余甘子叶中木脂素的发现及其抗氧化抗炎活性

IF 2.6 3区 医学 Q3 CHEMISTRY, MEDICINAL
Dian Luo , Min Yang , Yuan-Meng Li , Hong-Tao Zhu , Ping Zhao , Ying-Jun Zhang
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引用次数: 0

摘要

共鉴定出17种木脂素(1 ~ 17),其中5种为新化合物(1 ~ 5),其中10种为首次从该植物中分离得到。通过紫外、红外、核磁共振(1D和2D)、hresms、ECD计算以及与以往文献数据的比较,对其结构进行了细致的分析。木脂素5、8、10和15-17具有清除DPPH自由基的活性,IC50值为10.62 ~ 51.88 μM。此外,化合物8、11和17通过抑制脂多糖(LPS)刺激的RAW264.7巨噬细胞中一氧化氮(NO)的产生而表现出抗炎活性,IC50值在9.39 ~ 38.08 μM之间。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Discovery of lignans from leaves of Phyllanthus emblica L. and their antioxidant-antiinflammatory activity

Discovery of lignans from leaves of Phyllanthus emblica L. and their antioxidant-antiinflammatory activity
Seventeen lignans (117), including five new ones (15), were identified from the ethanolic extract of Phyllanthus emblica leaves, ten of which were isolated for the first time from the titled plant. Their structures were meticulously elucidated through comprehensive analysis utilizing UV, IR, NMR (1D and 2D), HRESIMS, ECD calculations, and comparison with previous literature data. The lignans 5, 8, 10, and 1517 exhibited DPPH radical scavenging activity with IC50 values of 10.62–51.88 μM. Moreover, compounds 8, 11, and 17 exhibited anti-inflammatory activity by suppressing nitric oxide (NO) production in lipopolysaccharide (LPS)- stimulated RAW264.7 macrophages with IC50 values ranging from 9.39 to 38.08 μM.
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来源期刊
Fitoterapia
Fitoterapia 医学-药学
CiteScore
5.80
自引率
2.90%
发文量
198
审稿时长
1.5 months
期刊介绍: Fitoterapia is a Journal dedicated to medicinal plants and to bioactive natural products of plant origin. It publishes original contributions in seven major areas: 1. Characterization of active ingredients of medicinal plants 2. Development of standardization method for bioactive plant extracts and natural products 3. Identification of bioactivity in plant extracts 4. Identification of targets and mechanism of activity of plant extracts 5. Production and genomic characterization of medicinal plants biomass 6. Chemistry and biochemistry of bioactive natural products of plant origin 7. Critical reviews of the historical, clinical and legal status of medicinal plants, and accounts on topical issues.
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