Evaluation of the Laxative-Like Activity of Andrographis Paniculata

IF 0.4 4区医学 Q4 NUTRITION & DIETETICS

Current Topics in Nutraceutical Research Pub Date : 2022-03-23 DOI:10.37290/ctnr2641-452x.20m:m17-m23

Vijayamahantesh K. Tandur, M. N. Inamdar, S. M. Asdaq, S. Rabbani, A. Alamri, M. Alhomrani, W. Alsanie

引用次数: 0

Abstract

Herbal medicine has been used since ancient times to treat chronic constipation. The present study has investigated the gut stimulatory activity of Andrographis peniculata, an herbal medicine common to many parts of the globe. Results of these studies show a dose-dependent increase in the contraction of smooth muscle from isolated rat colon, guinea pig ileum, and rabbit jejunum by A. peniculata extracts. Furthermore, it enhanced intestinal fecal transit in mice. Additional studies into its action suggested the involvement of a cholinergic mechanism.

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穿心莲类Laxative活性的评价

草药自古以来就被用来治疗慢性便秘。本研究调查了阴茎穿心莲的肠道刺激活性，这是一种在全球许多地区都很常见的草药。这些研究的结果表明，a.peniculata提取物对分离的大鼠结肠、豚鼠回肠和兔空肠平滑肌的收缩呈剂量依赖性增加。此外，它还增强了小鼠的肠道粪便转运。对其作用的进一步研究表明其参与了胆碱能机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Topics in Nutraceutical Research 医学-药学

CiteScore

1.10

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Current Topics in Nutraceutical Research is an international, interdisciplinary broad-based peer reviewed scientific journal for critical evaluation of research on chemistry, biology and therapeutic applications of nutraceuticals and functional foods. The major goal of this journal is to provide peer reviewed unbiased scientific data to the decision makers in the nutraceutical and food industry to help make informed choices about development of new products. To this end, the journal will publish two types of review articles. First, a review of preclinical research data coming largely from animal, cell culture and other experimental models. Such data will provide basis for future product development and/or human research initiatives. Second, a critical evaluation of current human experimental data to help market and deliver the product for medically proven use. This journal will also serve as a forum for nutritionists, internists, neurologists, psychiatrists, and all those interested in preventive medicine. The common denominator of all of the topic to be covered by the journal must include nutraceuticals and/functional food. The following is an example of some specific areas that may be of interest to the journal. i) Role of vitamins, minerals, antioxidants and phytonutrients on cardiovascular health, cancer, diabetes, ocular health, mental health, men’s health, women’s health, infant nutrition, ii) Role of herbals on human health, iii) Dietary supplements and sleep, iv) Components of diet that may have beneficial effect on human health, v) regulation of apoptosis and cell viability, vi) Isolation and characterization of bioactive components from functional foods, vii) Nutritional genomics, and viii) Nutritional proteomics.