Fitoterapia最新文献

{"title":"Shuteria involucrata alleviates OVA-induced asthma through the TLR4/NF-κB pathway","authors":"Lue Bao ,&nbsp;Lisha Wei ,&nbsp;Xiaohong Li ,&nbsp;Xiaoyun Jiang ,&nbsp;Rong Duan ,&nbsp;Lingrui Zhou ,&nbsp;Lu Liu ,&nbsp;Wenhong Tan ,&nbsp;Feng Huang ,&nbsp;Zhuya Yang","doi":"10.1016/j.fitote.2025.106520","DOIUrl":"10.1016/j.fitote.2025.106520","url":null,"abstract":"<div><div>The roots of <em>Shuteria involucrata</em> (Wall.) Wight &amp; Arn., known as “Tong-qian-ma-huang” in <em>Dai</em> folk medicine in China, are renowned for their efficacy in treating asthma. Despite the use of <em>S. involucrata</em> has been reported as ameliorating respiratory diseases, its mechanism of action remains unclear. This work described the effect of ethyl acetate extract of <em>S. involucrate</em> (SSE) on allergic asthma and its potential mechanism of action was assessed. Ovalbumin was used <em>in vivo</em> to establish a BALB/c asthma mouse model. Lipopolysaccharide was used <em>in vitro</em> to stimulate the human macrophage cell line THP-1 to establish an inflammatory model. <em>In vivo</em> and <em>in vitro</em> experiments showed that SSE effectively ameliorated pathological symptoms and attenuated airway inflammation and cellular inflammation in allergic asthma mice, with a mechanism of action potentially associated to the inhibition of the TLR4/NF-κB signaling pathway.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"183 ","pages":"Article 106520"},"PeriodicalIF":2.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143779446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of anti-arthritic and anti-inflammatory potential of Ajugarin-I from Ajuga Bracteosa wall ex. Benth against Freund's complete adjuvant induced arthritis","authors":"Fatima Zafar ,&nbsp;Hammad Ismail ,&nbsp;Ihsan-ul Haq","doi":"10.1016/j.fitote.2025.106517","DOIUrl":"10.1016/j.fitote.2025.106517","url":null,"abstract":"<div><div>Rheumatoid arthritis (RA) is a prolonged autoimmune disease that targets the lining of small joints, causing inflammation and destruction of bone and cartilage. Anti-inflammatory drugs are available but offer short-term relief with adverse side effects. The present research was planned to study the in-vivo antiarthritic potential of ajugarin-I, sequestered from the <em>Ajuga bracteosa</em>. In-vivo studies include anti-inflammatory, analgesic, antidepressant, hematology profile, histopathological, radiological, and antioxidant analysis. The in-vivo results revealed that a high dose (HD, 60 mg/kg) of ajugarin-I significantly decreased the inflammatory paw edema (40 ± 0.04 %). Ajugarin-I also showed excellent analgesic behavior with 89 ± 0.55 % and 85 ± 0.55 % increments in pain threshold induced by cold and hot stimuli. Whereas ajugarin-I showed 95.1 ± 0.04 % antidepressant activity. Moreover, it showed strong antioxidant potential by raising the level of catalase, glutathione-S-transferase, and reducing glutathione while decreasing MDA levels in the liver, kidney, brain, paw, and spleen. Reduced serum levels of alanine transaminase (ALT), aspartate transaminase (AST), and alkaline phosphatase (ALP) (with 67.5 ± 3.53 %, 83.5 ± 3.53 % and 85 ± 7.07 % respectively), were observed with HD of ajugarin-I. Furthermore, its 60 mg/kg dose restored hematological abnormalities by raising the Hb level (85 ± 0.7 %) RBCs (91 ± 0.5 %), MCV (83 ± 2 %), platelet count (83 ± 0.5 %) and lowered the WBC (68 ± 0.35 %) level. Abnormalities in histoarchitecture of paw, liver, and kidney were curtailed by HD of ajugarin-I demonstrating its regenerative properties. Radiological analysis of the left hind paw showed that ajugarin-I lessened the inflammation in articular areas. These findings will guide a novel area of research for exploiting ajugarin-I as novel anti-arthritic and anti-inflammatory agent.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"183 ","pages":"Article 106517"},"PeriodicalIF":2.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143779431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eight new C21-steroidal glycosides from the roots of Cynanchum auriculatum","authors":"Ya-Yu Wu ,&nbsp;Lan-Wen Gao ,&nbsp;Yu-Jun Tang ,&nbsp;Bo Hu ,&nbsp;Ya-Lin Hu ,&nbsp;Yu-Bo Zhang ,&nbsp;Guang-Xiong Zhou","doi":"10.1016/j.fitote.2025.106519","DOIUrl":"10.1016/j.fitote.2025.106519","url":null,"abstract":"<div><div>Eight new C₂₁-steroidal glycosides (<strong>1</strong>–<strong>8</strong>) and fourteen known analogs (<strong>9</strong>–<strong>22</strong>) were isolated from the roots of <em>Cynanchum auriculatum</em> Royle ex Wight (Asclepiadaceae). The structures of the new compounds were elucidated on the basis of their IR, HR-ESI-MS, and NMR data. The cytotoxicities of compounds <strong>1</strong>–<strong>22</strong> were evaluated against two prominent human cancer cell lines, SW480 and MDA-MB-231, leading to preliminary structure-activity relationships (SARs). Notably, compounds <strong>1</strong>, <strong>5</strong>, <strong>8</strong>, <strong>10</strong>, and <strong>22</strong> exhibited significant cytotoxic activity against both cell lines, with IC₅₀ values ranging from 8.76 ± 1.36 to 17.90 ± 1.77 μM for SW480 and from 10.97 ± 1.73 to 12.07 ± 1.13 μM for MDA-MB-231.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"183 ","pages":"Article 106519"},"PeriodicalIF":2.5,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-diabetic sesquiterpenoids from the heartwood of Entandrophragma cylindricum","authors":"Hong-Yan Mu ,&nbsp;Kai-Wen Kang ,&nbsp;Yan Zhang ,&nbsp;Ju-Cai Xu ,&nbsp;Dong-Li Li ,&nbsp;Jing-Wei Jin ,&nbsp;Jia-Le Gan ,&nbsp;Hong-Guang Li ,&nbsp;Li-She Gan","doi":"10.1016/j.fitote.2025.106515","DOIUrl":"10.1016/j.fitote.2025.106515","url":null,"abstract":"<div><div>(<img>)-(7<em>S</em>,8<em>S</em>)-10,11-dihydro-curcumene-3,8-diol (<strong>1</strong>) and one new cadinane-type sesquiterpenoid, (<img>)-(1<em>R</em>,4<em>S</em>,6<em>S</em>,7<em>S</em>,10<em>R</em>)-cadinan-1,4-diol (<strong>2</strong>), together with six known ones (<strong>3–8</strong>), were isolated from 95 % ethanol extract of the heartwood of <em>Entandrophragma cylindricum</em>. Structures of the new compounds were elucidated on the basis of detailed spectroscopic analysis and quantum chemical calculations, including GIAO calculation of NMR chemical shifts and TDDFT calculation of ECD spectrum, which verified the relative and absolute configurations on the flexible side chain of <strong>1</strong>, respectively. All sesquiterpenoids were evaluated for their potential to enhance glucose uptake in C2C12 myotubes. Compound <strong>2</strong> (20 μM) significantly increased glucose uptake to the same level as that of metformin (2 mM). Western blot analysis on AMPKα, GLUT4, and ACC1 revealed that compound <strong>2</strong> activated the AMPK-GLUT4 signaling pathway in C2C12 myotubes.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"183 ","pages":"Article 106515"},"PeriodicalIF":2.5,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143748315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cassane butenolides from the fruits of Caesalpinia pulcherrima","authors":"Huiping Xie ,&nbsp;Ting Long ,&nbsp;Yongchun Gao ,&nbsp;Dan Huang ,&nbsp;Liqin Wang","doi":"10.1016/j.fitote.2025.106500","DOIUrl":"10.1016/j.fitote.2025.106500","url":null,"abstract":"<div><div>Seven undescribed cassane diterpenes, caeslpulrins A-G (<strong>1, 3, 4,</strong> and <strong>6–9</strong>), the C-12 ethoxy derivatives of caeslpulrins A and C (<strong>2</strong> and <strong>5</strong>), along with five artificial or known cassane diterpenes (<strong>10</strong>–<strong>14</strong>) and eight known sesquiterpenoids (<strong>15</strong>–<strong>22</strong>) were isolated from the fruits of <em>Caesalpinia pulcherrima</em>. Their structures were elucidated by extensive spectroscopic analyses, including HR-ESI-MS, 1D and 2D NMR, and electronic circular dichroism (ECD) calculations. Caeslpulrins A-F were identified as a group of rare cassane butenolides possessing a C-3 benzoyloxy unit. This is the first report of a series of such cassane diterpenes from a <em>Caesalpinia</em> plants<em>.</em> Compounds <strong>1–7</strong> were evaluated their inhibitory effects on NO production in the LPS-induced RAW 264.7 macrophages, and their cytotoxicities against several human tumor cell lines using MTS method.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"183 ","pages":"Article 106500"},"PeriodicalIF":2.5,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143739317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ten-membered lactones with antifungal activity against the postharvest pathogens from Penicillium restrictum","authors":"Jing Sun ,&nbsp;Feng-Shuang Wei ,&nbsp;Tong-De Zhao ,&nbsp;Rong-Fei Ma ,&nbsp;Xiao-Xiao Hu ,&nbsp;Heng-Xiang Li ,&nbsp;Chao Liu ,&nbsp;Ju-Cheng Zhang ,&nbsp;Xue-Qiong Yang ,&nbsp;Ya-Bin Yang ,&nbsp;Zhong-Tao Ding","doi":"10.1016/j.fitote.2025.106495","DOIUrl":"10.1016/j.fitote.2025.106495","url":null,"abstract":"<div><div>Two undescribed ten-membered lactones, named penicirestricols A (<strong>1</strong>) and B (<strong>2</strong>), and two unprecedented ten-membered lactone-adenine hybrids, penicirestricols C (<strong>3</strong>) and D (<strong>4</strong>), along with four known compounds, decarestrictines B (<strong>5</strong>), A₁ (<strong>6</strong>), F (<strong>7</strong>), and I (<strong>8</strong>) were isolated from the endophytic fungus <em>Penicillium restrictum</em>. The structures were determined by 1D, 2D NMR techniques, mass spectrometry, ECD, and NMR calculations. Compounds <strong>3</strong>, <strong>7</strong>, and <strong>8</strong> from <em>P. restrictum</em> showed significant antifungal activities against postharvest pathogens <em>Fusarium asiaticum</em> and <em>Alternaria tenuissima</em> with MICs ≤8 μg/mL. Thus, the compounds isolated from <em>P. restrictum</em> have the potentiality to be developed as the novel antifungal agents.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"183 ","pages":"Article 106495"},"PeriodicalIF":2.5,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143739315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Four new meroterpenoid derivatives with cytotoxicity from the mangrove-derived fungus Penicillium sp. HLLG-122","authors":"Yu-Yue Qin ,&nbsp;Xiao-Bo Liu ,&nbsp;Tian-Tao Xiong ,&nbsp;Hong Xiao ,&nbsp;Xuan Zhang ,&nbsp;Xin-Ming Song ,&nbsp;Bin Gong ,&nbsp;Wan-Shan Li ,&nbsp;Guang-Ying Chen","doi":"10.1016/j.fitote.2025.106494","DOIUrl":"10.1016/j.fitote.2025.106494","url":null,"abstract":"<div><div>Four new meroterpenoids, including two <em>seco</em> isodhilarane-type meroterpenoids peniciacetals J-K (<strong>1</strong> and <strong>2</strong>), two austins-type meroterpenoids peniciacetals L-M (<strong>3</strong> and <strong>4</strong>), along with five known analogues (<strong>5–9</strong>) were isolated from the mangrove-derived fungus <em>Penicillium</em> sp. HLLG-122 based on the OSMAC approach. The structures, including absolute configurations of new compounds were elucidated by HRESIMS, 1D, 2D NMR spectroscopic data, X-ray diffraction analysis, and quantum chemical electronic circular dichroism (ECD) calculation. Peniciacetal J (<strong>1</strong>) was characterized with a unique 6/7/6/5/6/5 hexacyclic systems with a furan ring moiety. Compound <strong>3</strong> showed weak cytotoxicity against HepG2 and MCF-7 cell lines with IC₅₀ values of 38.9 and 34.1 μM, respectively. Compound <strong>8</strong> showed moderate cytotoxicity against HepG2 and MCF-7 cell lines with IC₅₀ values of 10.7 and 13.3 μM, respectively. Compound <strong>9</strong> exhibited good cytotoxicity against HepG2 cell line with the IC₅₀ value of 4.8 μM.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"183 ","pages":"Article 106494"},"PeriodicalIF":2.5,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143739316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular networking-based discovery of long chain fatty acid bearing iridal triterpenoids with neurite outgrowth promoting activity from Iris domestica rhizomes","authors":"Yen Thi Hoang Kieu ,&nbsp;Kosei Yamauchi ,&nbsp;Minh Tu Thi Nguyen ,&nbsp;Tohru Mitsunaga","doi":"10.1016/j.fitote.2025.106499","DOIUrl":"10.1016/j.fitote.2025.106499","url":null,"abstract":"<div><div>The plant family Iridaceae is a rich source of structurally rare iridal-type triterpenoids. In this study, we investigated the structural diversity of iridal triterpenoids contained in the rhizome of <em>Iris domestica</em> using metabolomics-based molecular networking. Guided by MS² features of iridal triterpenoids obtained from LC-MS²-based molecular networking, two new aliphatic fatty acid ester-bearing monocycloiridal type triterpenoids, named as 16-acetyliridal A (<strong>1</strong>) and 16-acetyliridal B (<strong>2</strong>), as well as a known compound (<strong>3</strong>), were isolated from the rhizomes of <em>I. domestica</em>. The structures of new compounds were elucidated based on the HR-ESIQTOFMS, MS² fragmentations, and NMR spectroscopy. Compound <strong>2</strong> is the first example of iridal-type homotriterpenoids featuring an unusual acyl moiety at a cyclohexane ring instead of a formyl group that is commonly shared in the iridal triterpenoids. All isolated compounds exhibited a high potency to promote neurite outgrowth activities with or without the supplementation of nerve growth factor on PC12 cells in a dose-dependent manner.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"183 ","pages":"Article 106499"},"PeriodicalIF":2.5,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143742113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In silico molecular docking and predictive ADME properties, in vitro antioxidant scavenging capacities, and in vivo pharmacological activities to study the potential of Pterocarpus mildbraedii's Harms (Fabaceae) in preventing vaginal dysbiosis and risk factors for cardiovascular disease in an estropause rat model","authors":"Mengue Ngadena Yolande Sandrine ,&nbsp;Bindzi Georges Michel ,&nbsp;Aboubakar Oumarou Bibi-Farouck ,&nbsp;Pierrette Ngo Bahebeck ,&nbsp;Owona Pascal Emmanuel ,&nbsp;Bilanda Danielle Claude ,&nbsp;Ronald Bidingha A Goufani ,&nbsp;Tcheutchoua Yannick Carlos ,&nbsp;Ambamba Akamba Bruno Dupon ,&nbsp;Ella Armand Fils ,&nbsp;Bouguem Yandja Paule Cynthia ,&nbsp;Ngueuko Talla Jude Ulrich ,&nbsp;Dzeufiet Djomeni Paul Désiré","doi":"10.1016/j.fitote.2025.106496","DOIUrl":"10.1016/j.fitote.2025.106496","url":null,"abstract":"<div><div>Vaginal dysbiosis (VaD) is a common issue among menopausal women, who are particularly susceptible to cardiovascular disease (CVD). <em>Pterocarpus</em> sp. are known to induce estrogen-like activities, which are the key pathways for menopause-related disorders. This study aims to evaluate the potential of <em>Pterocarpus mildbraedii</em> water extract on VaD and CVD risk factors using an estropause (EP) rat model. Furthermore, predictive ADME properties and molecular docking with target proteins were assessed to develop alternative medicinal treatments for menopause. The secondary metabolites in <em>P. mildbraedii</em> water extract (Pm) were analyzed using UHPLC-MS and quantitative phytochemistry methods. The extract's ability to scavenge free radicals was evaluated using DPPH, ABTS, and FRAP tests. Molecular docking assessed the extract's binding ability to various receptors. SwissADME and Molinspiration were utilized to predict its pharmacokinetic and bioactivity properties. Subsequently, the therapeutic potential of Pm was assessed in rats, focusing on its estrogen-like, eubiotic, and cardioprotective activities. UHPLC-MS enables us to identify several compounds. Predictive ADME analyses have indicated that most compounds comply with Lipinski's Rule of Five for oral drugs. Additionally, they inhibit CYP1A2 and bind to several receptors and enzymes through conventional hydrogen bonding. In rats, ovariectomy-induced EP reduced glycogen levels and vaginal lactic acid and decreased in the population of <em>Lactobacillus</em> spp., which is characteristic of VaD. This condition also increases CVD risk factors. Overall, this study underscores the potential of <em>Pterocarpus mildbraedii</em> in preventing VaD and CVD risk factors related to hypoestrogenism. This extract positions itself as a promising alternative treatment for menopause-related disorders.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"183 ","pages":"Article 106496"},"PeriodicalIF":2.5,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143724806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Monocyclic and polycyclic polyprenylated acylphloroglucinols with anti-steatohepatitis effect from the pericarps of Garcinia multiflora","authors":"Huijuan Luo ,&nbsp;Jun Cao ,&nbsp;Yujia Zhang ,&nbsp;Hao Dou ,&nbsp;Xu Liang ,&nbsp;Zheling Feng ,&nbsp;Yang Ye ,&nbsp;Lishe Gan ,&nbsp;Ligen Lin","doi":"10.1016/j.fitote.2025.106493","DOIUrl":"10.1016/j.fitote.2025.106493","url":null,"abstract":"<div><div>Natural products are an important source of drug candidates against fatty liver. Herein, two previously undescribed monocyclic polyprenylated acylphloroglucinols (MPAPs, <strong>1</strong> and <strong>2</strong>) and three new polycyclic polyprenylated acylphloroglucinols (PPAPs, <strong>3</strong>–<strong>5</strong>) were isolated from the pericarps of <em>Garcinia multiflora</em>, and structurally elucidated by comprehensive spectroscopic analyses and electronic circular dichroism (ECD) calculations, together with five known PPAPs. Compounds <strong>1</strong> and <strong>2</strong> are rare dinor-MPAPs. In lipopolysaccharide (LPS)-induced RAW264.7 macrophages, compounds <strong>1</strong>, <strong>3</strong> and <strong>4</strong> significantly suppressed nitric oxide production. Among them, compound <strong>3</strong> showed the best inhibitory effect with an IC₅₀ value of 4.12 ± 0.94 μМ. Furthermore, compound <strong>3</strong> effectively reduced interleukin-1β secretion in LPS plus nigericin-induced THP-1 macrophages by inhibiting NLRP3 inflammasome activation. Interestingly, the conditioned medium from LPS plus nigericin-stimulated THP-1 macrophages pre-treated with compound <strong>3</strong> attenuated lipid accumulation in oleic acid plus palmitic acid (2/1)-induced HepG2 hepatocytes. Taken together, these findings expand the chemical diversity of <em>G. multiflora</em>, and further demonstrate the potential of PPAPs as candidates for treating steatohepatitis.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"183 ","pages":"Article 106493"},"PeriodicalIF":2.5,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143715942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}