Current Topics in Nutraceutical Research最新文献

Vitamin D Regulates Cooperation Between Metadherin and Transcription Factor Lymphoid Enhancer-Binding Factor 1 in Prostate Cancer Development and Progression 维生素D调节Metadherin和转录因子淋巴增强结合因子1在前列腺癌发生和发展中的合作

4区医学

Current Topics in Nutraceutical Research Pub Date : 2024-06-27 DOI: 10.37290/ctnr2641-452x.22:1193-1204

Huan Cheng, Yichun Wang, Chengjian Ji, Yong Wang, Da Zhong, Ninghong Song

{"title":"Vitamin D Regulates Cooperation Between Metadherin and Transcription Factor Lymphoid Enhancer-Binding Factor 1 in Prostate Cancer Development and Progression","authors":"Huan Cheng, Yichun Wang, Chengjian Ji, Yong Wang, Da Zhong, Ninghong Song","doi":"10.37290/ctnr2641-452x.22:1193-1204","DOIUrl":"https://doi.org/10.37290/ctnr2641-452x.22:1193-1204","url":null,"abstract":"The incidence of prostate cancer is increasing, and its poor prognosis is associated with metadherin overexpression; however, its molecular mechanisms are unclear. This study used Western blot, quantitative real-time polymerase chain reaction, immunofluorescence, and tumorigenicity assays to investigate metadherin and epithelial-mesenchymal transition in prostate cancer. We found that metadherin was highly expressed in prostate cancer tissues, especially PC-3 cells. Metadherin overexpression promoted t epithelial-mesenchymal transition and tumor growth. Bioinformatics analysis and assays revealed that lymphoid enhancer-binding factor 1 directly activates the metadherin promoter. The epithelial-mesenchymal transition and tumorigenicity were suppressed by the silencing of lymphoid enhancer-binding factor 1; however, these effects were reversed by metadherin overexpression. Vitamin D treatment downregulated metadherin and lymphoid enhancer-binding factor 1, counteracting lymphoid enhancer-binding factor 1-induced metadherin upregulation. Our findings indicate that metadherin enhances epithelial-mesenchymal transition and tumorigenicity through lymphoid enhancer-binding factor 1, with vitamin D modulating this interaction in prostate cancer.","PeriodicalId":10976,"journal":{"name":"Current Topics in Nutraceutical Research","volume":"22 4","pages":"1193-1204"},"PeriodicalIF":0.0,"publicationDate":"2024-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147916490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Magnolol plays a protective role in the kidney of rats with diabetic nephropathy 厚朴酚对糖尿病肾病大鼠肾脏有保护作用

4区医学

Current Topics in Nutraceutical Research Pub Date : 2024-04-26 DOI: 10.37290/ctnr2641-452x.22:8-13

Meihua He, Chao Dong, Sha Xiang

{"title":"Magnolol plays a protective role in the kidney of rats with diabetic nephropathy","authors":"Meihua He, Chao Dong, Sha Xiang","doi":"10.37290/ctnr2641-452x.22:8-13","DOIUrl":"https://doi.org/10.37290/ctnr2641-452x.22:8-13","url":null,"abstract":"This study investigated the protective effects of magnolol on the kidneys of diabetic nephropathy (DN) rats via the mitogenactivated protein kinase/nuclear factor-kappa-B (MAPK/NF-κB) signaling pathway. Rats were divided into control, diabetic control, low-dose magnolol, and high-dose magnolol groups. The DN model was induced by a high-glucose/high-fat diet and streptozocin injection. The results showed that in the diabetic control group, various parameters indicative of DN worsened compared to the control group. However, in the magnolol-treated groups, there were improvements in glucose levels, urine volume, proteinuria, kidney function markers, inflammatory factors, and renal tissue morphology. Magnolol treatment also correlated with the decreased activation of extracellular regulated protein kinases, c-jun N-terminal kinase, p38 MAPK, and increased levels of the inhibitor of NF-κB, suggesting inhibition of the MAPK/NF-κB signaling pathway. These findings suggest that magnolol exerts a protective effect on DN rats by inhibiting the MAPK/NF-κB signaling pathway and reducing inflammatory cytokines, such as tumor necrosis factor-α, interleukin-6, and interleukin-1β.","PeriodicalId":10976,"journal":{"name":"Current Topics in Nutraceutical Research","volume":"23 1","pages":"8-13"},"PeriodicalIF":0.0,"publicationDate":"2024-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147877893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Platycodin D Exerts Anticancer Effects by Promoting Mitochondrial Apoptosis in Laryngeal Squamous Cell Carcinoma 桔梗素D通过促进喉鳞癌线粒体凋亡发挥抗癌作用

4区医学

Current Topics in Nutraceutical Research Pub Date : 2024-03-24 DOI: 10.37290/ctnr2641-452x.22:1018-1024

Meihua Kong, Yanzhi Cai, Qian He

{"title":"Platycodin D Exerts Anticancer Effects by Promoting Mitochondrial Apoptosis in Laryngeal Squamous Cell Carcinoma","authors":"Meihua Kong, Yanzhi Cai, Qian He","doi":"10.37290/ctnr2641-452x.22:1018-1024","DOIUrl":"https://doi.org/10.37290/ctnr2641-452x.22:1018-1024","url":null,"abstract":"Laryngeal squamous cell carcinoma is a challenging malignancy with increasing incidence globally, necessitating the exploration of novel therapeutic strategies. Platycodin D, a saponin derived from Platycodon grandiflorum, has shown promise in cancer therapy, exhibiting anticancer effects in various tumor types. However, the specific mechanisms of action of Platycodin D in laryngeal squamous cell carcinoma remain poorly understood. Therefore, our study aimed to investigate the anticancer effects of Platycodin D in laryngeal squamous cell carcinoma. We revealed that Platycodin D effectively inhibited the proliferation of laryngeal squamous cell carcinoma cells and induced mitochondrial apoptosis. Furthermore, we found that Platycodin D downregulated the expression of S-phase kinase-associated protein 2, indicating a novel target for PD’s action. Finally, the suppression of S-phase kinase-associated protein 2 by Platycodin D led to cell cycle arrest and enhanced apoptosis in laryngeal squamous cell carcinoma cells. Collectively, these findings underscore the potential of Platycodin D as a novel therapeutic agent for laryngeal squamous cell carcinoma, with implications for targeting mitochondrial apoptosis and S-phase kinase-associated protein 2 in cancer treatment.","PeriodicalId":10976,"journal":{"name":"Current Topics in Nutraceutical Research","volume":"22 3","pages":"1018-1024"},"PeriodicalIF":0.0,"publicationDate":"2024-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147883359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lonicerin Alleviates Interleukin-1β-Stimulated Extracellular Cartilage Matrix Degradation and Inflammation 忍冬素减轻白细胞介素-1β刺激的细胞外软骨基质降解和炎症

4区医学

Current Topics in Nutraceutical Research Pub Date : 2024-02-27 DOI: 10.37290/ctnr2641-452x.22:1006-1011

Jun Ma, Dong Gong, Xiaotao Chen

{"title":"Lonicerin Alleviates Interleukin-1β-Stimulated Extracellular Cartilage Matrix Degradation and Inflammation","authors":"Jun Ma, Dong Gong, Xiaotao Chen","doi":"10.37290/ctnr2641-452x.22:1006-1011","DOIUrl":"https://doi.org/10.37290/ctnr2641-452x.22:1006-1011","url":null,"abstract":"This study aimed to investigate the effects of lonicerin on an osteoarthritis model in vitro and determine its mechanism of action. We induced SW1353 cells with interleukin-1β to construct a cell model of osteoarthritis. The effects of lonicerin on cell viability were observed using cell counting kit-8 assays. Quantitative polymerase chain reaction, immunoblot, and enzyme-linked immune-sorbent assays revealed the effects of lonicerin on inflammation. Additionally, quantitative polymerase chain reaction and immunoblot assays showed the degree of extracellular matrix degradation. Immunoblot assays were further performed to confirm the mechanism of action of lonicerin. Lonicerin contributed to interleukin-1β-stimulated SW1353 cell viability. Furthermore, lonicerin restrained the inflammatory response of interleukin-1β-stimulated SW1353 cells, suppressed the extracellular matrix degradation of interleukin-1β-stimulated SW1353 cells, and increased collagen II expression. Mechanically, lonicerin suppressed the nuclear factor-kappa B pathway and prevented osteoarthritis progression. Lonicerin alleviates interleukin-1β-stimulated cartilage extracellular matrix and inflammation.","PeriodicalId":10976,"journal":{"name":"Current Topics in Nutraceutical Research","volume":"22 3","pages":"1006-1011"},"PeriodicalIF":0.0,"publicationDate":"2024-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147893756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cirsilineol Protects Renal Tubular Epithelial Cells from Hypoxia/Reoxygenation Injury by Inhibiting Inflammation and Pyroptosis cisilineol通过抑制炎症和焦亡保护肾小管上皮细胞免受缺氧/再氧化损伤

4区医学

Current Topics in Nutraceutical Research Pub Date : 2024-02-27 DOI: 10.37290/ctnr2641-452x.22:882-888

Fei Huang, Zi Liu

{"title":"Cirsilineol Protects Renal Tubular Epithelial Cells from Hypoxia/Reoxygenation Injury by Inhibiting Inflammation and Pyroptosis","authors":"Fei Huang, Zi Liu","doi":"10.37290/ctnr2641-452x.22:882-888","DOIUrl":"https://doi.org/10.37290/ctnr2641-452x.22:882-888","url":null,"abstract":"To investigate the effects of Cirsilineol on cell viability, pyroptosis, and inflammation in hypoxia/reoxygenation-induced renal tubular cells, we utilized the renal tubular epithelial cell line HK2. The in vitro renal injury model was induced by hypoxia/reoxygenation. Cell viability in hypoxia/reoxygenation-induced HK2 cells was determined using a methylthiazolyldiphenyl-tetrazolium bromide assay and lactate dehydrogenase releasing kit. The effects of Cirsilineol on inflammation and pyroptosis in HK2 cells were evaluated using enzyme-linked immunosorbent assay, flow cytometry, and immunoblot assays. Our results demonstrated that Cirsilineol promoted survival in hypoxia/reoxygenation-induced tubular cells, inhibited inflammation, and reduced pyroptosis in these cells. Further investigation revealed that the protective effects of Cirsilineol are mediated by the suppression of the Toll-like receptor 4/nuclear factor kappa B pathway, which mitigates the cellular response to hypoxia/reoxygenation injury. Our study suggests that Cirsilineol protects renal tubular epithelial cells from hypoxia/reoxygenation injury by inhibiting inflammation and pyroptosis, highlighting its potential therapeutic value in renal conditions characterized by ischemic injury.","PeriodicalId":10976,"journal":{"name":"Current Topics in Nutraceutical Research","volume":"22 3","pages":"882-888"},"PeriodicalIF":0.0,"publicationDate":"2024-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147908426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Luteolin Inhibits Lipopolysaccharide-Induced Inflammation and Epithelial–Mesenchymal Transition in Human Nasal Epithelial Cells 木犀草素抑制脂多糖诱导的人鼻上皮细胞炎症和上皮-间质转化

4区医学

Current Topics in Nutraceutical Research Pub Date : 2024-02-21 DOI: 10.37290/ctnr2641-452x.22:875-881

Qin Yang, Nimei Shen, Gang Gao

引用次数: 0

Bergamottin Attenuates Mitochondrial Activity and Oxidative Stress in Oxygen-Glucose Deprivation and Reperfusion-Induced Cardiomyocytes 佛手柑素降低氧糖剥夺和再灌注诱导心肌细胞的线粒体活性和氧化应激

4区医学

Current Topics in Nutraceutical Research Pub Date : 2024-01-10 DOI: 10.37290/ctnr2641-452x.22:901-907

M.J. Fu, Jinhuan Chen, Xiaoqian Che, Lu Huang, Yuping Mo

引用次数: 0

Enrichment of Sodium Alginate-Gum Arabic Composite Films with Oregano/Citronella Essential Oils for Fresh Goji Berry (Lycium Barbarum L.) Preservation 鲜枸杞用牛至/香茅精油富集海藻酸钠-阿拉伯树胶复合膜保存

4区医学

Current Topics in Nutraceutical Research Pub Date : 2023-11-08 DOI: 10.37290/ctnr2641-452x.22:657-671

Zi-Jing Guan, Wang-Wei Zhang, Jingjing Wang, Kiran Thakur, Fei Hu, Jian‐Guo Zhang

{"title":"Enrichment of Sodium Alginate-Gum Arabic Composite Films with Oregano/Citronella Essential Oils for Fresh Goji Berry (Lycium Barbarum L.) Preservation","authors":"Zi-Jing Guan, Wang-Wei Zhang, Jingjing Wang, Kiran Thakur, Fei Hu, Jian‐Guo Zhang","doi":"10.37290/ctnr2641-452x.22:657-671","DOIUrl":"https://doi.org/10.37290/ctnr2641-452x.22:657-671","url":null,"abstract":"This study reported the preparation of composite sodium alginate-gum Arabic films by incorporating nano emulsions and pickering emulsions loaded with mixed oregano and citronella essential oils. Nano emulsions and pickering emulsions were prepared with Tween 80 and whey protein isolate/inulin. The results of Fourier transform infrared, X-ray diffraction, thermo-gravimetric analysis, field emission scanning electron microscopy, and atomic force microscopy demonstrated that sodium alginate-gum Arabic and the emulsion-loaded mixed oregano and citronella essential oils were biocompatible. The mixed oregano and citronella essential oils was enclosed in Pickering emulsions in the film samples, which also improved the mechanical and water barrier qualities, slowed the release of the active components. The composite film was applied to the storage experiment of goji berries at 25°C. In comparison to the control group, the composite film containing 0.4% Pickering emulsions significantly decreased weight loss and fruit deterioration while also extending shelf life by 3 days. In conclusion, produced Pickering emulsions laminate film loaded with mixed oregano and citronella essential oils may be a viable material for the food packaging sector.","PeriodicalId":10976,"journal":{"name":"Current Topics in Nutraceutical Research","volume":"22 2","pages":"657-671"},"PeriodicalIF":0.0,"publicationDate":"2023-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147877263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Individualized Nursing Based on Stress Adaptation Theory on Nutritional Status and Gastrointestinal Motility of Preterm Infants 基于压力适应理论的个性化护理对早产儿营养状况和胃肠道蠕动的影响

IF 0.5 4区医学

Current Topics in Nutraceutical Research Pub Date : 2023-10-19 DOI: 10.37290/ctnr2641-452x.21:502-508

Huimin Li

引用次数: 0

Synergistic Effects of Chlorogenic Acid and Ganoderma Lucidum Polysaccharide on Hepatic Fat Accumulation 绿原酸和灵芝多糖对肝脏脂肪堆积的协同作用

4区医学

Current Topics in Nutraceutical Research Pub Date : 2023-10-18 DOI: 10.37290/ctnr2641-452x.22:792-802

Wang Tianyu, Xu He, Sun Yue, Hou Jumin, Yin Liying

{"title":"Synergistic Effects of Chlorogenic Acid and Ganoderma Lucidum Polysaccharide on Hepatic Fat Accumulation","authors":"Wang Tianyu, Xu He, Sun Yue, Hou Jumin, Yin Liying","doi":"10.37290/ctnr2641-452x.22:792-802","DOIUrl":"https://doi.org/10.37290/ctnr2641-452x.22:792-802","url":null,"abstract":"This study aimed to investigate the impact of different doses of chlorogenic acid and Ganoderma lucidum polysaccharide on lipid accumulation using an obese rat model. We utilized blood glucose assays, oil red O staining, and triglyceride content analysis to examine the effects of chlorogenic acid combined with G. lucidum polysaccharide on fat metabolism in rats. We found substantial potential in using chlorogenic acid combined with G. lucidum polysaccharide for weight control and metabolic regulation in obese rats. After a long-term dietary intervention, chlorogenic acid and G. lucidum polysaccharide markedly inhibited the expression of proteins related to fatty acid synthesis, including AMP-activated protein kinase, fatty acid synthase, and SREBP-1c, leading to reduced body weight and decreased hepatic fat deposition. Additionally, the combined treatment substantially affected enzymes and proteins involved in glucose metabolism, reducing glycogen synthase expression and indicating a potential mechanism for weight reduction through glycogen synthesis inhibition. Furthermore, elevated glucose kinase levels indicated that chlorogenic acid and G. lucidum polysaccharide may enhance hepatic glycogen degradation, thereby reducing hepatic fat accumulation. These findings reveal that chlorogenic acid combined with G. lucidum polysaccharide has a synergistic impact, providing a theoretical basis for their potential as a combined therapeutic approach for obesity.","PeriodicalId":10976,"journal":{"name":"Current Topics in Nutraceutical Research","volume":"22 2","pages":"792-802"},"PeriodicalIF":0.0,"publicationDate":"2023-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147883431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1