Four ambuic acid derivatives and one caryophyllene-type sesquiterpenoid from Pestalotiopsis chamaeropis

IF 2.6 3区 医学 Q3 CHEMISTRY, MEDICINAL
Hao Zheng, Qing Ting Zeng, Liuxuan Yao, Lan Wang, Tao Yuan, Nuan Zhang
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引用次数: 0

Abstract

Fourteen specialized metabolites, including four previously undescribed ambuic acid derivatives (compounds 1–4) and an unreported caryophyllene-type sesquiterpenoid (compound 5), were isolated and characterized from the endophytic fungus Pestalotiopsis chamaeropis associated with the medicinal plant Artemisia selengensis. Their structures were elucidated through comprehensive spectroscopic analysis (NMR, HR-ESI-MS) and electronic circular dichroism (ECD) calculations. Anti-inflammatory activity screening against LPS-stimulated RAW 264.7 macrophages revealed that only compound 3 exhibited moderate efficacy, with an IC50 value of 19.7 ± 1.2 μM, whereas the remaining derivatives showed no significant activity at tested concentrations.

Abstract Image

从拟盘多毛孢中提取4个氨酸衍生物和1个石竹烯型倍半萜
从药用植物青蒿(Artemisia selengensis)的内生真菌拟拟多毛孢(pstalotiopsis chamaeropis)中分离并鉴定了14种特殊代谢物,其中包括4种先前未被描述的琥珀酸衍生物(化合物1-4)和1种未被报道的石竹烯型倍半萜类(化合物5)。通过综合光谱分析(NMR, HR-ESI-MS)和电子圆二色性(ECD)计算对其结构进行了鉴定。对lps刺激的RAW 264.7巨噬细胞的抗炎活性筛选显示,只有化合物3具有中等的抗炎作用,IC50值为19.7±1.2 μM,而其余衍生物在测试浓度下均无显著活性。
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来源期刊
Fitoterapia
Fitoterapia 医学-药学
CiteScore
5.80
自引率
2.90%
发文量
198
审稿时长
1.5 months
期刊介绍: Fitoterapia is a Journal dedicated to medicinal plants and to bioactive natural products of plant origin. It publishes original contributions in seven major areas: 1. Characterization of active ingredients of medicinal plants 2. Development of standardization method for bioactive plant extracts and natural products 3. Identification of bioactivity in plant extracts 4. Identification of targets and mechanism of activity of plant extracts 5. Production and genomic characterization of medicinal plants biomass 6. Chemistry and biochemistry of bioactive natural products of plant origin 7. Critical reviews of the historical, clinical and legal status of medicinal plants, and accounts on topical issues.
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