Fitoterapia最新文献

{"title":"Six new compounds with neuroprotective activity from the leaves of Paeonia lactiflora Pall","authors":"Xin-Yu Min ,&nbsp;Jia-Tong Wu ,&nbsp;Meng-Ting Wang,&nbsp;Peng Jiang,&nbsp;Si-Yi Wang,&nbsp;Anam Naseem,&nbsp;Yu-Qing Wang,&nbsp;Gui-Qin Ma,&nbsp;Juan Pan,&nbsp;Meng-Meng Li,&nbsp;Wei Guan,&nbsp;Hai-Xue Kuang,&nbsp;Bing-You Yang,&nbsp;Yan Liu","doi":"10.1016/j.fitote.2025.106435","DOIUrl":"10.1016/j.fitote.2025.106435","url":null,"abstract":"<div><div>Twenty constituents, three new terpenes named Paeoniterpene A-C (<strong>1–3</strong>), and three new fatty glycosides named Paeoniglycoside A-C (<strong>4–6</strong>) were isolated from the leaves of Paeonia lactiflora Pall. The structures of compounds <strong>1</strong>–<strong>6</strong> were identified using extensive spectroscopic methods, such as NMR, MS, CD, IR, and UV. Compounds <strong>4</strong>–<strong>6</strong> were characterized through quantum chemical calculations and DP4⁺ probability analysis, and ECD definitively confirmed their structures. Additionally, all compounds were assessed for their neuroprotective effects against H₂O₂-induced damage in PC 12 cells. Compounds <strong>1</strong>–<strong>3</strong>, <strong>7</strong>, <strong>8</strong>, <strong>11</strong>, and <strong>12</strong> could significantly improve H₂O₂-induced PC 12 injury.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"182 ","pages":"Article 106435"},"PeriodicalIF":2.5,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143386645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Withanolide glycosides from Physalis volubilis","authors":"Ana-L. Pérez-Castorena ,&nbsp;Tonantzin G. Anguheven L. ,&nbsp;M. Azucena Martínez R. ,&nbsp;Jesús Morales-Jiménez ,&nbsp;Emma Maldonado ,&nbsp;Mahinda Martínez","doi":"10.1016/j.fitote.2025.106428","DOIUrl":"10.1016/j.fitote.2025.106428","url":null,"abstract":"<div><div>The study of the acetone and methanol extracts of the stems, leaves, and flowers of <em>Physalis volubilis</em> led to obtain four withanolide glycosides (<strong>4</strong>, <strong>6</strong>, <strong>10</strong>, and <strong>14</strong>). Compounds <strong>1</strong>–<strong>3</strong>, <strong>13</strong>, <strong>15</strong>, and a sterol glycoside were also isolated. The structures were established by analysis of spectroscopic and spectrometric data, and by chemical transformations. Nine of the obtained compounds (<strong>2</strong>, <strong>3</strong>, <strong>6</strong>, <strong>7</strong>, <strong>10</strong>, <strong>11</strong>, and <strong>13</strong>–<strong>15</strong>) were evaluated for their qualitative antibacterial activity against <em>Escherichia coli</em>, <em>Klebsiella pneumoniae</em>, <em>Pseudomonas aeruginosa</em>, <em>Staphylococcus aureus</em> and <em>Bacillus subtilis</em>. Compound <strong>2</strong> showed the highest inhibition of bacterial growth. Its minimum inhibitory concentrations against <em>S. aureus</em> ATCC® 25923™ and a clinical isolate of Methicillin-resistant <em>S. aureus</em> (MRSA) were 62.5 and 125 <em>μ</em>g/mL, respectively.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"182 ","pages":"Article 106428"},"PeriodicalIF":2.5,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143406493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Four pairs of meroterpenoid enantiomers with coumarin- and chromone-monoterpene skeletons from Gerbera piloselloides and their bioactive activities","authors":"Shi-lin Chen ,&nbsp;Chen-xu Zhao ,&nbsp;Ha Gao ,&nbsp;Zhong-mei Zou ,&nbsp;Tao Zhang","doi":"10.1016/j.fitote.2025.106436","DOIUrl":"10.1016/j.fitote.2025.106436","url":null,"abstract":"<div><div>Phytochemical investigations of the extracts from the whole plant of <em>Gerbera piloselloides</em> resulted in the isolation and identification of four pairs of previously unreported meroterpenoid enantiomers with coumarin- and chromone-monoterpene skeletons (<strong>1a</strong>/<strong>1b</strong>–<strong>4a</strong>/<strong>4b</strong>), including two pairs of 5-methylcoumarin monoterpenes and two pairs of 5-methylchromone monoterpenes. The structures and absolute configurations of these compounds were definitively determined through NMR and MS data, NMR calculation with DP4+ analysis, electronic circular dichroism (ECD) data, and X-ray diffraction analysis. Structurally, compounds <strong>1</strong>–<strong>4</strong> feature 5-methylphenylpropanoid-substituted monoterpene frameworks. All compounds were evaluated for neuroprotective activity and cytotoxicity against the human cancer cell line SGC-7901 <em>in vitro</em>. Compounds <strong>1</strong>, <strong>1a</strong>, and <strong>1b</strong> exhibited inhibitory effects with IC₅₀ values ranging from 12.07 to 12.44 μM against SGC-7901 compared with the positive control vorinostat (IC₅₀ value 0.37 μM). Furthermore, the hypothetical biogenetic pathways for these compounds were discussed.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"182 ","pages":"Article 106436"},"PeriodicalIF":2.5,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143406488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Six new metabolites from Ganoderma lucidum-derived endophytic Trichoderma sp. GLQ02 and their anti-inflammatory activities","authors":"Xin-Huan Qiu ,&nbsp;Xia Cheng ,&nbsp;Qi Luo ,&nbsp;Yun Ma","doi":"10.1016/j.fitote.2025.106439","DOIUrl":"10.1016/j.fitote.2025.106439","url":null,"abstract":"<div><div>Six undescribed trichophthalides A−F (<strong>1</strong>–<strong>6</strong>) and a known phthalide derivative (<strong>7</strong>) were isolated from <em>Ganoderma lucidum</em>-derived endophytic <em>Trichoderma</em> sp. GLQ02. Among them, meroterpenoids <strong>1</strong>, <strong>3</strong>, <strong>4</strong>, <strong>6</strong>, and <strong>7</strong> possessed an independent isoprenyl unit with varying degrees of oxidation. The structures and absolute configurations of these substances were elucidated on the basis of spectroscopic data, ECD and DP4+ calculations. Finally, compounds <strong>1</strong>, <strong>5</strong>, and <strong>7</strong> exhibited relatively weak abilities to inhibit the production of NO in LPS-stimulated RAW 264.7cells at a concentration of 60 μM.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"182 ","pages":"Article 106439"},"PeriodicalIF":2.5,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143406490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring wild Thymus sp. (L.) chemotypes across Pistoia Mountains provides thyme essential oil and hydrolate inhibiting fungal growth on paper","authors":"Felicia Menicucci ,&nbsp;Alfonso Crisci ,&nbsp;Waed Tarraf ,&nbsp;Costanza Santini ,&nbsp;Francesca Ieri ,&nbsp;Gabriele Cencetti ,&nbsp;Marco Michelozzi ,&nbsp;Andrea Ienco ,&nbsp;Eleonora Palagano","doi":"10.1016/j.fitote.2025.106418","DOIUrl":"10.1016/j.fitote.2025.106418","url":null,"abstract":"<div><div><em>Thymus</em> sp. (L.) encompasses over 500 aromatic species distributed in the Mediterranean area, in dry, rocky environments up to 1800 m above sea level. Plants of <em>Thymus</em> sp. (L.) from the <em>Serpyllum</em> group, growing in five areas of the Pistoia Mountains, were georeferenced and sampled for a chemical characterization of the terpene content. Fresh biomass was collected to distill thyme essential oil, and the derived hydrolate was recovered as byproduct of the process. The antifungal efficacy of the chemically characterized thyme essential oil and hydrolate was evaluated on two fungal biodeteriogens typically affecting paper objects, <em>Alternaria alternata</em> and <em>Cladosporium cladosporioides</em>. High thymol content thyme essential oil (about 75 %) and hydrolate (about 62 %) were obtained from steam distillation and used to perform <em>in vitro</em> tests on paper samples following a non-invasive approach. For both fungi, a significant growth reduction on inoculated Whatman paper was observed with both hydrolate and thyme essential oil. The GC–MS analysis of 94 thyme samples led to the characterization of seven chemotype classes, and a PCA was carried out to investigate the potential impact of different collection sites on the chemotypes variability. These findings highlight the necessity of an accurate selection of the plant material for an optimized production of thyme essential oil and hydrolate with improved antifungal efficacy.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"182 ","pages":"Article 106418"},"PeriodicalIF":2.5,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143390492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Catechin, taxifolin, and proanthocyanidin derivatives from Entada elephantina rhizome and their antimicrobial activity assessment","authors":"Fazila Zulfiqar ,&nbsp;Pankaj Pandey ,&nbsp;Zulfiqar Ali ,&nbsp;Yan-Hong Wang ,&nbsp;Alvaro M. Viljoen ,&nbsp;Amar G. Chittiboyina ,&nbsp;Ikhlas A. Khan","doi":"10.1016/j.fitote.2025.106417","DOIUrl":"10.1016/j.fitote.2025.106417","url":null,"abstract":"<div><div>Twenty-two compounds, predominantly catechin, taxifolin, and proanthocyanidin derivatives, were isolated and characterized from the methanol extract of <em>Entada elephantina</em> tuberous rhizomes. Five taxifolin-based metabolites, elephantinosides A–E (<strong>1</strong>–<strong>5</strong>) and one proanthocyanidin, elephantinoside F (<strong>19</strong>), were previously undescribed. Their structures were elucidated primarily based on 1D- and 2D-NMR and HRESIMS data. The absolute configuration of isolates was determined via NOESY NMR technique and experimental and calculated ECD analyses. None of the tested compounds <strong>3</strong>–<strong>6</strong>, <strong>8</strong>–<strong>10</strong>, <strong>13</strong>–<strong>17</strong>, and <strong>19</strong> exhibited antimicrobial activity against a panel of bacterial and fungal strains.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"182 ","pages":"Article 106417"},"PeriodicalIF":2.5,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143382048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of phytoproducts against pathogenic free-living amoebae - A scoping and critical review paving the way toward plant-based pharmaceuticals","authors":"Beni Jequicene Mussengue Chaúque ,&nbsp;Thaisla Cristiane Borella da Silva ,&nbsp;Eduardo Brittes Rott ,&nbsp;Felipe Brittes Rott ,&nbsp;Ana Paula Marçal Copetti Leite ,&nbsp;Guilherme Brittes Benitez ,&nbsp;Neuana Fernando Neuana ,&nbsp;José Roberto Goldim ,&nbsp;Marilise Brittes Rott ,&nbsp;Régis Adriel Zanette","doi":"10.1016/j.fitote.2025.106404","DOIUrl":"10.1016/j.fitote.2025.106404","url":null,"abstract":"<div><div>Infections caused by free-living amoebae (FLA) have increased worldwide and are expected to worsen. The lack of drugs that are effective (especially against cysts), affordable, and safe to treat these infections exacerbates the concern. Plants present a promising source of bioactive compounds for developing effective drugs; however, the scientific literature on this topic has yet to be adequately synthesized. This work provides a critical scoping review summarizing the amoebicidal performance of plant-derived products and their potential for developing effective drugs to treat FLA infections. Out of 5889 articles retrieved from multiple databases, 119 articles were selected, from which data on 180 plant species belonging to 127 genera and 62 families were extracted. The extracts, essential oils, and compounds from these plants exhibited a diverse range of potency against cysts and trophozoites. Among the compounds studied, periglaucine A, kolavenic acid, and (+)-elatol are promising cysticidal drug candidates due to their high potency, as well as their known low toxicity to non-target cells. Tovophillin A, gartinin, 8-deoxygartinin, garcinone E, 9-hydroxycalabaxanthone, γ-mangostin, and borneol also exhibit high cysticidal potency, but their selectivity profile is unknown. Resveratrol, rosmarinic acid, β-amyrin, and vanillic acid stand out for their high potency against trophozoites and low toxicity to mammalian cells. Another group of compounds with similarly high trophocidal potency includes (−)-epicatechin, (−)-epigallocatechin, apigenin, costunolide, demethoxycurcumin, kaempferol, methyl-β-orcinolcarboxylate, sakuraetin, (+)-elatol, debromolaurinterol, luteolin, (−)-rogiolol, cystomexicone B, epigallocatechin gallate, quercetin, and α-bisabolol. These compounds are priority candidates for further studies on in vivo efficacy, safety, pharmacokinetics, and pharmacodynamics.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"182 ","pages":"Article 106404"},"PeriodicalIF":2.5,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143372558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vitro evaluation of anti-inflammatory, anti-plaque efficacy, and biocompatibility of Norway spruce (Picea abies) resin extract for oral care applications","authors":"Kamilla Yamileva ,&nbsp;Simone Parrotta ,&nbsp;Evgen Multia","doi":"10.1016/j.fitote.2025.106410","DOIUrl":"10.1016/j.fitote.2025.106410","url":null,"abstract":"<div><div>The periodontal disease is globally highly prevalent, and calls for novel, effective, and preferably bio-based raw materials. Accumulation of dental plaque causes gingivitis, which is reversible by treatments that control the bacterial biofilm. If left untreated, the gingivitis can lead to gingival inflammation and potentially progress to periodontitis. In this study, a natural antimicrobial and anti-inflammatory Norway spruce (<em>Picea abies</em>) resin extract was evaluated as a potential option in supportive periodontal care. Lipopolysaccharide-induced macrophage-like cells were used to study the anti-inflammatory properties <em>in vitro</em>. The spruce resin extract at 20 % concentration had the highest anti-inflammatory effect, comparable to a corticosteroid's effect on pro-inflammatory cytokines interleukin-1 beta (IL-1β), tumor necrosis factor-alpha (TNF-α), and matrix metalloproteinase-3 (MMP-3). Consequently, the 20 % spruce resin extract was selected for toothpaste formulation. Its anti-plaque efficacy was evaluated by total aerobic colony counts and the proportions of streptococci grown on the surfaces of the treated glass rods using pooled human saliva. It was found that the toothpaste effectively reduced dental plaque biofilm, matching the anti-plaque efficacy of Corsodyl mouthwash, containing chlorhexidine digluconate. The toothpaste was also found to be non-damaging in biocompatibility studies on three-dimensional (3D) tissue models of human oral and gingival epithelium. These findings provide scientific validation of spruce resin's effectiveness in oral care, elucidating probable reasons why people have historically chewed resins for oral care purposes.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"182 ","pages":"Article 106410"},"PeriodicalIF":2.5,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143373860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Schisandraceae family fruits: Exploring chemophenetic significance, UPLC/MSn database, phytochemistry, and pharmacological potential","authors":"Guy Paulin Mouthe Kemayou ,&nbsp;Shi-qi Liu ,&nbsp;Steven Collins Njonte Wouamba ,&nbsp;Bin Li ,&nbsp;Huang-he Yu ,&nbsp;Xing Tian ,&nbsp;Yi-xing Qiu ,&nbsp;Hui-zhen Wang ,&nbsp;Simeon Fogue Kouam ,&nbsp;Wei Wang ,&nbsp;Yupei Yang","doi":"10.1016/j.fitote.2025.106415","DOIUrl":"10.1016/j.fitote.2025.106415","url":null,"abstract":"<div><div>Fruits from the Schisandraceae family are renowned for their exceptional medicinal and nutritional properties. These fruits exhibit distinctive shapes and are rich in nutrients, offering edible, ornamental, aesthetic, and therapeutic qualities. Traditional uses of Schisandraceae fruits include the treatment of conditions such as rheumatism, chronic diarrhea, chronic cough, and neurological disorders. Emerging scientific and clinical evidence suggests these fruits have significant potential for various applications in the life sciences. This comprehensive review seeks to achieve two main goals: first, to provide a thorough overview of the chemophenetic relationships among the isolated compounds in Schisandraceae fruits and their underlying significance; second, to describe the development of an important database containing the molecular formulas and molecular weights of all the compounds identified within the Schisandraceae family. This database can facilitate targeted and rapid chemical detection studies using UPLC/MSⁿ techniques. The information and findings discussedin this paper were obtained through a thorough search of digital databases, including SciFinder, Google Scholar, PubMed, Elsevier, and the China Knowledge Resource Integrated (CNKI) databases, covering the period from 1988 to 2024. Approximately 326 phytochemicals were reviewed and identified, with lignans representing the predominant chemotaxonomic markers (∼73 %) in the fruits of Schisandraceae species. Other reported compound classes include terpenoids, fatty acids, and phenolic compounds. Furthermore, the reviewed literature highlights the main pharmacological properties of these Schisandraceae compounds, which include antiviral, cytotoxic, anti-inflammatory, neuroprotective, antiproliferative, hepatoprotective, and antioxidant activities. This comprehensive information will inspire phytochemists to explore the rich chemical diversity of Schisandraceae fruits, potentially leading to the discovery of new medicines and advancing human health.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"182 ","pages":"Article 106415"},"PeriodicalIF":2.5,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143372559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plant endophytes: Secondary metabolites and biological activities.","authors":"Gustavo Souza Dos Santos","doi":"10.1016/j.fitote.2025.106416","DOIUrl":"https://doi.org/10.1016/j.fitote.2025.106416","url":null,"abstract":"","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":" ","pages":"106416"},"PeriodicalIF":2.5,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143382051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}