Fitoterapia最新文献

{"title":"In silico molecular docking and predictive ADME properties, in vitro antioxidant scavenging capacities, and in vivo pharmacological activities to study the potential of Pterocarpus mildbraedii's Harms (Fabaceae) in preventing vaginal dysbiosis and risk factors for cardiovascular disease in an estropause rat model","authors":"Mengue Ngadena Yolande Sandrine ,&nbsp;Bindzi Georges Michel ,&nbsp;Aboubakar Oumarou Bibi-Farouck ,&nbsp;Pierrette Ngo Bahebeck ,&nbsp;Owona Pascal Emmanuel ,&nbsp;Bilanda Danielle Claude ,&nbsp;Ronald Bidingha A Goufani ,&nbsp;Tcheutchoua Yannick Carlos ,&nbsp;Ambamba Akamba Bruno Dupon ,&nbsp;Ella Armand Fils ,&nbsp;Bouguem Yandja Paule Cynthia ,&nbsp;Ngueuko Talla Jude Ulrich ,&nbsp;Dzeufiet Djomeni Paul Désiré","doi":"10.1016/j.fitote.2025.106496","DOIUrl":"10.1016/j.fitote.2025.106496","url":null,"abstract":"<div><div>Vaginal dysbiosis (VaD) is a common issue among menopausal women, who are particularly susceptible to cardiovascular disease (CVD). <em>Pterocarpus</em> sp. are known to induce estrogen-like activities, which are the key pathways for menopause-related disorders. This study aims to evaluate the potential of <em>Pterocarpus mildbraedii</em> water extract on VaD and CVD risk factors using an estropause (EP) rat model. Furthermore, predictive ADME properties and molecular docking with target proteins were assessed to develop alternative medicinal treatments for menopause. The secondary metabolites in <em>P. mildbraedii</em> water extract (Pm) were analyzed using UHPLC-MS and quantitative phytochemistry methods. The extract's ability to scavenge free radicals was evaluated using DPPH, ABTS, and FRAP tests. Molecular docking assessed the extract's binding ability to various receptors. SwissADME and Molinspiration were utilized to predict its pharmacokinetic and bioactivity properties. Subsequently, the therapeutic potential of Pm was assessed in rats, focusing on its estrogen-like, eubiotic, and cardioprotective activities. UHPLC-MS enables us to identify several compounds. Predictive ADME analyses have indicated that most compounds comply with Lipinski's Rule of Five for oral drugs. Additionally, they inhibit CYP1A2 and bind to several receptors and enzymes through conventional hydrogen bonding. In rats, ovariectomy-induced EP reduced glycogen levels and vaginal lactic acid and decreased in the population of <em>Lactobacillus</em> spp., which is characteristic of VaD. This condition also increases CVD risk factors. Overall, this study underscores the potential of <em>Pterocarpus mildbraedii</em> in preventing VaD and CVD risk factors related to hypoestrogenism. This extract positions itself as a promising alternative treatment for menopause-related disorders.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"183 ","pages":"Article 106496"},"PeriodicalIF":2.5,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143724806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Monocyclic and polycyclic polyprenylated acylphloroglucinols with anti-steatohepatitis effect from the pericarps of Garcinia multiflora","authors":"Huijuan Luo ,&nbsp;Jun Cao ,&nbsp;Yujia Zhang ,&nbsp;Hao Dou ,&nbsp;Xu Liang ,&nbsp;Zheling Feng ,&nbsp;Yang Ye ,&nbsp;Lishe Gan ,&nbsp;Ligen Lin","doi":"10.1016/j.fitote.2025.106493","DOIUrl":"10.1016/j.fitote.2025.106493","url":null,"abstract":"<div><div>Natural products are an important source of drug candidates against fatty liver. Herein, two previously undescribed monocyclic polyprenylated acylphloroglucinols (MPAPs, <strong>1</strong> and <strong>2</strong>) and three new polycyclic polyprenylated acylphloroglucinols (PPAPs, <strong>3</strong>–<strong>5</strong>) were isolated from the pericarps of <em>Garcinia multiflora</em>, and structurally elucidated by comprehensive spectroscopic analyses and electronic circular dichroism (ECD) calculations, together with five known PPAPs. Compounds <strong>1</strong> and <strong>2</strong> are rare dinor-MPAPs. In lipopolysaccharide (LPS)-induced RAW264.7 macrophages, compounds <strong>1</strong>, <strong>3</strong> and <strong>4</strong> significantly suppressed nitric oxide production. Among them, compound <strong>3</strong> showed the best inhibitory effect with an IC₅₀ value of 4.12 ± 0.94 μМ. Furthermore, compound <strong>3</strong> effectively reduced interleukin-1β secretion in LPS plus nigericin-induced THP-1 macrophages by inhibiting NLRP3 inflammasome activation. Interestingly, the conditioned medium from LPS plus nigericin-stimulated THP-1 macrophages pre-treated with compound <strong>3</strong> attenuated lipid accumulation in oleic acid plus palmitic acid (2/1)-induced HepG2 hepatocytes. Taken together, these findings expand the chemical diversity of <em>G. multiflora</em>, and further demonstrate the potential of PPAPs as candidates for treating steatohepatitis.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"183 ","pages":"Article 106493"},"PeriodicalIF":2.5,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143715942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In silico and in vitro evidence on the anti-diabetic effect of grandidentatin from Salix acmophylla Boiss","authors":"Gauhar Rehman ,&nbsp;Adil Sher ,&nbsp;Abdur Rauf ,&nbsp;Zafar Ali Shah ,&nbsp;Walaa F. Alsanie ,&nbsp;Abdulhakeem S. Alamri ,&nbsp;Majid Alhomrani ,&nbsp;Giovanni Ribaudo","doi":"10.1016/j.fitote.2025.106497","DOIUrl":"10.1016/j.fitote.2025.106497","url":null,"abstract":"<div><div>Current pharmacological treatments against diabetes do not reach optimal results in many conditions, and the attention of medicinal chemists is currently dedicated to multi-target compounds with antioxidant, anti-inflammatory and anti-diabetic properties. In this connection, medicinal plants represent valuable sources.</div><div>Grandidentatin is a phenolic glycoside isolated from the leaves of <em>Salix acmophylla</em> Boiss., and in the current study its anti-inflammatory activity was investigated <em>in vitro</em> through red blood cells membrane stabilization and protein denaturation assays, and it was comparable to that of the positive control diclofenac sodium. Additionally grandidentatin was effective in the glucose uptake assay, used to assess the blood sugar lowering action, in the same concentration range of metformin. Computational studies were also enrolled to investigate the physico-chemical properties and the mechanism of action, showing that the molecule possesses the features to be defined as a “drug-like” compound, and that it may target aldose reductase as observed by docking studies.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"183 ","pages":"Article 106497"},"PeriodicalIF":2.5,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143706432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Five new alkaloids from the endophytic fungus Penicillium sizovae in Ferula sinkiangensis","authors":"Shuhui Tan ,&nbsp;Leiling Shi ,&nbsp;Xudong Xu ,&nbsp;Guoping Wang ,&nbsp;Jun Zhu ,&nbsp;Yuan Li ,&nbsp;Congzhao Fan ,&nbsp;Yaqin Zhao","doi":"10.1016/j.fitote.2025.106498","DOIUrl":"10.1016/j.fitote.2025.106498","url":null,"abstract":"<div><div>Five new alkaloids, ferupencines A–E, featuring a pyrrol-oxazine core with a C₃- C₄O₂N framework, were isolated from the secondary metabolites of the endophytic fungus <em>Penicillium sizovae</em> residing in <em>Ferula sinkiangensis</em>. Their structures were elucidated through comprehensive 1D and 2D NMR spectroscopy, along with mass spectrometric analysis, experimental and calculated (ECD) spectra, and other complementary methods. The absolute configuration of compound <strong>1</strong> was determined via X-ray crystallography, supported by experimental and calculated electronic circular dichroism (ECD) data. Notably, this is the first report of these compounds being isolated from endophytic fungi. The cytotoxicity of ferupencines A–E (<strong>1–5</strong>) was evaluated against three human tumor cell lines: HeLa, SGC-7901, and SHG-44. Compound <strong>2</strong> exhibited moderate cytotoxic activity against HeLa and SGC-7901 cells, with IC₅₀ values of 18.6 μM and 14.2 μM, respectively. Additionally, compound <strong>5</strong> showed an IC₅₀ value of 23.8 μM against HeLa cells, indicating moderate cytotoxic potential.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"183 ","pages":"Article 106498"},"PeriodicalIF":2.5,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143729393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vitro antioxidant activity and toxicity assay of some chemical constituents from Landolphia violaceae lianas (Apocynaceae)","authors":"Daniela Djipmegne Ntomi ,&nbsp;Gwladys Djikam Sime ,&nbsp;Norbert Mbabi Nyemeck II ,&nbsp;Auguste Abouem A Zintchem ,&nbsp;Sammer Yousouf ,&nbsp;Ul-Haq Ihsan ,&nbsp;Dominique Serge Ngono Bikobo ,&nbsp;Muhammad Iqbal Choudhary ,&nbsp;Dieudonné Emmanuel Pegnyemb","doi":"10.1016/j.fitote.2025.106483","DOIUrl":"10.1016/j.fitote.2025.106483","url":null,"abstract":"<div><div><em>Landolphia</em> genus is known in West Africa for its various ethnomedicinal uses. Therefore, the lianas of <em>Landolphia violaceae</em> (Apocynaceae) were investigated to characterize/identify its chemical constituents as well as the antioxidant activities and toxicity of samples. The investigation of the AcOEt extract of this plant led to the isolation of three previously unknown compounds named: landolphioside A (<strong>1</strong>), landolphioside B (<strong>2</strong>) and landolphioside C (<strong>3</strong>) along with 5 known compounds. Their structures were determined on the basis of their spectroscopic data. <strong>1</strong> and <strong>2</strong> represent rare flavonoids with a <em>C</em>–benzylcarbonyl group on ring A identified from Apocynaceae family. The free radical scavenging activity using 1,1-diphenyl-2-picrylhydrazyl radical (DPPH), the Total Reducing Power (TRP) assay and the Total Antioxidant Capacity (TAC) were carried on the AcOEt extract and the isolates <strong>1</strong>–<strong>4</strong> and <strong>6</strong>. The toxicity of the extracts was investigated through Brine Shrimp Lethality Assay (BSLA). The AcOEt extract displayed a high total antioxidant capacity corresponding to 218.81 ± 0.17 mg/g of dried extract (ascorbic acid equivalent) and demonstrated significant DPPH free radical scavenging activity (IC₅₀ = 12.81 ± 0.21 μg/mL). Else, it appeared relatively toxic (greater than 80 % at 200 μg/mL) against brine shrimp lethality (<em>Artemia salina</em>), when compounds <strong>3</strong>, <strong>4</strong> and <strong>6</strong> showed high to moderate toxicity with LC₅₀ values (in μM) of 87.82, 139.18 and 336.44 respectively. These results highlighted the plausible medicinal use of L. <em>violaceae</em> which henceforth can be considered as a source of potent bioactive compounds, with presumably antioxidant and moderate toxic effects.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"183 ","pages":"Article 106483"},"PeriodicalIF":2.5,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antidiabetic protolimonoids from the bark of Entandrophragma angolense","authors":"Binh T.D. Trinh ,&nbsp;Nhung T.H. Nguyen ,&nbsp;Ngoc T.N. Ngo ,&nbsp;Ly T.T. Nguyen ,&nbsp;Lien-Hoa D. Nguyen ,&nbsp;Le-Thu T. Nguyen","doi":"10.1016/j.fitote.2025.106487","DOIUrl":"10.1016/j.fitote.2025.106487","url":null,"abstract":"<div><div>Three new protolimonoids, entandrophins A-C (<strong>1</strong>–<strong>3</strong>), together with two known compounds, methyl angolensate (<strong>4</strong>) and stigmas-4-en-3-one (<strong>5</strong>), were isolated from the bark of <em>Entandrophragma angolense</em>. Their structures were elucidated based on spectroscopic analyses, mainly 1D and 2D NMR spectral data. The compounds were evaluated for their cytotoxicity against HepG2 cells and α-glucosidase inhibitory activity. Compounds <strong>1</strong>–<strong>4</strong> displayed very weak activity against HepG2 cells but compounds <strong>2</strong> and <strong>3</strong> exhibited significant <em>α</em>-glucosidase inhibition with IC₅₀ values of 57.5 ± 1.5 and 32.5 ± 0.9 μM, respectively.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"183 ","pages":"Article 106487"},"PeriodicalIF":2.5,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioactive secondary metabolites from Dentipellis fragilis with anti-inflammatory and cytotoxic activity","authors":"Dae-Cheol Choi ,&nbsp;Yoon Hee Kim ,&nbsp;Min-Ju Park ,&nbsp;Da Young Hwang ,&nbsp;Ji-Yul Kim ,&nbsp;Yeong-Seon Won ,&nbsp;In-Kyoung Lee ,&nbsp;Dae-Won Ki ,&nbsp;Bong-Sik Yun","doi":"10.1016/j.fitote.2025.106492","DOIUrl":"10.1016/j.fitote.2025.106492","url":null,"abstract":"<div><div>Two new compounds, a benzofuran derivative (<strong>1</strong>) and a benzoate derivative (<strong>2</strong>), along with four known γ-pyrones (<strong>3</strong>–<strong>6</strong>), were isolated from the culture broth of <em>Dentipellis fragilis</em>. Their chemical structures were elucidated via spectroscopic analysis. The anti-inflammatory and cytotoxic effects of these compounds were assessed. Compound <strong>4</strong> exhibited significant anti-inflammatory activity, inhibiting approximately 60 % of NO production at 0.005 μM without cytotoxic effects. Additionally, compound <strong>2</strong> showed moderate cytotoxicity against HCT-116 and Mia Paca-2 human cancer cells, with IC₅₀ values.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"183 ","pages":"Article 106492"},"PeriodicalIF":2.5,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioactive coumarins from Notopterygium incisum root: A step toward natural ant-infammatory candidates","authors":"Li-Shi Jiang ,&nbsp;Hong-Xiang Li ,&nbsp;Chuan-Yang Zhang ,&nbsp;Yu-Ting Mu ,&nbsp;Meng-Jiao Zhang ,&nbsp;Yun-Jie Hu ,&nbsp;Da-Le Guo ,&nbsp;Yun Deng","doi":"10.1016/j.fitote.2025.106491","DOIUrl":"10.1016/j.fitote.2025.106491","url":null,"abstract":"<div><div>Five novel coumarins (<strong>1–5</strong>) were isolated from the root of <em>Notopterygium incisum</em>, and their chemical structures were elucidated based on HRESIMS and NMR spectral data. The anti-inflammatory activities of compounds <strong>1–5</strong> were evaluated in a lipopolysaccharide-induced RAW 264.7 cell model by measuring the levels of pro-inflammatory cytokines (IL-1β, IL-6, and TNF-α). The results demonstrated that all five compounds exhibited significant anti-inflammatory potential. Further studies showed that compound <strong>5</strong> (at a concentration of 7.5–30 μM) displayed potent anti-inflammatory effects by inhibiting the expression of inflammatory mediators (COX-2, iNOS) and reducing nitric oxide (NO) production. Mechanistic studies revealed that compound <strong>5</strong> exerted its anti-inflammatory effects by inhibiting the NF-κB signaling pathway. These findings highlight the potential of coumarins as anti-inflammatory agents and provide a foundation for their further exploration as therapeutic candidates.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"182 ","pages":"Article 106491"},"PeriodicalIF":2.5,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143682694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the effective components and underlying mechanisms of Feiyanning formula in acute lung injury based on the pharmacokinetics, metabolomics and network pharmacology technology","authors":"Xuanxuan Zhu ,&nbsp;Lan Miao ,&nbsp;Junmei Li ,&nbsp;Xinwei Wang ,&nbsp;Li Lin ,&nbsp;Ying Zhang ,&nbsp;Mingqian Sun ,&nbsp;Shuo Meng ,&nbsp;Junguo Ren ,&nbsp;Qing Peng ,&nbsp;Jianxun Liu","doi":"10.1016/j.fitote.2025.106486","DOIUrl":"10.1016/j.fitote.2025.106486","url":null,"abstract":"<div><div>This study aimed to explore the mechanisms of Feiyanning formula (FYN) on acute lung injury (ALI) using pharmacokinetics combined with network pharmacology strategy. Firstly, pharmacokinetic studies of 13 major bioactive components in normal and ALI mice were conducted using ultra-high performance liquid chromatography-triple quadrupole mass spectrometry (UPLC-QQQ-MS/MS). Secondly, metabolomics was utilized to explore the metabolites affected by FYN. Finally, the network pharmacology was used to analyze the pharmacological mechanism of FYN's pharmacokinetic target components in ALI treatment, with western blotting (WB) experiment performed for verification. The pharmacokinetic results showed that compared to normal mice, the <em>C</em>_<em>max</em> and AUC_0-t of wogonin, oroxylin A, liquiritigenin, tetrandrine, and fangchinoline were significantly increased in ALI mice. The results of the lung tissue distribution showed that compared to normal mice, the AUC_0-t of wogonin and oroxyloside was significantly increased in ALI mice; the <em>C</em>_<em>max</em> of wogonoside and norwogonin was significantly increased in ALI mice. Metabolomics analysis showed that FYN may alleviate LPS-induced lung inflammation in mice by regulating related pathways including purine metabolism, and phenylalanine, tyrosine and tryptophan biosynthesis in both serum and lung tissue. Network pharmacology identified 110 overlapping genes between the 13 absorbed components and ALI-related targets. In KEGG enrichment analysis, the PI3K/AKT signaling pathway was identified as a significant pathway. WB experiment confirmed that FYN reduced the expression ratios of p-PI3K/PI3K, p-AKT1/AKT1, p-EGFR/EGFR, and TLR4 levels in lung tissue of ALI mice. This study might offer a solid foundation for evaluating the clinical efficacy of FYN.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"183 ","pages":"Article 106486"},"PeriodicalIF":2.5,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Isolation, structural transformation and neuroprotective activity of abietane diterpenoids from the roots of Clerodendrum trichotomum","authors":"Lishe Gan ,&nbsp;Jianghuan Ke ,&nbsp;Fan Xu ,&nbsp;Changxin Zhou ,&nbsp;Shuying Li ,&nbsp;Jing Chen","doi":"10.1016/j.fitote.2025.106488","DOIUrl":"10.1016/j.fitote.2025.106488","url":null,"abstract":"<div><div>Seven abietane diterpenoids (<strong>1</strong>–<strong>7</strong>) were isolated from the roots of <em>Clerodendrum trichotomum</em>, and the most abundant compounds, uncintone (<strong>1</strong>) and teuvincenone B (<strong>3</strong>), were subjected to structural modification to produce eleven derivatives (<strong>8</strong>–<strong>18</strong>). Their structures were elucidated using spectroscopic methods and quantum chemical calculations. The neuroprotective activities of these diterpenoids were assessed using HT22 cell models damaged by glutamate and acrolein. Most compounds exhibited promising neuroprotective effects against neuronal injury induced by these toxins at a concentration of 10 μM. These findings provide a promising basis for the further investigation of abietane diterpenoids as candidates in neuroprotective drug development.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"183 ","pages":"Article 106488"},"PeriodicalIF":2.5,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143686859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}