Fitoterapia最新文献_第10页

The mechanistic role of Poria cocos in cancer treatment: Antitumor activity and adjuvant potential in chemotherapy 茯苓在癌症治疗中的作用机制：抗肿瘤活性和化疗的辅助作用。

IF 2.6 3区医学

Fitoterapia Pub Date : 2026-01-01 Epub Date: 2025-12-04 DOI: 10.1016/j.fitote.2025.107016

Joanna Japhet Tibenda , Qian Gu , Shuai Duan , Chuang Song , Yuhua Du , Xiaofang Huang , Jianjun Zhao , Yi Nan , Ling Yuan

{"title":"The mechanistic role of Poria cocos in cancer treatment: Antitumor activity and adjuvant potential in chemotherapy","authors":"Joanna Japhet Tibenda , Qian Gu , Shuai Duan , Chuang Song , Yuhua Du , Xiaofang Huang , Jianjun Zhao , Yi Nan , Ling Yuan","doi":"10.1016/j.fitote.2025.107016","DOIUrl":"10.1016/j.fitote.2025.107016","url":null,"abstract":"<div><div><em>Poria cocos</em> is a prominent traditional fungal medicine that has been utilized in China for over a millennium. Its major bioactive constituents include triterpenes and polysaccharides, along with other minor components such as steroids, histidine, choline, amino acids, and essential minerals, which exhibit diverse pharmacological mechanisms, including antitumor, antibacterial, immunomodulatory, anti-aging, antioxidant, anti-inflammatory, hepatoprotective, neuroprotective, and cardioprotective effects.</div><div>Globally, cancer remains a leading cause of mortality, accounting for approximately nine million deaths annually. Despite advances in current conventional therapies, complete tumor eradication remains elusive, and these treatments are often accompanied by severe adverse effects.</div><div>To comprehensively evaluate the therapeutic potential of <em>poria cocos</em>, publications from 2002 to 2025 were systematically reviewed from PubMed, Web of Science, ScienceDirect, and Google Scholar. This review elucidates the antitumor properties of <em>poria cocos</em> on various cancers, including lung, colorectal, breast, and gastric cancers. Furthermore, it highlights its adjuvant role in enhancing the efficacy of chemotherapeutic agents through multiple mechanisms, such as inhibition of cellular proliferation and metastasis, induction of apoptosis and cell cycle arrest, and modulation of immune, inflammatory, and oxidative signaling pathways.</div><div>Collectively, these findings demonstrate the promising antitumor and adjuvant potential of <em>poria cocos</em> in cancer therapy. Nevertheless, further investigations are required to determine optimal dosages, toxicity profiles, and clinical efficacy. Rigorous quality control, standardization, and well-designed clinical trials are essential to validate its safety and effective clinical application.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"188 ","pages":"Article 107016"},"PeriodicalIF":2.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145695894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phytochemical diversity, extraction techniques, and therapeutic potential of Erica species 埃里卡植物的化学多样性，提取技术和治疗潜力。

IF 2.6 3区医学

Fitoterapia Pub Date : 2026-01-01 Epub Date: 2025-12-04 DOI: 10.1016/j.fitote.2025.107011

Anfel Benmanseur , Abdelmalek Rezgui , Mustapha Tacherfiout , Widad Sobhi , Norbert M. Maier , Susanne K. Wiedmer

{"title":"Phytochemical diversity, extraction techniques, and therapeutic potential of Erica species","authors":"Anfel Benmanseur , Abdelmalek Rezgui , Mustapha Tacherfiout , Widad Sobhi , Norbert M. Maier , Susanne K. Wiedmer","doi":"10.1016/j.fitote.2025.107011","DOIUrl":"10.1016/j.fitote.2025.107011","url":null,"abstract":"<div><div>This review systematically examines the scientific literature on the genus Erica (heathers), with a focus on their phytochemical diversity and pharmacological potential. The objective is to critically analyze how extraction methods and species origin influence the profiles of bioactive compounds responsible for therapeutic effects. A comprehensive evaluation of phytochemical data is presented for widely studied species, including <em>Erica arborea</em>, <em>Erica andevalensis, Erica australis</em>, <em>Erica manipuliflora</em>, <em>Erica cinerea</em>, <em>Erica verticillata</em>, <em>Erica carnea</em>, <em>Erica scoparia</em>, <em>Erica spiculifolia</em>, <em>Erica multiflora</em>, and <em>Erica mannii</em>. Evidence indicates that extraction techniques and solvent polarity strongly affect the yield and diversity of secondary metabolites such as phenolic acids, flavonoids, and terpenoids, which are associated with antioxidant, anti-inflammatory, antimicrobial, diuretic, and anticancer activities. Importantly, this review highlights pronounced taxonomic and geographic sampling biases: most studies focus on European and Mediterranean Erica species, with very limited representation from Africa despite its exceptional species richness. These findings emphasize the need to optimize extraction protocols and expand research to underrepresented taxa. Overall, this synthesis underscores the therapeutic promise of Erica species and provides a foundation for future drug discovery efforts guided by phytochemical characterization and bioactivity screening.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"188 ","pages":"Article 107011"},"PeriodicalIF":2.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145695884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to “Anti-diabetic compounds from the seeds of Psoralea corylifolia” [Fitoterapia 139 (2019) 104373] “补骨脂种子抗糖尿病化合物”的勘误表[Fitoterapia 139(2019) 104373]。

IF 2.6 3区医学

Fitoterapia Pub Date : 2026-01-01 Epub Date: 2025-12-15 DOI: 10.1016/j.fitote.2025.107036

Gaohui Zhu, Yanhong Luo, Xuejiao Xu, Huijiao Zhang, Min Zhu

引用次数: 0

Unraveling the active ingredients and molecular mechanisms of Qinghua Changyan granule against irritable bowel syndrome with diarrhea: Effects on gut microbiota and glutamine transport via an integrative approach combining UHPLC-MS/MS and experimental verification 清肠炎颗粒抗肠易激综合征伴腹泻的有效成分及分子机制研究：UHPLC-MS/MS结合实验验证对肠道菌群及谷氨酰胺转运的影响

IF 2.6 3区医学

Fitoterapia Pub Date : 2026-01-01 Epub Date: 2025-10-30 DOI: 10.1016/j.fitote.2025.106960

Jiayu Yang , Yuchen Wang , Shirong Wang , Zikun Liu , Xiao Chen , Rong Jia , Jie Wang , Feixia Wang , Qin Yang , Li Tang , Weifeng Miao

{"title":"Unraveling the active ingredients and molecular mechanisms of Qinghua Changyan granule against irritable bowel syndrome with diarrhea: Effects on gut microbiota and glutamine transport via an integrative approach combining UHPLC-MS/MS and experimental verification","authors":"Jiayu Yang , Yuchen Wang , Shirong Wang , Zikun Liu , Xiao Chen , Rong Jia , Jie Wang , Feixia Wang , Qin Yang , Li Tang , Weifeng Miao","doi":"10.1016/j.fitote.2025.106960","DOIUrl":"10.1016/j.fitote.2025.106960","url":null,"abstract":"<div><div>Irritable bowel syndrome with diarrhea (IBS-D) is a prevalent functional gut disorder, with conventional treatments limited by incomplete symptom relief and side effects. Qinghua Changyan Granules (QHCYG), a traditional Chinese medicine, has clinical efficacy in treating IBS-D, though its molecular mechanisms are unclear. This study aimed to elucidate these mechanisms. Key components of QHCYG were identified via UHPLC-MS/MS and network pharmacology, with quercetin, kaempferol, luteolin, naringenin, and nobiletin confirmed as major active components. Pharmacodynamic results showed QHCYG significantly ameliorated IBS-D-related symptoms, including reduced fecal water content, diarrhea frequency, Bristol stool scale scores, and visceral hypersensitivity. Furthermore, QHCYG restored gut microbial diversity, increased the abundance of beneficial taxa (<em>Akkermansia</em>, <em>Bifidobacterium</em>) and decreased <em>Allobaculum</em> proportion; it also upregulated the expression of key intestinal barrier proteins, including zonula occludens-1 (ZO-1), epithelial cadherin (E-cadherin), catenin beta-1 (β-catenin), Claudin-1. Molecular docking indicated QHCYG's active components could bind to alanine-serine-cysteine-preferring transporter 2 (ASCT2), and QHCYG further elevated intestinal glutamine concentrations and ASCT2 expression. Notably, depletion of gut microbiota by antibiotics abolished all these therapeutic effects, confirming a microbiota-dependent mechanism. In conclusion, QHCYG alleviates IBS-D through restoring gut microbiota, enhancing intestinal barrier function, and promoting ASCT2-mediated glutamine transport, revealing a “Microbiota-Glutamine axis-Intestinal barrier” multi-target regulatory mechanism.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"188 ","pages":"Article 106960"},"PeriodicalIF":2.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145426473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Toonasonoids A-K, limonoids from Toona ciliata M. Roem, attenuate inflammatory response through mediating the PI3K/AKT/NF-κB pathway 香椿类A-K，香椿纤毛中的柠檬素，通过介导PI3K/AKT/NF-κB通路减轻炎症反应。

IF 2.6 3区医学

Fitoterapia Pub Date : 2026-01-01 Epub Date: 2025-11-01 DOI: 10.1016/j.fitote.2025.106962

Kang-Hong Zhao , Xu-Tong Fang , Jia-Le Deng , Hui-Lan Yue , Qiang-Qiang Shi

{"title":"Toonasonoids A-K, limonoids from Toona ciliata M. Roem, attenuate inflammatory response through mediating the PI3K/AKT/NF-κB pathway","authors":"Kang-Hong Zhao , Xu-Tong Fang , Jia-Le Deng , Hui-Lan Yue , Qiang-Qiang Shi","doi":"10.1016/j.fitote.2025.106962","DOIUrl":"10.1016/j.fitote.2025.106962","url":null,"abstract":"<div><div>Eleven previously undescribed limonoids, toonasonoids A-K (<strong>1−11</strong>), and a known semi-synthetic analogue (<strong>12</strong>) with three basic carbon skeletons, were isolated from the twigs of <em>Toona ciliata</em> M. Roem. Among them, compounds <strong>1–3</strong> possessed a six-membered <em>α,β</em>-unsaturated ketone moiety in ring A, <strong>4–9</strong> characterized with a seven-membered <em>α,β</em>-unsaturated lactone A-ring, and <strong>10–11</strong> featured ring B-<em>seco</em> and formed a B<em>′</em> tetrahydrofuran ring. The relative structures of the undescribed compounds were established via comprehensive spectroscopic analyses and NMR calculation united with DP4+ probability analysis, and their absolute configurations were assigned by ECD calculations. The cytotoxicity, anti-inflammatory, and the action mechanisms of these isolates on the PI3K/AKT/NF-κB signaling pathway were also evaluated. The results demonstrated that compounds <strong>1</strong>, <strong>3</strong>, <strong>8</strong>, and <strong>9</strong> effectively reduced nitric oxide (NO) release with IC<sub>50</sub> values ranging from 4.41 to 9.84 μM. Notably, compounds <strong>1</strong> and <strong>9</strong> could inhibit the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase 2 (COX-2), and block NF-κB (p65) nuclear translocation by triggering the PI3K/AKT pathway, indicating their considerable anti-inflammatory effects.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"188 ","pages":"Article 106962"},"PeriodicalIF":2.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145437871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In vitro anti-diabetic activities of phytochemicals isolated from Cornus officinalis fruits 山茱萸果实植物化学物质体外抗糖尿病活性研究。

IF 2.6 3区医学

Fitoterapia Pub Date : 2026-01-01 Epub Date: 2025-11-10 DOI: 10.1016/j.fitote.2025.106984

Zhi-you Hao , Xiao-lan Wang , Meng Yang , Shi-qi Zhou , Chao-yuan Xiao , Jun-yang Zhang , Shuang-shuang Xie , Meng Li , Yan-gang Cao , Yan-jun Sun , Xiao-ke Zheng , Wei-sheng Feng

{"title":"In vitro anti-diabetic activities of phytochemicals isolated from Cornus officinalis fruits","authors":"Zhi-you Hao , Xiao-lan Wang , Meng Yang , Shi-qi Zhou , Chao-yuan Xiao , Jun-yang Zhang , Shuang-shuang Xie , Meng Li , Yan-gang Cao , Yan-jun Sun , Xiao-ke Zheng , Wei-sheng Feng","doi":"10.1016/j.fitote.2025.106984","DOIUrl":"10.1016/j.fitote.2025.106984","url":null,"abstract":"<div><div>Four previously undescribed compounds, including two dihydroisocoumarin glycosides (<strong>1</strong> and <strong>2</strong>), a truxillic acid derivative (<strong>4</strong>), and a cadinane-type sesquiterpene (<strong>5</strong>), were isolated from the fruits of <em>Cornus officinalis</em> Sieb. et Zucc., along with seven known ones (<strong>3</strong>, <strong>6</strong>–<strong>11</strong>). Their chemical structures were determined by extensive spectroscopic methods and computational analyses. All isolated compounds were evaluated for the effects on glucose consumption in insulin-resistant (IR) HepG2 cells. The compounds exhibited no significant cytotoxicity at 10.0 μM in the CCK-8 assay. Compounds <strong>2</strong>, <strong>3</strong>, and <strong>8</strong> significantly increased glucose consumption (<em>P</em> < 0.05) at 5.0 and 10.0 μM. The 2-NBDG labeling indicated that compounds <strong>2</strong> and <strong>8</strong> significantly increased glucose uptake at 10 μM. Moreover, compounds <strong>2</strong> and <strong>8</strong> also significantly increased insulin receptor (INSR) expression, indicating their potential to upregulate the INSR in the cytomembrane and enhance glucose uptake.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"188 ","pages":"Article 106984"},"PeriodicalIF":2.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145503035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antimicrobial activity of naturally occurring tuliposides and tulipalins, and synthetic tulipalin analogs against bacterial and yeast strains 天然郁金香脂苷和郁金香素，以及合成郁金香素类似物对细菌和酵母菌株的抗菌活性。

IF 2.6 3区医学

Fitoterapia Pub Date : 2026-01-01 Epub Date: 2025-11-26 DOI: 10.1016/j.fitote.2025.107006

Yasuo Kato, Taiji Nomura

{"title":"Antimicrobial activity of naturally occurring tuliposides and tulipalins, and synthetic tulipalin analogs against bacterial and yeast strains","authors":"Yasuo Kato, Taiji Nomura","doi":"10.1016/j.fitote.2025.107006","DOIUrl":"10.1016/j.fitote.2025.107006","url":null,"abstract":"<div><div>Glucose esters of α-methylene-γ-hydroxybutyrates known as tuliposides (Pos) are accumulated in tulip and are enzymatically converted to bioactive tulipalins (Pa) by a carboxylesterase, a tuliposide-converting enzyme. Herein, we evaluated the antibacterial and anti-yeast activities of naturally occurring variants of Pos and Pa, along with synthetic Pa analogs, including ring-opened hydroxy acids of Pa (PaA/B-acids) and their methyl esters, predicted PaB degradation products, and ring-expanded analogs of Pa, by determining their half-maximal inhibitory concentration values through turbidimetric assays. To enhance compound stability during the assay, we developed a modified minimal medium. PaA-forming (A-type) Pos (6-PosA, 1-PosA, PosD, PosG, and PosK–M) and PaA showed little or no antibacterial activity, whereas PaB-forming (B-type) Pos (6-PosB and PosF) and PaB showed markedly higher activity. Among the PaA/B-acids and methyl esters, only PaB-acid methyl ester showed activity, likely because of its ability to form active PaB. All tested PaB degradation products and their analogs exhibited no antibacterial activity. The activity trend of the ring-expanded analogs of PaA/B was similar to that of A- or B-type analogs. In anti-yeast assays, both PaA and PaB displayed weak and comparable activities, suggesting different modes of action against bacteria and yeast. These results enhance our understanding of the natural roles and potential applications of Pos, Pa, and their analogs as antimicrobial agents.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"188 ","pages":"Article 107006"},"PeriodicalIF":2.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145631660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Amide alkaloids from Piper polysyphorum and their antifungal activities 红椒酰胺类生物碱及其抗真菌活性研究。

IF 2.6 3区医学

Fitoterapia Pub Date : 2026-01-01 Epub Date: 2025-11-08 DOI: 10.1016/j.fitote.2025.106981

Ling-Yan Liu , Fang Yue , Rui-Han Zhang , Ling Liu , Shan-Peng Xu , Chang Li , Yue-Hu Pei

引用次数: 0

Chemistry and biological properties of Ascaridole: A systematic review 蛔虫素的化学和生物学特性：系统综述。

IF 2.6 3区医学

Fitoterapia Pub Date : 2026-01-01 Epub Date: 2025-11-08 DOI: 10.1016/j.fitote.2025.106982

Andres Camilo Moreno Abadia, Simone Cristina Baggio Gnoatto

{"title":"Chemistry and biological properties of Ascaridole: A systematic review","authors":"Andres Camilo Moreno Abadia, Simone Cristina Baggio Gnoatto","doi":"10.1016/j.fitote.2025.106982","DOIUrl":"10.1016/j.fitote.2025.106982","url":null,"abstract":"<div><div>Ascaridole is an endoperoxide monoterpene with a distinctive peroxide bridge, predominantly sourced from <em>Dysphania ambrosioides</em>. This compound exhibits broad-spectrum biological activities including antiparasitic (antileishmanial, antimalarial, antitrypanosomal), anticancer, antimicrobial, and anti-inflammatory effects. Studies suggest that its mechanism of action involves ROS generation through peroxide group activation, which may induce oxidative stress and mitochondrial dysfunction <em>via</em> artemisinin-like pathways. Although its efficacy has been demonstrated in various experimental models, its therapeutic application faces limitations, mainly due to the scarcity of studies evaluating its activity as an isolated compound. Future investigations should prioritize rigorous preclinical and clinical studies using purified ascaridole to establish comprehensive safety profiles and validate its development as a therapeutic agent. This systematic review addresses the underexplored therapeutic potential of ascaridole by providing an integrated analysis of its chemical, phytochemical, and biological properties. The review synthesizes current knowledge, identifies existing research limitations, and outlines strategic perspectives for advancing ascaridole development as a novel therapeutic candidate.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"188 ","pages":"Article 106982"},"PeriodicalIF":2.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145488306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aloe Kanti, a natural anti-aging gel, modulates exogenous insult- and aging-induced aberrations in keratinocytes, dermal fibroblasts, melanocytes, and protects Caenorhabditis elegans from UVB photoaging 芦荟Kanti，一种天然抗衰老凝胶，调节外源性损伤和衰老诱导的角化细胞、真皮成纤维细胞、黑素细胞畸变，并保护秀丽隐杆线虫免受UVB光老化。

IF 2.6 3区医学

Fitoterapia Pub Date : 2026-01-01 Epub Date: 2025-11-19 DOI: 10.1016/j.fitote.2025.107000

Acharya Balkrishna , Vivek Gohel , Anushka Singh , Nishit Pathak , Meenu Tomer , Rishabh Dev , Anurag Varshney

{"title":"Aloe Kanti, a natural anti-aging gel, modulates exogenous insult- and aging-induced aberrations in keratinocytes, dermal fibroblasts, melanocytes, and protects Caenorhabditis elegans from UVB photoaging","authors":"Acharya Balkrishna , Vivek Gohel , Anushka Singh , Nishit Pathak , Meenu Tomer , Rishabh Dev , Anurag Varshney","doi":"10.1016/j.fitote.2025.107000","DOIUrl":"10.1016/j.fitote.2025.107000","url":null,"abstract":"<div><div>Chronological aging, exposure to ultraviolet radiation, and various environmental insults deteriorate structure and function of skin. Lack of proper skincare further augments skin aging and related disorders. The objective of current study was to investigate phytochemical composition and bioactivity of Aloe Kanti (Aloe K), an <em>Aloe vera</em>-based topical herbal skincare gel formulation. Chemical characterization of Aloe K was performed using UHPLC, GC-FID, UPLC/MS-QToF, and HPTLC analytical platforms. To decipher the molecular mechanisms of Aloe K, HaCaT, HDFa, and B16F10 cells were used as <em>in vitro</em> model. Additionally, photoaged (UVB-exposed) N2, TP12, and CF1553 strains of <em>Caenorhabditis elegans</em> were used as <em>in vivo</em> models. In HaCaT cell, Aloe K treatment significantly increased levels of GSH, catalase, SOD; and decreased release of IL-6, IL-8 cytokines. A decrease in activity of TNF-α, NF-κB, IL-1β, IFN-γ was also observed in the reporter cells. Compared to control, Aloe K treatment enhance migration of keratinocytes by 24.4 %, displayed a 43.6 % inhibition of AGEs formation, and enhanced collagen production in HDFa cells by 27.8 %. Further, in melanocytes, Aloe K significantly decreased enzyme activity of Tyrosinase and TRP2; and melanin biosynthesis. Additionally, Aloe K treatment decreased molecular markers of aging (SA-β-gal, ΔΨm) in HDFa cells. Anti-oxidant and anti-aging properties of Aloe K was also reflected in photoaged <em>C. elegans</em>. Aloe K treatment also modulated genes involved in cell proliferation, collagen production, and aging. Collectively, Aloe Kanti assimilates several molecular responses to act against signs of skin aging and could impart enhanced skin health.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"188 ","pages":"Article 107000"},"PeriodicalIF":2.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145573336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0