Fitoterapia最新文献

{"title":"A review of the traditional uses, phytochemistry, pharmacology and toxicity for the genus Geum (Rosaceae)","authors":"Xiyan Mo ,&nbsp;Yangkun Zhou ,&nbsp;Meng Zhan ,&nbsp;Ying Zhang ,&nbsp;Jun Liu ,&nbsp;Hongfeng Quang ,&nbsp;Lin Dong","doi":"10.1016/j.fitote.2024.106333","DOIUrl":"10.1016/j.fitote.2024.106333","url":null,"abstract":"<div><div>The genus <em>Geum</em> (family Rosaceae) comprises about 70 species, of which several species have been characterized from Eurasia as notably as folk medicines for the treatment of anti-inflammatory, antiseptic, diuretics and astringent. Phytochemical analysis indicated that <em>Geum</em> species produce monoterpenoids, sesquiterpenes, triterpenoids, flavonoids, tannins, phenylpropanoids, and others compounds. Additionally, modern studies have found they possess diverse pharmacological activities such as antioxidant, anti-inflammatory, neuroprotective, antimicrobial, anti-diabetic, cardiovascular, and anti<strong>tumor</strong> effects. Regardless of the remarkable medical potential of <em>Geum</em> extracts, clinical studies are limited and need to be performed to produce safer and less expensive plant-based drugs. This literature review aims to provide a comprehensive overview of <em>Geum</em> species, covering their traditional uses, phytochemistry, and pharmacological activities, and to summarize the current research status to better understand the application value of <em>Geum</em> plants in modern phytotherapy.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"180 ","pages":"Article 106333"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142812430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing medicinal proteins production in plant bioreactors: A focal review on promoters","authors":"Cai Xiaoqi ,&nbsp;Ning Kang ,&nbsp;Xu Pei","doi":"10.1016/j.fitote.2024.106338","DOIUrl":"10.1016/j.fitote.2024.106338","url":null,"abstract":"<div><div>The use of plant bioreactors for the production of medicinal proteins has emerged as a promising and cost-effective alternative to traditional microbial and mammalian cell culture systems. This review provides a focused examination of the critical role of promoters in enhancing the production of therapeutic proteins within plant-based platforms. We discuss the latest advancements in promoter discovery, modification, and optimization for the expression of medicinal proteins in plants. The review highlights the challenges and opportunities associated with various types of promoters, including constitutive, tissue-specific, and inducible promoters, and their impact on medicinal protein yield and quality. Case studies are presented to illustrate the successful application of these promoter engineering techniques in plant bioreactors, emphasizing the potential for scalable and sustainable production of pharmaceutical proteins. Additionally, we explore the strategies for improving promoter function. This review is intended to guide researchers and industry professionals in the selection and design of promoters for the enhanced production of medicinal proteins in plant bioreactors.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"180 ","pages":"Article 106338"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142817591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research on the anti-hepatic fibrosis effects and active components of the medicinal plant Tithonia diversifolia","authors":"Jialin Wang ,&nbsp;Haini Li ,&nbsp;Ting Wang ,&nbsp;Haifeng Xie ,&nbsp;Yang Ruan ,&nbsp;Chaofeng Zhang","doi":"10.1016/j.fitote.2024.106317","DOIUrl":"10.1016/j.fitote.2024.106317","url":null,"abstract":"<div><h3>Background</h3><div>The medicinal folk plant <em>Tithonia diversifolia</em> A. Gray has traditionally been used to treat hepatitis and liver cancer. However, the anti-fibrotic effect of this plant extract and its main active substances remain unclear.</div></div><div><h3>Objective</h3><div>This study aims to elucidate the anti-fibrotic effect of <em>T. diversifolia</em> ethanol extract, identify the main active substances, and explore their possible molecular mechanisms.</div></div><div><h3>Methods</h3><div>Firstly, carbon tetrachloride (CCl₄) was injected intraperitoneally to induce liver fibrosis in mice to investigate the protective effect of <em>T. diversifolia</em> ethanol extract. Then, thirty compounds in this extract were identified through liquid chromatography-mass spectrometry (LC-MS/MS) analysis, column chromatography, and spectroscopic analysis. In addition, the anti-fibrotic effect of sesquiterpene lactone compounds were investigated on TGF-β-induced hepatic stellate cell activation.</div></div><div><h3>Results</h3><div>The <em>T. diversifolia</em> ethanol extract significantly inhibits symptoms of carbon tetrachloride-induced liver fibrosis and the collagen deposition in pathological tissues by suppressing the protein expression of various pro-fibrotic factors. A comprehensive profile of thirty-one compounds was established, including nine sesquiterpenes, six phenolic acids, six fatty acids, five phenylpropanoids, and three flavonoids. Notably, one previously unreported sesquiterpene lactone, namely 1β-ethoxydiversifolin 3-<em>O</em>-methyl ether (1), together with twenty-nine known compounds were obatined<em>.</em> Sesquiterpene Tagitinin C shows significant anti-fibrotic effects on TGFβ1-induced HSC-T6 activation by inducing cell apoptosis and regulating the TGF-β1/Smad pathway.</div></div><div><h3>Conclusion</h3><div>The above results indicate that the <em>T. diversifolia</em> extract can effectively alleviate liver fibrosis, with sesquiterpene lactones being a major component. In the future, the germacranolides-type of sesquiterpene lactone Tagitinin C can be developed as a precursor compound for anti-fibrotic therapy.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"180 ","pages":"Article 106317"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142750076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"One new polyketide and four new sesquiterpenes derivatives from the fungicolous fungi aspergillus nidulans LZ8 of Ganoderma lingzhi","authors":"Hong Zhang ,&nbsp;Zhuoda Zhou ,&nbsp;Minghua Yang ,&nbsp;Shengyu Li ,&nbsp;Xia Liu ,&nbsp;Lu Jin ,&nbsp;Qiyang Shou ,&nbsp;Huiying Fu","doi":"10.1016/j.fitote.2024.106339","DOIUrl":"10.1016/j.fitote.2024.106339","url":null,"abstract":"<div><div>One new polyketide asperfuranone D (<strong>1</strong>), four new sesquiterpenes derivatives aspergillone C-F (<strong>2</strong>–<strong>5</strong>) and three known compounds (<strong>6</strong>–<strong>8</strong>) were successfully isolated from <em>Aspergillus nidulans</em> LZ8, a fungicolous fungi from the macrofungal <em>Ganoderma lingzhi</em>. The structures of these compounds were elucidated by extensive spectroscopic analyses including ultraviolet-visible spectroscopy (UV), mass spectrometry (MS), nuclear magnetic resonance (NMR), and electronic circular dichroism (ECD) calculation. In addition, the anti-inflammatory activities of the new compounds were evaluated using LPS-induced RAW 264.7 cells. The results revealed that compound <strong>5</strong> showed moderate nitric oxide (NO) inhibitory activity with the IC₅₀ value of 13.19 ± 1.05 μM, while the IC₅₀ value of the positive control L-NMMA was 41.88 ± 0.91 μM.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"180 ","pages":"Article 106339"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142806519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improved production of palitantin by design of experiments and semi-synthesis of palitantin derivatives for bioactivity assessment","authors":"Pedro M. Santucci ,&nbsp;Caroline R. de Oliveira ,&nbsp;Afif F. Monteiro ,&nbsp;Giovana R. Mendes ,&nbsp;Marcelo R. de Amorim ,&nbsp;Gabriel H.S. Rosa ,&nbsp;Lara D. Sette ,&nbsp;Rafael C. Marchi ,&nbsp;Victor M. Deflon ,&nbsp;Pedro H.T. dos Santos ,&nbsp;Gabriela G. Carvalho ,&nbsp;Marcelo Brocchi ,&nbsp;Rafael V.C. Guido ,&nbsp;Antonio G. Ferreira ,&nbsp;Kleber T. de Oliveira ,&nbsp;Roberto G.S. Berlinck","doi":"10.1016/j.fitote.2024.106310","DOIUrl":"10.1016/j.fitote.2024.106310","url":null,"abstract":"<div><div>A new method for the production and isolation of (+)-palitantin (<strong>1</strong>) is herein reported, from cultures of the fungal strain <em>Penicillium</em> sp. AMF1a. (+)-Palitantin was isolated in 160 mg/L yield, as an alternative procedure to obtain <strong>1</strong> at a larger scale. The complete spectroscopic characterization, including conformational analysis, is presented for (+)-palitantin (<strong>1</strong>) and for its derivatives 3-<em>α</em>-palitantol (<strong>2</strong>), 3-<em>β</em>-palitantol (<strong>3</strong>), (<em>Z</em>)-palinitrorin (<strong>4</strong>), (<em>Z</em>)-paliphenin (<strong>5</strong>), (<em>Z</em>)-palifluorin (<strong>6</strong>) and (<em>E</em>)-palifluorin (<strong>7</strong>). The absolute configuration of the palitantin portion was confirmed by X-ray analysis of compound <strong>4</strong>. The (4-(trifluoromethyl)benzyl)-hydrazone derivatives (<strong>6</strong> and <strong>7</strong>) displayed moderate biological activities. (<em>Z</em>)-Palifluorin (<strong>6</strong>) exhibited moderate antiplasmodial activity, while (<em>E</em>)-palifluorin (<strong>7</strong>) displayed weak antibacterial activity against <em>E. faecalis</em> and <em>S. aureus</em>, while palitantin itself was inactive in the same bioassays, indicating that the semi-synthesis of nitrogenated derivatives of <strong>1</strong> may be of potential interest to generate bioactive palitantin derivatives.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"180 ","pages":"Article 106310"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142767618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"C17-Labdane diterpenoid alkaloids bearing a rare skeleton with anti-inflammatory and anti-oxidant activities from Forsythia suspensa","authors":"Jia-Huan Liu ,&nbsp;Yue Wang ,&nbsp;Sheng-Jun Dai ,&nbsp;De-Wu Zhang ,&nbsp;Xi-Dian Yue","doi":"10.1016/j.fitote.2024.106345","DOIUrl":"10.1016/j.fitote.2024.106345","url":null,"abstract":"<div><div>Two undescribed C₁₇-Labdane diterpenoid alkaloids, named forsylinfenines A and B (<strong>1</strong>–<strong>2)</strong>, attributable to a rare 4,4,10,13-tetramethyl-1(2),3(4),5(10),6(7)-octahydrobenzo[<em>f</em>]quinolin skeleton, along with three known <em>β</em>-carboline-type alkaloids (<strong>3</strong>–<strong>5</strong>), were isolated. The chemical structures including absolute configurations of two undescribed compounds were established by means of integrated spectroscopic techniques and electronic circular dichroism (ECD) calculations. In addition, a plausible biosynthetic pathway for the formation of compounds <strong>1</strong> and <strong>2</strong> was proposed. <em>In vitro</em>, five alkaloids (<strong>1</strong>–<strong>5</strong>), especially two undescribed alkaloids with rare skeleton (<strong>1</strong>–<strong>2</strong>), exhibited significant anti-inflammatory activities due to inhibiting the release of TNF-<em>α</em>, IL-6, and IL-1<em>β</em>, as well as effective anti-oxidant activities owing to preventing the production of ROS in the LPS-induced RAW264.7 cells.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"180 ","pages":"Article 106345"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142817523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-platform comparison and phytochemical insights of Tripleurospermum taxa from Greece","authors":"Eleftherios Kalpoutzakis,&nbsp;Christodoulos Anagnostou,&nbsp;Sofia Mitakou,&nbsp;Eleni V. Mikropoulou,&nbsp;Maria Halabalaki","doi":"10.1016/j.fitote.2024.106340","DOIUrl":"10.1016/j.fitote.2024.106340","url":null,"abstract":"<div><div>The <em>Tripleurospermum</em> (L.) Sch.Bip, (Asteraceae) genus, comprises 30 to 40 species widely spread in the northern hemisphere, and across the Mediterranean region. Out of the seven taxa encountered in Greece, four can only be found in specific areas, with limited spread throughout the country. The current work describes the phytochemical investigation, using modern analytical techniques, of the differences between the aerial parts of <em>T. tempskyanum</em> and <em>T. rosellum</em> collected from two floristic regions of Greece (Lesvos isl. and Mt. Parnon) and the common chamomile (<em>Matricaria recutita</em>). GC–MS was first applied for the analysis of the essential oils and dichloromethane extracts, significantly differentiating <em>M. recutita</em> from the <em>Tripleurospermum</em> taxa. Afterwards, a fractionation of <em>T. tempskyanum</em> ‘s non-polar and polar extracts afforded their major compounds, thus assisting to the unambiguous distinction of different isomers of matricaria lactone, as well as the first-time isolation of demethyl brevisnosideyne. Finally, the polar extracts were analyzed by means of UPLC–Orbitrap–HRMS/MS, revealing similarities among the species, with profiles dominated by cinnamic and flavonoid derivatives and fatty acids, with quantitative differences being observed for specific groups of compounds. Overall, the current study provides novel insight on the phytochemical differentiation between the studied genera and species.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"180 ","pages":"Article 106340"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142817633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Highly modified lanostane triterpenoids from natural fruiting bodies of Ganoderma cf. hochiminhense","authors":"Somporn Palasarn ,&nbsp;Wilunda Choowong ,&nbsp;Natthawut Wiriyathanawudhiwong ,&nbsp;Rattaket Choeyklin ,&nbsp;Masahiko Isaka","doi":"10.1016/j.fitote.2024.106336","DOIUrl":"10.1016/j.fitote.2024.106336","url":null,"abstract":"<div><div>Eight previously undescribed highly modified lanostane triterpenoids, ganoboninketals G–K (<strong>1</strong>–<strong>5</strong>), ganoboninone I (<strong>6</strong>), ganoderlactone G (<strong>7</strong>), and (24<em>E</em>)-3,11-dioxolanosta-8,24-dien-26-oic acid (<strong>8</strong>), were isolated from natural fruiting bodies of <em>Ganoderma</em> cf. <em>hochiminhense</em>. The structures were elucidated on the basis of NMR spectroscopic and mass spectrometry data. Ganoboninketals G (<strong>1</strong>), H (<strong>2</strong>), and J (<strong>4</strong>) exhibited antimalarial activity against <em>Plasmodium falciparum</em> K1 (multidrug-resistant strain) with IC₅₀ values of 17, 16, and 5.1 μM, respectively.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"180 ","pages":"Article 106336"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142823970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Terpenoids mediated cell apoptotsis in cervical cancer: Mechanisms, advances and prospects","authors":"Peng Zhang ,&nbsp;Hong Liu ,&nbsp;Yuan Yu ,&nbsp;Shiyang Peng ,&nbsp;Anqi Zeng ,&nbsp;Linjiang Song","doi":"10.1016/j.fitote.2024.106323","DOIUrl":"10.1016/j.fitote.2024.106323","url":null,"abstract":"<div><h3>Background</h3><div>Cervical cancer remains one of the most common malignancies among women globally, causing hundreds of thousands of deaths annually. Despite widespread vaccination and screening programs, the incidence of cervical cancer remains high in developing countries.</div></div><div><h3>Objective</h3><div>This review aims to systematically summarize the existing terpenoids effective in preventing cervical cancer, elucidate their potential mechanisms in the prophylaxis and treatment of cervical cancer, and assess the limitations of current studies.</div></div><div><h3>Results</h3><div>Studies have shown that terpenoids can decrease the incidence of cervical cancer and promote apoptosis of cancer cells through various signaling pathways, including the PI3K/AKT pathway, the endoplasmic reticulum stress (ERS) pathway, and the mitochondria- and caspase-dependent cell death pathways. Furthermore, some terpenoids have been found to enhance the sensitivity to chemotherapy drugs, thus improving patients' quality of life.</div></div><div><h3>Conclusion</h3><div>Terpenoids play a significant role in inhibiting the progression of cervical cancer. However, due to their diversity and complex mechanisms of action, further research is necessary to investigate their specific targets and bioactivities to advance their clinical trials and applications.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"180 ","pages":"Article 106323"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142779573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New flavonoid glycosides from the stems and leaves of Astragalus membranaceus","authors":"Jin-Yan Tan ,&nbsp;Jia-Xin Zhao ,&nbsp;Yun Zang ,&nbsp;Pei Li ,&nbsp;Si-Qi Yang ,&nbsp;Xiao-Mao Li ,&nbsp;Ying-Li Wang ,&nbsp;Yan-Gang Cheng","doi":"10.1016/j.fitote.2024.106321","DOIUrl":"10.1016/j.fitote.2024.106321","url":null,"abstract":"<div><div><em>Astragalus membranaceus</em>, a well-known traditional medicine and food, has been extensively studied for its roots. However, comparatively little attention has been paid to its stems and leaves. In this study, we successfully isolated and identified three new flavonoid glycosides (<strong>1–3</strong>), and eight known analogues (<strong>4–11</strong>) from the stems and leaves of <em>A. membranaceus</em>. Notably, compound <strong>10</strong> exhibited significant anti-inflammatory activities in LPS-induced BV2 cells, with IC₅₀ value of <em>1.11 ± 0.04 μM</em>. These findings highlight flavonoids as the key bioactive components present in the stems and leaves of <em>A. membranaceus</em>.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"180 ","pages":"Article 106321"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142784924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}