Fitoterapia最新文献_第5页

Bioactive constituents from Clerodendrum trichotomum and their α-glucosidase inhibitory and PPAR-γ agonist activities 毛蕊花的生物活性成分及其α-葡萄糖苷酶抑制剂和 PPAR-γ 激动剂活性。

IF 2.5 3区医学

Fitoterapia Pub Date : 2024-10-20 DOI: 10.1016/j.fitote.2024.106266

Yingbo Yang , Qian Zhang , Jia Wang , Haijun Hu , Meng Wang , Zhengtao Wang , Zhuzhen Han , Ying Xiao , Li Yang

{"title":"Bioactive constituents from Clerodendrum trichotomum and their α-glucosidase inhibitory and PPAR-γ agonist activities","authors":"Yingbo Yang , Qian Zhang , Jia Wang , Haijun Hu , Meng Wang , Zhengtao Wang , Zhuzhen Han , Ying Xiao , Li Yang","doi":"10.1016/j.fitote.2024.106266","DOIUrl":"10.1016/j.fitote.2024.106266","url":null,"abstract":"<div><div>Three new neoclerodane diterpenoids (<strong>1–3</strong>), two new steroids (<strong>4–5</strong>), one new monoterpene (<strong>6</strong>), one new derivative of benzaldehyde (<strong>7</strong>) and one new iridoid glycoside (<strong>8</strong>), along with 19 known phenolic compounds, were isolated from <em>Clerodendrum trichotomum</em>. Their structures were established by a combination of detailed spectroscopic analyses (1D and 2D NMR) and high resolution electrospray ionization mass spectroscopy (HRESIMS). The isolated compounds were screened on <em>α</em>-glucosidase inhibitory and the peroxisome proliferator-activated receptor gamma (PPAR-<em>γ</em>) agonist activities, and the results showed that three phenylethanoid glycosides, verbascoside (<strong>9</strong>), leucosceptoside a (<strong>10</strong>), and isoacteoside (<strong>13</strong>), and two flavonoids, apigenin (<strong>22</strong>) and luteolin (<strong>26</strong>) showed potent inhibitory effects against α-glucosidase, with IC<sub>50</sub> values in the range from 15 to 700 μM. In addition, four flavonoids apigenin 7<em>-O-β</em>-D-glucuronide (<strong>19</strong>), apigenin (<strong>22</strong>), luteolin (<strong>26</strong>), and quercetin (<strong>27</strong>) exhibited significant PPAR-<em>γ</em> agonistic activities with EC<sub>50</sub> values in the range 2.3–24.9 μM.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"179 ","pages":"Article 106266"},"PeriodicalIF":2.5,"publicationDate":"2024-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142497680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Six new prenylated flavonoids from Dodonaea viscosa with anti-Zika virus activity 具有抗寨卡病毒活性的六种来自 Dodonaea viscosa 的新前基黄酮类化合物。

IF 2.5 3区医学

Fitoterapia Pub Date : 2024-10-18 DOI: 10.1016/j.fitote.2024.106264

Wen-Hui Pang , Bin-Bao Wang , Yong-Xiang Huang , Xue-Mei Zhou , Xue-Wen Wu , Muhammad Aurang Zeb , Rui-Han Zhang , Ning Huang , Xiao-Li Li , Chang-Bo Zheng , Wei-Lie Xiao

引用次数: 0

Flavonoids from Camellia oleifera flower ameliorate type 2 diabetes mellitus by regulating the p53 pathway 油茶花中的黄酮类化合物通过调节 p53 通路改善 2 型糖尿病。

IF 2.5 3区医学

Fitoterapia Pub Date : 2024-10-18 DOI: 10.1016/j.fitote.2024.106267

Ruining Yu , Dier Shi , Qi Ru , Qiuping Chen , Jianfu Shen

{"title":"Flavonoids from Camellia oleifera flower ameliorate type 2 diabetes mellitus by regulating the p53 pathway","authors":"Ruining Yu , Dier Shi , Qi Ru , Qiuping Chen , Jianfu Shen","doi":"10.1016/j.fitote.2024.106267","DOIUrl":"10.1016/j.fitote.2024.106267","url":null,"abstract":"<div><h3>Background</h3><div>Camellia oleifera flower (COF) is rich in flavonoids and polyphenols, strongly preventing postprandial hyperglycemia and improving diabetes. However, research on the effective ingredients in COF extracts that have hypoglycemic effects is limited, and the mechanism by which COF extracts improve liver insulin resistance and glucose and lipid metabolism still needs to be clarified, requiring further investigation.</div></div><div><h3>Aim</h3><div>To systematically clarify the role of COF extracts in improving insulin resistance in diabetes mice and to explore their key targets and mechanisms in anti-type 2 diabetes (T2DM).</div></div><div><h3>Materials and methods</h3><div>Ultrafiltration combined with liquid chromatography-mass spectrometry (UPLC-Q-MS) was used to analyze α-glucosidase inhibitors in COF extracts qualitatively. Blood glucose, lipid, oxidative stress, and liver function indicators were detected in the db/db type 2 diabetes mouse model. Then, RNA-seq was used to identify differentially expressed mRNAs (DEGs) in the liver, screen for key genes and metabolic pathways, and validate the results' accuracy through qPCR experiments.</div></div><div><h3>Results</h3><div>17 α-glucosidase inhibitors were identified as flavonoids from COF. Through db/db type 2 diabetes mouse model, it was indicated that COF could significantly improve symptoms of hyperglycemia and hyperlipidemia, alleviate oxidative stress, and protect liver and pancreatic tissues by regulating key differential genes expressed, including Nek2, Cdk1, Ccnb1, and Ccnb2 via the p53 signaling pathway and ameliorate the insulin resistance effect.</div></div><div><h3>Conclusion</h3><div>This study demonstrated the anti-diabetic effect of COF, explored its potential hypoglycemic target, and provided data support for future T2DM prevention and drug treatment.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"179 ","pages":"Article 106267"},"PeriodicalIF":2.5,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142461353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pulsatilla suppository prevents recurrent vulvovaginal candidiasis in a rat model via the TLR/MyD88/NLRP3 signaling pathway 白头翁栓通过TLR/MyD88/NLRP3信号通路预防大鼠模型中复发性外阴阴道念珠菌病。

IF 2.5 3区医学

Fitoterapia Pub Date : 2024-10-18 DOI: 10.1016/j.fitote.2024.106250

Hao Zhang , Can Li , Hui Wu , Ziyi Li , Daqiang Wu , Jing Shao , Tianming Wang , Changzhong Wang

{"title":"Pulsatilla suppository prevents recurrent vulvovaginal candidiasis in a rat model via the TLR/MyD88/NLRP3 signaling pathway","authors":"Hao Zhang , Can Li , Hui Wu , Ziyi Li , Daqiang Wu , Jing Shao , Tianming Wang , Changzhong Wang","doi":"10.1016/j.fitote.2024.106250","DOIUrl":"10.1016/j.fitote.2024.106250","url":null,"abstract":"<div><div>Fungal infection caused by <em>Candida albicans</em> is a serious health problem, and as drug resistance worsens, new sources for therapeutic compounds are needed. Traditional Chinese medicine represents a wealth of such sources, and can be designed as suppositories for the treatment of recurrent vulvovaginal candidiasis (RVVC). This study aimed to develop a Pulsatilla suppository containing the n-butanol extract of Pulsatilla decoction (BEPD) to treat RVVC. A Pulsatilla suppository containing BEPD was prepared, and its performance, weight, drug content, dissolution time and percentage, stability, toxicology, and pharmacodynamics were evaluated. Biological compatibility tests and clinical evaluations were performed in female Sprague–Dawley rats. The Pulsatilla suppository melted completely within 30 min. In vitro anti-<em>C. albicans</em> activity, stability changes, and toxicology tests indicated stability and safety in the rats. Compared with RVVC model rats, high-dose BEPD suppository (40, 60 mg/kg) can significantly reduce the vaginal fungal load of rats, relieve neutrophil infiltration, reduce the content of TLR/MyD88 pathway-related proteins, and reduce the expression of inflammatory factors such as NLRP3, demonstrating the efficacy of the Pulsatilla suppository in RVVC.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"179 ","pages":"Article 106250"},"PeriodicalIF":2.5,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142461356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aculeaquamides B and C, two new paraherquamides from the co-culture of Aspergillus aculeatinus WHUF0198 and Penicillium sp. DM27 Aculeaquamides B 和 C，两种新的对位喹酰胺，来自黑曲霉 WHUF0198 和青霉 DM27 的共培养。

IF 2.5 3区医学

Fitoterapia Pub Date : 2024-10-18 DOI: 10.1016/j.fitote.2024.106251

Philomina Panin Edjah , Mao-Fang Lu , Wei-Chen Chen , Jun Wu , Yu-Ting Zhong , Mu Li , Qi Chen , Kong-Kai Zhu , Rui-Ying Yuan , Wei-Xin Tao , Ke-Jia Wu , You-Sheng Cai

引用次数: 0

Herbal drugs in chronic venous disease treatment: An update 慢性静脉疾病治疗中的草药：最新进展。

IF 2.5 3区医学

Fitoterapia Pub Date : 2024-10-16 DOI: 10.1016/j.fitote.2024.106256

Tímea Bencsik , Viktória Lilla Balázs , Ágnes Farkas , Eszter Csikós , Adrienn Horváth , Kamilla Ács , Marianna Kocsis , Martin Doseděl , Silvia Bittner Fialová , Szilvia Czigle , Milan Nagy , Jaroslav Tóth , Michele Protti , Laura Mercolini , Přemysl Mladěnka , József Szentpéteri , Györgyi Horváth

{"title":"Herbal drugs in chronic venous disease treatment: An update","authors":"Tímea Bencsik , Viktória Lilla Balázs , Ágnes Farkas , Eszter Csikós , Adrienn Horváth , Kamilla Ács , Marianna Kocsis , Martin Doseděl , Silvia Bittner Fialová , Szilvia Czigle , Milan Nagy , Jaroslav Tóth , Michele Protti , Laura Mercolini , Přemysl Mladěnka , József Szentpéteri , Györgyi Horváth","doi":"10.1016/j.fitote.2024.106256","DOIUrl":"10.1016/j.fitote.2024.106256","url":null,"abstract":"<div><div>The prevalence of chronic venous disease (CVD) is relatively high, it affects 20–80 % of the population worldwide. CVD may affect any veins in the human body, however, the veins of the lower extremities are the most susceptible to this condition. Among therapeutic possibilities for CVD, mainly chronic venous insufficiency, some medicinal plants (<em>Ruscus aculeatus</em> L., <em>Aesculus hippocastanum</em> L., <em>Centella asiatica</em> (L.) Urb.) and their active compounds (ruscoside, aescin, asiaticoside) or close derivatives also have important places. This review describes shortly the updated knowledge on pathophysiology, clinical manifestations, evaluation, and diagnostics of CVD as well as treatment modalities. The primary focus of this review is on the existing knowledge about botanical medications for treating chronic venous disease (CVD). It covers the chemical makeup of these plant drugs, their pharmacological effects, results from clinical trials involving humans, and any associated safety concerns.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"179 ","pages":"Article 106256"},"PeriodicalIF":2.5,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142461354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Six new phenolic glycosides from the roots of Scrophularia ningpoensis 从宁波黄芩根中提取的六种新的酚苷。

IF 2.5 3区医学

Fitoterapia Pub Date : 2024-10-16 DOI: 10.1016/j.fitote.2024.106258

You-Chen Li , Peng Liu , Ying-Ying Su , Chang Xu , Meng Sun , Wei Zhang , Bin Liu

引用次数: 0

Hermansones A and B: Bioactive naphthazarin congeners from the European crust fungus Hermanssonia centrifuga Hermansones A 和 B：欧洲结壳真菌 Hermanssonia centrifuga 中具有生物活性的萘甲萘嗪同系物。

IF 2.5 3区医学

Fitoterapia Pub Date : 2024-10-16 DOI: 10.1016/j.fitote.2024.106261

Winnie Chemutai Sum , Sherif S. Ebada , Jackson M. Muema , Harald Kellner , Attila Mándi , Tibor Kurtán , Marc Stadler

引用次数: 0

Chemical structures of polyketides and alkaloids isolated from a culture of fungus Curvularia moringae 从 Curvularia moringae 真菌培养物中分离出的多酮类化合物和生物碱的化学结构。

IF 2.5 3区医学

Fitoterapia Pub Date : 2024-10-16 DOI: 10.1016/j.fitote.2024.106263

Takahiro Matsumoto , Miho Hamai , Yayako Inui , Tomoe Ohta , Tatsusada Yoshida , Naoto Kojima , Hayato Yoshikawa , Raku Kutose , Shiori Ando , Tetsushi Watanabe

引用次数: 0

Polyphenols with anti-inflammatory activity isolated from the whole herbs of Delphinium forrestii var. Viride 从蕨类植物 Delphinium forrestii var. Viride 的全草中分离出的具有抗炎活性的多酚

IF 2.5 3区医学

Fitoterapia Pub Date : 2024-10-15 DOI: 10.1016/j.fitote.2024.106259

Yang Xu , Zhiqi Zhang , Bin Liu , Dejuan Sun , Hua Li , Lixia Chen

{"title":"Polyphenols with anti-inflammatory activity isolated from the whole herbs of Delphinium forrestii var. Viride","authors":"Yang Xu , Zhiqi Zhang , Bin Liu , Dejuan Sun , Hua Li , Lixia Chen","doi":"10.1016/j.fitote.2024.106259","DOIUrl":"10.1016/j.fitote.2024.106259","url":null,"abstract":"<div><div><em>Delphinium</em> belongs to Ranunculaceae, which is widely distributed in Northwest China. In folk, this genus of plants has analgesic, anti-inflammatory, and insecticidal effects. By studying non-alkaloid components in the whole herbs of <em>Delphinium forrestii</em>, we obtained a total of 11 compounds (<strong>1</strong>−<strong>11</strong>), including five new (<strong>1</strong>–<strong>5</strong>) and six known polyphenols (<strong>6</strong>–<strong>11</strong>). On the basis of chemical evidences and spectral data analysis (UV, Optical rotation data, 1D/2D-NMR and HR-ESI-MS), the structures of new compounds were elucidated. The inhibitory effect of compounds <strong>1</strong>–<strong>11</strong> on lipopolysaccharide (LPS) induced NO production in RAW 264.7 cells was detected. Compounds <strong>4</strong> and <strong>11</strong> showed significant inhibitory effects. This study indicated the presence of compounds with good anti-inflammatory activity among non-alkaloid components in the whole herbs of <em>Delphinium forrestii</em>.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"179 ","pages":"Article 106259"},"PeriodicalIF":2.5,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142445992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0