Current Topics in Nutraceutical Research最新文献_第10页

Coptisine Reduces the Progression of Cervical Cancer Through Induction of Autophagy Coptisine通过自噬诱导减少宫颈癌症的进展

IF 0.5 4区医学

Current Topics in Nutraceutical Research Pub Date : 2022-08-10 DOI: 10.37290/ctnr2641-452x.21:18-24

Yaping Zhao, Xia Gao

引用次数: 0

Role of Nutrients on Platelets Participation in Leukocyte Recruitment and Inflammation Resolution in Inflammatory Diseases, Including Covid-19 营养素对包括新冠肺炎在内的炎症性疾病中血小板参与白细胞补充和炎症解决的作用

IF 0.5 4区医学

Current Topics in Nutraceutical Research Pub Date : 2022-08-08 DOI: 10.37290/ctnr2641-452x.20:662-665

M-Y Sung, Kuo-Hung Liao, Jiunn-Sheng Wu, I-Shing Tzeng, Lou Sun, C. Kuo

引用次数: 0

Ling-Gui-Zhu-Gan Decoction Alleviates Cognitive Deficits in Alzheimer’s Disease by Activating the Nuclear Factor-Erythroid Factor 2-Related Factor 2/The Antioxidant Responsive Element Signaling Pathway 灵归竹肝汤通过激活核因子-红细胞因子2相关因子2/抗氧化反应元件信号通路减轻阿尔茨海默病的认知缺陷

IF 0.5 4区医学

Current Topics in Nutraceutical Research Pub Date : 2022-07-25 DOI: 10.37290/ctnr2641-452x.21:1-9

Jingyuan Zhang, Dongqing Yang, Juan Zhao, Yun Ling, Chunxiang Zhou

{"title":"Ling-Gui-Zhu-Gan Decoction Alleviates Cognitive Deficits in Alzheimer’s Disease by Activating the Nuclear Factor-Erythroid Factor 2-Related Factor 2/The Antioxidant Responsive Element Signaling Pathway","authors":"Jingyuan Zhang, Dongqing Yang, Juan Zhao, Yun Ling, Chunxiang Zhou","doi":"10.37290/ctnr2641-452x.21:1-9","DOIUrl":"https://doi.org/10.37290/ctnr2641-452x.21:1-9","url":null,"abstract":"Alzheimer’s disease is a common neurodegenerative disorder. Ling-Gui-Zhu-Gan decoction has anti-inflammatory, anti-tumor, and immune-regulating effects and is a representative agent for strengthening the spleen and promoting water retention. The present study aimed to investigate the underlying mechanism of Ling-Gui-Zhu-Gan decoction in alleviating Alzheimer’s disease. Alzheimer’s disease in vitro and in vivo models were constructed by exposing SH-SY5Y cells to β-amyloid 1-42 and injecting β-amyloid 1-42 into Sprague-Dawley rats, respectively. The Morris water maze test was used to assess cognitive decline in rats. Cell counting kit-8, flow cytometry analysis, and enzyme-linked immunosorbent assay were conducted to determine cell viability, apoptosis, and inflammation. β-amyloid 1-42 treatment induced SH-SY5Y cell apoptosis, evoked inflammation response and oxidative stress while hindering cell proliferation. Ling-Gui-Zhu-Gan decoction antagonized the effect of β-amyloid 1-42 on SH-SY5Y cells by activating the nuclear factor erythroid 2-related factor 2/antioxidant response element signaling pathway. In addition, Ling-Gui-Zhu-Gan decoction improved memory and learning abilities and alleviated neuropathologic lesions, inflammation response, and neurotoxicity in Alzheimer’s disease rats in a dose-dependent manner by upregulating nuclear factor erythroid 2-related factor 2/antioxidant response element pathway. The Ling-Gui-Zhu-Gan decoction improved the spatial learning and memory ability of Alzheimer’s disease rats by upregulating the nuclear factor erythroid 2-related factor 2/antioxidant response element signaling pathway to counteract the imbalance in the body’s oxidative stress levels and the damage caused by neuroinflammation.","PeriodicalId":10976,"journal":{"name":"Current Topics in Nutraceutical Research","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2022-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44115203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Complementary and Alternative Medicine for Liver Diseases 肝脏疾病的补充和替代医学

IF 0.5 4区医学

Current Topics in Nutraceutical Research Pub Date : 2022-07-21 DOI: 10.37290/ctnr2641-452x.20:666-668

Chun-Hsien Yu, Ya-Hsuan Lin, Ching-Feng Cheng, C. Kuo

引用次数: 0

Efficacy Evaluation of Probiotics Combined with Quadruple Therapy in Treating Helicobacter pylori Infection 益生菌联合三联疗法治疗幽门螺杆菌感染的疗效评价

IF 0.5 4区医学

Current Topics in Nutraceutical Research Pub Date : 2022-07-15 DOI: 10.37290/ctnr2641-452x.20:705-709

Yu Dong, Xiaoran Shen, Yifeng Zhang

{"title":"Efficacy Evaluation of Probiotics Combined with Quadruple Therapy in Treating Helicobacter pylori Infection","authors":"Yu Dong, Xiaoran Shen, Yifeng Zhang","doi":"10.37290/ctnr2641-452x.20:705-709","DOIUrl":"https://doi.org/10.37290/ctnr2641-452x.20:705-709","url":null,"abstract":"To evaluate the efficacy of probiotics combined with quadruple therapy in treating Helicobacter pylori infection, 240 elderly H. pylori-infected patients were recruited and divided equally into control and treatment groups. The control group received quadruple therapy (rabeprazole sodium + colloidal bismuth pectin dry suspension + amoxicillin + clarithromycin), and the treatment group was given additional bifid-triple viable (probiotics composed of Enterococcus, Lactobacillus acidophilus, and Bifidobacterium) capsules orally. The gastric function, inflammatory cytokine levels, gastric mucosa histopathological change scores, clinical symptom scores, clinical efficacy, and adverse reactions were compared between the two groups. Total curative effect rate was higher in the treatment group than the control group. The symptom scores of acid reflux and belching, nausea and vomiting, and epigastric pain were also lower in the treatment group than the control group. Also, the incidence of adverse reactions was lower in the treatment group (20.00%) than the control group (36.67%). Furthermore, the treatment group had higher decrease in gastric mucosa histopathological change scores, gastrin and motilin levels, and interleukin-8, and tumor necrosis factor levels than the control group. In conclusion, probiotics combined with quadruple therapy can suppress release of serum inflammatory cytokines, facilitate digestive function improvement and mucosal healing, elevate H. pylori eradication rate, and reduce therapy-related adverse reactions in H. pylori-infected patients.","PeriodicalId":10976,"journal":{"name":"Current Topics in Nutraceutical Research","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2022-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44148205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ligustrazine Alleviates Kidney Injury in a Rat Model of Uremia via Attenuation of Wnt/β-Catenin Signaling Pathway 川芎嗪通过抑制Wnt/β-Catenin信号通路减轻尿毒症大鼠肾损伤

IF 0.5 4区医学

Current Topics in Nutraceutical Research Pub Date : 2022-07-06 DOI: 10.37290/ctnr2641-452x.20:698-704

Xian Guan, Shanmai Guo

{"title":"Ligustrazine Alleviates Kidney Injury in a Rat Model of Uremia via Attenuation of Wnt/β-Catenin Signaling Pathway","authors":"Xian Guan, Shanmai Guo","doi":"10.37290/ctnr2641-452x.20:698-704","DOIUrl":"https://doi.org/10.37290/ctnr2641-452x.20:698-704","url":null,"abstract":"Uremia is associated with kidney injury and contributes to chronic renal failure. Ligustrazine, a bioactive alkaloid from traditional Chinese herb Ligusticum wallichii Franchat, exerts renal-protective effect against acute kidney injury. The role of ligustrazine in uremia-associated kidney injury was investigated. To induce uremia, rats were subjected to 5/6 nephrectomy and intravenously administered with saline. Survival rate of rats was decreased by 5/6 nephrectomy, and levels of blood urea nitrogen, serum creatinine, and 24 h urine protein were elevated. Daily administration of ligustrazine to these rats increased the survival rate and reduced levels of blood urea nitrogen, serum creatinine, and 24 h urine protein output. Moreover, analysis of kidney histology showed that ligustrazine also ameliorated pathological changes in kidney. Finally, ligustrazine reduced levels of proinflammatory cytokines and suppressed renal apoptosis in the kidney tissues of uremic rats. In addition, ligustrazine downregulated protein expression of Wnt1 and β-catenin and inhibited nuclear distribution of β-catenin in uremic rats. In conclusion, ligustrazine protects rats against uremia-associated kidney injury and renal inflammation through inactivation of Wnt1/β-catenin pathway.","PeriodicalId":10976,"journal":{"name":"Current Topics in Nutraceutical Research","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2022-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47174129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Calycosin Alleviates Oxidative Stress and Pyroptosis Induced by High Glucose in Human Retinal Capillary Endothelial Cells Induced by High Glucose Calycosin减轻高糖诱导的人视网膜毛细血管内皮细胞氧化应激和Pyroposis

IF 0.5 4区医学

Current Topics in Nutraceutical Research Pub Date : 2022-07-06 DOI: 10.37290/ctnr2641-452x.21:40-46

Juan Wang, Jianyong Zhang, Yan Zhao

引用次数: 1

Feiji Recipe Elevates the Quality of Life of the Elderly with Lung Cancer on Docetaxel Plus Cisplatin Chemotherapy 肺己方提高老年肺癌多西他赛联合顺铂化疗患者的生存质量

IF 0.5 4区医学

Current Topics in Nutraceutical Research Pub Date : 2022-07-04 DOI: 10.37290/ctnr2641-452x.20:669-674

Lianyou Wang, Cuixia Yang, Nanning Lv, Lantao Zhao, Liang Wang

{"title":"Feiji Recipe Elevates the Quality of Life of the Elderly with Lung Cancer on Docetaxel Plus Cisplatin Chemotherapy","authors":"Lianyou Wang, Cuixia Yang, Nanning Lv, Lantao Zhao, Liang Wang","doi":"10.37290/ctnr2641-452x.20:669-674","DOIUrl":"https://doi.org/10.37290/ctnr2641-452x.20:669-674","url":null,"abstract":"We have evaluated the effect of Feiji recipe on efficacy of docetaxel plus cisplatin treatment on the quality of life of the elderly with lung cancer. To this end, 186 lung cancer patients receiving treatment at the Second People’s Hospital of Lianyungang, Lianyungang City, Jiangsu Province were recruited between January 2017 and December 2021 and randomly divided into control (receiving docetaxel + cisplatin) and treatment (receiving docetaxel + cisplatin + Feiji recipe) groups of 93 patients. Both groups received hydration on the day of cisplatin use and received preventive treatment for emesis, liver protection, acid suppression, and mucosal protection. Post-treatment depletion of cluster of differentiation 3 protein, cluster of differentiation 4 protein, and cluster of differentiation 4 protein/cluster of differentiation 8 protein levels in the treatment group were significantly (P < 0.05) ameliorated/enhanced compared to the control group. Cluster of differentiation 3 protein and cluster of differentiation 4 protein/cluster of differentiation 8 protein levels in the treatment group were upregulated relative to controls (P < 0.05), whereas cytokeratin 19 fragment antigen, cancer antigen 125, and carcinoembryonic antigen levels in the treatment group were depleted relative to controls after treatment (P < 0.05). However, there was no significant difference in natural killer cell counts in the two groups before and after treatment (P > 0.05). The overall treatment effectiveness (74.18% and 90.32%) and the progressive disease rates (25.82% and 9.68%) in the control and treatment groups, respectively (P < 0.05). The physical/emotional/cognitive/role function scores in the treatment group were markedly increased compared to the control group (P < 0.05). In conclusion, Feiji recipe markedly enhanced efficacy of all measures of treating lung cancer by docetaxel + cisplatin.","PeriodicalId":10976,"journal":{"name":"Current Topics in Nutraceutical Research","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2022-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42637315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Randomized Controlled Pilot Study to Compare the Efficacy of Different Iron Formulations: Sucrosomal Ferric Pyrophosphate, Micronized Microencapsulated Ferric Pyrophosphate, and Intravenous Ferric Gluconate 一项比较不同铁制剂疗效的随机对照试验研究:酶切体焦磷酸铁、微胶囊焦磷酸铁和静脉注射葡萄糖酸铁

IF 0.5 4区医学

Current Topics in Nutraceutical Research Pub Date : 2022-06-23 DOI: 10.37290/ctnr2641-452x.20:685-690

R. Mallaci Bocchio, M. Lo Monaco, G. Natoli, S. Scibetta, S. Corrao

{"title":"A Randomized Controlled Pilot Study to Compare the Efficacy of Different Iron Formulations: Sucrosomal Ferric Pyrophosphate, Micronized Microencapsulated Ferric Pyrophosphate, and Intravenous Ferric Gluconate","authors":"R. Mallaci Bocchio, M. Lo Monaco, G. Natoli, S. Scibetta, S. Corrao","doi":"10.37290/ctnr2641-452x.20:685-690","DOIUrl":"https://doi.org/10.37290/ctnr2641-452x.20:685-690","url":null,"abstract":"Despite their gastrointestinal side effects, oral iron supplements are the first-line therapy in iron deficiency anemia. This study aims to compare different iron formulations in anemic outpatients. One-hundred and six outpatients with sideropenic microcytic hypochromic anemia (Hb < 12 g/dL for women, Hb < 13 g/dL for men) were enrolled and divided into two groups (Hb > 10 g/dL and Hb < 10 g/dL). One group was randomized (1:1) to receive sucrosomal ferric pyrophosphate or micronized microencapsulated ferric pyrophosphate, while the other group was randomized (1:1:1) to receive sucrosomal ferric pyrophosphate, micronized microencapsulated ferric pyrophosphate or intravenous ferric gluconate. After 3 months of follow-up, hemoglobin was significantly higher in the micronized microencapsulated ferric pyrophosphate group than in the sucrosomal ferric pyrophosphate group (1.87 vs 1.10; P = 0.04). No significant difference in adverse events was registered between the two groups. In patients with Hb > 10 g/dL, the pyrophosphate or micronized microencapsulated ferric pyrophosphate (30 mg/day) treatment in combination with folic acid (400 mcg), lactoferrin (10 mg), and vitamin C (180 mg) we found out to bring in a significant increase in hemoglobin, without any significant side effects. The reason for this effectiveness is probably due to its favorable bioavailability. Further comparative studies are needed with other forms of iron.","PeriodicalId":10976,"journal":{"name":"Current Topics in Nutraceutical Research","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2022-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42454880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Knowledge and Perception of Health Care Providers About Probiotics in Saudi Arabia 沙特阿拉伯卫生保健提供者对益生菌的知识和认知

IF 0.5 4区医学

Current Topics in Nutraceutical Research Pub Date : 2022-05-18 DOI: 10.37290/ctnr2641-452x.20m:m24-m29

Sehad Al-Arifi, M. Alharbi

{"title":"Knowledge and Perception of Health Care Providers About Probiotics in Saudi Arabia","authors":"Sehad Al-Arifi, M. Alharbi","doi":"10.37290/ctnr2641-452x.20m:m24-m29","DOIUrl":"https://doi.org/10.37290/ctnr2641-452x.20m:m24-m29","url":null,"abstract":"An online semistructured survey assessing probiotics knowledge and perception of health care providers in Saudi Arabia was conducted in Riyadh city between March and December 2020. A total of 333 participants were randomly sampled from King Khaled University Hospital and the Saudi Health Commission database. The mean, standard deviation, frequency, and percentages were used to present the demographic features of the participating professionals. Analysis of variance and Tukey multiple comparison tests were used to evaluate probiotic knowledge considering the demography of more than two subcategories. From the initial group, 95.7% of health professionals participated in this study. The group was made up of 52.3% female, aged 30–44 (62.8%), mostly nurses (46.8%). A total of 85.3% of participants were familiar with the term “probiotic” and 64% considered probiotics safe for general health; beneficial to gut health and irritable bowel syndrome (42.6% and 32.4%, respectively). However, only 25.5% and 24.6% of participants thought probiotics could moderately benefit ulcerative colitis and Crohn’s disease, respectively. A great majority of participants have no concerns about probiotics use (77.5%), and only minor concerns about safety (22.5%). This research concluded that health professionals were better aware of probiotic knowledge despite their limited understanding of the probiotics used for inflammatory bowel disease. In Saudi Arabia, building new guidelines for probiotics, their types, and their uses in the health sector is needed.","PeriodicalId":10976,"journal":{"name":"Current Topics in Nutraceutical Research","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2022-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41856813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0