HPLC-guided isolation and characterization of monoterpene glycosides from the dried roots bark of Paeonia × suffruticosa Andr

IF 2.6 3区医学 Q3 CHEMISTRY, MEDICINAL

Fitoterapia Pub Date : 2025-09-24 DOI:10.1016/j.fitote.2025.106900

Lan Chen , Yan-gang Cao , Yan-ling Liu , Xu Chen , Di Lu , Bing-xian Zhao , Ying Niu , Xiao-ke Zheng , Wei-sheng Feng

引用次数: 0

Abstract

Three undescribed monoterpene glycosides (1–3), along with seventeen known analogues (4–20), were isolated from the dried roots bark of Paeonia × suffruticosa Andr. based on high-performance liquid chromatography (HPLC) analysis and small molecule accurate recognition technology (SMART). Their structures were assigned by spectroscopic techniques, and the absolute configurations of compounds 1–3 were elucidated by comparing the computed and experimental electronic circular dichroism (ECD) spectra. Additionally, compound 2 exhibited moderate inhibitory effect on acetylcholinesterase (AChE) with the IC₅₀ value of 18.54 ± 2.60 μM. Compound 13 showed significantly activity on DPPH with the IC₅₀ value of 9.04 ± 2.33 μM.

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芍药根皮单萜苷的hplc分离与表征。

从芍药根皮中分离得到3个未描述的单萜苷（1-3）和17个已知的类似物（4-20）。基于高效液相色谱（HPLC）分析和小分子精确识别技术（SMART）。化合物1 ~ 3的绝对构型通过比较计算和实验的电子圆二色性（ECD）光谱得到。化合物2对乙酰胆碱酯酶（AChE）有中等抑制作用，IC50值为18.54 ± 2.60 μM。化合物13对DPPH具有显著活性，IC50值为9.04 ± 2.33 μM。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Fitoterapia 医学-药学

CiteScore

5.80

自引率

2.90%

发文量

198

审稿时长

1.5 months

期刊介绍： Fitoterapia is a Journal dedicated to medicinal plants and to bioactive natural products of plant origin. It publishes original contributions in seven major areas: 1. Characterization of active ingredients of medicinal plants 2. Development of standardization method for bioactive plant extracts and natural products 3. Identification of bioactivity in plant extracts 4. Identification of targets and mechanism of activity of plant extracts 5. Production and genomic characterization of medicinal plants biomass 6. Chemistry and biochemistry of bioactive natural products of plant origin 7. Critical reviews of the historical, clinical and legal status of medicinal plants, and accounts on topical issues.