Current Topics in Nutraceutical Research最新文献_第3页

Augmentation of the Clinical Efficacy of Levofloxacin and Antituberculosis Drugs by Chinese Herbal Preparations in Pulmonary Tuberculosis 中药制剂提高左氧氟沙星联合抗结核药物治疗肺结核的临床疗效

4区医学

Current Topics in Nutraceutical Research Pub Date : 2023-10-09 DOI: 10.37290/ctnr2641-452x.21:356-360

Chunyang Yin, Weiwei Gao, Xiaoli Tang

{"title":"Augmentation of the Clinical Efficacy of Levofloxacin and Antituberculosis Drugs by Chinese Herbal Preparations in Pulmonary Tuberculosis","authors":"Chunyang Yin, Weiwei Gao, Xiaoli Tang","doi":"10.37290/ctnr2641-452x.21:356-360","DOIUrl":"https://doi.org/10.37290/ctnr2641-452x.21:356-360","url":null,"abstract":"This study was designed to explore whether Chinese herbals could enhance the clinical efficacy of levofloxacin and a combination of antituberculosis drugs. To this end, a group of pulmonary patients were treated with pyrazinamide, isoniazid, ethambutol, and levofloxacin (control), and the other group (treatment) also received a combination of extra Chinese herbal compounds. After 6 months of therapy, the total efficiency of lesion absorption in the treatment group was higher than in the control group. The treatment group had a higher peak expiratory flow rate, a higher percentage of forced vital capacity, a higher percentage of the first second of forced expiration, higher levels of immunoglobulin A, immunoglobulin G, immunoglobulin M, and CD4+, and lower levels of CD8+ compared to the control group. The levels of proinflammatory cytokines were lower, the sputum conversion rate was higher, and the recurrence rate was lower in the treatment group than the control group. After therapy, the treatment group had higher scores in the quality of daily life, spirit, appetite, fatigue, and sleep assessments. In conclusion, therapy with levofloxacin and antituberculosis drugs combined with Chinese herbal compounds for patients with pulmonary tuberculosis could effectively relieve the inflammatory reaction, promote lesion absorption, and thus improve their lung function and promote recovery.","PeriodicalId":10976,"journal":{"name":"Current Topics in Nutraceutical Research","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135043613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of Vitamin D on Lumbar Disk Degeneration Based on PINK1/Parkin Signaling Pathway 基于PINK1/Parkin信号通路的维生素D对腰椎间盘退变的影响

4区医学

Current Topics in Nutraceutical Research Pub Date : 2023-09-27 DOI: 10.37290/ctnr2641-452x.22:237-245

Zhe Shen, Tao Lan, Weizhuang Guo

{"title":"Effects of Vitamin D on Lumbar Disk Degeneration Based on PINK1/Parkin Signaling Pathway","authors":"Zhe Shen, Tao Lan, Weizhuang Guo","doi":"10.37290/ctnr2641-452x.22:237-245","DOIUrl":"https://doi.org/10.37290/ctnr2641-452x.22:237-245","url":null,"abstract":"Vitamin D affects calcium homeostasis and is a crucial factor in cytoplasmic and mitochondrial interactions implicated in muscle energy metabolism. This study probed the effect of vitamin D on lumbar disk degeneration based on the PINK1/Parkin signaling pathway. Primary nucleus pulposus cells from Sprague-Dawley rats were cultured to construct a model of oxidative stress in vitro, and the expression and activity of target proteins in related genes and signaling pathways were detected via real-time quantitative polymerase chain reaction and western blotting. We simulated disk degeneration by inducing high levels of oxidative stress in nucleus pulposus cells with 100 μM hydrogen peroxide. Vitamin D treatment could effectively increase the expression of genes related to the nucleus pulposus matrix as well as decrease disk degeneration factors’ expression. Further mechanism results displayed that vitamin D effectively reduced oxidative stress indexes in nucleus pulposus cell s and alleviated hydrogen peroxide-mediated degeneration of nucleus pulposus cells by activating the PINK1/Parkin pathway. We confirm that vitamin D activates the PINK1/Parkin pathway to play an antioxidative stress role and delay the aging and degeneration of nucleus pulposus cells.","PeriodicalId":10976,"journal":{"name":"Current Topics in Nutraceutical Research","volume":"22 1","pages":"237-245"},"PeriodicalIF":0.0,"publicationDate":"2023-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147887115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Behavioral Training with Nursing Intervention Improves Postoperative Rehabilitation and Nutritional Status of Elderly Patients with Benign Prostatic Hyperplasia 行为训练配合护理干预对老年良性前列腺增生患者术后康复及营养状况的改善

4区医学

Current Topics in Nutraceutical Research Pub Date : 2023-09-27 DOI: 10.37290/ctnr2641-452x.21:478-484

Lei He

{"title":"Behavioral Training with Nursing Intervention Improves Postoperative Rehabilitation and Nutritional Status of Elderly Patients with Benign Prostatic Hyperplasia","authors":"Lei He","doi":"10.37290/ctnr2641-452x.21:478-484","DOIUrl":"https://doi.org/10.37290/ctnr2641-452x.21:478-484","url":null,"abstract":"The effect of behavioral training and nursing intervention on the postoperative recovery and nutritional status of elderly patients with benign prostatic hyperplasia was examined. The frequency and duration of bladder spasm episodes and the incidence of adverse effects were lower in the patients receiving research than in the control group (P < 0.05). The self-rating anxiety scale and the self-rating depression scale decreased in both groups after the nursing intervention and were lower in the research group than in the control group (P < 0.05), while the General Quality of Life Assessment Questionnaire scores increased in both groups and were higher in the research group (P < 0.05). Furthermore, the level of satisfaction was significantly higher in the research group than the control group (P < 0.05). Finally, the number of people with good nutritional status was higher in the research group, and the neutrophil-to-lymphocyte ratio was lower than in the control group (P < 0.05). Thus, we recommend behavioral training in nursing for benign prostatic hyperplasia patients in the future to improve their postoperative rehabilitation and nutritional status.","PeriodicalId":10976,"journal":{"name":"Current Topics in Nutraceutical Research","volume":"205 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134904041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Tongmai Tangyanming Capsules on Diabetic Retinopathy in Zebrafish 通脉糖炎明胶囊对斑马鱼糖尿病视网膜病变的影响

IF 0.5 4区医学

Current Topics in Nutraceutical Research Pub Date : 2023-09-10 DOI: 10.37290/ctnr2641-452x.21:321-325

Qian Guo, Honggang Ni, Xinjie Wang, Long Ling

引用次数: 0

The Efficacy of Sophora Flavescens Fumigation in Improving Anal Health After Anal Fistula Surgery 苦参熏蒸对肛瘘术后肛门健康的影响

4区医学

Current Topics in Nutraceutical Research Pub Date : 2023-09-05 DOI: 10.37290/ctnr2641-452x.21:461-467

Jian Liu, Changzhu Sun, Xiaoling Chu

{"title":"The Efficacy of Sophora Flavescens Fumigation in Improving Anal Health After Anal Fistula Surgery","authors":"Jian Liu, Changzhu Sun, Xiaoling Chu","doi":"10.37290/ctnr2641-452x.21:461-467","DOIUrl":"https://doi.org/10.37290/ctnr2641-452x.21:461-467","url":null,"abstract":"We are in the process of recovering patients undergoing treatments with Sophora flavescens (experimental) or potassium permanganate (control) fumigation following anal fistula surgery. The experimental group had a shorter wound healing time and lower pain measurement on the Visual Analogue Scale on postoperative days 7 and 14 than the control group (P < 0.05). Although no inter-group notable difference was identified in clinical efficacy (P > 0.05), the anal function of the experimental group was improved, and the levels of pro-inflammatory cytokines were lower after treatment (P < 0.05). Assessment of the nutritional status after surgery, key to postoperative recovery, showed that the weight and upper arm circumference decreased in both groups after treatment, but the experimental group was higher than the control group (P < 0.05), and prealbumin, albumin, and transferrin were also higher in the experimental group than in the control group after treatment (P < 0.05). Finally, the two groups did not differ significantly in adverse reactions and relapse (P > 0.05). SF facilitates wound healing after anal fistula surgery, mitigates patient pain, and improves anal health.","PeriodicalId":10976,"journal":{"name":"Current Topics in Nutraceutical Research","volume":"307 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135369601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High Efficacy of Pingxiao Capsule Combines with Docetaxel and Cisplatin Induction Chemotherapy on Oral Squamous Cell Carcinoma in Mice 平消胶囊联合多西他赛、顺铂诱导化疗治疗小鼠口腔鳞状细胞癌疗效观察

4区医学

Current Topics in Nutraceutical Research Pub Date : 2023-08-31 DOI: 10.37290/ctnr2641-452x.22:100-107

Caijun Zhao, Xinguang Han, Chongyun Bao

{"title":"High Efficacy of Pingxiao Capsule Combines with Docetaxel and Cisplatin Induction Chemotherapy on Oral Squamous Cell Carcinoma in Mice","authors":"Caijun Zhao, Xinguang Han, Chongyun Bao","doi":"10.37290/ctnr2641-452x.22:100-107","DOIUrl":"https://doi.org/10.37290/ctnr2641-452x.22:100-107","url":null,"abstract":"This study explored the effect of docetaxel and cisplatin on oral squamous cell carcinoma and its modulation by the traditional Chinese medicine Pingxiao capsule. To this end, CAL27 cells were injected subcutaneously into the right axilla of the nude mice to produce solid tumors. The tumor-bearing mice were treated with docetaxel, cisplatin, Pingxiao capsule, cisplatin + docetaxel, cisplatin + Pingxiao capsule, docetaxel + Pingxiao capsule, or cisplatin + docetaxel + Pingxiao capsule, and the treatment outcomes were compared with control. The outcome measures included tumor size, mouse body weight, and tumor histopathology. The results revealed that a single dose of docetaxel, cisplatin, and Pingxiao capsules was effective in suppressing mice tumor volume and body weight, enhancing apoptotic index, and reducing proliferation index. However, the use of a combination of drugs had better effects than the use of any single drug. To conclude, the combination of docetaxel, cisplatin, and Pingxiao capsule has high efficacy in repressing tumor growth by repressing tumor cell proliferation and facilitating tumor cell apoptosis.","PeriodicalId":10976,"journal":{"name":"Current Topics in Nutraceutical Research","volume":"22 1","pages":"100-107"},"PeriodicalIF":0.0,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147891464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cordycepin Abrogates Methotrexate-Induced Suppression of Osteoclastogenesis 虫草素可消除甲氨蝶呤诱导的破骨细胞生成抑制

4区医学

Current Topics in Nutraceutical Research Pub Date : 2023-08-30 DOI: 10.37290/ctnr2641-452x.21:485-489

Lin Lei, Baohua Hao, Zhiyu Jia, Pengfei Qu

引用次数: 0

Postoperative Oral Iodine-131 Combined with Nutritional Management for the Management of Thyroid Cancer: A Meta-Analysis 术后口服碘-131与营养管理相结合治疗甲状腺癌：元分析

IF 0.5 4区医学

Current Topics in Nutraceutical Research Pub Date : 2023-08-29 DOI: 10.37290/ctnr2641-452x.22:1-7

Yifan Liu, Jintang Jia

{"title":"Postoperative Oral Iodine-131 Combined with Nutritional Management for the Management of Thyroid Cancer: A Meta-Analysis","authors":"Yifan Liu, Jintang Jia","doi":"10.37290/ctnr2641-452x.22:1-7","DOIUrl":"https://doi.org/10.37290/ctnr2641-452x.22:1-7","url":null,"abstract":"Iodine nutrition plays a central role in the normal physiological function of the thyroid gland, and it is a major factor in thyroid hormone synthesis. A meta-analysis was used to measure the efficacy of oral iodine-131 combined with nutritional management in thyroid cancer patients after surgery. Computer searches were conducted on various databases, with the search time limited to January 2011 to December 2021, and the literature retrieved was limited to randomized controlled trials. Data extraction and quality evaluation were performed for the included literature, and meta-analysis was conducted by RevMan 5.3 software. A total of 9 literatures were obtained, all in English, with a sample size of 10,219 cases, containing 6,845 cases in the study group (oral iodine-131 + nutritional management) together with 3,374 cases in the control group (oral iodine-131 alone). The study group received oral administration of iodine-131 and nutritional management (low-iodine diet). The outcomes of the meta-analysis revealed that the clinical symptoms of thyroid cancer patients were improved after oral administration of iodine-131 after surgery. No statistical differences could be observed in the incidence of adverse reactions, recurrence rate, or metastasis rate of outcome indicators. To sum up, oral administration of iodine-131 combined with nutritional management has certain clinical effects in patients with thyroid cancer after surgery, but due to the limited literature included and low data quality, the conclusions of this study still need to be further verified.","PeriodicalId":10976,"journal":{"name":"Current Topics in Nutraceutical Research","volume":"37 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139348552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Yishen Juanbi Decoction Combined with Predictive Nursing Intervention Improves the Prognosis, Pain, and Nutritional Status of Patients with Ankylosing Spondylitis 益参蠲痹汤联合预测性护理干预可改善强直性脊柱炎患者的预后、疼痛和营养状况

IF 0.5 4区医学

Current Topics in Nutraceutical Research Pub Date : 2023-08-22 DOI: 10.37290/ctnr2641-452x.21:509-515

Wenting Zhou, Zhenhua Zhao, Yu Zhang, Zhensuo Zhao, Zhiguang Zhai

{"title":"Yishen Juanbi Decoction Combined with Predictive Nursing Intervention Improves the Prognosis, Pain, and Nutritional Status of Patients with Ankylosing Spondylitis","authors":"Wenting Zhou, Zhenhua Zhao, Yu Zhang, Zhensuo Zhao, Zhiguang Zhai","doi":"10.37290/ctnr2641-452x.21:509-515","DOIUrl":"https://doi.org/10.37290/ctnr2641-452x.21:509-515","url":null,"abstract":"We have examined the effect of Yishen Juanbi decoction combined with predictive nursing intervention on the prognosis, pain, and nutritional status of patients with ankylosing spondylitis. Ankylosing spondylitis patients received oral Yishen Juanbi decoction, followed by routine nursing intervention or predictive nursing intervention. The visual analog scale score and bath ankylosing spondylitis functional index score in the predictive nursing intervention were lower relative to the routine nursing intervention (P < 0.05). The predictive nursing intervention also had better quality of life than the routine nursing intervention group (P < 0.05). Serum total protein and albumin levels were higher in the predictive nursing intervention group than the routine nursing intervention group (P < 0.05), while serum IgA, IgM, and IgG levels were lower (P < 0.05). The nursing satisfaction of patients in the predictive nursing intervention group was higher compared to the routine nursing intervention group (P < 0.05). In conclusion, Yishen Juanbi decoction combined with predictive nursing can reduce pain, improve the nutritional status, and promote the motor function and quality of life of ankylosing spondylitis patients.","PeriodicalId":10976,"journal":{"name":"Current Topics in Nutraceutical Research","volume":"12 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139349605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antimigraine Effects of Awei Wu Wei Pills, A Monk’s Medicine 阿魏五味丸的抗偏头痛功效--僧侣的良药

IF 0.5 4区医学

Current Topics in Nutraceutical Research Pub Date : 2023-08-18 DOI: 10.37290/ctnr2641-452x.21:516-523

Xiaorong Wang, Wenjing Hu, Tuya Wang, Gaowa Wuyun

引用次数: 0