肺己方提高老年肺癌多西他赛联合顺铂化疗患者的生存质量

IF 0.4 4区医学 Q4 NUTRITION & DIETETICS

Current Topics in Nutraceutical Research Pub Date : 2022-07-04 DOI:10.37290/ctnr2641-452x.20:669-674

Lianyou Wang, Cuixia Yang, Nanning Lv, Lantao Zhao, Liang Wang

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引用次数: 0

摘要

我们评价肺积方对多西他赛联合顺铂治疗老年肺癌患者生活质量的影响。为此，选取2017年1月至2021年12月在江苏省连云港市连云港市第二人民医院接受治疗的肺癌患者186例，随机分为对照组(多西他赛+顺铂组)和治疗组(多西他赛+顺铂+非极方组)93例。两组患者均在顺铂用药当日饮水，并给予预防呕吐、保肝、抑酸、保护粘膜等治疗。治疗后，治疗组分化簇3蛋白、分化簇4蛋白、分化簇4蛋白/分化簇8蛋白水平均较对照组显著改善/增强(P < 0.05)。治疗后，治疗组分化簇3蛋白和分化簇4蛋白/分化簇8蛋白水平较对照组上调(P < 0.05)，而细胞角蛋白19片段抗原、癌抗原125、癌胚抗原水平较对照组降低(P < 0.05)。两组治疗前后自然杀伤细胞计数比较，差异无统计学意义(P < 0.05)。对照组和治疗组总有效率分别为74.18%和90.32%，进展率分别为25.82%和9.68%，差异有统计学意义(P < 0.05)。治疗组身体/情绪/认知/角色功能评分均显著高于对照组(P < 0.05)。综上所述，肺芪方对多西紫杉醇+顺铂治疗肺癌的各项指标均有显著提高。

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Feiji Recipe Elevates the Quality of Life of the Elderly with Lung Cancer on Docetaxel Plus Cisplatin Chemotherapy

We have evaluated the effect of Feiji recipe on efficacy of docetaxel plus cisplatin treatment on the quality of life of the elderly with lung cancer. To this end, 186 lung cancer patients receiving treatment at the Second People’s Hospital of Lianyungang, Lianyungang City, Jiangsu Province were recruited between January 2017 and December 2021 and randomly divided into control (receiving docetaxel + cisplatin) and treatment (receiving docetaxel + cisplatin + Feiji recipe) groups of 93 patients. Both groups received hydration on the day of cisplatin use and received preventive treatment for emesis, liver protection, acid suppression, and mucosal protection. Post-treatment depletion of cluster of differentiation 3 protein, cluster of differentiation 4 protein, and cluster of differentiation 4 protein/cluster of differentiation 8 protein levels in the treatment group were significantly (P < 0.05) ameliorated/enhanced compared to the control group. Cluster of differentiation 3 protein and cluster of differentiation 4 protein/cluster of differentiation 8 protein levels in the treatment group were upregulated relative to controls (P < 0.05), whereas cytokeratin 19 fragment antigen, cancer antigen 125, and carcinoembryonic antigen levels in the treatment group were depleted relative to controls after treatment (P < 0.05). However, there was no significant difference in natural killer cell counts in the two groups before and after treatment (P > 0.05). The overall treatment effectiveness (74.18% and 90.32%) and the progressive disease rates (25.82% and 9.68%) in the control and treatment groups, respectively (P < 0.05). The physical/emotional/cognitive/role function scores in the treatment group were markedly increased compared to the control group (P < 0.05). In conclusion, Feiji recipe markedly enhanced efficacy of all measures of treating lung cancer by docetaxel + cisplatin.

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来源期刊

Current Topics in Nutraceutical Research 医学-药学

CiteScore

1.10

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Current Topics in Nutraceutical Research is an international, interdisciplinary broad-based peer reviewed scientific journal for critical evaluation of research on chemistry, biology and therapeutic applications of nutraceuticals and functional foods. The major goal of this journal is to provide peer reviewed unbiased scientific data to the decision makers in the nutraceutical and food industry to help make informed choices about development of new products. To this end, the journal will publish two types of review articles. First, a review of preclinical research data coming largely from animal, cell culture and other experimental models. Such data will provide basis for future product development and/or human research initiatives. Second, a critical evaluation of current human experimental data to help market and deliver the product for medically proven use. This journal will also serve as a forum for nutritionists, internists, neurologists, psychiatrists, and all those interested in preventive medicine. The common denominator of all of the topic to be covered by the journal must include nutraceuticals and/functional food. The following is an example of some specific areas that may be of interest to the journal. i) Role of vitamins, minerals, antioxidants and phytonutrients on cardiovascular health, cancer, diabetes, ocular health, mental health, men’s health, women’s health, infant nutrition, ii) Role of herbals on human health, iii) Dietary supplements and sleep, iv) Components of diet that may have beneficial effect on human health, v) regulation of apoptosis and cell viability, vi) Isolation and characterization of bioactive components from functional foods, vii) Nutritional genomics, and viii) Nutritional proteomics.