Fitoterapia最新文献_第9页

Integrated serum pharmacochemistry, network pharmacology and experimental verification to explore the mechanism of Angelicae Pubescentis Radix in the treatment of NASH 结合血清药物化学、网络药理学和实验验证，探讨短毛当归治疗NASH的作用机制

IF 2.5 3区医学

Fitoterapia Pub Date : 2025-06-16 DOI: 10.1016/j.fitote.2025.106685

Xunhai Huang , Zirui Ding , Tianyan Feng , Zijie Xia , Hailong Xu , Lianghao Wei , Youbo Zhang , Gaigai Deng

{"title":"Integrated serum pharmacochemistry, network pharmacology and experimental verification to explore the mechanism of Angelicae Pubescentis Radix in the treatment of NASH","authors":"Xunhai Huang , Zirui Ding , Tianyan Feng , Zijie Xia , Hailong Xu , Lianghao Wei , Youbo Zhang , Gaigai Deng","doi":"10.1016/j.fitote.2025.106685","DOIUrl":"10.1016/j.fitote.2025.106685","url":null,"abstract":"<div><div>This study aimed to evaluate the therapeutic potential of <em>Angelicae Pubescentis Radix</em> (APR) against non-alcoholic steatohepatitis (NASH) and elucidate its underlying mechanisms through an integrated approach combining network pharmacology, molecular docking and experimental validation. Serum pharmacochemistry and network pharmacology were employed to identify bioactive compounds in APR and their potential targets related to NASH. A choline-deficient, L-amino acid-defined, high-fat diet (CDAHFD)-induced NASH mouse model was established to evaluate the therapeutic effects of APR. Serum analysis identified eight bioactive compounds derived from APR. The possible targets and key pathways of the components absorbed into serum of APR were predicted by network pharmacology. Molecular docking studies confirmed strong binding affinities between the core bioactive compounds and their respective targets. In vivo experiments demonstrated that APR significantly alleviated liver injury and improved serum lipid profiles in NASH mice. Furthermore, APR partially restored the mRNA levels of candidate targets and downregulated the expression of the macrophage activation marker F4/80. Additionally, APR modulated key protein expression levels in the liver, including Caspase-3, Cleaved Caspase-3, and Bcl-2, consistent with the proposed mechanism of action. These findings systematically revealed that the multi-target therapeutic effects of APR against NASH are mediated through the regulation of the apoptosis pathway, providing novel insights into the hepatoprotective mechanisms of APR. In conclusion, this study highlights the potential of APR as a promising therapeutic agent for NASH and elucidates its multi-target pharmacological mechanism, offering a foundation for further research and clinical applications.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"185 ","pages":"Article 106685"},"PeriodicalIF":2.5,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144314419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Natural cyclic peptides produced by the Ganoderma lucidum-associated endophytic Trichoderma sp. GLQ02 由灵芝相关内生木霉sp. GLQ02产生的天然环肽

IF 2.5 3区医学

Fitoterapia Pub Date : 2025-06-16 DOI: 10.1016/j.fitote.2025.106677

Xin-Huan Qiu , Qing Guo , Dong-Yu Wang , Jia-Hao Xue , Xia Cheng , Rui Zhang , Qi Luo

引用次数: 0

Bioactive diterpenoids from the leaves of Callicarpa formosana Rolfe 台湾海参叶中的生物活性二萜。

IF 2.5 3区医学

Fitoterapia Pub Date : 2025-06-16 DOI: 10.1016/j.fitote.2025.106690

Panpan Gao , Yulu Tian , Haowen Luo, Jie Ma, Yingda Zang, Mingbao Lin, Dan Zhang, Dongming Zhang, Chuangjun Li

引用次数: 0

Optimization of fucoxanthin production in Phaeodactylum tricornutum and its anti-inflammatory potential in skin cells 三角褐指藻岩藻黄素的优化及其对皮肤细胞的抗炎作用。

IF 2.5 3区医学

Fitoterapia Pub Date : 2025-06-16 DOI: 10.1016/j.fitote.2025.106692

Silu Ma, Bing Gong, Xiaoyu Wei, Yajun Yan, Zhaokai Wang

引用次数: 0

Comparison in chemical constituents and anti-inflammatory and analgesic effects of different medicinal parts from a Vitex negundo L. var. cannabifolia 大麻黄荆不同药用部位化学成分及抗炎镇痛作用的比较。

IF 2.5 3区医学

Fitoterapia Pub Date : 2025-06-16 DOI: 10.1016/j.fitote.2025.106693

Shanshan Zhu , Yi Shen , Qiaoyan Zhang

{"title":"Comparison in chemical constituents and anti-inflammatory and analgesic effects of different medicinal parts from a Vitex negundo L. var. cannabifolia","authors":"Shanshan Zhu , Yi Shen , Qiaoyan Zhang","doi":"10.1016/j.fitote.2025.106693","DOIUrl":"10.1016/j.fitote.2025.106693","url":null,"abstract":"<div><div><em>Vitex negundo</em> L. var. cannabifolia (VN) is a traditional Chinese medicine (TCM) and has long been used for rheumatic arthralgia and rheumatoid arthritis. However, pharmacological and mechanistic studies confirming these clinical effects have not yet been published. This study compared the anti-inflammatory and analgesic effects of different medicinal parts of VN. The root, stems and leaves, and fruit of VN were refluxed with 70 % ethanol to obtain the VNR, VNSL and VNF extract, respectively. Chemical compositions of them were analyzed by UPLC-Q-TOF/MS. Xylene-induced ear edema in mice and complete Freund's adjuvant-induced arthritis (AA) in rats as well as acetic acid-induced pain in mice were used to evaluate the anti-inflammatory and analgesic effects of VNR, VNSL and VNF. UPLC-Q-TOF/MS analysis showed that VNR, VNSL and VNF mainly contained flavonoids, lignans, terpenes, phenylpropanoids, and phenolic acids. In addition, VNR, VNSL, and VNF significantly inhibited ear edema in mice, alleviated paw swelling, decreased the serum levels of IL-1β, IL-6 and NO, as well as improved synovial tissue inflammation in AA rats. Similarly, VNR, VNSL and VNF also markedly suppressed the number of twists and prolonged writhing reaction time in acetic acid-induced writhing in mice. The results suggested that the anti-inflammatory effects of VNSL and the analgesic effects of VNF are more significant. In sum, replacing VNR with VNSL and VNF can provide scientific basis for the resource utilization and TCM development of VN.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"185 ","pages":"Article 106693"},"PeriodicalIF":2.5,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Brazilian propolis: Chemical composition, regional variability, and bioactive potential 巴西蜂胶：化学成分、区域差异和生物活性潜力

IF 2.5 3区医学

Fitoterapia Pub Date : 2025-06-16 DOI: 10.1016/j.fitote.2025.106687

Isabela Motta Felício , Alexya Mikelle Teixeira Cavalcanti , Kevin Baranger , Raimundo Gonçalves de Oliveira Junior , Benjamin Poirot , Laurent Picot , Fabiana de Andrade Cavalcante

{"title":"Brazilian propolis: Chemical composition, regional variability, and bioactive potential","authors":"Isabela Motta Felício , Alexya Mikelle Teixeira Cavalcanti , Kevin Baranger , Raimundo Gonçalves de Oliveira Junior , Benjamin Poirot , Laurent Picot , Fabiana de Andrade Cavalcante","doi":"10.1016/j.fitote.2025.106687","DOIUrl":"10.1016/j.fitote.2025.106687","url":null,"abstract":"<div><div>Propolis, a natural product with a complex chemical composition produced by <em>Apis mellifera</em> bees, has been used in traditional medicine for centuries for its antimicrobial, anti-inflammatory, and wound-healing properties, as well as for treating respiratory infections, gastrointestinal disorders, and oral health issues. The phytochemical composition of propolis is strongly influenced by the local flora, leading to regional variations in bioactive compounds and thus therapeutic properties. This study specifically focuses on the latest research on Brazilian propolis and examines the phytochemical composition and biological activities of the green, red, and brown types. Brazil is one of the largest global propolis producers, exporting between 140 and 150 tons annually, primarily to Japan. The chemical characterization of propolis is performed using advanced analytical techniques, such as high-performance liquid chromatography (HPLC), gas chromatography coupled with mass spectrometry (GC–MS), Fourier-transform infrared spectroscopy (FTIR), and nuclear magnetic resonance (NMR), enabling the identification of various bioactive compounds, including polyphenols, benzoic acids, and terpene alcohols. Propolis exhibits a wide range of biological activities, such as antimicrobial, antioxidant, anti-inflammatory, and antitumor effects. This review lists the main chemical compounds and their biological activities in light of regional variations in the composition of Brazilian propolis, emphasizing the importance of strategies that address these variations to optimize its therapeutic and industrial potential.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"185 ","pages":"Article 106687"},"PeriodicalIF":2.5,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144306617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Flavonoids from the stems of Ammopiptanthus nanus and their in vitro and in vivo anti-inflammatory activities 牡丹茎中的黄酮类化合物及其体内外抗炎活性

IF 2.5 3区医学

Fitoterapia Pub Date : 2025-06-16 DOI: 10.1016/j.fitote.2025.106678

Ruili Zhang , Qianqian Yang , Yanpei Sun , Hongjuan Zhang , Jia Zhang , Xu Lu , Munire Satiwald , Pengpeng Zhang , Yang Jin , Jing Ji , Lina Chen

{"title":"Flavonoids from the stems of Ammopiptanthus nanus and their in vitro and in vivo anti-inflammatory activities","authors":"Ruili Zhang , Qianqian Yang , Yanpei Sun , Hongjuan Zhang , Jia Zhang , Xu Lu , Munire Satiwald , Pengpeng Zhang , Yang Jin , Jing Ji , Lina Chen","doi":"10.1016/j.fitote.2025.106678","DOIUrl":"10.1016/j.fitote.2025.106678","url":null,"abstract":"<div><div><em>Ammopiptanthus nanus</em> (M. Pop.) Cheng f. (<em>A. nanus</em>) is known for its anti-rheumatoid arthritis effects in folk medicine. This study conducted an anti-inflammatory activity-guided exploration of <em>A. nanus</em> stem crude extract. Twenty-five flavonoids, including five isoflavonoids with novel structures, were isolated and identified. Their structures were determined by using HRESIMS, NMR, IR, UV, optical rotation data and X-ray crystallography. Among them, compound <strong>1</strong> features a unique dihydropyran skeleton connected to the A-ring of the isoflavone. The obtained flavonoids were screened for their anti-inflammatory effects in LPS-induced RAW 264.7 cells. Notably, lupiwighteone (<strong>14</strong>) with an IC<sub>50</sub> value of 22.76 ± 3.37 μM, showed the most potent inhibitory effect, which could suppress the release of NO by inhibiting the expression of iNOS protein. Further <em>in vivo</em> experiment results revealed that lupiwighteone (<strong>14</strong>) might improve the survival rates in mice subjected to LPS-induced septic shock and selectively suppress the release of IL-1β to inhibit NLRP3 inflammasome.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"185 ","pages":"Article 106678"},"PeriodicalIF":2.5,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144322265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New approach of using medicinal mushrooms for managing and curing multiple sclerosis 药用蘑菇治疗多发性硬化症的新方法。

IF 2.5 3区医学

Fitoterapia Pub Date : 2025-06-15 DOI: 10.1016/j.fitote.2025.106684

Golchehr Pourmohammadi, Hamid Moghimi

{"title":"New approach of using medicinal mushrooms for managing and curing multiple sclerosis","authors":"Golchehr Pourmohammadi, Hamid Moghimi","doi":"10.1016/j.fitote.2025.106684","DOIUrl":"10.1016/j.fitote.2025.106684","url":null,"abstract":"<div><div>Multiple Sclerosis (MS) is a worldwide condition related to the central nervous system (CNS). This disease affects women more than men. Various neurological symptoms characterize this disease, which can permanently disrupt the nervous system and gradually increase disability over time, weakening medical, socioeconomic and physical well-being. Currently, side effects and financial issues have largely limited the use of chemical drugs to cure MS. Another promising option for curing MS is the use of herbal remedies, especially medicinal mushrooms. Numerous studies suggest that medicinal mushrooms are helpful in the treatment of MS due to their active compounds, particularly polysaccharides, terpenes and peptides. Key factors that may be responsible for the therapeutic benefits of these mushrooms in MS treatment include increased production of antioxidant enzymes, improved function of organs such as the liver and gut, increased immune system performance, increased B and T cells, anti-inflammatory effects and nerve cell protection. In this review article, we assess the latest advances in MS treatment, address the side effects of chemical medications for this disease, and examine the potential benefits of using herbs and medicinal mushrooms. In addition, we have analyzed the mechanisms by which their active ingredients might help in the treatment of MS. It is worth mentioning that medicinal mushrooms could play an important role in the treatment of MS in the near future.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"185 ","pages":"Article 106684"},"PeriodicalIF":2.5,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144316235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative analysis of phytochemical constituents of Ginkgo Biloba flowers and leaves, and evaluation of their biological activities 银杏花与叶的植物化学成分比较分析及其生物活性评价

IF 2.5 3区医学

Fitoterapia Pub Date : 2025-06-15 DOI: 10.1016/j.fitote.2025.106673

Yu-Ying Wang , Rui-Hong Li , Xin Sun , Zi-Ming Xia , Guang-Jie Zhang , Bin Li , Ying Tian , Min Li , Shu-Chen Liu

{"title":"Comparative analysis of phytochemical constituents of Ginkgo Biloba flowers and leaves, and evaluation of their biological activities","authors":"Yu-Ying Wang , Rui-Hong Li , Xin Sun , Zi-Ming Xia , Guang-Jie Zhang , Bin Li , Ying Tian , Min Li , Shu-Chen Liu","doi":"10.1016/j.fitote.2025.106673","DOIUrl":"10.1016/j.fitote.2025.106673","url":null,"abstract":"<div><h3>Backgrounds</h3><div><em>Ginkgo biloba</em> L. has attracted much attention for its unique pharmacological properties; research on <em>Ginkgo biloba</em> flowers (GBF) is still in its infancy than <em>Ginkgo biloba</em> leaves (GBL).</div></div><div><h3>Methods</h3><div>In this study, the chemical constituents of both were identified by UPLC-Q-orbitrap HRMS, and the contents of amino acids, fatty acids, inorganic elements, purines, and ceramides of both were determined. Meanwhile, the anti- ferroptosis and anti-radiation activity of GBF and GBL were comparatively studied by cellular experiments.</div></div><div><h3>Results</h3><div>The results showed that GBF was rich in flavonoids, and a total of 73 flavonoids were identified, of which 57 flavonoids were higher than GBL, and the components with the highest response values were isorhamnetin-3-o-neohespeidoside, neoisorutin, and hyperoside, etc. The total amino acid content of GBF was approximately 15.7 times, the total fatty acid content was about 7.4 times of that of GBL, and the content of purines, ceramides, and inorganic elements were all rich. In addition, their protective effects and mechanisms against erastin-induced ferroptosis in PC12 cells and the radioprotective effects of both were investigated. All concentrations of GBF inhibited ferroptosis better than GBL and suppressed the disruption of ROS, LPO, SOD, and Fe<sup>2+</sup>. GBF had stronger neuroprotective activity against erastin-induced PC12 cells and stronger radioprotective effects.</div><div>Through in-depth analyses of the chemical and nutritional compositions of GBF and GBL, the present study reveals the possible material basis for the stronger activity of GBF and provides theoretical support for development of functional nutraceuticals and radiation protection drugs with higher health benefits.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"185 ","pages":"Article 106673"},"PeriodicalIF":2.5,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144306515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phytochemistry analysis of the above-ground parts of Sanguisorba officinalis L. and its effects on myocardial cell metabolism 地榆地上部植物化学分析及其对心肌细胞代谢的影响。

IF 2.5 3区医学

Fitoterapia Pub Date : 2025-06-15 DOI: 10.1016/j.fitote.2025.106686

Baobao Zhang , Qingling Zhang , Zhenzhen Liu , Yangyang Zhai , Peifen Jin , Huiling Luan

{"title":"Phytochemistry analysis of the above-ground parts of Sanguisorba officinalis L. and its effects on myocardial cell metabolism","authors":"Baobao Zhang , Qingling Zhang , Zhenzhen Liu , Yangyang Zhai , Peifen Jin , Huiling Luan","doi":"10.1016/j.fitote.2025.106686","DOIUrl":"10.1016/j.fitote.2025.106686","url":null,"abstract":"<div><div><em>Sanguisorba officinalis</em> L. (<em>S. officinalis</em>) has been shown to alleviate inflammation, lipid metabolism and glycolysis, yet the constituents of the above-ground parts of <em>S. officinalis</em> and its effects on these abnormal metabolic processes is still unclear. In this paper, the constituents of the above-ground parts of <em>S. officinalis</em> was identified by UPLC-Q-TOF-MS/MS, and its effects on metabolism was evaluated in isoproterenol-treated H9C2 cell and C57BL/6 mice. Results revealed that 69 ingredients was determined in the above-ground parts of <em>S. officinalis</em>, including 13 flavonoids and their glycosides, 36 phenolic acids and their glycosides, 13 sapogenins and their glycosides, and 7 other types of compounds. Meanwhile, results also revealed that the above-ground parts of <em>S. officinalis</em> could inhibit the accumulation of lipids via HIF-1α/HSP70 pathway, decrease the over-activation of glycolysis via HKII and PFKFB3, and decrease the over-activation of inflammation via NF-κB p65 and iNOS in vitro. Moreover, the similar results were determined in vivo, and the effects of the above-ground parts of <em>S. officinalis</em> on the expressions of related proteins were determined by immunohistochemistry and western blot. Consequently, the above-ground parts of <em>S. officinalis</em> could effectively improve metabolic abnormalities in myocardial infarction model, and it could be serve as a potential drug for preventing and treating myocardial infarction.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"185 ","pages":"Article 106686"},"PeriodicalIF":2.5,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144316254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0