通过调节腺苷5′-单磷酸活化蛋白激酶信号通路减轻大鼠脊髓损伤后亚局灶性骨丢失和炎症

IF 0.4 4区医学 Q4 NUTRITION & DIETETICS

Current Topics in Nutraceutical Research Pub Date : 2022-04-21 DOI:10.37290/ctnr2641-452x.20:648-653

Xiaokai Yang, Shuai Liu, Z. Wang

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引用次数: 1

摘要

脊髓损伤是一种终身性损伤，抑制骨质流失是减轻脊髓损伤所致运动功能障碍的途径之一。从豆科植物中提取的异黄酮，包括芒草苷，花萼异黄酮-7- o -β-葡萄糖苷等，已被证明具有治疗骨科疾病的潜力。虽然茴香素有改善脊髓损伤运动功能的潜力，但这方面的研究还很缺乏。为此，我们在脊髓损伤动物模型中检测了苦参素的改善作用。我们的研究结果表明，木柄草苷通过促进腺苷5′-单磷酸激活的蛋白激酶信号通路，降低了脊髓损伤大鼠的炎症反应，减少了股骨骨丢失，促进了成骨细胞的形成。

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Ononin Alleviates Sublesional Bone Loss and Inflammation Following Spinal Cord Injury in Rats by Regulating Adenosine 5′-Monophosphate-Activated Protein Kinase Signaling Pathway

Inhibition of bone loss is one of the ways to alleviate motor dysfunction caused by spinal cord injury, a lifelong and lifechanging injury. Isoflavone from legumes that include ononin, Calycosin-7-O-β-Glucoside, and others have been shown to have potential for the treatment of orthopedic diseases. While there are potentials for ononin to improve the motor function of spinal cord injury, studies on the subject are lacking. To this end, we examined the ameliorative role of ononin in an animal model of spinal cord injury. Our results show the ononin reduced inflammatory response, decreased femoral bone loss, and promoted osteoblast formation in rats with spinal cord injury through promotion of adenosine 5′′-monophosphate-activated protein kinase signaling pathway.

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来源期刊

Current Topics in Nutraceutical Research 医学-药学

CiteScore

1.10

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Current Topics in Nutraceutical Research is an international, interdisciplinary broad-based peer reviewed scientific journal for critical evaluation of research on chemistry, biology and therapeutic applications of nutraceuticals and functional foods. The major goal of this journal is to provide peer reviewed unbiased scientific data to the decision makers in the nutraceutical and food industry to help make informed choices about development of new products. To this end, the journal will publish two types of review articles. First, a review of preclinical research data coming largely from animal, cell culture and other experimental models. Such data will provide basis for future product development and/or human research initiatives. Second, a critical evaluation of current human experimental data to help market and deliver the product for medically proven use. This journal will also serve as a forum for nutritionists, internists, neurologists, psychiatrists, and all those interested in preventive medicine. The common denominator of all of the topic to be covered by the journal must include nutraceuticals and/functional food. The following is an example of some specific areas that may be of interest to the journal. i) Role of vitamins, minerals, antioxidants and phytonutrients on cardiovascular health, cancer, diabetes, ocular health, mental health, men’s health, women’s health, infant nutrition, ii) Role of herbals on human health, iii) Dietary supplements and sleep, iv) Components of diet that may have beneficial effect on human health, v) regulation of apoptosis and cell viability, vi) Isolation and characterization of bioactive components from functional foods, vii) Nutritional genomics, and viii) Nutritional proteomics.