黄芪叶中8个新的三萜皂苷邦吉及其神经保护作用

IF 2.5 3区医学 Q3 CHEMISTRY, MEDICINAL

Fitoterapia Pub Date : 2025-04-19 DOI:10.1016/j.fitote.2025.106559

Wen-xiang Xu , Zhen-yun Liu , Qing-yue Bu , Peng Jiang , Yi-qiang Zhang , Yu-meng Luo , Wei Guan , Xiao-chi Ma , Meng-meng Li , Qing-shan Chen , Li-li Zhang , Hai-xue Kuang , Bing-you Yang , Yan Liu

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引用次数: 0

摘要

从黄芪叶的70%乙醇溶液中分离得到8个新的三萜皂苷，命名为黄七叶皂苷IV ~ XI（1-8）和3个先前鉴定的化合物（9-11）。邦吉。这些化合物是通过各种柱层析技术分离出来的，包括那些使用硅胶，ODS和制备液相色谱的技术。通过综合光谱分析，包括1D和2D-NMR， hremsims和IR，以及与现有文献的比较，对它们的结构进行了阐明。此外，用d -半乳糖刺激HT22细胞，评估所有分离化合物的神经保护潜力。结果表明，化合物3和7-9具有显著的神经保护作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Eight new triterpenoid saponins from the leaves of Astragalus membranaceus (Fisch.) Bunge and their neuroprotective effects

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Eight new triterpenoid saponins from the leaves of Astragalus membranaceus (Fisch.) Bunge and their neuroprotective effects

Eight new triterpenoid saponins, named huangqiyesaponin IV to XI (1–8), along with three previously identified compounds (9–11), were isolated from the 70 % ethanol solution of the leaves of Astragalus membranaceus (Fisch.) Bunge. These compounds were isolated through various column chromatography techniques, including those using silica gel, ODS, and preparative liquid chromatography. Their structures were elucidated based on comprehensive spectral analyses, including 1D and 2D-NMR, HRESIMS, and IR, as well as comparisons with existing literature. Additionally, HT22 cells stimulated with D-galactose were employed to assess the neuroprotective potential of all isolated compounds. The findings revealed that compounds 3 and 7–9 demonstrated notable neuroprotective effects.

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来源期刊

Fitoterapia 医学-药学

CiteScore

5.80

自引率

2.90%

发文量

198

审稿时长

1.5 months

期刊介绍： Fitoterapia is a Journal dedicated to medicinal plants and to bioactive natural products of plant origin. It publishes original contributions in seven major areas: 1. Characterization of active ingredients of medicinal plants 2. Development of standardization method for bioactive plant extracts and natural products 3. Identification of bioactivity in plant extracts 4. Identification of targets and mechanism of activity of plant extracts 5. Production and genomic characterization of medicinal plants biomass 6. Chemistry and biochemistry of bioactive natural products of plant origin 7. Critical reviews of the historical, clinical and legal status of medicinal plants, and accounts on topical issues.