Fitoterapia最新文献

{"title":"Identification of bioactive compounds in Brassica oleracea var. capitata L. with enzyme-inhibitory activity against postprandial hyperglycemia","authors":"Jonatan Jafet Uuh Narvaez ,&nbsp;Guillermo Emilio Moguel Ojeda ,&nbsp;José A. Guerrero-Analco ,&nbsp;Juan L. Monribot-Villanueva ,&nbsp;Abraham Vidal-Limon ,&nbsp;Guiomar Melgar Lalanne ,&nbsp;Rafael Rojas Herrera ,&nbsp;Maira Rubi Segura Campos","doi":"10.1016/j.fitote.2024.106343","DOIUrl":"10.1016/j.fitote.2024.106343","url":null,"abstract":"<div><div>Postprandial hyperglycemia is a hallmark of diabetes, and inhibition of key carbohydrate digestion enzymes such as α-amylase (α-AMY) and α-glucosidase (α-GLU) is an effective therapeutic target. A potential unexplored source of inhibitory compounds of these enzymes is <em>Brassica oleracea</em> var. <em>capitata</em> L (BOCE). This study explored the <em>in vitro</em> inhibition mechanism of BOCE and studied <em>in silico</em> the interaction of its compounds identified and quantified by UPLC-QTOF-MS on α-AMY and α-GLU. BOCE demonstrated IC₅₀ values of 3.08 mg/mL for α-AMY and 22.63 mg/mL for α-GLU, indicating competitive and mixed-type inhibitions, respectively. Untargeted metabolomics identified 21 compounds, primarily phenolic acids such as t-cinnamic, sinapic, and caffeoylquinic acid. In the targeted analysis, 11 compounds were quantified, mainly phenolic acids. The most impactful biosynthetic pathways identified were phenylpropanoids and brassinosteroids. <em>In silico</em> analysis revealed that for α-AMY and α-GLU, castasterone and 26-hydroxybrassinolide displayed the lowest binding free energies with specific hydrogen bond patterns to catalytic residues in the binding site, respectively. <em>B. oleracea</em> is a promising source of compounds with the ability to modulate key enzymes related to hyperglycemia. Specifically, compounds such as castasterone and 26-hydroxybrassinolide show potential against α-AMY and α-GLU inhibition, offering a novel approach to diabetes.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"180 ","pages":"Article 106343"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142817628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Jatrophane diterpenoids from Jatropha curcas with multidrug resistance reversal activity","authors":"Yi-Lin He ,&nbsp;Lan-Jun Zhang ,&nbsp;Guo-Li Li ,&nbsp;Hong-Ying Yang ,&nbsp;Lei Zhang ,&nbsp;Zheng Gong ,&nbsp;Kun Gao","doi":"10.1016/j.fitote.2024.106331","DOIUrl":"10.1016/j.fitote.2024.106331","url":null,"abstract":"<div><div>Nine jatrophane diterpenoids, including six previously undescribed compounds, were extracted and purified from whole plants of <em>Jatropha curcas</em> L. Their structures including absolute configurations were characterized by spectroscopic, quantum chemical Nuclear Magnetic Resonance Spectroscopy, Electronic Circular Dichroism calculation, and Single Crystal X-Ray Diffraction methods. These compounds were evaluated for their ability to reverse multidrug resistance. Among the above compounds, compound <strong>6</strong> showed significant potential as a multidrug resistance modulator, exhibiting higher chemo reversal effects and lower toxicity compared to the positive control verapamil. These findings suggest that compound <strong>6</strong> has promising anticancer properties.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"180 ","pages":"Article 106331"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142784977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The protective effect of Argan oil and its main constituents against xenobiotics-induced toxicities","authors":"Ayoub Amssayef ,&nbsp;Hamza Elbouny ,&nbsp;Bouchra Soulaimani ,&nbsp;Oumayma Abdessadak ,&nbsp;Hajar Chihab ,&nbsp;Jaouad El Hilaly ,&nbsp;Mohamed Eddouks","doi":"10.1016/j.fitote.2024.106325","DOIUrl":"10.1016/j.fitote.2024.106325","url":null,"abstract":"<div><h3>Background</h3><div>Argan oil (AO) is a vegetable oil extracted from the fruits of <em>Argania spinosa</em> L. tree, belonging to the Sapotaceae family, primarily found in Morocco. Research studies have demonstrated that AO exhibits diverse pharmacological properties, including antioxidant, antimicrobial, anticancer, antiinflammatory, antidiabetic, antihypercholesterolemic, antiatherogenic, and immunomodulatory effects. These effects are attributed to its main constituents, including oleic acid, linoleic acid, γ-tocopherol, α-tocopherol, and ferulic acid.</div></div><div><h3>Objective</h3><div>This review aimed to present the protective role of AO and its main constituents against xenobiotics-induced toxicities.</div></div><div><h3>Material and methods</h3><div>Based on results from various <em>in vitro</em> and <em>in vivo</em> investigations published in the main scientific databases, the beneficial action of AO against xenobiotics-induced toxicities was analyzed.</div></div><div><h3>Results</h3><div>AO and its main constituents have reduced neurotoxicity, hepatotoxicity, nephrotoxicity, pneumotoxicity, thyroid toxicity, hematotoxicity, immunotoxicity, genotoxicity, and colon toxicity induced by different natural and chemical xenobiotics. Different mechanisms of action are involved in these effects, including enhancement of antioxidant defense, reduction of oxidative stress, modulation of inflammation, stimulation of fatty acid oxidation, suppression of apoptosis, regulation of miRNAs expression, elevation of acetylcholinesterase activity, activation of Krebs cycle enzymes, and restoration of mitochondrial function.</div></div><div><h3>Conclusion</h3><div>The study shows clearly the beneficial effect of Argan oil against xenobiotics-induced toxicities was analyzed. However, clinical trials are necessary to verify the protective effects of this oil in human intoxications caused by both natural and chemical xenobiotics.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"180 ","pages":"Article 106325"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142790664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Two new sesquiterpenol caffeates from Bauhinia brychycarpa Wall. ex Benth. and their α-glucosidase inhibitory activity","authors":"Xingping Zhang ,&nbsp;Wenjie Ma ,&nbsp;Kepu Huang ,&nbsp;Congxi Gao ,&nbsp;Xiaoxue Jiang ,&nbsp;Mingming Li ,&nbsp;Kou Wang","doi":"10.1016/j.fitote.2024.106327","DOIUrl":"10.1016/j.fitote.2024.106327","url":null,"abstract":"<div><div>Two new sesquiterpenol caffeates, bausesquitate A (<strong>1</strong>) and bausesquitate B (<strong>2</strong>), were isolated from the stems and leaves of <em>Bauhinia brychycarpa</em>. Structures of two compounds were confirmed by UV, IR, HR-ESI-MS, 1D and 2D NMR, ECD spectra and DP4+ probability analysis. In vitro, compounds <strong>1</strong> and <strong>2</strong> showed better inhibitory effect on <em>α</em>-glucosidase than acarbose (IC₅₀ = 280.50 ± 6.27 μM) with the IC₅₀ values of 1.81 ± 0.12 μM and 3.79 ± 0.27 μM. Additionally, molecular docking and molecular dynamics simulation were performed to analyze the potential binding sites.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"180 ","pages":"Article 106327"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142791313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polyphenolics and triterpenoids from the whole herbs of Melastoma dodecandrum Lour. and their anti-inflammatory activity","authors":"Zhiqi Zhang ,&nbsp;Yang Xu ,&nbsp;Junming Liang ,&nbsp;Dejuan Sun ,&nbsp;Hua Li ,&nbsp;Lixia Chen","doi":"10.1016/j.fitote.2024.106337","DOIUrl":"10.1016/j.fitote.2024.106337","url":null,"abstract":"<div><div><em>Melastoma dodecandrum</em> Lour. is a creeping shrub belonging to the Melastomataceae family. It has been widely used as a medicine and food in South China and is recognized as a safe and effective anti-inflammatory agent. 35 compounds (<strong>1</strong>–<strong>35</strong>) were isolated from the whole herbs of <em>M. dodecandrum</em>, including two undescribed polyphenolics (<strong>1</strong> and <strong>2</strong>), two undescribed triterpenoids (<strong>3</strong> and <strong>4</strong>), twenty-eight known polyphenolics (<strong>5</strong>–<strong>32</strong>) and three known triterpenoids (<strong>33</strong>–<strong>35</strong>). Based on chemical evidence and spectral data analysis (UV, Optical rotation data, 1D and 2D-NMR, and HR-ESI-MS), the structures of undescribed compounds were elucidated. Compounds <strong>1</strong>–<strong>35</strong> were tested for their inhibitory activity on NO production in LPS-induced RAW264.7 cells. Among them, compound <strong>8</strong> exhibited the most excellent inhibitory activity with IC₅₀ value of 14.50 ± 4.69 μM.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"180 ","pages":"Article 106337"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142812395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alstoscholarisine L, a novel caged monoterpenoid indole alkaloid with antifungal activity from Alstonia scholaris","authors":"Hao-Fei Yu ,&nbsp;Cai-Feng Ding ,&nbsp;Lan-Chun Zhang ,&nbsp;Khalid-Hassan Mohamed ,&nbsp;Zhi Dai ,&nbsp;Xin Wei ,&nbsp;Xiao-Nian Li ,&nbsp;Ya-Ping Liu ,&nbsp;Rong-Ping Zhang ,&nbsp;Xiao-Dong Luo","doi":"10.1016/j.fitote.2024.106341","DOIUrl":"10.1016/j.fitote.2024.106341","url":null,"abstract":"<div><div>Alstoscholarisine L is an architecturally complex monoterpenoid indole alkaloid with a unique ring fusion pattern, isolated from the leaves of <em>Alstonia scholaris</em>. The 6/5/5/6/6/6-membered rings contain two lactonic rings and one aminal carbon and possess seven contiguous aligned stereocenters, three of which are quaternary. Its structure was elucidated by extensive spectroscopic data analyses, quantum chemical computations, and single-crystal X-ray diffraction. The unusual highly fused, cage-like skeleton is possibly derived from picrinine. The fascinating compound exhibited potential antifungal activity against <em>Candida albicans</em>, and its activity was roughly comparable to the first line antifungal drug fluconazole and significantly more effective than the plant-derived antibacterial drug berberine.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"180 ","pages":"Article 106341"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142817572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the antiproliferative and antioxidant potential of xanthoxylin and of essential oil isolated from Pulicaria incisa (Lam.) DC. herbal medicine","authors":"Antonella Porrello ,&nbsp;Alessia Postiglione ,&nbsp;Natale Badalamenti ,&nbsp;Maurizio Bruno ,&nbsp;Adriana Basile ,&nbsp;Lucia Capasso ,&nbsp;Paola Bontempo ,&nbsp;Viviana Maresca","doi":"10.1016/j.fitote.2024.106344","DOIUrl":"10.1016/j.fitote.2024.106344","url":null,"abstract":"<div><div>In this study have been evaluated the antiproliferative and antioxidant activities of Israeli <em>Pulicaria incisa</em> (Lam.) DC. essential oil (<strong>Pi1</strong>), of essential oil partially purified by xanthoxylin (<strong>Pi2</strong>), one of its feature metabolites, and the isolated xanthoxylin (<strong>Xan</strong>). From the compositional analysis carried out by GC–MS oxygenated monoterpenes class was the main class (71.18 %), with <em>cis</em>-chrysanthenol (55.66 %) as the most abundant components, following by carvotanacetone (11.68 %). Other metabolites represented the second class (20.33 %), being xanthoxylin (15.35 %) the principal metabolites, isolated and characterized by NMR tecniques. <strong>Pi1</strong> and <strong>Xan</strong> showed good antioxidant activity causing a clear reduction in ROS levels and an increase in CAT and SOD activity, while <strong>Pi2</strong> showed a reduction in enzymatic activity. Furthermore, <strong>Pi1</strong> and <strong>Xan</strong> demonstrated an apoptotic antiproliferative effect in a dose-dependent manner on solid and hematological tumors, unlike <strong>Pi2</strong> which showed lower activity. These data showed that <em>P. incisa</em> EO had interesting antioxidant and antitumor activity and that the biological activities exhibited by the essential oil as a whole are mainly due to xanthoxylin.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"180 ","pages":"Article 106344"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142817631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Undescribed and known phenolic acid derivatives with significant antioxidant activity from the Scorzonera parviflora Jacq. roots","authors":"Özlem Bahadır Acıkara ,&nbsp;Ufuk Ataman ,&nbsp;Christian Zidorn ,&nbsp;Josef Cvacka ,&nbsp;Ekin Kurtul ,&nbsp;Milos Buděšínský ,&nbsp;Lucie Bednarova ,&nbsp;Sezen Yılmaz Sarıaltın","doi":"10.1016/j.fitote.2024.106328","DOIUrl":"10.1016/j.fitote.2024.106328","url":null,"abstract":"<div><div>The antioxidant activity of <em>Scorzonera parviflora</em> Jacq. roots were assessed by measuring their ability to scavenge ABTS and DPPH radicals. Bioactivity-guided fractionation was utilized to identify the compound(s) responsible for this activity. The most active phase, ethyl acetate, was isolated using column chromatography. The resulting fractions were then purified using preparative TLC on reverse phase and semi-preparative HPLC. The structures of the pure compounds were elucidated by spectral analysis (MS and ¹H, ¹³C, 2D-NMR). Three undescribed phenolic acid derivatives, namely parvifloric acid A <strong>(1)</strong>, B <strong>(2)</strong>, and C <strong>(3)</strong>, and one new sesquiterpene lactone, parviflorin <strong>(4)</strong> together with seven known compounds were isolated and identified as scopolin <strong>(5)</strong>, scopoletin <strong>(6)</strong>, caffeic acid <strong>(7)</strong>, protocatechuic acid <strong>(8)</strong>, 4,5-<em>O</em>-dicaffeoylquinic acid <strong>(9)</strong> 3,5-<em>O</em>-dicaffeoylquinic acid <strong>(10)</strong>, and 3,5-<em>O</em>-dicaffeoylquinic acid methyl ester <strong>(11)</strong>. Finally, the pure compounds obtained were tested to evaluate their antioxidant capacities, using ABTS and DPPH radical scavenging potencies. The highest activity was observed with 3,5-<em>O</em>-dicaffeoylquinic acid <strong>(10)</strong>, followed by its methyl ester.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"180 ","pages":"Article 106328"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142791285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction notice to “Quercetin: A flavonol with multifaceted therapeutic applications?” [Fitoterapia 106 (2015) 256–271]","authors":"Gabriele D'Andrea","doi":"10.1016/j.fitote.2024.106320","DOIUrl":"10.1016/j.fitote.2024.106320","url":null,"abstract":"","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"180 ","pages":"Article 106320"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142767622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chemical constituents, anti-rheumatic potential, and anti-inflammatory properties of the aqueous extract from the aerial parts of Aristolochia esperanzae Kuntze","authors":"Camila Fortes Corrêa ,&nbsp;Natália de Matos Balsalobre ,&nbsp;Elisangela dos Santos-Procopio ,&nbsp;Claudia Andrea Lima Cardoso ,&nbsp;Maria do Carmo Vieira ,&nbsp;Luciano da Silva Pinto ,&nbsp;Carlos André Ferreira Moraes ,&nbsp;Victor Augusto Ferres Chacon ,&nbsp;Joelcio Freitas ,&nbsp;Silvia Cristina Heredia-Vieira ,&nbsp;Cláudio Rodrigo Nogueira ,&nbsp;Candida Aparecida Leite Kassuya","doi":"10.1016/j.fitote.2024.106342","DOIUrl":"10.1016/j.fitote.2024.106342","url":null,"abstract":"<div><div>Although <em>Aristolochia</em> plants remain controversial due to their toxicity, this group of perianth-bearing plants, which includes the medicinal species <em>Aristolochia esperanzae</em>, is among the most relevant from an ethnobotanical perspective. All parts of <em>A. esperanzae</em> are used in popular medicine in the form of infusion for the treatment of rheumatism. Thus, the anti-inflammatory properties and the chemical composition of the aqueous extract (AELS) obtained from <em>A. esperanzae</em> aerial parts were examined in this research. AELS was analyzed using chromatographic, hyphenated, spectrometric techniques, and a total of 35 compounds, seven alkaloids, one alkamide, seven flavonoids, four phenolic compounds, one terpene lactone, three epoxylignans, two dibenzylbutyrolactolic, five dibenzylbutyrolactone, three furofuran lignans, and two labdane diterpenes, were found in this extract. Four doses of AELS (3−300 mg/kg) were administered, by oral route (p.o.), to female Swiss mice in the carrageenan pleurisy test. The dose of 100 mg/kg was tested in Swiss mice in two models: carrageenan, complete adjuvant Freunds (CFA) and zymosan inflammatory models. The AELS extract was assayed using the methylthiazolidiphenyl-tetrazolium bromide (MTT) test to verify the leukocyte viability, and this showed no cytotoxicity in vitro. AELS significantly interfered with nitric oxide production and reduced leukocyte migration to the pleura following carrageenan stimulation. AELS significantly inhibited nitric oxide production, leukocyte migration, and mechanical hyperalgesia after zymosan-stimulated joint inflammatory process. Therefore, the present study demonstrated that AELS exhibits anti-inflammatory properties and is rich in compounds known for their anti-inflammatory potential, thereby supporting the traditional use of <em>A. esperanzae</em> in treating rheumatism.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"180 ","pages":"Article 106342"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142817532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}