Fitoterapia最新文献

{"title":"Chemistry and bioactivity of marine algal toxins and their geographic distribution in China","authors":"Changrong Lai ,&nbsp;Xiaojun Dai ,&nbsp;Danmei Tian ,&nbsp;Songhui Lv ,&nbsp;Jinshan Tang","doi":"10.1016/j.fitote.2024.106193","DOIUrl":"10.1016/j.fitote.2024.106193","url":null,"abstract":"<div><p>Marine algal toxins are usually produced by some toxic algae during toxic algal blooms which can be accumulated in marine organisms through food chains, leading to contamination of aquatic products. Consumption of the contaminated seafood often results in poisoning in human being. Although algal toxins are harmful for human health, their unique structures and broad spectrum of biological activities have attracted widespread attention of chemists and pharmacologists. Marine algal toxins are not only a reservoir of biological active compound discovery, but also powerful tools for exploring life science. This review first provides a comprehensive overview of the chemistry and biological activities of marine algal toxins, with the aim of providing references for biological active compound discovery. Additionally, typical shellfish poisoning incidents occurred in China in the past 15 years and the geographical distribution of the marine algal toxins in China Sea are discussed, for the purpose of enhancing public awareness of the possible dangers of algal toxins.</p></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"178 ","pages":"Article 106193"},"PeriodicalIF":2.5,"publicationDate":"2024-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142072404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytochemical investigation of Chrysanthellum americanum Vatke and its constituents- a targeted approach for the treatment of leishmaniasis","authors":"Aneela Fayaz ,&nbsp;Muhammad Yousuf ,&nbsp;Abdoulaye Segda ,&nbsp;Atia-tul-Wahab ,&nbsp;Humaira Zafar ,&nbsp;Muhammad Kamran ,&nbsp;Roland Nâg-Tiéro Meda ,&nbsp;Yan Wang ,&nbsp;M. Iqbal Choudhary","doi":"10.1016/j.fitote.2024.106192","DOIUrl":"10.1016/j.fitote.2024.106192","url":null,"abstract":"<div><p>The present study is focused on the isolation and identification of new therapeutic candidates from <em>Chrysanthellum americanum</em> Vatke., and their efficacy against pteridine reductase-1 (PTR1), a valid chemotherapeutic target in the <em>Leishmania</em> parasite. Henceforth, a new compound, chrysanamerine (<strong>1</strong>), along with 7 known compounds, polyacetylene <strong>2</strong>, and flavonoids <strong>3</strong>–<strong>8</strong>, were isolated from <em>C. americanum</em>. Their structures were determined by chemical and spectroscopic analyses and compared with the reported spectroscopic data. All compounds were evaluated for their anti-leishmanial activity against PTR1 <em>via</em> biochemical mechanism-based assay. The <em>in vitro</em> results showed five potential hits including a new compound, chrysanamerine (<strong>1</strong>), and four known compounds against the PTR1 enzyme. Among them, compound <strong>1</strong> showed a potent enzyme inhibition with an IC₅₀ of 31.02 ± 2.36 μM, whereas a moderate inhibition was observed in cases of compounds <strong>5</strong> and <strong>6</strong> (IC₅₀ = 59.86 ± 3.32, and 45.32 ± 3.5 μM, respectively). Whereas, compounds <strong>3</strong> and <strong>8</strong> showed mild inhibition (IC₅₀ = 72.12 ± 1.12, and 97.18 ± 1.23 μM, respectively) against PTR1, compared with trimethoprim (positive control) (IC₅₀ = 21.07 ± 1.6 μM). Moreover, the results were further validated <em>via</em> molecular docking and molecular dynamics (MD) simulations. Compound <strong>1</strong> showed a strong affinity to the binding site with a docking score of −11.83, along with the formation of a stable protein-ligand complex over the trajectory of 100 ns. Besides, compounds <strong>1</strong>–<strong>8</strong> were found to be non-cytotoxic on BJ (human fibroblast) cells.</p></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"178 ","pages":"Article 106192"},"PeriodicalIF":2.5,"publicationDate":"2024-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142072405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction notice to “Beneficial effects of asiaticoside on cognitive deficits in senescence-accelerated mice” [Fitoterapia 87 (2013) 69–77].","authors":"Xing Lin ,&nbsp;Renbin Huang ,&nbsp;Shijun Zhang ,&nbsp;Ling Wei ,&nbsp;Lang Zhuo ,&nbsp;Xiaoyan Wu ,&nbsp;Aicun Tang ,&nbsp;Quanfang Huang","doi":"10.1016/j.fitote.2024.106191","DOIUrl":"10.1016/j.fitote.2024.106191","url":null,"abstract":"","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"178 ","pages":"Article 106191"},"PeriodicalIF":2.5,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0367326X24003745/pdfft?md5=fa5d7256fbe36687019e62625eedd6e0&pid=1-s2.0-S0367326X24003745-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142035628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structures, activities, and putative biosynthetic pathways of characteristic polyphenolic compounds from Morus plants: A review","authors":"Runjie Shi ,&nbsp;Shengzhi Liu ,&nbsp;Yu Zhao ,&nbsp;Wei Zhu ,&nbsp;Ping Wang ,&nbsp;Jingkui Tian","doi":"10.1016/j.fitote.2024.106181","DOIUrl":"10.1016/j.fitote.2024.106181","url":null,"abstract":"<div><p><em>Morus</em> plants played a pivotal role in ancient Chinese sericulture and silk production, which served as critical components of economy and culture. Besides, many parts of mulberry trees, including roots, leaves, stems, and fruits, hold various medicinal value, and have been utilized in traditional medicine for thousands of years. The chemical composition of mulberry has been reported in many literatures, while the characteristic compounds have not been systematically summarized. In this review, we focused on the polyphenolic compounds in mulberry, including flavonoids, 2-arylbenzofurans, and Diels–Alder (D–A) adducts, and summarized their structural features, structure-activity relationships, and potential biosynthetic pathways. The results revealed a characteristic class of 2′-hydroxylated flavonoids and stilbenes which played an important role in the biosynthesis of downstream 2-arylbenzofurans and D–A adducts in mulberry but had been overlooked by most studies. The prenylated modifications of different compounds were also discussed and their function as precursors of D–A adducts was emphasized. We also describe the effects of different modifications on biological activities. Besides, the chemical composition of <em>Morus</em> was most similar to that of <em>Artocarpus</em> in the Moraceae family in that they had almost identical characteristic compounds. Finally, a putative total biosynthetic pathway of D–A adducts in mulberry was proposed based on structure derivation and combination of verified reactions. This review contributes to the understanding of the biological activity and biosynthesis of the characteristic components of <em>Morus</em> plants.</p></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"178 ","pages":"Article 106181"},"PeriodicalIF":2.5,"publicationDate":"2024-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141999660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic effect of iridoid and xanthone glycosides components extracted from Swertia Mussotti on calculous cholecystitis and its clinical complications by targeting COX2","authors":"Hong-mei Li ,&nbsp;Tao Chen ,&nbsp;Li-xia Qian ,&nbsp;Shuo Wang ,&nbsp;Cheng Shen ,&nbsp;Liang-cheng Li ,&nbsp;Yu-lin Li","doi":"10.1016/j.fitote.2024.106189","DOIUrl":"10.1016/j.fitote.2024.106189","url":null,"abstract":"<div><p><em>Swertia Mussotti</em> is used as febrifuge, analgesic and to treat calculous cholecystitis, however, the underling mechanism remains unclear. This study investigates the therapeutic effect of the active fraction named iridoid and xanthone glycoside (IXG) extracted from <em>S. mussotii</em> on six animal models related to calculous cholecystitis and its complications, and to explore its potential target proteins. Four main compounds including swertiamarin (STR), sweroside (SRS), gentiopicroside (GPS) and mangiferin (MGR) were identified from the IXG by UHPLC-TOF-MS. The <em>in vivo</em> experiments results confirmed that IXG significantly decreased the level of total bilirubin (TBIL), direct bilirubin (DBIL) and cyclooxygenase-2 (COX2) in calculous cholecystitis. IXG treatment dramatically reduced the number of twists and the time of clicking foot in 2^nd phase induced by glacial acetic acid and formalin, however, no effect was showed on central pain established by hot plate test. IXG also significantly decreased the anal temperature induced by yeast and 2,4-dinitrophenol. These results indicated that IXG alleviate calculous cholecystitis and its clinical symptom. In addition, IXG suppressed the expression of Prostaglandin E2 (PGE2) <em>in vitro</em>. Mechanistically, COX2 was identified as the direct target of IXG in RAW264.7 cells, and downregulated the protein levels of COX2. The results confirmed that IXG ameliorates calculous cholecystitis and its clinical symptom (pain and fever) by suppressing the production of PGE2 through targeting COX2.</p></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"178 ","pages":"Article 106189"},"PeriodicalIF":2.5,"publicationDate":"2024-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141999661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Catechin and flavonoid glycosides from the Ulmus genus: Exploring their nutritional pharmacology and therapeutic potential in osteoporosis and inflammatory conditions","authors":"Chanhyeok Jeong ,&nbsp;Chang Hyung Lee ,&nbsp;Jiwon Seo ,&nbsp;Jung Han Yoon Park ,&nbsp;Ki Won Lee","doi":"10.1016/j.fitote.2024.106188","DOIUrl":"10.1016/j.fitote.2024.106188","url":null,"abstract":"<div><p>This review investigates the therapeutic effects of <em>Ulmus</em> species extracts, traditionally used as tea ingredients in East Asia, on bone health and inflammatory conditions. Through the analysis of 9757 studies, narrowing down to 56 pertinent ones, we evaluated the safety and efficacy of <em>Ulmus</em> extracts. The focus was on catechin glycosides (CG) and flavonoid glycosides (FG), key compounds identified for their potential benefits. The research highlights the extracts' role in enhancing bone mineral density (BMD) by stimulating osteoblast activity and suppressing osteoclast differentiation, suggesting a protective effect against osteoporosis. Furthermore, the extracts demonstrated significant anti-inflammatory properties by modulating inflammatory markers and pathways. The findings confirm the historical use of <em>Ulmus</em> extracts in East Asia for health benefits and recommend further exploration into functional foods and nutraceuticals. The review calls for more rigorous research, including clinical trials, to establish optimal use and integration into modern health solutions. It underscores the potential of <em>Ulmus</em> extracts in promoting bone health and managing inflammation, advocating for a bridge between traditional practices and contemporary scientific validation. In conclusion, <em>Ulmus</em> extracts, a material long consumed as tea ingredients in East Asia, exhibit significant potential for improving bone health and reducing inflammation. This review calls for additional research to explore their full therapeutic capabilities, emphasizing the need for optimized extraction methods and clinical trials. It reinforces the importance of bridging traditional knowledge with contemporary scientific approaches to health and dietary solutions, promoting overall wellness.</p></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"178 ","pages":"Article 106188"},"PeriodicalIF":2.5,"publicationDate":"2024-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141995592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neo-5,10-seco-clerodane diterpenoids from Schnabelia terniflora","authors":"Yi Chen ,&nbsp;Xu-Lan Bai ,&nbsp;Ting-Ting Du ,&nbsp;Hong-Tao Xu ,&nbsp;Yong-Li Wang ,&nbsp;Le-Yi Huang ,&nbsp;Xu-Dong Mao ,&nbsp;Gui-Xin Chou","doi":"10.1016/j.fitote.2024.106190","DOIUrl":"10.1016/j.fitote.2024.106190","url":null,"abstract":"<div><p>Three new <em>neo</em>-5,10-<em>seco</em>-clerodane diterpenoids (<strong>1</strong>–<strong>3</strong>), four previously undescribed ethoxy/methoxy acetal analogues (<strong>4</strong>–<strong>7</strong>), one new etherified labdane diterpenoid (<strong>8</strong>), and seven known diterpenoids (<strong>9</strong>–<strong>15</strong>) were isolated from the whole plant of <em>Schnabelia terniflora</em>. Their structures were established on the basis of extensive spectroscopic analysis, single-crystal X-ray diffraction data, calculated electronic circular dichroism (ECD), and Mo₂(OAc)₄-induced circular dichroism. Compounds <strong>2</strong> and <strong>3</strong> represent the first examples of <em>neo</em>-5,10-<em>seco</em>-clerodane diterpenoids containing a 1<em>H</em>-pyrrole-2,5-dione and a pyrrolidine-2,5-dione moiety, respectively. A plausible biosynthetic pathway for <strong>1</strong>–<strong>3</strong> is proposed. All diterpenoids were evaluated for their cytotoxic activity against non-small-cell lung cancer lines (A549 and H460) and gastric cancer lines (HGC27 and AGS). Among them, <strong>2</strong> and <strong>14</strong> showed moderate cytotoxicity against four cell lines.</p></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"178 ","pages":"Article 106190"},"PeriodicalIF":2.5,"publicationDate":"2024-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141995604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Total flavonoids from the aerial parts of Tetrastigma hemsleyanum prevent LPS-induced ALI by modulating the TLR4/NF-κB pathway in mice","authors":"Jiheng Feng,&nbsp;Chenjun Shen,&nbsp;Shasha Tian,&nbsp;Xingcan Chen,&nbsp;Fangmei Zhou,&nbsp;Mingyuan Zhou,&nbsp;Bingqi Zhu,&nbsp;Xiaoyan Li,&nbsp;Zhishan Ding","doi":"10.1016/j.fitote.2024.106175","DOIUrl":"10.1016/j.fitote.2024.106175","url":null,"abstract":"<div><h3>Background</h3><p>The traditional Chinese medicine <em>Tetrastigma Hemsleyanum</em> (TH) is employed in treating respiratory diseases; however, the aerial parts by which its total flavonoids alleviate acute lung injury (ALI) are still unknown. This study investigated the protective effect and mechanism of Tetrastigma Hemsleyanum flavonoids (THF) in lipopolysaccharide (LPS)-induced ALI in mice.</p></div><div><h3>Methods</h3><p>Firstly, the total flavonoids from the above-ground part of TH were extracted. Subsequently, the composition of THF was analyzed using LC-MS. In vivo, the impact of THF on ALI mice was assessed through lung histopathology and the evaluation of various inflammatory factors' expression in mice. After treating RAW264.7 cells with THF in vitro, changes in inflammatory markers were examined upon LPS stimulation, and mRNA expression levels of inflammatory factors were detected using RT-qPCR. Finally, Western blot analysis was performed to determine TLR4/NF-κB pathway-associated proteins expression.</p></div><div><h3>Results</h3><p>In summary, a total of 24 flavonoids have been identified in THF. In vivo and vitro results show that THF effectively reduces the damage caused by LPS inflammation by blocking the expression and release of inflammatory factors. THF alleviates inflammatory injury by modulating the TLR4/NF-KB pathway.</p></div><div><h3>Conclusion</h3><p>The results suggest that flavonoids exhibit a potent anti-inflammatory effect and effectively mitigate LPS-induced injury both in vivo and in vitro. We suggested that these flavonoids exert their therapeutic effects by modulating the TLR4/NF-KB pathway. In conclusion, the development of THF is anticipated to represent a promising new pharmaceutical for treatingALI.</p></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"178 ","pages":"Article 106175"},"PeriodicalIF":2.5,"publicationDate":"2024-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141995606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the chemistry, biological effects, and mechanism insights of natural coumaroyltyramine: First report","authors":"Saad Bakrim ,&nbsp;Youssef Elouafy ,&nbsp;Jihane Touhtouh ,&nbsp;Tarik Aanniz ,&nbsp;Kawtar El Kadri ,&nbsp;Asaad Khalid ,&nbsp;Shereen Fawzy ,&nbsp;M. Ahmed Mesaik ,&nbsp;Learn-Han Lee ,&nbsp;Imane Chamkhi ,&nbsp;Abdelhakim Bouyahya","doi":"10.1016/j.fitote.2024.106182","DOIUrl":"10.1016/j.fitote.2024.106182","url":null,"abstract":"&lt;div&gt;&lt;p&gt;Today, pharmaceutical drugs have been shown to have serious side effects, while the bioactive components of botanical plants are proven to be effective in the treatment of several diseases marked by enhanced oxidative stress and mild inflammation, often associated with minimal adverse events. Coumaroyltyramine, designated by various nomenclatures such as paprazine, &lt;em&gt;N-p-&lt;/em&gt;trans-coumaroyltyramine, &lt;em&gt;p&lt;/em&gt;-coumaroyltyramine and &lt;em&gt;N-p-&lt;/em&gt;coumaroyltyramine, could be a promising bioactive ingredient to address health issues thanks to its powerful anti-inflammatory and antioxidant effects. This review represents the first in-depth analysis of coumaroyltyramine, an intriguing phenylpropanoid substance found in many species of plants. In fact, an in-depth examination of coumaroyltyramine's biological characteristics, chemical attributes, and synthesis process has been undertaken. All previous research relating to the discovery, extraction, biosynthesis, and characterization of the biologically and pharmacologically active properties of coumaroyltyramine has been reviewed and taken into consideration in this analysis. All articles published in a peer-reviewed English-language journal were examined between the initial compilations of the appropriate database until February 12, 2024. A variety of phytochemicals revealed that coumaroyltyramine is a neutral amide of hydroxycinnamic acid that tends to concentrate in plants as a reaction against infection caused by pathogens and is extracted from several medicinal herbs such as &lt;em&gt;Cannabis sativa&lt;/em&gt;, &lt;em&gt;Solanum melongena&lt;/em&gt;, &lt;em&gt;Allium bakeri&lt;/em&gt;, &lt;em&gt;Annona cherimola&lt;/em&gt;, &lt;em&gt;Polygonatum zanlanscianense, and Lycopersicon esculentum&lt;/em&gt;. Thanks to its effectiveness in suppressing the effect of the enzyme α-glucosidase, coumaroltyramine has demonstrated antihyperglycemic activity and could have an impact on diabetes and metabolic disorders. It has considerable anti-inflammatory and antioxidant effects. These results were obtained through biological and pharmacological studies &lt;em&gt;in silico, in vivo&lt;/em&gt;, and &lt;em&gt;in vitro&lt;/em&gt;. In addition, coumaroyltyramine has demonstrated hypocholesterolemic and neuroprotective benefits, thereby diminishing heart and vascular disease incidence and helping to prevent neurological disorders. Other interesting properties of coumaroltyramine include anticancer, antibacterial, anti-urease, antifungal, antiviral, and antidysmenorrheal activities. Targeted pathways encompass activity at different molecular levels, notably through induction of endoplasmic reticulum stress-dependent apoptosis, arrest of the cell cycle, and inhibition of the growth of cancer cells, survival, and proliferation. Although the findings from &lt;em&gt;in silico&lt;/em&gt;, &lt;em&gt;in vivo,&lt;/em&gt; and &lt;em&gt;in vitro&lt;/em&gt; experiments illustrate coumaroyltyramine's properties and modes of action, further research is needed to fully exploit its therapeutic potential. To improve our understanding of the","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"178 ","pages":"Article 106182"},"PeriodicalIF":2.5,"publicationDate":"2024-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141995603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The multiple mechanisms and therapeutic significance of rutin in metabolic dysfunction-associated fatty liver disease (MAFLD)","authors":"Qianzhuo Wang ,&nbsp;Yingjuan Zhang ,&nbsp;Ruiling Lu ,&nbsp;Qingwen Zhao ,&nbsp;Yue Gao","doi":"10.1016/j.fitote.2024.106178","DOIUrl":"10.1016/j.fitote.2024.106178","url":null,"abstract":"<div><p>The global incidence of metabolic dysfunction-associated fatty liver disease (MAFLD) has been steadily increasing, making it a leading chronic liver disease. MAFLD refers to a metabolic syndrome linked with type 2 diabetes mellitus, obesity. However, its pathophysiology is complex, there are currently no effective and approved medicines for therapy. Rutin, a naturally occurring polyphenolic flavonoid, is widely distributed in fruits, vegetables, and other plants. It exhibits a plethora of bioactive properties, such as antioxidant, anticancer, and anti-inflammatory and neuroprotective activities, making it an extremely promising phytochemical. Rutin has shown great potential in the treatment of a wide variety of metabolic diseases and received considerable attention in recent years. Fortuitously, various research studies have validated rutin's extensive biological functions in treating metabolic disorders. Despite the fact that the exact pathophysiological mechanisms through which rutin has a hepatoprotective effect on MAFLD are still not fully elucidated. This review comprehensively outlines rutin's multifaceted preventive and therapeutic effects in MAFLD, including the modulation of lipid metabolism, reduction of insulin resistance, diminution of inflammation and oxidative stress, combatting of obesity, and influence on intestinal flora. This paper details the known molecular targets and pathways of rutin in MAFLD pathogenesis. It endeavored to provide new ideas for treating MAFLD and accelerating its translation from bench to bedside.</p></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"178 ","pages":"Article 106178"},"PeriodicalIF":2.5,"publicationDate":"2024-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141995605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}