Phenylpropanoid glycosides from the fruits of Lycium chinense and their potential anti-diabetic activity

IF 2.6 3区医学 Q3 CHEMISTRY, MEDICINAL

Fitoterapia Pub Date : 2025-09-16 DOI:10.1016/j.fitote.2025.106878

Yv-Xin Fan , Yu-Guo Ma , Yan-Jie Zhu , Ji-Le Xin , Xiang-Yang Dai , Kun Du , Yan-Gang Cao , Yan-Jun Sun , Xiao-Ke Zheng , Wei-Sheng Feng , Hui Chen

{"title":"Phenylpropanoid glycosides from the fruits of Lycium chinense and their potential anti-diabetic activity","authors":"Yv-Xin Fan , Yu-Guo Ma , Yan-Jie Zhu , Ji-Le Xin , Xiang-Yang Dai , Kun Du , Yan-Gang Cao , Yan-Jun Sun , Xiao-Ke Zheng , Wei-Sheng Feng , Hui Chen","doi":"10.1016/j.fitote.2025.106878","DOIUrl":null,"url":null,"abstract":"<div><div>Phytochemical study of the fruits of Lycium chinense Mill. allowed the identification of eight undescribed phenylpropanoid glycosides, namely lychinosides A-H (1–8), along with five known compounds (9–13). The structures of the new compounds were elucidated through detailed analysis of spectroscopic data (HRESIMS, 1D and 2D NMR) and acid hydrolysis experiment. Compounds 1, 3–6, 8–10, 12, and 13 could significantly increase the glucose consumption in insulin-resistant HepG2 cells at 50 μM, and compounds 1 and 9 could improve the glucose uptake capacity of insulin-resistant HepG2 cells and enhance the hexokinase and pyruvate kinase activities. In addition, compound 9 exhibited excellent inhibitory activities against α-glucosidase with an IC50 value of 16.8 μM, comparable to that of the positive control acarbose (300.0 μM).</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"187 ","pages":"Article 106878"},"PeriodicalIF":2.6000,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Fitoterapia","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0367326X25005040","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}

引用次数: 0

Abstract

Phytochemical study of the fruits of Lycium chinense Mill. allowed the identification of eight undescribed phenylpropanoid glycosides, namely lychinosides A-H (1–8), along with five known compounds (9–13). The structures of the new compounds were elucidated through detailed analysis of spectroscopic data (HRESIMS, 1D and 2D NMR) and acid hydrolysis experiment. Compounds 1, 3–6, 8–10, 12, and 13 could significantly increase the glucose consumption in insulin-resistant HepG2 cells at 50 μM, and compounds 1 and 9 could improve the glucose uptake capacity of insulin-resistant HepG2 cells and enhance the hexokinase and pyruvate kinase activities. In addition, compound 9 exhibited excellent inhibitory activities against α-glucosidase with an IC₅₀ value of 16.8 μM, comparable to that of the positive control acarbose (300.0 μM).

Abstract Image

查看原文本刊更多论文

枸杞子苯丙苷及其潜在的抗糖尿病活性。

枸杞果实的植物化学研究。鉴定了8种未描述的苯丙苷，即荔枝苷A-H(1-8)，以及5种已知化合物（9-13）。通过详细的光谱数据分析（hresms， 1D和2D NMR）和酸水解实验对新化合物的结构进行了鉴定。化合物1、3 ~ 6、8 ~ 10、12、13在50 μM时能显著增加胰岛素抵抗HepG2细胞的葡萄糖消耗，化合物1、9能提高胰岛素抵抗HepG2细胞的葡萄糖摄取能力，提高己糖激酶和丙酮酸激酶活性。此外，化合物9对α-葡萄糖苷酶具有良好的抑制活性，IC50值为16.8 μM，与阳性对照阿卡波糖（300.0 μM）相当。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Fitoterapia 医学-药学

CiteScore

5.80

自引率

2.90%

发文量

198

审稿时长

1.5 months

期刊介绍： Fitoterapia is a Journal dedicated to medicinal plants and to bioactive natural products of plant origin. It publishes original contributions in seven major areas: 1. Characterization of active ingredients of medicinal plants 2. Development of standardization method for bioactive plant extracts and natural products 3. Identification of bioactivity in plant extracts 4. Identification of targets and mechanism of activity of plant extracts 5. Production and genomic characterization of medicinal plants biomass 6. Chemistry and biochemistry of bioactive natural products of plant origin 7. Critical reviews of the historical, clinical and legal status of medicinal plants, and accounts on topical issues.