The Effects of Nitrate-Based Nutritional Formula on Oxygen Saturation and Patient-Reported Outcomes in COVID-19 Patients: A Randomized Controlled Trial

IF 0.4 4区医学 Q4 NUTRITION & DIETETICS

Current Topics in Nutraceutical Research Pub Date : 2022-04-13 DOI:10.37290/ctnr2641-452x.20:720-724

N. Todorovic, V. Štajer, A. Milovančev, Danijela Musulin Banjanin, Milijana Celarevic, L. Rátgéber, J. Betlehem, P. Ács, Ron Kramer, Alexander Nicolaidis, P. Drid, N. Maksimović, S. Ostojić

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引用次数: 0

Abstract

The main objective of this randomized controlled trial was to analyze the acute effects of a nitrate-based nutritional formula on peripheral oxygen saturation (SpO2), patient-reported outcomes, and safety indices in patients with acute COVID-19 infection. The participants completing the protocol for the trial (n = 71) were allocated in a double-blind design to receive either a multicomponent nutritional formula (containing 1200 mg of potassium nitrate, 200 mg of magnesium, 50 mg of zinc, and 1000 mg of citric acid), or a placebo (2.5 g of inulin) during a 72-h monitoring period. All participants were requested to take an intervention (four capsules; weight of each capsule was ~2.5 g) every 4 h during the intervention period. A two-way mixed model ANOVA with repeated measures revealed a significant difference in SpO2 between interventions (P = 0.007). As many as 30 out of 38 patients (78.9%) receiving nitrate-based nutritional formula, who all started the treatment with SpO2 ≤ 95%, finished the intervention with SpO2 of at least 95% at 72-h follow-up, whereas in the placebo group, 13 patients out of 33 (39.4%) finished the trial with SpO2 of at least 95% (P < 0.05). The hospital admission rate after the 72-h follow-up was 21.1% in patients receiving nitrate-based formula compared to 33.3% in the placebo group (P = 0.25). The nitrate-based formula might be recognized as a potent strategy to tackle hypoxemia and concomitant features of the COVID-19 pandemic. In conclusion, it appears that the novel nitrated-based nutritional formulation described here was able to improve oxygen saturation and clinical outcomes in COVID-19 patients. Although the exact mechanism of action remains unknown, the nitrate-based formula might be recognized as a potent, safe, and convenient strategy to tackle hypoxemia and concomitant features of the COVID-19 pandemic.

查看原文本刊更多论文

硝酸盐营养配方对COVID-19患者血氧饱和度和患者报告结局的影响:一项随机对照试验

这项随机对照试验的主要目的是分析硝酸盐营养配方对急性新冠肺炎感染患者外周血氧饱和度（SpO2）、患者报告结果和安全性指标的急性影响。在72小时的监测期内，完成试验方案的参与者（n=71）以双盲设计被分配接受多组分营养配方奶粉（含有1200 mg硝酸钾、200 mg镁、50 mg锌和1000 mg柠檬酸）或安慰剂（2.5 g菊粉）。所有参与者被要求在干预期间每4小时服用一次干预（四粒胶囊；每粒胶囊的重量约为2.5克）。重复测量的双向混合模型方差分析显示，干预措施之间的SpO2存在显著差异（P=0.007）。38名接受硝酸盐营养配方奶粉的患者中，有多达30名（78.9%）在开始SpO2≤95%的治疗时，在72小时随访时完成了SpO2至少95%的干预，而在安慰剂组中，33名患者中有13名（39.4%）完成了试验，SpO2至少为95%（P<0.05）。72小时随访后，服用硝酸盐配方奶粉的患者的住院率为21.1%，而安慰剂组为33.3%（P=0.25）。硝酸盐配方可能被认为是解决新冠肺炎大流行低氧血症和伴随特征的有效策略。总之，本文描述的新型硝酸盐营养配方似乎能够改善新冠肺炎患者的血氧饱和度和临床结果。尽管确切的作用机制尚不清楚，但硝酸盐配方奶粉可能被认为是解决新冠肺炎大流行低氧血症和伴随特征的有效、安全和方便的策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Topics in Nutraceutical Research 医学-药学

CiteScore

1.10

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Current Topics in Nutraceutical Research is an international, interdisciplinary broad-based peer reviewed scientific journal for critical evaluation of research on chemistry, biology and therapeutic applications of nutraceuticals and functional foods. The major goal of this journal is to provide peer reviewed unbiased scientific data to the decision makers in the nutraceutical and food industry to help make informed choices about development of new products. To this end, the journal will publish two types of review articles. First, a review of preclinical research data coming largely from animal, cell culture and other experimental models. Such data will provide basis for future product development and/or human research initiatives. Second, a critical evaluation of current human experimental data to help market and deliver the product for medically proven use. This journal will also serve as a forum for nutritionists, internists, neurologists, psychiatrists, and all those interested in preventive medicine. The common denominator of all of the topic to be covered by the journal must include nutraceuticals and/functional food. The following is an example of some specific areas that may be of interest to the journal. i) Role of vitamins, minerals, antioxidants and phytonutrients on cardiovascular health, cancer, diabetes, ocular health, mental health, men’s health, women’s health, infant nutrition, ii) Role of herbals on human health, iii) Dietary supplements and sleep, iv) Components of diet that may have beneficial effect on human health, v) regulation of apoptosis and cell viability, vi) Isolation and characterization of bioactive components from functional foods, vii) Nutritional genomics, and viii) Nutritional proteomics.