Fitoterapia最新文献

{"title":"Sesquiterpenes from the fruits of Piper longum L. and their anti-inflammatory activity","authors":"Guanghui Gou ,&nbsp;Nannan Xu ,&nbsp;Hongliang Li ,&nbsp;Jun Li ,&nbsp;Haji Akber Aisa","doi":"10.1016/j.fitote.2024.106260","DOIUrl":"10.1016/j.fitote.2024.106260","url":null,"abstract":"<div><div>The fruits of <em>Piper longum</em> are called long pepper, which are well-known culinary spice as well as traditional medicine. In present work, thirteen sesquiterpenes including four undescribed compounds were isolated from <em>P. longum</em> fruits. Compound <strong>1</strong> was a rare methylated bisabolane-type sesquiterpene. Compounds (−)-<strong>3</strong> and (+)-<strong>3</strong> were a pair of enantiomers of an uncommon humulane which were separated by chiral HPLC. The absolute configurations of compounds <strong>1</strong>–<strong>3</strong> were confirmed through the means of spectroscopic data analyses, ¹³C NMR calculations employing DP4+ probability analyses, and ECD calculations. Compounds <strong>2</strong> and <strong>11</strong> presented moderated inhibitory effect on the NO release in LPS-induced RAW264.7 cells with IC₅₀ values of 30.65 ± 0.90 and 38.48 ± 2.42 <em>μ</em>M, respectively. Above results enriched the chemical information of <em>P. longum</em> fruits, and meanwhile provided scientific evidences for the anti-inflammatory function of <em>P. longum</em> fruits.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"179 ","pages":"Article 106260"},"PeriodicalIF":2.5,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142461363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chemical constituents from the rhizomes of Paris xuefengshanensis","authors":"Ying-Li Yang ,&nbsp;Xue Bai ,&nbsp;Xing-Zhi Yang ,&nbsp;Ji-Feng Luo ,&nbsp;Xiao-Yan Duan ,&nbsp;Dong-Bao Hu ,&nbsp;Jun Yang ,&nbsp;Yue-Hu Wang","doi":"10.1016/j.fitote.2024.106257","DOIUrl":"10.1016/j.fitote.2024.106257","url":null,"abstract":"<div><div>Five new steroidal saponins, xuefengshanosides A–E; one new stilbene trimer, xuefengshansin; and 16 known compounds were isolated from the rhizomes of <em>Paris xuefengshanensis</em> (Melanthiaceae). The chemical structures of the compounds were elucidated by MS and NMR data analyses, ECD calculations, and acidic hydrolysis experiments. The cytotoxicity and antimicrobial activities of the selected compounds were evaluated. Ophiopogonin C′, paris saponin I, paris saponin H, and paris saponin VII showed the most inhibitory activity against five human cancer cell lines and one normal cell line. Xuefengshansin showed weak cytotoxic and antibacterial activities. Paris saponin I was the most active compound against the five tested fungal strains. This species contains structurally diverse compounds that exhibit significant anticancer and antimicrobial activities, suggesting its potential for future development and utilization.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"179 ","pages":"Article 106257"},"PeriodicalIF":2.5,"publicationDate":"2024-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142461361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antitrypanosomal activity of Crossopteryx febrifuga and phytochemical profiling using LC-MS/MS analysis coupled to molecular network and SIRIUS","authors":"Esaïe Tchetan ,&nbsp;Sergio Ortiz ,&nbsp;Pascal Abiodoun Olounladé ,&nbsp;Erick Virgile Bertrand Azando ,&nbsp;Claire Avril ,&nbsp;Dominique Demblon ,&nbsp;Sylvie Mawule Hounzangbe-Adote ,&nbsp;Fernand Ahokanou Gbaguidi ,&nbsp;Joëlle Quetin-Leclercq","doi":"10.1016/j.fitote.2024.106255","DOIUrl":"10.1016/j.fitote.2024.106255","url":null,"abstract":"<div><div><em>Crossopteryx febrifuga</em> (Rubiaceae) is a plant widely used in traditional African medicine to treat tryapnosomiasis. The aim of our study was to evaluate the antitrypanosomal activity of <em>C. febrifuga</em> extracts and to identify the compounds responsible for this activity. We prepared 4 extracts by successive maceration of plant leaf powder in <em>n-hexane</em>, dichloromethane, methanol and water. The antitrypanosomal activity of the extracts was assessed on <em>Trypanosoma brucei brucei</em> and their selectivity on <em>Leishmania mexicana mexicana</em> and human non cancer WI38 fibroblast cells. The dichloromethane extract, the most antitrypanosomal (IC₅₀ of 9.3 ± 0.8 μg/mL) was fractionated on an Open Column Chromatography to give 14 fractions. Fractions 6–9 were the most active with an IC₅₀ ranging from 1.3 to 2.1 μg/mL. All fractions were analyzed by UPLC-ZenoTOFHRMS, followed by manual dereplication of metabolites detected in the most active fractions. Manual dereplication was aided by the Molecular Network (MN) and SIRIUS. Metabolic profiling of fractions 6–9 has enabled us to identify 33 compounds, most of which were reported for the first time in <em>C. febrifuga</em>. These include buddlenol C (<strong>6</strong>), naringenin (<strong>7</strong>), maslinic acid (<strong>22</strong>), corosolic acid or isomer (<strong>24</strong>), asperphenamate (<strong>25</strong>), hydroxyoctadecenoic acid (<strong>29</strong>), sumaresinolic acid or isomer I and II (<strong>30</strong> and <strong>31</strong>), glycyrrhetinic acid (<strong>32</strong>) and oleanolic acid (<strong>36</strong>). The bioactivity-based approach identified maslinic (<strong>22</strong>), corosolic (<strong>24</strong>), and oleanolic (<strong>36</strong>) acids as linked to the antitrypanosomal activity. The data obtained support the traditional use of <em>C. febrifuga</em> in the traditional treatment of trypanosomiasis. Further studies are required to verify the activity observed <em>in vivo</em>.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"179 ","pages":"Article 106255"},"PeriodicalIF":2.5,"publicationDate":"2024-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142461359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ginseng fruit rare saponins (GFRS) improved inflammatory response: In vitro and in vivo assessment","authors":"Yifei Zheng ,&nbsp;Hongyan Tan ,&nbsp;Jiayi Chai ,&nbsp;Linlin Han ,&nbsp;Changzhen Zhai ,&nbsp;Jungjoon Lee ,&nbsp;Xiaomin Li ,&nbsp;Yuqing Zhao","doi":"10.1016/j.fitote.2024.106244","DOIUrl":"10.1016/j.fitote.2024.106244","url":null,"abstract":"<div><div>Inflammation is the body's protective immune response to tissue damage. Ginseng has a long history of medicinal use, and its active ingredient ginsenosides have anti-inflammatory effects. Ginseng fruit rare saponins (GFRS) is a transformation product of ginseng saponins and rich in a variety of rare saponins. We used HPLC-DAD method to study GFRS rare saponins with ginsenoside F4, <em>R</em>-Rg₃, <em>S</em><img>Rg₃, Rk₁, Rg₆, Rg₅, Rk₃ and Rh₄. However, there is no study on the use of GFRS to reduce skin inflammation. This study enriched the action pathway of GFRS through network pharmacology and revealed the anti-inflammatory effect of GFRS for the first time. <em>In vitro</em> experiments showed that GFRS could significantly reduce the release of NO in lipopolysaccharide (LPS) -induced RAW264.7 cells and HaCaT cells, and reduce the secretion and expression of inflammation-related factors Interleukin-6 (IL-6), Tumor necrosis factor-α (TNF-α) and Interleukin-17 A (IL-17 A), thereby reducing cell inflammatory damage. In the imiquimod (IMQ) -induced mouse inflammatory model, the therapeutic effect of GFRS on the pathogenesis of psoriasis-like dermatitis was studied. <em>In vivo</em> experiments showed that the skin erythema, scales, thickness and inflammatory infiltration of GFRS-treated mice were reduced, and the psoriasis area severity index score was significantly lower than that of IMQ group. GFRS restored IMQ-induced spleen size and reduced the secretion and expression of TNF-α, IL-6, Interferon-γ (IFN-γ) and IL-17 A in serum. In summary, our results demonstrate that GFRS alleviates IMQ-induced dermatitis symptoms, effectively reduces the secretion of inflammatory factors, and inhibits IL-17 A expression.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"179 ","pages":"Article 106244"},"PeriodicalIF":2.5,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142441539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lignans and phenols with potential anti-inflammatory effect from the stems of Mallotus paxii Pamp","authors":"Yan Huang ,&nbsp;Ping Hou ,&nbsp;Liwei Pan ,&nbsp;Jian Li ,&nbsp;Xiaoqin Liang ,&nbsp;Chenyang Ren ,&nbsp;Liuting Peng ,&nbsp;Chunqiu Gan ,&nbsp;Weifeng Xu ,&nbsp;Ruiyun Yang ,&nbsp;Jun Li ,&nbsp;Xinlan Guan","doi":"10.1016/j.fitote.2024.106253","DOIUrl":"10.1016/j.fitote.2024.106253","url":null,"abstract":"<div><div>Phytochemical investigation of the stems of <em>Mallotus paxii</em> Pamp. led to the isolation and identification of four new compounds, including three neolignans (<strong>1</strong>–<strong>3</strong>) and one phenol (<strong>13</strong>), along with eight known neolignans (<strong>4</strong>–<strong>12</strong>) and one known phenol (<strong>14</strong>). Their structures were determined by spectroscopic methods, including NMR, MS and ECD analyses. Bioassay demonstrated that malloapelin A (<strong>4</strong>) exhibited a most potent anti-inflammatory activity to NO release with IC₅₀ value of 21.32 μM. Furthermore, malloapelin A (<strong>4</strong>) markedly decreased the secretion of TNF-<em>α</em>, iNOS, and NF-<em>κ</em>B and inhibited the expression of COX-2 and NF-<em>κ</em>B/p65 in LPS-induced RAW264.7 cells in a dose-dependent manner.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"179 ","pages":"Article 106253"},"PeriodicalIF":2.5,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142445991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of morroniside isolated from Cornus officinalis fruits on functional gastrointestinal disorders and gastric ulcer in mice","authors":"Yoshiyuki Kimura ,&nbsp;Masahiko Taniguchi","doi":"10.1016/j.fitote.2024.106249","DOIUrl":"10.1016/j.fitote.2024.106249","url":null,"abstract":"<div><div>The dried fruits of <em>Cornus officinalis</em> (Cornaceae) are used in Kampo medicine (e.g. Hachimigan and Goshajinkigan) to treat senile osteoporosis, diabetes, gastric atony, frequent urination, and diarrhea/constipation associated with aging. The present study investigated the effects of a <em>C. officinalis</em> fruit extract and morroniside, an iridoid compound from isolated these fruits, on the reduction in gastric emptying small intestinal motility caused by 5-hydroxytryptamine (5-HT) and 1-(3-chlorophenyl) biguanide (5-HT₃ receptor agonist), and gastric ulcers induced by 150 or 75 mM HCl/90 % EtOH (HCl-EtOH) and/or 5-HT in mice. <em>C. officinalis</em> extract (500 mg/kg) and morroniside (20 and 50 mg/kg) suppressed the reduction in gastric emptying induced by 5-HT- and 5-HT₃ agonist. <em>C. officinalis</em> extract, morroniside and 5-HT₃ receptor antagonist (ramosetron) attenuated 5-HT-induced diarrhea. Furthermore, morroniside (20 and 50 mg/kg) prevented EtOH/HCl-induced gastric ulcers and those caused by 5-HT. Morroniside (20 and 50 mg/kg) attenuated elevations in the plasma levels of corticosterone, corticotropin-releasing factor (CRF), and adrenocorticotropic hormone (ACTH) in 75 mM HCl/90 % EtOH- and 5-HT-treated mice. The results obtained herein suggest the potential of morroniside as an effective treatment for irritable bowel syndrome, such as diarrhea and functional dyspepsia (reductions in gastric emptying and small intestinal motility), caused by 5-HT. The present study suggests a role for morroniside in the regulation of elevations in CRF, ACTH, and corticosterone levels through hypothalamic-pituitary-adrenal axis activity induced by stress loading, such as a 5-HT treatment and/or HCl/EtOH stimulation.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"179 ","pages":"Article 106249"},"PeriodicalIF":2.5,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142461352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acremochlorin S and other prenylated chlorophenol antimicrobial metabolites from the fungus Acremonium sp. Strain MNA-F-1","authors":"Mohamed S. Elnaggar ,&nbsp;Nada M. Mostafa ,&nbsp;Ahmed M. Elissawy ,&nbsp;Kunthida Phutthacharoen ,&nbsp;Paul Eckhardt ,&nbsp;Birthe Sandargo ,&nbsp;Lasse van Geelen ,&nbsp;Sherif S. Ebada ,&nbsp;Till Opatz ,&nbsp;Abdel Nasser B. Singab ,&nbsp;Rainer Kalscheuer","doi":"10.1016/j.fitote.2024.106254","DOIUrl":"10.1016/j.fitote.2024.106254","url":null,"abstract":"<div><div>Chemical prospection for the mycelial extract of the fungus <em>Acremonium</em> sp. Strain MNA-F-1, derived from the inner tissue of anise roots (<em>Pimpnella anisum</em> L., family Apiaceae), led to the isolation and characterization of one previously undescribed natural product, acremochlorin S (<strong>1</strong>), together with five related derivatives (<strong>2</strong>–<strong>6</strong>) and an alkaloidal metabolite, ilicicolin H (<strong>7</strong>). Structure elucidation of the isolated compounds was determined through comprehensive 1D/2D NMR spectroscopic analyses and HR-ESI-MS measurements. The absolute configuration of acremochlorin S (<strong>1</strong>) was concluded based on the comparison of its experimental and calculated electronic circular dichroism (ECD) spectra implementing Time-dependent density functional theory (TDDFT). All isolated compounds were assessed for their antibacterial activity against <em>Staphylococcus aureus</em>, <em>Escherichia coli</em> and <em>Mycobacterium tuberculosis</em>, where several compounds revealed potent activities against tested Gram-positive strains.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"179 ","pages":"Article 106254"},"PeriodicalIF":2.5,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142441540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioactivities of Sargassum elegans, Bryopsis myosuroides, Callophyllis variegata seaweeds on diabetes and obesity-related biochemical parameters: A comparative in vitro study","authors":"S'thandiwe N. Magwaza ,&nbsp;Kolawole A. Olofinsan ,&nbsp;Almahi I. Mohamed ,&nbsp;Balaji Meriga ,&nbsp;Md. Shahidul Islam","doi":"10.1016/j.fitote.2024.106252","DOIUrl":"10.1016/j.fitote.2024.106252","url":null,"abstract":"<div><div>Diabesity’ is the occurrence of diabetes in the presence of obesity. Numerous reports have shown that seaweeds possess beneficial biological activities. This study assessed the effects of three seaweeds <em>Bryopsis myosuroides</em> (green)<em>, Callophyllis variegata</em> (red), and <em>Sargassum elegans</em> (brown)<em>,</em> on diabetes and obesity-related parameters <em>in vitro</em>. The antioxidant potential, carbohydrate and lipid digestive enzyme inhibitory activity, and glucose uptake activities of ethanolic and sulphated polysaccharides (SPs) rich extracts were evaluated. The SP-rich or ethanolic extracts of <em>S. elegans</em> showed the greater inhibition of 2,2-diphenyl-1-picrylhydrazyl (DPPH) (IC₅₀ 46.6 ± 1.00 g/mL), hydroxyl radical (OH<img>) (IC₅₀ 353.70 ± 2.01 μg/mL), and nitric oxide (NO) (IC₅₀ 407.5 ± 0.95 μg/mL) compared to other seaweeds. Moreover, the SP-rich extract of <em>S. elegans</em> exhibited higher inhibition of α- glucosidase (IC₅₀ 123.8 ± 1.69 μg/mL), whereas <em>B. myosuroides</em> SP-rich extract had better α-amylase (IC₅₀ 55.7 ± 0.98 μg/mL) and pancreatic lipase inhibitory activities (IC₅₀ 481.1 ± 0.9 μg/mL) compared to other seaweeds. Liquid Chromatography Mass Spectroscopy (LC-MS) was used to identify the compounds present in the seaweed extracts. These include Taxifolin, Amentoflavone-7,4′,4″‘-Trimethyl Ether, Chrysophenol, and Glucotropaeolin, which have been previously reported to possess biological activities beneficial to human health. Although all three seaweeds evaluated in this study demonstrated antioxidant, digesting enzyme inhibitory and glucose uptake activity to different extents, <em>S. elegans</em> (brown) depicted the highest activity in most assays compared to the other seaweeds. However, further research is required to assess the effects of these seaweed extracts on diabetes and obesity <em>via ex vivo</em> and <em>in vivo</em> experimental animal models.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"179 ","pages":"Article 106252"},"PeriodicalIF":2.5,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142461360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DMOA-derived polycyclic meroterpenoids with antiviral activities from the deep-sea-derived fungus Penicillium pancosmium A6A","authors":"Ziming Chen ,&nbsp;Yinghui Lv ,&nbsp;Zhuhua Luo ,&nbsp;Bihong Hong ,&nbsp;Siwen Niu","doi":"10.1016/j.fitote.2024.106248","DOIUrl":"10.1016/j.fitote.2024.106248","url":null,"abstract":"<div><div>Two undescribed 3,5-dimethylorsellinic acid (DMOA) derived meroterpenoids, namely pancosterpenoids A (<strong>1</strong>) and B (<strong>2</strong>), were discovered from the EtOAc extract of the deep-sea sediment-derived fungus <em>Penicillium pancosmium</em> A6A. The gross structures were established by detailed analysis of the spectroscopic data (NMR and HRESIMS spectra), while their absolute configurations were resolved by comparing the experimental and calculated ECD data as well as X-ray single crystal diffraction analysis. Pancosterpenoid A (<strong>1</strong>) was the first representative of DMOA-derived meroterpenoids possessing a 6/6/6/5/5 pentacyclic system, while pancosterpenoid B (<strong>2</strong>) belongs to a class of rare 13-nor-citreohybridone meroterpenoids. Two metabolites were evaluated the antiviral effects against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) trVLP pseudovirus. As a result, compounds <strong>1</strong> and <strong>2</strong> showed moderately inhibitory activities with IC₅₀ values of 22.37 and 18.12 μM, respectively.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"179 ","pages":"Article 106248"},"PeriodicalIF":2.5,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142461362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Apocarotenoids from the fresh roots of Rehmannia glutinosa and their anti-pulmonary fibrosis activity","authors":"Xiang-Da Li ,&nbsp;Yan-Gang Cao ,&nbsp;Yu-Han Zhang ,&nbsp;Ying-Jie Ren ,&nbsp;Meng-Nan Zeng ,&nbsp;Yan-Ling Liu ,&nbsp;Xu Chen ,&nbsp;Xin-Yi Ma ,&nbsp;Bing-Xian Zhao ,&nbsp;Xiao-Ke Zheng ,&nbsp;Wei-Sheng Feng","doi":"10.1016/j.fitote.2024.106247","DOIUrl":"10.1016/j.fitote.2024.106247","url":null,"abstract":"<div><div>Six undescribed compounds (<strong>1</strong>–<strong>6</strong>) and twenty-three known analogues (<strong>7</strong>–<strong>29</strong>) were isolated from the fresh roots of <em>Rehmannia glutinosa</em>. The structures of the compounds (<strong>1</strong>–<strong>29</strong>) were established through the application of spectroscopic analysis. Compounds <strong>3</strong>, <strong>4</strong>, <strong>6</strong>, <strong>8</strong>, <strong>13</strong>, <strong>18</strong>, <strong>21</strong>, <strong>22</strong>, <strong>25</strong>, and <strong>28</strong> exhibited excellent anti-pulmonary fibrosis activity. The potential mechanistic pathway of <strong>3</strong> was also investigated, whose results indicate that compound <strong>3</strong> ameliorate TGF-β1 induced BEAS-2B cell injury via PI3K/AKT/NF-κB signaling pathway.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"179 ","pages":"Article 106247"},"PeriodicalIF":2.5,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142432574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}