived endophytic fungus Talaromyces malicola","authors":"Chen-yu Yang ,&nbsp;Ke-liang Chen ,&nbsp;Yang Liu,&nbsp;Xing-bao Jia,&nbsp;Cheng Yi,&nbsp;Yu-wei Niu,&nbsp;Ya-nan Tian,&nbsp;Yun-bao Liu","doi":"10.1016/j.fitote.2024.106262","DOIUrl":"10.1016/j.fitote.2024.106262","url":null,"abstract":"<div><div>The metabolites from the endophytic fungus <em>Talaromyces malicola</em> hosted in the gastrointestinal tract of the arthropods <em>Armadillidium vulgare</em> were investigated, and six undescribed fusicoccane diterpenoids, talarmalnoids A–F (<strong>1</strong>–<strong>6</strong>), along with three known analogs were isolated. Talarmalnoid C (<strong>3</strong>) was an unprecedented fusicoccane diterpenoid with two sugar units, i.e., 6-<em>O</em>-methyl-<em>α</em>-<span>d</span>-glucose and <em>α</em>-<span>d</span>-glucose. Talarmalnoids D and E (<strong>4</strong> and <strong>5</strong>) were fusicoccane-type diterpenoids with unusual seven-membered rings attached at the C-3′ and C-4′ positions. Their structures and absolute configurations were identified by NMR, HRESIMS analyses, X-ray single crystal diffraction, GC–MS, ECD analyses, ¹³C NMR calculations, and DP4+ probability analyses. Bioassay results showed that talarmalnoid B (<strong>2</strong>) exhibited significant inhibitory activities against the LPS-inducted production of NO in RAW 264.7 cells, with IC₅₀ value of 0.83 μM.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"179 ","pages":"Article 106262"},"PeriodicalIF":2.5,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142497676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New chalcone derivatives containing morpholine-thiadiazole: Design, synthesis and evaluation of against tobacco mosaic virus","authors":"Wei Zeng,&nbsp;Zhiling Sun,&nbsp;Yufang Zhang,&nbsp;Yuzhi Hu,&nbsp;Qing Zhou,&nbsp;Yujiao Qiu,&nbsp;Jieyu Li,&nbsp;Wei Xue","doi":"10.1016/j.fitote.2024.106272","DOIUrl":"10.1016/j.fitote.2024.106272","url":null,"abstract":"<div><div>Twenty chalcone derivatives containing morpholine-thiadiazole were designed and synthesized from the natural product chalcone. The bioactivity test results indicate that some compounds exhibit good antiviral activity against tobacco mosaic virus (TMV). In particular, the EC₅₀ values for the curative and protective activity of <strong>S14</strong> against TMV were 91.8 and 130.6 <em>μ</em>g/mL, which was better than that of the antiviral agent ningnanmycin (NNM, 237.8, 220.6 <em>μ</em>g/mL). The results of preliminary mechanism study indicated that <strong>S14</strong> had strong binding capacity and affinity to tobacco mosaic virus coat protein (TMV-CP). In the chlorophyll content assay, the chlorophyll content of tobacco leaves increased significantly after the action of <strong>S14,</strong> so that it can enhance the photosynthetic capacity of plants. In addition, the results of malondialdehyde (MDA) content assay also indicated that <strong>S14</strong> could improve the disease resistance of tobacco.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"179 ","pages":"Article 106272"},"PeriodicalIF":2.5,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142497681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Triterpenoids from the rhizomes and roots of Gentiana scabra Bge. and their cytotoxic activities","authors":"Guan-Ke Liu ,&nbsp;Bing-Yang Zhang ,&nbsp;Zheng Niu ,&nbsp;Jia-Qi Chen ,&nbsp;Chun-Yu Fan ,&nbsp;Xin-Yue Deng ,&nbsp;Fan-Qing Ye ,&nbsp;Shi-Jie Cao ,&nbsp;Ning Kang ,&nbsp;Tie Yao ,&nbsp;Feng Qiu","doi":"10.1016/j.fitote.2024.106268","DOIUrl":"10.1016/j.fitote.2024.106268","url":null,"abstract":"<div><div>Phytochemical investigation on the rhizomes and roots of <em>Gentiana scabra</em> (Gentianaceae) led to the isolation of five new triterpenoids (<strong>1</strong>–<strong>5</strong>), together with seven known ones (<strong>6</strong>–<strong>12</strong>). The structures and absolute configurations of the new compounds were elucidated by spectroscopic data interpretation, ECD calculation and X-ray crystallographic analysis. Noticeably, compound <strong>4</strong> was an uncommon 3,4-<em>seco</em>-pentacyclic triterpenoid in natural products. The <em>in vitro</em> cytotoxic activities of all isolates against human cancer cell lines (HepG2, Hep3B, HCT116, and U87) were measured using MTT assay. Among them, compounds <strong>2</strong>–<strong>9</strong>, <strong>11</strong>, and <strong>12</strong> exhibited anti-proliferative effects against these tumor cell lines.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"180 ","pages":"Article 106268"},"PeriodicalIF":2.5,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142497677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The medicinal plant Peucedanum japonicum Thunberg: A review of traditional use, phytochemistry, and pharmacology","authors":"Tran Quang Hai ,&nbsp;Nguyen Thi Huong ,&nbsp;Ninh The Son","doi":"10.1016/j.fitote.2024.106270","DOIUrl":"10.1016/j.fitote.2024.106270","url":null,"abstract":"<div><div><em>Peucedanum japonicum</em> (the family Umbelliferae) is a perennial herbaceous plant with various crucial traditional values for coughs, colds, headaches, and inflammatory responses. For drug developments, the current research aims to offer an overview of the previous results in the three main aspects of traditional use, phytochemistry, pharmacological values, and molecular mechanisms regarding this medicinal species. By chromatographic analysis and separation, more than 120 isolated compounds have been obtained. Khellactone-type coumarins and phenolic compounds are the primary phytochemical classes with some coumarins, such as calipteryxin, praerutorin A, and pteryxin, being the main metabolites. Pharmacological activities of <em>P. japonicum</em> constituents included anticancer, antioxidative, antimicrobial, antiviral, antiplatelet, and tyrosine inhibitory activities, especially anti-inflammation and anti-obesity. It is worth mentioning that the obtained constituents joined to protect the neurons, bone, and urine systems, and exerted vasorelaxant. In general, the underlying mechanism of anti-inflammatory action can be explained by mitogen-activated protein kinase/nuclear factor-kappa B (MAPK/NF-κB) signaling pathway, whereas anti-obesity activity is deduced from regulating lipid metabolism-related genes. It also noted that pteryxin is the most active compound, but the clinical studies and synthesis of new derivatives containing enhanced medicinal values have been still limited, which should be improved.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"179 ","pages":"Article 106270"},"PeriodicalIF":2.5,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142497682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}