Current Topics in Nutraceutical Research最新文献_第9页

Isoalantolactone Regulates the Activity of Mitogen-Activated Protein Kinases and Nuclear-Factor Erythroid 2-Related Factor 2 Pathways to Attenue Angiotensin II-Induced Cardiomyocyte Hypertrophy and Oxidative Stress 异丙氨酸内酯调节有丝分裂原活化蛋白激酶和核因子红细胞2相关因子2的活性以减轻血管紧张素II诱导的心肌细胞肥大和氧化应激

IF 0.5 4区医学

Current Topics in Nutraceutical Research Pub Date : 2023-01-06 DOI: 10.37290/ctnr2641-452x.21:72-79

Ying Yang, Yuan Xie, Hui-nan Xu, Peng Xi, Fangfang Zheng

{"title":"Isoalantolactone Regulates the Activity of Mitogen-Activated Protein Kinases and Nuclear-Factor Erythroid 2-Related Factor 2 Pathways to Attenue Angiotensin II-Induced Cardiomyocyte Hypertrophy and Oxidative Stress","authors":"Ying Yang, Yuan Xie, Hui-nan Xu, Peng Xi, Fangfang Zheng","doi":"10.37290/ctnr2641-452x.21:72-79","DOIUrl":"https://doi.org/10.37290/ctnr2641-452x.21:72-79","url":null,"abstract":"While isoalantolactone is a sesquiterpene lactone known for its anti-inflammatory and antioxidant activities, its role in cardiac hypertrophy is unknown. This study aimed to explore the role and mechanism of isoalantolactone in cardiomyocyte hypertrophy using angiotensin II-treated H9C2 cells as a model. The Western blot analysis was used to evaluate changes in the cardiac hypertrophy marker proteins atrial natriuretic peptide and brain natriuretic peptide and the activity of nuclear-factor erythroid 2-related factor 2/mitogen-activated protein kinase signaling pathway. Rhodamine-phalloidin staining was used to measure the surface area of cardiomyocytes. Apoptosis and intracellular reactive oxygen species levels were measured by flow cytometry. The results showed that isoalantolactone inhibited angiotensin II-induced H9C2 cell hypertrophy and cardiomyocyte apoptosis and reduced intracellular reactive oxygen species and cytochrome C levels in a dose-dependent manner. Furthermore, isoalantolactone upregulated the nuclear factor erythroid 2-related factor 2/heme oxygenase-1 and inhibited extracellular signal-regulated kinase, c-Jun NH2-terminal kinase, and p38 (a stress-stimulated kinase) activation. Collectively, the findings suggest that isoalantolactone can enhance the antioxidant capacity of H9C2 cells, reduce apoptosis, and inhibit cardiac hypertrophy, and these protective effects may be related to the regulation of nuclear-factor erythroid 2-related factor 2 and mitogen-activated protein kinase pathway activity by isoalantolactone.","PeriodicalId":10976,"journal":{"name":"Current Topics in Nutraceutical Research","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2023-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42505676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optimization of Ultrasonic-Assisted Extraction of Flavonoids from Ilex Latifolia Thunb by Response Surface Methodology and their Influence over the Activity of Xanthine Oxidase 响应面法优化超声辅助提取黄酮类化合物及其对黄嘌呤氧化酶活性的影响

IF 0.5 4区医学

Current Topics in Nutraceutical Research Pub Date : 2023-01-06 DOI: 10.37290/ctnr2641-452x.21:66-71

Zhong-Xi Lu, Mengqin Zhang, Xiangtao Chen, Junjie Lei

{"title":"Optimization of Ultrasonic-Assisted Extraction of Flavonoids from Ilex Latifolia Thunb by Response Surface Methodology and their Influence over the Activity of Xanthine Oxidase","authors":"Zhong-Xi Lu, Mengqin Zhang, Xiangtao Chen, Junjie Lei","doi":"10.37290/ctnr2641-452x.21:66-71","DOIUrl":"https://doi.org/10.37290/ctnr2641-452x.21:66-71","url":null,"abstract":"We have examined the ultrasonic ethanol extraction of Ilex latifolia Thunb flavonoids and the inhibitory effect of these flavo¬noids on xanthine oxidase. Four single-factor extraction conditions were examined: ethanol concentration (%), solid–liquid ratio (g/mL), ultrasonic extraction temperature (°C), and ultrasonic extraction time (min). With these data, the response surface methodology was adopted to optimize the ultrasonic extraction parameters. The optimal ultrasonic extraction parameters were determined to be the ethanol concentration of 49%, the solid-to-liquid ratio of 1:27, the ultrasonic extraction temperature of 74°C, and the ultrasonic extraction time of 97 min. Under the optimal conditions described ear¬lier, the experimental yield of flavonoids was 6.367% with a relative standard deviation of 1.9%, which was comparable to the theoretical extraction rate. The half maximal inhibitory concentration of flavonoids for xanthine oxidase is 5.50 mg/mL. The inhibitory effect was competitive and reversible, with an inhibitory kinetic constant Ki of 2.35 mg/mL.","PeriodicalId":10976,"journal":{"name":"Current Topics in Nutraceutical Research","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2023-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45386819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In Vitro Probiotic Characteristics of the Lactococcus Lactis Subsp. Hordniae Strain UAB10 Isolated from Aloe Vera 乳酸乳球菌亚群的体外益生菌特性从芦荟中分离的Hordniae菌株UAB10

IF 0.5 4区医学

Current Topics in Nutraceutical Research Pub Date : 2023-01-06 DOI: 10.37290/ctnr2641-452x.21:60-65

Hyung-Jin Lim, Yeong‐Seon Won, S. Bak, Soyoung Lee, Bomi Ryu, Seon-Heui Cha, Taeoh Kwon, K. Shim, Jisu Jeon, Hyuck Se Kwon, S. Lee, Seung-Jae Lee, M. Rho

{"title":"In Vitro Probiotic Characteristics of the Lactococcus Lactis Subsp. Hordniae Strain UAB10 Isolated from Aloe Vera","authors":"Hyung-Jin Lim, Yeong‐Seon Won, S. Bak, Soyoung Lee, Bomi Ryu, Seon-Heui Cha, Taeoh Kwon, K. Shim, Jisu Jeon, Hyuck Se Kwon, S. Lee, Seung-Jae Lee, M. Rho","doi":"10.37290/ctnr2641-452x.21:60-65","DOIUrl":"https://doi.org/10.37290/ctnr2641-452x.21:60-65","url":null,"abstract":"We have isolated 15 bacterial strains from Aloe vera gel. Among them, we selected the Lactococcus lactis subsp. hordniae strain UAB10 based on its inhibition of IL-6-induced STAT3 activation and its ability to adhere to intestinal epithelial cells. UAB10 showed strong inhibition of interleukin-6-induced signal transducer and activator of transcription 3 activation. The UAB10 isolate showed superior adhesion to Caco-2 cells compared with KTCT 3768, a reference L. lactis subsp. hordniae strain. The UAB10 isolate displayed no hemolytic activity and more potent anti-Shigella flexneri activity than KTCT 3768. Furthermore, UAB10 was able to survive better than KTCT 3768 in oxgall-containing De Man, Rogosa, and Sharpe agar media and low-pH De Man, Rogosa, and Sharpe agar media. Finally, UAB10 did not show any resistance against the eight tested antibiotics, including ampicillin, vancomycin, and gentamicin. These results highlight the potential for the use of UAB10 as a commercial probiotic.","PeriodicalId":10976,"journal":{"name":"Current Topics in Nutraceutical Research","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2023-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45198752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gypenosides Improve Lipid Homeostasis by Regulating Fatty Acid Metabolism in the Liver 绞股蓝总皂甙通过调节肝脏脂肪酸代谢改善脂质稳态

IF 0.5 4区医学

Current Topics in Nutraceutical Research Pub Date : 2023-01-06 DOI: 10.37290/ctnr2641-452x.21:94-101

Zunping Wu, Yanzhe Xu, Ruoyu Zhou, Hao Liu, Hua Ling, Yimei Du, Yanliu Lu, Yuqi He

引用次数: 0

Paeoniflorin Protects Retinal Ganglion Cells in Experimental Glaucoma 芍药苷对实验性青光眼视网膜神经节细胞的保护作用

IF 0.5 4区医学

Current Topics in Nutraceutical Research Pub Date : 2023-01-06 DOI: 10.37290/ctnr2641-452x.21:86-93

Lina Wu, Zhen Chen

{"title":"Paeoniflorin Protects Retinal Ganglion Cells in Experimental Glaucoma","authors":"Lina Wu, Zhen Chen","doi":"10.37290/ctnr2641-452x.21:86-93","DOIUrl":"https://doi.org/10.37290/ctnr2641-452x.21:86-93","url":null,"abstract":"Glaucoma is a progressive neurodegenerative eye disease characterized by raised intraocular pressure and a loss of retinal ganglion cells, resulting in partial or total vision loss. We have investigated whether paeoniflorin could reduce intraocular pressure and improve retinal ganglion cell survival in glaucoma-induced rats. In rats with raised intraocular pressure induced by injecting hypertonic saline solution into the limbal veins, oral paeoniflorin markedly brought down the elevated intraocular pressure and significantly prevented retinal ganglion cell loss, as determined by the terminal deoxynucleotidyl transferase dUTP nick end labeling assay and Fluoro-Gold labeling. The expression of the transforming growth factor β protein was effectively diminished by paeoniflorin administration. Also, the expression of extracellular matrix components matrix metalloproteinase 9 a tissue inhibitor of metalloproteinase 1—laminin, collagen I, and collagen IV in the optic nerve head and retinal ganglion cell layer were effectively diminished. Paeoniflorin substantially upregulated the activation of Janus kinase-2/signal transducer and activator of transcription proteins-3 signaling, which plays a crucial role in retinal ganglion cell survival. These results illustrate a protective effect of paeoniflorin through reduction of intraocular pressure, retinal ganglion cell loss, and changes in the extracellular matrix by regulating transforming growth factor β2 signaling and Janus kinase-2/signal transducer and activator of transcription protein-3 signaling. The present work demonstrates that paeoniflorin may be a promising therapeutic agent for glaucoma.","PeriodicalId":10976,"journal":{"name":"Current Topics in Nutraceutical Research","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2023-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48366650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Jiawei Sijunzi Soup Inhibits Inflammation and Oxidative Stress in the Rat Model of Diabetic Gastroparesis 加味四君子汤对糖尿病胃轻瘫模型大鼠炎症和氧化应激的抑制作用

IF 0.5 4区医学

Current Topics in Nutraceutical Research Pub Date : 2023-01-06 DOI: 10.37290/ctnr2641-452x.21:80-85

Yi Zhang, Xu Wang, Yiwen Yang, Ya-qin Wei, Li Sheng, Lu Yu

引用次数: 0

Recombinant Interferon α-2B Gel Combined with Lactobacillus as a Vaginal Capsule in Patients with Cervical High-Risk Human Papillomavirus 重组干扰素α-2B凝胶联合乳酸杆菌阴道胶囊治疗宫颈高危型人乳头瘤病毒

IF 0.5 4区医学

Current Topics in Nutraceutical Research Pub Date : 2022-10-26 DOI: 10.37290/ctnr2641-452x.21:47-52

Lin Kong, Jie Kong, Zhihong Chai, Guo‐Xian Tao, Xianli Cai, Lingxiao Ying, Jinmei Shi

{"title":"Recombinant Interferon α-2B Gel Combined with Lactobacillus as a Vaginal Capsule in Patients with Cervical High-Risk Human Papillomavirus","authors":"Lin Kong, Jie Kong, Zhihong Chai, Guo‐Xian Tao, Xianli Cai, Lingxiao Ying, Jinmei Shi","doi":"10.37290/ctnr2641-452x.21:47-52","DOIUrl":"https://doi.org/10.37290/ctnr2641-452x.21:47-52","url":null,"abstract":"This study was performed to investigate the effects of Lactobacillus vaginal capsules combined with recombinant human interferon α-2b gel on clinical efficacy, vaginal microbial function indicators, vaginal microecological balance, inflammation levels, and drug safety in patients with persistent cervical high-risk human papillomavirus infection. Patients with human papillomavirus infection (n = 128) were randomly divided into control and observation groups of equal size. Patients in the control group were treated with recombinant human interferon α-2b gel alone. Patients in the observation group were treated with Lactobacillus vaginal capsules and human interferon α-2b gel. After treatment, the clinical efficiency, microbial function index, and human papillomavirus-DNA conversion rate of patients in the observation group were significantly higher than those in the control group. Further, pH, Nugent scores, human papillomavirus-DNA viral load, vaginal microecological dysregulation rate, and inflammation level were significantly lower than those in the control group. Lactobacillus vaginal capsules in combination with recombinant human interferon α-2b gel improved clinical outcomes and disease regression rates in patients with human papillomavirus infection, while also improving vaginal microecological balance and suppressing inflammatory responses.","PeriodicalId":10976,"journal":{"name":"Current Topics in Nutraceutical Research","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2022-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48252207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

6-(Methylsulfinyl) Hexyl Isothiocyanate from Wasabia Japonica for Inflammatory Diseases and Carcinogenesis 日本Wasabia的6-（甲基亚磺酰基）己基异硫氰酸酯对炎症性疾病和致癌作用的研究

IF 0.5 4区医学

Current Topics in Nutraceutical Research Pub Date : 2022-10-06 DOI: 10.37290/ctnr2641-452x.21:38-39

Chih-Hung Lin, Han-Fang Tseng, Chang-Ti Lee, C. Kuo

引用次数: 0

Ligustilide Attenuates Intracerebral Hemorrhage-Induced Cardiac Damage via Nuclear Factor-Kappa B and Nuclear-Factor Erythroid 2-Related Factor 2 Pathways 藁本内酯通过核因子- κ B和核因子-红细胞2相关因子2通路减轻脑出血引起的心脏损伤

IF 0.5 4区医学

Current Topics in Nutraceutical Research Pub Date : 2022-09-06 DOI: 10.37290/ctnr2641-452x.21:31-37

Chuanyang Dai, Guofeng Wu

{"title":"Ligustilide Attenuates Intracerebral Hemorrhage-Induced Cardiac Damage via Nuclear Factor-Kappa B and Nuclear-Factor Erythroid 2-Related Factor 2 Pathways","authors":"Chuanyang Dai, Guofeng Wu","doi":"10.37290/ctnr2641-452x.21:31-37","DOIUrl":"https://doi.org/10.37290/ctnr2641-452x.21:31-37","url":null,"abstract":"Ligustilide is a bioactive component of the traditional Chinese herb Angelica sinensis that exhibits analgesic, anti-inflammatory, anticancer, neuroprotection, and anti-atherosclerosis pharmacological activities. Herein, the role of ligustilide in intracerebral hemorrhage-induced cardiac damage has been assessed. An autologous blood injection was used to induce intracerebral hemorrhage in CD-1 mice that resulted in an increase in systolic and diastolic blood pressure. Intraperitoneal administration of ligustilide reduced systolic and diastolic blood pressure, decreased plasma levels of adrenaline and noradrenaline in mice with intracerebral hemorrhage. Also, cardiac injury was observed in mice with intracerebral hemorrhage, as demonstrated by the upregulation of creatine kinase-MB, lactic dehydrogenase, and aspartate transaminase. Moreover, Picrosirius red staining showed cardiac fibrosis in intracerebral hemorrhage mice that was attenuated by ligustilide. Lastly, ligustilide reduced levels of interleukin-1β, tumor necrosis factor-α, interleukin-6, and reactive oxygen species in mice with intracerebral hemorrhage. Cardiac apoptosis in mice with intracerebral hemorrhage was also inhibited by ligustilide, as shown by reduced protein expression of phospho-p65, enhanced nuclear factor erythroid 2-related factor 2, and heme oxygenase-1 expression.","PeriodicalId":10976,"journal":{"name":"Current Topics in Nutraceutical Research","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2022-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41816058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effectiveness of Honey on Radiation-Induced Oral Mucositis Among Patients with Head and Neck Malignancies: A Systematic Review and Meta-Analysis 蜂蜜对头颈部恶性肿瘤患者放射性口腔粘膜炎的疗效：系统评价和荟萃分析

IF 0.5 4区医学

Current Topics in Nutraceutical Research Pub Date : 2022-08-23 DOI: 10.37290/ctnr2641-452x.21:53-59

Ying-Li Dong, Weiqian Hou, Chong Zhang, Xiaozhong Cao, Zhen-Yu Li

{"title":"Effectiveness of Honey on Radiation-Induced Oral Mucositis Among Patients with Head and Neck Malignancies: A Systematic Review and Meta-Analysis","authors":"Ying-Li Dong, Weiqian Hou, Chong Zhang, Xiaozhong Cao, Zhen-Yu Li","doi":"10.37290/ctnr2641-452x.21:53-59","DOIUrl":"https://doi.org/10.37290/ctnr2641-452x.21:53-59","url":null,"abstract":"While radiotherapy remains the cornerstone of head and neck cancer treatment, oral mucositis is a very serious side effect, especially grade III/IV oral mucositis. Oral mucositis not only seriously reduces the quality of life of patients, but also affects the ongoing treatment of patients. Use of honey for the remediation of oral mucositis promising, but clinically controversial. Therefore, to further ascertain its role in oral mucositis, an extensive literature search was performed in the Pubmed, Embase and Cochrane databases. Thirteen randomized controlled trials with 899 patients were included in the analysis. Pooled Odds ratio with 95% confidence intervals was analyzed. The results show that a significantly fewer number of patients treated with honey experienced grade III/IV oral mucositis after radiotherapy (OR 0.24, 95% CI 0.13–0.44, p < 0.001). The administration of honey concurrently with radiotherapy decreased the rate of graded III/IV oral mucositis. Thus, the use of honey during radiotherapy may represent a feasible strategy for preserving tolerance.","PeriodicalId":10976,"journal":{"name":"Current Topics in Nutraceutical Research","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2022-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43998822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0