Fitoterapia最新文献

{"title":"Phytochemistry and pharmacological activities of Cannabis sativa fruit (Cannabis Fructus)","authors":"Lijia Guo,&nbsp;Yanping Sun,&nbsp;Meng Wang,&nbsp;Yunwei Liu,&nbsp;Zhenyue Wang,&nbsp;Zhibin Wang","doi":"10.1016/j.fitote.2024.106214","DOIUrl":"10.1016/j.fitote.2024.106214","url":null,"abstract":"<div><p><em>Cannabis sativa</em> fruit (Cannabis Fructus) refers to the dried and ripe fruit of <em>Cannabis sativa</em> L. It is widely distributed in the northeast, North, and South China. It has medicinal, ecological, and economic values. This study aimed to review the chemical constituents and pharmacological activities of Cannabis Fructus, providing a reference for further exploration of Cannabis Fructus. Comprehensive information on Cannabis Fructus was collected <em>via</em> electronic searches (<em>e.g.</em>, Google Scholar, PubMed, Sci Finder, and Web of Science) and from books on phytochemistry. Cannabis Fructus contains various compounds such as phenylpropanoids, flavonoids, steroids and terpenoids, cannabinoids, fatty acids, alkaloids, phenanthrenes, proteins, and polysaccharides. Its active ingredients exhibit anti-inflammatory, anti-oxidant, anti-bacterial, anti-aging, anti-fatigue, anti-tumor, anti-constipation, neuroprotective, lipoid-regulating, hepatoprotective, and immunomodulatory properties.</p></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"179 ","pages":"Article 106214"},"PeriodicalIF":2.5,"publicationDate":"2024-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142244066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vasorelaxant and tracheorelaxant effects of Bocconia arborea and their isolated benzophenanthridine alkaloids1","authors":"Emmanuel Gaona-Tovar ,&nbsp;Samuel Estrada-Soto ,&nbsp;Armando Ramírez-Hernández ,&nbsp;Luis Arias-Durán ,&nbsp;Hugo Tlahuext ,&nbsp;Rafael Villalobos-Molina ,&nbsp;Julio C. Almanza-Pérez","doi":"10.1016/j.fitote.2024.106212","DOIUrl":"10.1016/j.fitote.2024.106212","url":null,"abstract":"<div><p><em>Bocconia arborea S. Watson</em> (Papaveraceae) is an abundant medicinal plant in the North of Morelos State, Mexico, which is used for the treatment of several diseases. The aim of current investigation was to isolate the compounds responsible of the relaxant effect shown by the active extracts. Thus, phytochemical bio-guided fractionation allowed the isolation of angoline (<strong>1</strong>), dihydrosanguinarine (<strong>2</strong>), bocconarborine A (<strong>3</strong>), oxisanguinarine (<strong>4</strong>), and oxychelerithrine (<strong>5</strong>) from dichloromethanic and methanolic extracts from the bark of <em>Bocconia arborea</em> (Papaveraceae). The relaxant study on aortic and tracheal rat rings of all benzophenanthridines indicates that <strong>1</strong> was the most active compound of the entire series investigated. Angoline (<strong>1</strong>) induces its relaxant effect by a concentration-dependent manner through the calcium channel blockade in both tissues.</p></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"179 ","pages":"Article 106212"},"PeriodicalIF":2.5,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142271473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Untargeted metabolomics profiling of Morus alba twigs extract and antibacterial activity of pure metabolites","authors":"Ernesto Gargiulo ,&nbsp;Carmina Sirignano ,&nbsp;Sabrina Arpini ,&nbsp;Emanuele Ribatti ,&nbsp;Mario Falzoni ,&nbsp;Francesca Lembo ,&nbsp;Elisabetta Buommino ,&nbsp;Giuseppina Chianese ,&nbsp;Orazio Taglialatela-Scafati","doi":"10.1016/j.fitote.2024.106213","DOIUrl":"10.1016/j.fitote.2024.106213","url":null,"abstract":"<div><p>Plant natural products offer promise in combating multi-drug resistance by acting as antibacterial agents through various mechanisms. A metabolomic-guided phytochemical investigation, based on a LC-HRMS/MS and Molecular Networking combined approach, was carried out on an extract of <em>M. alba</em> L. (mulberry) twigs, a common of byproduct of mulberry utilization. Molecular Networking uncovered different clusters of prenylated polyphenols, glycosylated phenolic compounds, and Diels-Alder dimers, steering the phytochemical profiling of this extract. This led to the swift annotation and subsequent isolation of 17 secondary metabolites including stilbenoids, flavonoids, and flavanones. Isolated metabolites were tested for their antimicrobial activity against <em>Staphylococcus</em> species. The most active compound resulted to be kuwanon C, exhibiting a MIC value of 8 μg/mL against the methicillin resistant <em>S. aureus</em> (MRSA) strain and a biofilm producer strain of <em>S. epidermidis</em>. We also observed an interaction between 4 μg/mL of kuwanon C in combination with low oxacillin dosage against the MRSA. Thanks to the high chemical structure similarity of isolated metabolites, structure-activity relationships of these versatile scaffolds have been postulated.</p></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"179 ","pages":"Article 106213"},"PeriodicalIF":2.5,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0367326X24003964/pdfft?md5=865b9db44d44f1f97487624e8d038989&pid=1-s2.0-S0367326X24003964-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142244258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Depside and depsidone-rich hydroalcoholic extract, resourced from the lichen Parmelinella wallichiana (Taylor) Elix & Hale selectively restricts Non-Small Cell Lung Cancer by modulating p53, FOXO1 and PALLADIN genes","authors":"Saparja Saha,&nbsp;Ribhu Ray,&nbsp;Santanu Paul","doi":"10.1016/j.fitote.2024.106211","DOIUrl":"10.1016/j.fitote.2024.106211","url":null,"abstract":"<div><p>The non-specificity of contemporary cancer therapeutics has enticed us to develop safer, anticancer alternatives from natural resources. Lichens are unique natural entities which have long been neglected for explorations in cancer therapy, despite their vast potential. Our present study aims to investigate the anti-cancer potential of a wild lichen <em>Parmelinella wallichiana</em>. The anti-proliferative efficacy of the lichen extracts were screened through MTT assay against a panel of cell lines and the potent hydroalcoholic extract was selected for further evaluation against the most sensitive lung-cancer cell line A549 by implementing a wide range of microscopic and flow cytometric applications. The observations suggest that the extract could selectively induce apoptosis by augmenting ROS and disrupting the mitochondrial membrane potentiality. It was also found that the lichen-induced apoptosis was regulated by two crucial tumor suppressor genes, <em>FOXO1</em>, and <em>p53</em>, along with cell cycle inhibitor <em>p21</em> which ultimately resulted in robust apoptosis through the up-regulation of pro-apoptotic <em>BAX</em> expression. Moreover, the extract also restricted the cancer progression by down-regulating the <em>PALLADIN</em> expression. Further, an LC-MS-based metabolomic profile highlighted a number of depsides, depsidones and dibenzofurans, which included atranorin, physodalic acid, salazinic acid, constictic acid and usnic acid. Then, an in silico docking with these lichen-derived metabolites against the PI3Kα receptor predicted these compounds has a binding affinity close to a standard PI3Kα inhibitor copanlisib. The study concludes that the extract restricts lung cancer possibly through the PI3Kα/FOXO1 axis and thus <em>Parmelinella wallichiana</em> represents a potential resource for anti-lung cancer drug development in future.</p></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"179 ","pages":"Article 106211"},"PeriodicalIF":2.5,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142244257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cytotoxic, antioxidant, and enzyme inhibitory activities of Centaurea stapfiana extracts and their HPLC-ESI-QTOF-MS profiles: Insights into an unexplored Centaurea species","authors":"Gokhan Zengin ,&nbsp;Álvaro Fernández-Ochoa ,&nbsp;María de la Luz Cádiz-Gurrea ,&nbsp;Francisco-Javier Leyva Jiménez ,&nbsp;Abdullahi Ibrahim Uba ,&nbsp;Gunes Ak ,&nbsp;Sanam Iram Soomro ,&nbsp;Maruf Balos ,&nbsp;Ugur Cakilcioglu ,&nbsp;Maria João Rodrigues ,&nbsp;Catarina G. Pereira ,&nbsp;Luísa Custódio","doi":"10.1016/j.fitote.2024.106207","DOIUrl":"10.1016/j.fitote.2024.106207","url":null,"abstract":"<div><p>The members of the genus <em>Centaurea</em> have a great interest in pharmaceutical and nutraceutical fields due to their biological potential. Based on this information, we aimed to evaluate the biological properties (antioxidant, enzyme inhibition and cytotoxicity) and chemical profile of the extract of <em>Centaurea stapfiana</em>, an unstudied species. The highest total phenolic content was found in the ethanol/water extract with 32.17 mg GAE/g. A total of 102 of them were identified by HPLC-ESI-QTOF-MS analysis. These compounds were mainly hydroxybenzoic acid and hydroxycinnamic acid as well as flavonoids. In the antioxidant tests, the ethanol/water extract had the best free radical scavenging and reducing ability. However, in the enzyme inhibition test, the ethanol extract was the most active. The extracts were also tested on two tumour cell lines (RAW 264.7 and HepG2) and one non-tumour cell line (S17). The ethanol extract showed the promising effect on HepG2 (cell viability: 28.6 % at 50 g/ml). Furthermore, we examined the interactions between the compounds and enzymatic and cellular targets. A good interaction was found between quercetin-3-xylosyl-(1- &gt; 6)-glucoside and iNOS. In summary, our results suggest that <em>C. stapfiana</em> can be considered as a versatile raw material for the development of health-promoting applications in the pharmaceutical and cosmeceutical fields.</p></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"179 ","pages":"Article 106207"},"PeriodicalIF":2.5,"publicationDate":"2024-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142163509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep-improving effect and the potential mechanism of Morus alba L. on mice","authors":"Xiaoran Kong ,&nbsp;Xiaolu Zhou ,&nbsp;Rui Li ,&nbsp;Qiaozhen Kang ,&nbsp;Limin Hao ,&nbsp;Jiaqing Zhu ,&nbsp;Jike Lu","doi":"10.1016/j.fitote.2024.106205","DOIUrl":"10.1016/j.fitote.2024.106205","url":null,"abstract":"<div><p>As insufficient sleep has become a widespread concern in modern society, potential sleep-improving effect of mulberry (<em>Morus alba</em> L.) leaf ethanol extract (MLE) and the related mechanism were investigated in the present study. According to the results, MLE could significantly shorten sleep latency by 33 %, extend sleep duration by 56 % and increase sleep ratio of mice through increasing 5-HT and GABA release in serum, hypothalamus and hippocampus. Metabonomic analysis showed that phenylalanine metabolism, arginine and proline metabolism might be the potential pathways of MLE to improve sleep. Network pharmacological and LC-MS analysis suggested that the key sleep-improving active ingredients in MLE might be luteolin, kaempferol, naringenin, morin, stigmasterol and β-sitosterol. Further molecular docking and qRT-PCR results demonstrated that the key targets for MLE to improve sleep might be MAOA, GABRA1 and GABRA2. In conclusion, MLE showed outstanding sleep-improving effect and great potential for the application as novel sleep-improving functional food.</p></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"179 ","pages":"Article 106205"},"PeriodicalIF":2.5,"publicationDate":"2024-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142228884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive review of Hesperetin: Advancements in pharmacokinetics, pharmacological effects, and novel formulations","authors":"Bocui Song ,&nbsp;Meihan Hao ,&nbsp;Shuang Zhang ,&nbsp;Wenqi Niu ,&nbsp;Yuqi Li ,&nbsp;Qian Chen ,&nbsp;Shuang Li ,&nbsp;Chunyu Tong","doi":"10.1016/j.fitote.2024.106206","DOIUrl":"10.1016/j.fitote.2024.106206","url":null,"abstract":"<div><p>Hesperetin is a flavonoid compound naturally occurring in the peel of <em>Citrus</em> fruits from the Rutaceae family. Previous studies have demonstrated that hesperetin exhibits various pharmacological effects, such as anti-inflammatory, anti-tumor, antioxidative, anti-aging, and neuroprotective properties. In recent years, with the increasing prevalence of diseases and the rising awareness of traditional Chinese medicine, hesperetin has garnered growing attention for its wide-ranging pharmacological effects. To substantiate its health benefits and elucidate potential mechanisms, knowledge of pharmacokinetics is crucial. However, the limited solubility of hesperetin restricts its bioavailability, thereby diminishing its efficacy as a beneficial health agent. To enhance the bioavailability of hesperetin, various novel formulations have been developed, including nanoparticles, liposomes, and cyclodextrin inclusion complexes. This article reviews recent advances in the pharmacokinetics of hesperetin and methods to improve its bioavailability, as well as its pharmacological effects and mechanisms, aiming to provide a theoretical basis for clinical applications.</p></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"179 ","pages":"Article 106206"},"PeriodicalIF":2.5,"publicationDate":"2024-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142168529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction notice to “Helenalin attenuates alcohol-induced hepatic fibrosis by enhancing ethanol metabolism, inhibiting oxidative stress and suppressing HSC activation” [Fitoterapia 95 (2014) 203–213]","authors":"Xing Lin ,&nbsp;Shijun Zhang ,&nbsp;Renbin Huang ,&nbsp;Ling Wei ,&nbsp;Shimei Tan ,&nbsp;Shuang Liang ,&nbsp;Yuanchun Tian ,&nbsp;Xiaoyan Wu ,&nbsp;Zhongpeng Lu ,&nbsp;Quanfang Huang","doi":"10.1016/j.fitote.2024.106195","DOIUrl":"10.1016/j.fitote.2024.106195","url":null,"abstract":"","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"178 ","pages":"Article 106195"},"PeriodicalIF":2.5,"publicationDate":"2024-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0367326X24003782/pdfft?md5=21613c0c08e4026e20de7f9373677003&pid=1-s2.0-S0367326X24003782-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142105845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Untargeted metabolic analysis of Epaltes mexicana by LC-QTOF-MS: Terpenes with activity against human cancer cell lines","authors":"Tamara Juárez-Velázquez ,&nbsp;José Arnold González-Garrido ,&nbsp;Irma Sánchez-Lombardo ,&nbsp;Nelly del Carmen Jiménez-Pérez ,&nbsp;Ivonne María Olivares-Corichi ,&nbsp;José Rubén García-Sánchez ,&nbsp;Oswaldo Hernández-Abreu","doi":"10.1016/j.fitote.2024.106194","DOIUrl":"10.1016/j.fitote.2024.106194","url":null,"abstract":"<div><p><em>Epaltes mexicana</em> is a plant widely used in traditional medicine and as a food in Mexico; however, its phytochemical and pharmacological studies are limited. This study aimed to identify the active secondary metabolites of <em>Epaltes mexicana</em> and determine its cytotoxic activity on cancer cell lines. Three organic extracts were obtained by maceration using <em>n</em>-hexane, dichloromethane, and methanol. The <em>n</em>-hexane extract was fractioned by simple column chromatography. Eight terpenes were annotated in collection 6 (<strong>C6</strong>) by LC-QTOF-MS using a gradient elution and Electrospray Ionization (ESI) in positive ion mode: <strong>1)</strong> Gibberellin A15, <strong>2)</strong> farfugin A, <strong>3)</strong> dehydromyodesmone, <strong>4)</strong> eremopetasitenin A1, <strong>5)</strong> hydroxyisonobilin, <strong>6)</strong> anhydrocinnzeylanine, <strong>7)</strong> nigakilactone H and <strong>8)</strong> taxodione. On the other hand, <strong>C6</strong> showed a concentration-dependent cytotoxic effect on cancer cell lines MCF-7 (E_max = 74.69 ± 6.19 % and IC₅₀ = 6.31 μg/mL), MDA-MB-231 (E_max = 79.28 ± 12.12 % and IC₅₀ = 124.21 μg/mL), and SiHa (E_max = 82.96 ± 6.02 % and IC₅₀ = 124.31 μg/mL). The <strong>C6</strong> did not show a cytotoxic effect against DU-145 and non-cancerous cells from the mammary glands MCF-10A. These results indicate cytotoxic specificity on cancer cell lines and support the hypothesis that terpenes identified in <em>E. mexicana</em> must be investigated and developed for non-clinical and clinical trials as potential anti-cancer drugs.</p></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"179 ","pages":"Article 106194"},"PeriodicalIF":2.5,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142105846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nano-cubosomes of the phyto-active principle in Withania somnifera: LC-MS-NMR, anti-microbial, and insights of the anti-neuropathic and anti-inflammatory mechanism","authors":"Karim M. Raafat ,&nbsp;Ibrahim A. Abdelwahab ,&nbsp;Sally A. El-Zahaby","doi":"10.1016/j.fitote.2024.106196","DOIUrl":"10.1016/j.fitote.2024.106196","url":null,"abstract":"<div><p><em>Withania somnifera</em> (<em>W. somnifera</em>) has a long history of safety in the amelioration of neuro-active ailments. The current study aims to explore <em>Withania somnifera</em> phyto-active principle anti-microbial, ant-neuropathic, and anti-inflammatory activities, and to modify these activities utilizing nano-cubosomes exploiting their mechanisms of action. Bio-guided fractionation technique was utilized, to identify the most phyto-active compound, using LC-MS-NMR online technique and biological models of diabetes, neuropathy, and inflammation. <em>In-vitro</em> antibacterial activity was also monitored. The HbA1c, <em>in-vivo</em> antioxidant (serum-catalase, TBARS, and GSH), serum insulin, and pro-inflammatory serum cytokines (TNF alpha, IL-six, and IL-ten) levels have been assessed to establish the anti-neuropathic and anti-inflammatory mechanisms. The nano-cubosomal formulations (CUB 1–3) were utilized to improve the <em>W. somnifera</em> most active compound efficacy. <em>W. somnifera</em> has shown ten major peaks; coagulin Q (10.2 %), dihydrowithanolide A (2.4 %), dihydrowithaferin D (1.8 %), physagulin D (7.6 %), withanoside V (2.3 %), withanolide A (WDA, 10.3 %), withafrin A (4.9 %), withaferin D (7.7 %), withanone 9 (9.9 %), withanolide D (4.8 %). The bio-guided fractionation technique utilizing LC-MS-NMR technique has proved that withanolide A (WDA) is the most phyto-active compound in <em>W. somnifera</em>. The latter has shown better results than WDA, which might be due to other effective compounds in Ws. However, CUB 3 (WDA nano-cubosomes dispersion) has shown more prominent anti-diabetic, anti-neuropathic, anti-inflammatory, and anti-bacterial potentials than Ws and WDA. Thus, CUB 3 modified WDA activity, and improved its efficacy. The normalization of HbA1c levels, increased insulin secretagogue potential, and the amelioration of the oxidative-stress may be the underlying Ws, WDA, and CUB 3 antidiabetic neuropathy mechanism. Moreover, the Ws, WDA, and CUB 1–3 anti-inflammatory mechanism might be due to the amelioration of the pro-inflammatory serum cytokines (decreasing TNF alpha and IL-six levels and increasing IL-ten). Thus, CUB 3 might be a powerful tool in augmenting <em>Withania somnifera</em> activity as an oral drug-delivery system and improving its efficacy against neuropathy and inflammation.</p></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"178 ","pages":"Article 106196"},"PeriodicalIF":2.5,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142105844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}