{"title":"Botany, traditional uses, phytochemistry, pharmacology, processing, and applications of Cibotium barometz (L.) J. Sm.: A review","authors":"Xin-Rui Xu, Jing-Yuan Wang, Xing-Yu Wang, Hai-Zheng Bi, Qian-Xiang Bai, Meng Wang","doi":"10.1016/j.fitote.2025.106843","DOIUrl":null,"url":null,"abstract":"<div><div><em>Cibotium barometz</em> (L.) J. Sm. (<em>C. barometz</em>), an ancient fern has a long history as a natural medicine in China, India, Vietnam, and other countries. In the traditional medical system, it is often used to treat bone pain, urinary system diseases, reproductive disorders, and so on. This paper aims to provide a comprehensive overview of current research on botany, traditional uses, phytochemistry, pharmacology, processing, and applications of <em>C. barometz</em>. In addition, resource conservation, quality control, and perspectives for future research on <em>C. barometz</em> are also discussed. Recent phytochemical studies of <em>C. barometz</em> have shown that over 100 compounds have been isolated from the plant, including phenylpropanoids, polyphenols, flavonoids, terpenoids, steroids, polysaccharides, and other compounds. Modern pharmacological studies have also confirmed that <em>C. barometz</em> has anti-osteoporosis activity, anti-microorganism activity, anti-osteoarthritis activity, anti-cancer activity, hepatoprotective activity, protective activity on muscle, alleviating Alzheimer's disease, and so on. As an important means of preclinical application, the type and content of the components contained in <em>C. barometz</em> changed significantly before and after processing, and the strength of its pharmacological activity also changed. Furthermore, it has many applications in the fields of compound preparations and biomedicine, which have great development potential. Nevertheless, there are also some research gaps in <em>C. barometz</em>. This review appeals for more studies on <em>C. barometz</em> to better understand its pharmacological mechanism and active substance basis. Besides, more research on resource conservation and quality control is also necessary to ensure its sustainable use and development.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"186 ","pages":"Article 106843"},"PeriodicalIF":2.6000,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Fitoterapia","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0367326X25004691","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
引用次数: 0
Abstract
Cibotium barometz (L.) J. Sm. (C. barometz), an ancient fern has a long history as a natural medicine in China, India, Vietnam, and other countries. In the traditional medical system, it is often used to treat bone pain, urinary system diseases, reproductive disorders, and so on. This paper aims to provide a comprehensive overview of current research on botany, traditional uses, phytochemistry, pharmacology, processing, and applications of C. barometz. In addition, resource conservation, quality control, and perspectives for future research on C. barometz are also discussed. Recent phytochemical studies of C. barometz have shown that over 100 compounds have been isolated from the plant, including phenylpropanoids, polyphenols, flavonoids, terpenoids, steroids, polysaccharides, and other compounds. Modern pharmacological studies have also confirmed that C. barometz has anti-osteoporosis activity, anti-microorganism activity, anti-osteoarthritis activity, anti-cancer activity, hepatoprotective activity, protective activity on muscle, alleviating Alzheimer's disease, and so on. As an important means of preclinical application, the type and content of the components contained in C. barometz changed significantly before and after processing, and the strength of its pharmacological activity also changed. Furthermore, it has many applications in the fields of compound preparations and biomedicine, which have great development potential. Nevertheless, there are also some research gaps in C. barometz. This review appeals for more studies on C. barometz to better understand its pharmacological mechanism and active substance basis. Besides, more research on resource conservation and quality control is also necessary to ensure its sustainable use and development.
期刊介绍:
Fitoterapia is a Journal dedicated to medicinal plants and to bioactive natural products of plant origin. It publishes original contributions in seven major areas:
1. Characterization of active ingredients of medicinal plants
2. Development of standardization method for bioactive plant extracts and natural products
3. Identification of bioactivity in plant extracts
4. Identification of targets and mechanism of activity of plant extracts
5. Production and genomic characterization of medicinal plants biomass
6. Chemistry and biochemistry of bioactive natural products of plant origin
7. Critical reviews of the historical, clinical and legal status of medicinal plants, and accounts on topical issues.