Fitoterapia最新文献

{"title":"Integrative multivariate analysis of agro-chemical and genotypic traits in Indian catmint (Nepeta cataria L.) half-sib populations","authors":"Trishna Chaturvedi ,&nbsp;Yash Pandey ,&nbsp;Anil Kumar Gupta ,&nbsp;Ramesh Kumar Srivastava ,&nbsp;Gunjan Tiwari","doi":"10.1016/j.fitote.2024.106308","DOIUrl":"10.1016/j.fitote.2024.106308","url":null,"abstract":"<div><div>This investigation conducted a comprehensive multivariate analysis on thirty half-sib populations of <em>Nepeta cataria</em> L., derived from natural populations based on oil yield. The study addresses the lack of comprehensive data on genetic, phenotypic, and chemical diversity in <em>Nepeta cataria</em>, which is essential for material selection and for conducting effective breeding programs. A substantial amount of phenotypic diversity was observed for all eleven quantitative traits measured in the present study. The phenotypic diversity was assessed using Euclidean distance-based agglomerative hierarchical clustering and principal component analysis (PCA) which showed more than 50 % diversity existing among the studied populations. These methods delineated the populations into three primary clusters, where herb yield was a key discriminator. The GC and GC/MS-based chemical profiling of these populations identified eleven major phytochemicals. Though, significant variances in the concentrations of various nepetalactone isomers were noted, correlating with the phenotypic clusters, the major differentiation was observed for cis-trans Nepetalactone (<strong>73.45%–93.20 %).</strong> Three distinct chemical clusters were defined, each characterized by unique chemical signatures. Molecular diversity was evaluated using 21 Start Codon Targeted Polymorphic (SCoT) and 20 CAAT box-derived DNA Polymorphic (CBDP) markers, revealing high levels of polymorphism. Populations were again grouped into three clusters. A correlative Mantel test performed to determine the association between agro-chemical and genotypic traits revealed minimal correlation between them, indicating a complex interplay between genetic makeup and phenotypic traits across these populations. This study underscores the genetic and chemical diversity within <em>Nepeta cataria</em> half-sib populations, providing insights that could influence future breeding and conservation efforts. The distinct clustering based on agronomic, chemical, and genotypic data highlights the potential for targeted selection and breeding programs within this species. Future research should focus on integrating these findings into breeding strategies for enhancing commercial cultivation.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"180 ","pages":"Article 106308"},"PeriodicalIF":2.5,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142695339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structural diversity, biological activities and biosynthetic pathways of [2 + 2] and [4 + 2] amide alkaloid dimers from Piperaceae: An updated review","authors":"Guanghui Gou ,&nbsp;Wenli Bao ,&nbsp;Jun Li","doi":"10.1016/j.fitote.2024.106305","DOIUrl":"10.1016/j.fitote.2024.106305","url":null,"abstract":"<div><div>The Piperaceae family is distributed widely in tropical and subtropical areas. It encompasses around 5 genera and over 3000 species. They are distinguished by the substantial chemical diversity and potential medicinal applications. Amide alkaloids, as the main secondary metabolites in the Piperaceae family, exhibit various biological activities, and the discovery of [2 + 2] and [4 + 2] amide alkaloid dimers has led to a surge in phytochemical research on Piperaceae plants. Although the identification of these dimers has been gradually increasing in recent years, there remains a lack of comprehensive and systematic evaluations of these compounds. This review aims to summarize the latest advancements in the research on natural amide alkaloid dimers, focusing on their structural diversity, biological activities and biosynthetic pathways, and the enzymatic advances of [2 + 2] and [4 + 2] cyclase enzymes. Until October 2024, research has documented 99 amide alkaloid dimers, including 37 dimers possessing [2 + 2] cyclobutanes skeletons and 62 [4 + 2] cyclohexene skeletons derived from the Piperaceae family. These compounds demonstrate a range of <em>in vitro</em> biological activities including anti-inflammatory, anticancer, acetylcholinesterase inhibitory, anti-platelet aggregation, hepatoprotective, antimalarial, antitubercular, anti-diabetic and notable interactions with CYP3A4 and CYP2D6 enzymes. A systematic review of these [2 + 2] and [4 + 2] amide alkaloid dimers in Piperaceae family can provide a critical scientific foundation and theoretical support for the discovery and development of novel pharmaceutical agents.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"180 ","pages":"Article 106305"},"PeriodicalIF":2.5,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142692843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacology, phytochemistry, and traditional uses of Huperzia serrata (Thunb. ex Murray) Trev.","authors":"Zhuoliang Chu,&nbsp;Qingmei Sun,&nbsp;Meiqin Mao,&nbsp;Yutong Wu,&nbsp;Le Yu,&nbsp;Jingyi Xu,&nbsp;Kaohua Liu,&nbsp;Luping Qin,&nbsp;Bo Zhu","doi":"10.1016/j.fitote.2024.106304","DOIUrl":"10.1016/j.fitote.2024.106304","url":null,"abstract":"<div><div><em>Huperzia serrata</em> (HS) has been a staple of traditional Chinese medicine for centuries, revered for its efficacy in treating various ailments such as pain relief, hemostasis, detoxification, dehumidification, and heat clearing. This review offers an in-depth summary of the botany, traditional utilization, pharmacology, pharmacokinetics, phytochemistry, and safety profile of HS and intends to shed light on potential future research directions and applications of this plant. Information on HS was gathered from ScienceDirect, PubMed, Springer, Sci Finder, Baidu Scholar, and Google Scholar. Over 94 compounds have been separated and identified from HS, including alkaloids, terpenoids, volatile oils, flavonoids, and polysaccharides. Both crude extracts and purified compounds from HS have shown promise in treating a spectrum of conditions, including Alzheimer's disease, epilepsy, pain, cancer, and inflammation. These extracts and compounds exhibit diverse pharmacological properties, including neuroprotective, anti-Alzheimer's, anti-epileptic, analgesic, cardioprotective, hepatoprotective, antioxidant, and anticancer activities. Pharmacological investigations support the traditional use of HS and may validate the folk medicinal use of HS to treat many chronic diseases. Current literature suggests that the bioactivity of HS is largely attributed to its alkaloids and polysaccharides. However, further exploration is warranted to comprehensively understand the structure-function relationship of these constituents, molecular mechanisms, and their potential synergistic and antagonistic interactions. Moreover, additional modern pharmacological explorations are necessary to validate the traditional use of HS such as promoting hemostasis, treating tuberculosis, hemorrhoids, and diarrhea. Therefore, there is a pressing need for comprehensive investigations to fully assess HS' medicinal properties and therapeutic potential.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"180 ","pages":"Article 106304"},"PeriodicalIF":2.5,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142686281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diterpenoids and lignans from the stems of Tripterygium wilfordii and their anti-inflammatory activities","authors":"Yulu Tian ,&nbsp;Yazi Wei ,&nbsp;Haowen Luo,&nbsp;Xinyi Chen,&nbsp;Jie Ma,&nbsp;Yingda Zang,&nbsp;Tiantai Zhang,&nbsp;Dongming Zhang,&nbsp;Chuangjun Li","doi":"10.1016/j.fitote.2024.106306","DOIUrl":"10.1016/j.fitote.2024.106306","url":null,"abstract":"<div><div>Two undescribed diterpenoids (<strong>1</strong>–<strong>2</strong>) and three lignans (<strong>3a</strong>/<strong>3b</strong>, <strong>4a</strong>), together with sixteen known compounds (<strong>4b</strong>, <strong>5</strong>–<strong>9</strong>, <strong>10a/10b</strong>–<strong>14a/14b</strong>) were obtained from the stems of <em>Tripterygium wilfordii</em> (<em>T. wilfordii</em>). The structures of these new compounds were elucidated by detailed spectroscopic analyses, and their absolute configurations were estabished by ECD calculations. Some compounds exhibited moderate inhibitory activities against IL-6 production in LPS-stimulated RAW 264.7 macrophages <em>in vitro</em>. Compound <strong>5</strong> showed significant anti-inflammatory activity <em>in vitro</em> (IC₅₀, 0.77 <em>μ</em>M) and inhibited macrophage polarization towards a pro-inflammatory phenotype.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"180 ","pages":"Article 106306"},"PeriodicalIF":2.5,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142686350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Qualitative chemical characterization of salva-de-marajó (Lippia origanoides, Verbenaceae) preparations","authors":"Rayane da Cruz Albino ,&nbsp;Marcos Vinicius Toledo e Silva ,&nbsp;Victor Paulo Ferreira ,&nbsp;Anna Paola Trindade Rocha Pierucci ,&nbsp;Humberto Ribeiro Bizzo ,&nbsp;Paola Ervatti Gama ,&nbsp;Nina Claudia Barboza da Silva ,&nbsp;Mariana Cunha de Paula Freitas ,&nbsp;Suzana Guimarães Leitão ,&nbsp;Danilo Ribeiro de Oliveira","doi":"10.1016/j.fitote.2024.106302","DOIUrl":"10.1016/j.fitote.2024.106302","url":null,"abstract":"<div><div><em>Lippia origanoides</em> Kunth (LO, Verbenaceae), commonly known in Brazil as <em>salva-de-marajó</em>, is an aromatic plant native to the Americas. <em>Quilombola</em> women from Oriximiná (Pará State, Brazil) use decoctions and decoction vapors of LO aerial parts orally or in sitz baths to alleviate symptoms of dysmenorrhea. This study aimed to evaluate LO decoctions and essential oils through a chemo-qualitative approach. Aerial parts of LO were collected from two individuals, and other two commercial samples were acquired from a public market. Aqueous extract of each sample was obtained by decoction and spray drying. The spray-dried decoctions were chemically characterized using UPLC–APCI(−)–IT–MS² and cluster heatmap analysis to discern compositional patterns. Essential oils were obtained through hydrodistillation and analyzed using GC–MS and GC–FID. In total, 12 compounds were tentatively identified from LO decoctions. Their product ion spectra were characteristic of flavonoid aglycones (5) and glycosides (4), and phenylpropanoids, including two stilbene glycosides and one hydroxycinnamic acid glycoside. Variations were noted in the chemical fingerprints of the decoctions, but the flavonoid glycosides orientin, isoorientin, and vitexin emerged as potential markers for the species. The essential oils of the samples contained high amounts of oxygenated monoterpenoids, with a predominance of the <em>p</em>-menthanes carvacrol (up to 61.9 %) and/or thymol (up to 17.0 %), and <em>p</em>-cymene (up to 24.9 %). This study was the first to explore the chemical composition of decoctions derived from LO, highlighting the species as an untapped source of phenolic glycosides, an aspect that has received limited discussion thus far.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"180 ","pages":"Article 106302"},"PeriodicalIF":2.5,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142692842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ten limonoids and three protolimonoids from the Thai mangrove Xylocarpus moluccensis","authors":"Li-Fu Liu ,&nbsp;Wei Zhao ,&nbsp;Patchara Pedpradab ,&nbsp;Jun Wu ,&nbsp;Li Shen","doi":"10.1016/j.fitote.2024.106307","DOIUrl":"10.1016/j.fitote.2024.106307","url":null,"abstract":"<div><div>Ten new limonoids, named xylomolones E–N (<strong>1</strong>−<strong>10</strong>), and two new protolimonoids, named xylomolones O (<strong>11</strong>) and P (<strong>12</strong>), were isolated from seeds of the Thai mangrove <em>Xylocarpus moluccensis</em>, together with the known compound, hispidone acetonide (<strong>13</strong>). The structures of these compounds were established by extensive NMR spectroscopic data, single-crystal X-ray diffraction analysis, and comparison of experimental ECD spectra. The absolute configurations of xylomolones E (<strong>1</strong>) and L (<strong>8</strong>) were unambiguously determined by single-crystal X-ray diffraction analyses, conducted with Cu Kα radiation. Xylomolones E–L (<strong>1</strong>–<strong>8</strong>) are mexicanolide-type limonoids, among which xylomolones <em>J</em> (<strong>6</strong>) and K (<strong>7</strong>) contain a C₇/C₂₈ <em>δ</em>-lactone ring, whereas xylomolones M (<strong>9</strong>) and N (<strong>10</strong>) are phragmalin-type limonoids. Xylomolones O (<strong>11</strong>) and P (<strong>12</strong>) are two new protolimonoids. In addition, the ¹H and ¹³C NMR spectroscopic data for hispidone acetonide (<strong>13</strong>) was first assigned completely. In bioassay, xylomolones F (<strong>2</strong>), M (<strong>9</strong>), and P (<strong>12</strong>) exhibited moderate inhibitory activity against the production of NO in LPS-induced RAW 264.7 cells with IC₅₀ values of 31.54 ± 7.27, 62.84 ± 17.62, and 22.7 ± 6.56 μM, respectively.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"180 ","pages":"Article 106307"},"PeriodicalIF":2.5,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142686287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrated workflows using metabolomics, genome mining, and biological evaluation reveal oxepine‑sulfur-containing anti-cryptococcal diketopiperazine produced by the endophyte Penicillium setosum","authors":"Cláudia Maria da Silva Costa de Oliveira ,&nbsp;Milena Costa Bassicheto ,&nbsp;Renan Santini Barbosa ,&nbsp;Kiandro de Oliveira Gomes Neves ,&nbsp;Caroline dos Santos Monteiro ,&nbsp;Miriam Uemi ,&nbsp;Renata Castiglioni Pascon ,&nbsp;Gilvan Ferreira da Silva ,&nbsp;Hector Henrique Ferreira Koolen ,&nbsp;Lívia Soman de Medeiros","doi":"10.1016/j.fitote.2024.106301","DOIUrl":"10.1016/j.fitote.2024.106301","url":null,"abstract":"<div><div>Cryptococcosis is a fungal infection for which treatment relies on old antifungal agents usually leading to drawbacks such as high toxicity and mainly low efficiency since drug resistance of microorganisms is strongly widespread. The discovery of new antifungal agents is urgent and investigations about underexplored Natural Product (NP) can yield the necessary outcomes to guide the discovery of new prototypes to anti-cryptococcal molecules development. In this scenario, an integrated strategy involving metabolomic data analysis, biological assessement and genome mining of <em>P. setosum</em> CMLD 18, revealed the biosynthesis of bis(methyl-sulfanyl) oxepine-containing diketopiperazine derivative, the bisdethiobis(methylthio)acetylaranotine (<strong>1</strong>) by the endophyte. The molecule showed a minimum inhibitory concentration (MIC) value of 0.125 mM when tested against <em>C. neoformans</em>. Evidence about the corresponding biosynthetic gene cluster (BGC) responsible for the biosynthesis of (<strong>1</strong>) in <em>P. setosum</em> were found. Moreover, other putative analogues of (<strong>1</strong>) were also detected, suggesting this microorganism may represent an important source of likely anti-cryptococcal molecules to be further investigated.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"180 ","pages":"Article 106301"},"PeriodicalIF":2.5,"publicationDate":"2024-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142667300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kakuol and asarinin protecting liver injury via HSP90AA1/CDK2/mTOR signaling pathway","authors":"Ling Jiang ,&nbsp;Cai-Bo Tian ,&nbsp;Rui-Han Ye ,&nbsp;Nian Shi ,&nbsp;Xing-Chao He ,&nbsp;Yun-Li Zhao ,&nbsp;Xiao-Dong Luo","doi":"10.1016/j.fitote.2024.106297","DOIUrl":"10.1016/j.fitote.2024.106297","url":null,"abstract":"<div><div>Drug-induced liver injury caused acute hepatic failure and hepatitis frequently. In this investigation, kakuol and asarinin reduced the levels of serum alanine transaminase (ALT), aspartate transaminase (AST) and malondialdehyde (MDA) dramatically, and ameliorated the pathological damage of liver tissues in APAP-induced mice. Furthermore, both compounds increased the viabilities of APAP-induced L-O2 cells and extracellular glutathione (GSH) levels accompanied significantly by reducing the level of intracellular ROS <em>in vitro</em>. In addition, HSP90AA1/CDK2/mTOR signaling pathway and five target proteins (CDK2, HSP90AA1, HRAS, MMP1, mTOR) were proposed from network pharmacology and molecular docking prediction, and then the up-regulation of protein expression of CDK2, mTOR and down-regulation of HSP90AA1, HRAS, MMP1 by kakuol and asarinin in western blotting supported their mechanism.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"180 ","pages":"Article 106297"},"PeriodicalIF":2.5,"publicationDate":"2024-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142647050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of lapachol's anti-inflammatory effectiveness in mitigating sepsis-induced acute lung injury","authors":"Kavita Joshi ,&nbsp;Vaishnavi Singh ,&nbsp;Samit Chatterjee ,&nbsp;Poonam Khandelwal ,&nbsp;Rashmy Nair ,&nbsp;Sameer Qureshi ,&nbsp;Snigdha Siddh ,&nbsp;Vandana Nunia","doi":"10.1016/j.fitote.2024.106298","DOIUrl":"10.1016/j.fitote.2024.106298","url":null,"abstract":"<div><div>Sepsis-induced Acute Lung Injury (ALI) and Acute Respiratory Distress Syndrome (ARDS) pose life-threatening risks due to an excessive activation of proinflammatory cytokines <em>via</em> the JAK pathway. Currently, no confirmed drug treatment exists for ALI. In this study, we explored JAK1 as a potential therapeutic target to address this issue. This study evaluates lapachol, a bioactive secondary metabolite, for its potential in treating sepsis-induced Acute Lung Injury (ALI). Lapachol was selected based on <em>in-silico</em> analyses such as binding energy, RMSD, RMSF, H-bond graphs, and lig plots supported the hypothesis that Lapachol binds to JAK1 in a manner similar to Tofacitinib JAK1/3 inhibitor (Positive control). Lapachol, derived from the heartwood of <em>Tecomella undulata</em>, was used in this investigation. Swiss albino mice were categorized into control, LPS treated, positive control (Tofacitinib), and experimental groups (Lapachol at 20 and 40 mg/kg doses). Throughout the experiment, mice behaviour was monitored, and euthanasia was performed at 12 and 24-h intervals. Various analyses, including body weight, W/D ratio, lung weight/body weight ratio, flow cytometry of BAL fluid (at 12 and 24 h), histology, myeloperoxidase assays were performed. Results indicated that both Tofacitinib and Lapachol significantly reduced ALI markers, including lung weight/body weight ratio, cell counts, and granulocytes in bronchoalveolar lavage fluid. Moreover, histopathology and MPO analysis suggested that Lapachol, particularly at 40 mg/kg, exhibited anti-inflammatory effects comparable to Tofacitinib. Conclusively, the findings suggest that Lapachol possesses the potential to inhibit JAK1 kinase domains and mitigate ALI associated with sepsis similar to Tofacitinib.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"180 ","pages":"Article 106298"},"PeriodicalIF":2.5,"publicationDate":"2024-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142675441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytochemical characterization, toxicity and pharmacological profile of the central effects of the fixed fruit pulp oil of Mauritia flexuosa L.F. (buriti)","authors":"Isaac Moura Araújo ,&nbsp;Andressa de Alencar Silva ,&nbsp;Luís Pereira-de-Morais ,&nbsp;Debora de Menezes Dantas ,&nbsp;Maysa de Oliveira Barbosa ,&nbsp;Giovana Mendes Lacerda Leite ,&nbsp;Carla de Fátima Alves Nonato ,&nbsp;José Galberto Martins da Costa ,&nbsp;Raimundo Luiz Silva Pereira ,&nbsp;Marta Regina Kerntopf Mendonça ,&nbsp;Henrique Douglas Melo Coutinho ,&nbsp;Gyllyandeson de Araújo Delmondes","doi":"10.1016/j.fitote.2024.106303","DOIUrl":"10.1016/j.fitote.2024.106303","url":null,"abstract":"<div><div>Anxiety and depression are mental disorders that have been exponentially increasing over the last decades. Psychopharmacology emerged to try to alleviate the symptoms of these disorders; however, the side effects and the time it takes to achieve the desired effect are factors that decrease the search for and adherence to treatment. To remedy this situation, new compounds capable of improving the performance of these medications and reducing their adverse effects have been sought. The use of medicinal plants has been widely employed for this purpose. <em>Mauritia flexuosa</em> F.L., a palm tree with high incidence in Brazil, has been heavily targeted as all its parts are usable. The objective of this study is to evaluate the effects of fixed oil from the fruit of the buriti palm in models of depression and anxiety. The phytochemical profile of this oil and its toxicity were also investigated. The experiments conducted included the open field, rotarod, forced swim, and elevated plus maze tests. As a result, it was observed that the fixed oil from buriti palm presented 18 compounds, with elaidic acid being the major one, and showed no signs of toxicity. However, it demonstrated a possible stimulating activity in the open field test and had no effect on the motor system in the rotarod test. Furthermore, it exhibited an antidepressant-like effect in the forced swim test but an anxiety-like effect in the elevated plus maze test. Therefore, buriti oil may potentially be used in new formulations to assist in the treatment of anxiety and depression.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"180 ","pages":"Article 106303"},"PeriodicalIF":2.5,"publicationDate":"2024-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142675539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}