Fu-Xin Hu , Ben-Song Xin , Gu-Xue Zhang , Zi-Hao Ge , Shuang Qiu , Guo-Dong Yao , Xiao-Xiao Huang , Shao-Jiang Song
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引用次数: 0
Abstract
Isopentenyl flavonoids were important chemical components in Daphne giraldii Nitsche with significant cytotoxic activities against hepatocellular carcinoma cells in previous study. In this study, Feature-Based Molecular Networking was utilized to perform the targeted isolation of the phytochemical investigation of D. giraldii. As a result, five undescribed isopentenyl flavonoids (1, 2a/2b, 3, and 4) were isolated from D. giraldii. Their structures and configurations were established by comprehensive spectral analysis and comparing experimental ECD and calculated data. In addition, all isolated compounds were evaluated for cytotoxic activities against hepatocellular carcinoma HepG2 and Hep3B cell lines. Specifically, compound 2 exhibited significant cytotoxic activities with IC50 values of 11.63 ± 0.22 μM and 0.10 ± 0.02 μM, respectively.
期刊介绍:
Fitoterapia is a Journal dedicated to medicinal plants and to bioactive natural products of plant origin. It publishes original contributions in seven major areas:
1. Characterization of active ingredients of medicinal plants
2. Development of standardization method for bioactive plant extracts and natural products
3. Identification of bioactivity in plant extracts
4. Identification of targets and mechanism of activity of plant extracts
5. Production and genomic characterization of medicinal plants biomass
6. Chemistry and biochemistry of bioactive natural products of plant origin
7. Critical reviews of the historical, clinical and legal status of medicinal plants, and accounts on topical issues.