大戟烯和麻风碱二萜：潜在的降脂剂

IF 2.6 3区医学 Q3 CHEMISTRY, MEDICINAL

Fitoterapia Pub Date : 2025-08-19 DOI:10.1016/j.fitote.2025.106830

Sheng Chen , Wen-Zheng Zhao , Zhi-Yan Zhang , Hui-Lan Yue , Qiang-Qiang Shi

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引用次数: 0

摘要

从大戟属植物中分离到了4个新的大戟二萜类化合物，即helioranes A- c（1-3）和heliophane A(4)，以及6个已知的类似物。其中化合物1-3是典型的随取代基变化的蒽类化合物，化合物4是罕见的7,8-邻麻风烷二萜。通过结合光谱分析和量子化学计算的综合方法，明确了新化合物的结构。3个T3-L1细胞的降脂活性筛选表明，化合物3和9对脂质积累具有潜在的抑制作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Lathyrane and jatrophane diterpenoids: Potential lipid-lowering agents from Euphorbia helioscopia L

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Lathyrane and jatrophane diterpenoids: Potential lipid-lowering agents from Euphorbia helioscopia L

Four new Euphorbia diterpenoids, helioranes A-C (1–3) and heliophane A (4), and six know analogues were isolated from the whole plants of Euphorbia helioscopia. Among them, compounds 1–3 are typical lathyranes varying with substituents, compound 4 is a rare 7,8-seco-jatrophane diterpenoid. The structures of the novel compounds were unequivocally established through an integrated approach combining spectroscopic analyses and quantum chemical calculations. Lipid-lowering activity screening in 3 T3-L1 cells demonstrated that compound 3 and 9 exhibited potential inhibitory effects on lipid accumulation.

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来源期刊

Fitoterapia 医学-药学

CiteScore

5.80

自引率

2.90%

发文量

198

审稿时长

1.5 months

期刊介绍： Fitoterapia is a Journal dedicated to medicinal plants and to bioactive natural products of plant origin. It publishes original contributions in seven major areas: 1. Characterization of active ingredients of medicinal plants 2. Development of standardization method for bioactive plant extracts and natural products 3. Identification of bioactivity in plant extracts 4. Identification of targets and mechanism of activity of plant extracts 5. Production and genomic characterization of medicinal plants biomass 6. Chemistry and biochemistry of bioactive natural products of plant origin 7. Critical reviews of the historical, clinical and legal status of medicinal plants, and accounts on topical issues.