乌头的二萜类生物碱。它们的抗炎活性

IF 2.5 3区医学 Q3 CHEMISTRY, MEDICINAL

Fitoterapia Pub Date : 2025-04-21 DOI:10.1016/j.fitote.2025.106553

Chengfeng Gao , Man Zhu , Yang Xu , Yali Wang , Dejuan Sun , Hua Li , Lixia Chen

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引用次数: 0

摘要

乌头属植物地上部分的研究。鉴定出三种未描述的二萜类生物碱gymnaconitines H-J(1-3)，以及11种已知的类似物（4-14）。基于1D/2D NMR和hresms，成功确定了这些化合物的结构。此外，在脂多糖诱导的RAW264.7细胞中，评估了所有化合物对NO生成的抑制作用。值得注意的是，化合物1、3和6的IC50值分别为10.36±1.02 μM、12.87±1.11 μM和19.67±1.29 μM，具有明显的抑制作用。利用靶点筛选和分子对接技术，推测化合物1可能通过与Flamin-B结合发挥抗炎作用。

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Diterpenoid alkaloids from Aconitum gymnandrum Maxim. and their anti-inflammatory activity

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Diterpenoid alkaloids from Aconitum gymnandrum Maxim. and their anti-inflammatory activity

Research on the aerial parts of Aconitum gymnandrum Maxim. led to identifying three undescribed diterpenoid alkaloids gymnaconitines H-J (1–3), along with eleven known analogues (4–14). Based on 1D/2D NMR and HRESIMS, the structures of these compounds were successfully determined. Additionally, the inhibitory effects of all compounds on NO production were evaluated in lipopolysaccharide-induced RAW264.7 cells. It is noteworthy that compounds 1, 3 and 6 demonstrated significant inhibitory effects, showing IC₅₀ values of 10.36 ± 1.02 μM, 12.87 ± 1.11 μM, and 19.67 ± 1.29 μM, respectively. Using target screening and molecular docking technology, it is hypothesized that compound 1 may play an anti-inflammatory role by combining with Flamin-B.

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来源期刊

Fitoterapia 医学-药学

CiteScore

5.80

自引率

2.90%

发文量

198

审稿时长

1.5 months

期刊介绍： Fitoterapia is a Journal dedicated to medicinal plants and to bioactive natural products of plant origin. It publishes original contributions in seven major areas: 1. Characterization of active ingredients of medicinal plants 2. Development of standardization method for bioactive plant extracts and natural products 3. Identification of bioactivity in plant extracts 4. Identification of targets and mechanism of activity of plant extracts 5. Production and genomic characterization of medicinal plants biomass 6. Chemistry and biochemistry of bioactive natural products of plant origin 7. Critical reviews of the historical, clinical and legal status of medicinal plants, and accounts on topical issues.