Network Pharmacology-Based Strategy to Reveal the Mechanism of Action of Cistanche Against Cataracts

IF 0.4 4区医学 Q4 NUTRITION & DIETETICS

Current Topics in Nutraceutical Research Pub Date : 2023-07-13 DOI:10.37290/ctnr2641-452x.21:454-460

Jian Zeng, Zonghan Zhou

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引用次数: 0

Abstract

Cistanche is known to relieve cataracts; however, the active ingredients and mechanism of action of cistanche to relieve cataracts are unclear. At present, the active ingredients of cistanche were screened through the Traditional Chinese Medicine Systems Pharmacology website, and a total of six active ingredients were identified. Drug and disease targets were obtained through Swiss target prediction and the Genecard website, and a total of 172 common targets were identified. The biological functions and Kyoto Encyclopedia of Genes and Genomes pathway enrichment of the targets were found to be concentrated in the phosphatidylinositol 3-kinase/protein kinase B, forkhead family of transcription factors, and mitogen-activated protein kinases pathways. The protein–protein interaction network was established, and phosphatidylinositol 3-kinase and protein kinase B-related genes were found to be the key genes. Molecular docking was carried out between the active ingredient and the key target, and it was found that the combination of the active ingredient and the key target was stable. In summary, cistanche can reduce cataracts by regulating the key targets of the active ingredients and thus alleviating cataracts.

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基于网络药理学策略揭示肉苁蓉防治白内障的作用机制

众所周知，肉苁蓉可缓解白内障，但肉苁蓉缓解白内障的有效成分和作用机制尚不清楚。目前，通过中药系统药理学网站对肉苁蓉的有效成分进行了筛选，共确定了 6 种有效成分。通过瑞士靶点预测和 Genecard 网站获得了药物和疾病靶点，共确定了 172 个常见靶点。研究发现，这些靶点的生物学功能和京都基因组百科全书途径富集集中在磷脂酰肌醇 3- 激酶/蛋白激酶 B、转录因子叉头家族和丝裂原活化蛋白激酶途径。建立了蛋白-蛋白相互作用网络，发现磷脂酰肌醇 3- 激酶和蛋白激酶 B 相关基因是关键基因。活性成分与关键靶点进行了分子对接，发现活性成分与关键靶点的结合是稳定的。综上所述，肉苁蓉可以通过调节活性成分的关键靶点来减少白内障，从而缓解白内障。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Topics in Nutraceutical Research 医学-药学

CiteScore

1.10

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Current Topics in Nutraceutical Research is an international, interdisciplinary broad-based peer reviewed scientific journal for critical evaluation of research on chemistry, biology and therapeutic applications of nutraceuticals and functional foods. The major goal of this journal is to provide peer reviewed unbiased scientific data to the decision makers in the nutraceutical and food industry to help make informed choices about development of new products. To this end, the journal will publish two types of review articles. First, a review of preclinical research data coming largely from animal, cell culture and other experimental models. Such data will provide basis for future product development and/or human research initiatives. Second, a critical evaluation of current human experimental data to help market and deliver the product for medically proven use. This journal will also serve as a forum for nutritionists, internists, neurologists, psychiatrists, and all those interested in preventive medicine. The common denominator of all of the topic to be covered by the journal must include nutraceuticals and/functional food. The following is an example of some specific areas that may be of interest to the journal. i) Role of vitamins, minerals, antioxidants and phytonutrients on cardiovascular health, cancer, diabetes, ocular health, mental health, men’s health, women’s health, infant nutrition, ii) Role of herbals on human health, iii) Dietary supplements and sleep, iv) Components of diet that may have beneficial effect on human health, v) regulation of apoptosis and cell viability, vi) Isolation and characterization of bioactive components from functional foods, vii) Nutritional genomics, and viii) Nutritional proteomics.