Astragalin Inhibits Insulin Resistance and Oxidative Stress in Palmitic Acid-Induced HEPG2 Cells

IF 0.4 4区医学 Q4 NUTRITION & DIETETICS

Current Topics in Nutraceutical Research Pub Date : 2022-04-26 DOI:10.37290/ctnr2641-452x.20:635-640

H. Du, Shidong Duan, Rui Lei, Xiao-Yu Liu

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引用次数: 0

Abstract

Insulin resistance is an element of metabolic syndrome, manifested as a decrease in glucose uptake, which often leads to a variety of complications, including type 2 diabetes. Astragalin is a natural flavonoid, isolated from traditional medicinal plants, such as Cuscuta chinensis, that has been shown to exhibit a variety of pharmacological activities with anti-inflammatory, antioxidant, neuroprotective, cardioprotective, antiobesity, antiosteoporotic, anticancer, antiulcer, and antidiabetic properties. However, the mechanism of astragalin on insulin resistance has not yet been elucidated. To this end, we examined the effect of astragalin on palmitic acid-induced insulin resistance in HepG2 cells. The effects of the co-incubation of PA and astragalin on the cell viability, superoxide dismutase, fat content, and markers of oxidative stress in HepG2 cells were measured. The results show that astragalin restored the cell viability, reduced oxidative stress, and insulin resistance in palmitic acid treated HepG2 cells. The protective effect of astragalin on palmitic acid-induced lipotoxicity in HepG2 cells was through inhibition of NF-was through inhibition of NF-κ and JNK signaling pathways.

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黄芪甲苷抑制棕榈酸诱导的HEPG2细胞胰岛素抵抗和氧化应激

胰岛素抵抗是代谢综合征的一个因素，表现为葡萄糖摄取减少，通常导致各种并发症，包括2型糖尿病。黄芪苷是一种天然黄酮类化合物，从传统药用植物中分离出来，如Cuscuta chinensis，已被证明具有多种药理活性，具有抗炎，抗氧化，神经保护，心脏保护，抗肥胖，抗骨质疏松，抗癌，抗溃疡和抗糖尿病的特性。然而，黄芪甲苷对胰岛素抵抗的作用机制尚未阐明。为此，我们研究了黄芪甲苷对棕榈酸诱导的HepG2细胞胰岛素抵抗的影响。观察PA与黄芪甲苷共孵育对HepG2细胞活力、超氧化物歧化酶、脂肪含量及氧化应激标志物的影响。结果表明，黄芪甲苷能恢复棕榈酸处理的HepG2细胞活力，降低氧化应激和胰岛素抵抗。黄芪甲苷对棕榈酸诱导的HepG2细胞脂毒性的保护作用是通过抑制NF-κ和JNK信号通路实现的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Topics in Nutraceutical Research 医学-药学

CiteScore

1.10

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Current Topics in Nutraceutical Research is an international, interdisciplinary broad-based peer reviewed scientific journal for critical evaluation of research on chemistry, biology and therapeutic applications of nutraceuticals and functional foods. The major goal of this journal is to provide peer reviewed unbiased scientific data to the decision makers in the nutraceutical and food industry to help make informed choices about development of new products. To this end, the journal will publish two types of review articles. First, a review of preclinical research data coming largely from animal, cell culture and other experimental models. Such data will provide basis for future product development and/or human research initiatives. Second, a critical evaluation of current human experimental data to help market and deliver the product for medically proven use. This journal will also serve as a forum for nutritionists, internists, neurologists, psychiatrists, and all those interested in preventive medicine. The common denominator of all of the topic to be covered by the journal must include nutraceuticals and/functional food. The following is an example of some specific areas that may be of interest to the journal. i) Role of vitamins, minerals, antioxidants and phytonutrients on cardiovascular health, cancer, diabetes, ocular health, mental health, men’s health, women’s health, infant nutrition, ii) Role of herbals on human health, iii) Dietary supplements and sleep, iv) Components of diet that may have beneficial effect on human health, v) regulation of apoptosis and cell viability, vi) Isolation and characterization of bioactive components from functional foods, vii) Nutritional genomics, and viii) Nutritional proteomics.