Three new polyketones from mangrove endophytic fungus aspergillus sp. HMGh1–1 and their insecticidal activity

IF 2.6 3区医学 Q3 CHEMISTRY, MEDICINAL

Fitoterapia Pub Date : 2025-08-15 DOI:10.1016/j.fitote.2025.106803

Wenjun Li, Meijing Tan, Shichao Ju, Fan He, Jiao Wu, Youquan Wei, Jinyu Wen, Baoliang Li, Xishan Huang

引用次数: 0

Abstract

A new phenylacetic acid, methoxy-graphislactones C (1), a new anthraquinone (1′E)-6,8-di-O-methyl averanti (2), a new phenanthrene derivative, 12-methyl entonaemin A (3) and five previously reported compounds (4–8) were isolated from the fermented extracts of the mangrove endophytic fungus Aspergillus sp. HMGh1–1. The structures and absolute configurations of the new compounds were determined by spectroscopic techniques (high-resolution mass spectrometry, NMR), ECD calculations, and single-crystal X-ray analysis. Compounds 1–8 were screened for insecticidal activity against Diaphorina citri Kuwayama, and compound 3 exhibited significant insecticidal activity, with a corrected efficacy of 90.97 %.

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红树林内生真菌aspergillus sp. hmgh1中3个新聚酮及其杀虫活性

从红树林内生真菌Aspergillus sp. HMGh1-1的发酵提取物中分离到一个新的苯乙酸、甲氧基-石墨烯内酯C(1)、一个新的蒽醌(1 ' e)-6,8-二- o -甲基阿维安蒂(2)、一个新的菲衍生物、12-甲基阿维安胺A(3)和五个先前报道的化合物（4-8）。新化合物的结构和绝对构型通过光谱技术（高分辨率质谱，核磁共振），ECD计算和单晶x射线分析确定。对化合物1 ~ 8进行了杀虫活性筛选，其中化合物3具有显著的杀虫活性，校正后的杀虫率为90.97%。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Fitoterapia 医学-药学

CiteScore

5.80

自引率

2.90%

发文量

198

审稿时长

1.5 months

期刊介绍： Fitoterapia is a Journal dedicated to medicinal plants and to bioactive natural products of plant origin. It publishes original contributions in seven major areas: 1. Characterization of active ingredients of medicinal plants 2. Development of standardization method for bioactive plant extracts and natural products 3. Identification of bioactivity in plant extracts 4. Identification of targets and mechanism of activity of plant extracts 5. Production and genomic characterization of medicinal plants biomass 6. Chemistry and biochemistry of bioactive natural products of plant origin 7. Critical reviews of the historical, clinical and legal status of medicinal plants, and accounts on topical issues.