术后肠外营养支持和新辅助化疗与细胞修复手术相结合可提高生活质量，但不能提高存活率或并发症发生率

IF 0.4 4区医学 Q4 NUTRITION & DIETETICS

Current Topics in Nutraceutical Research Pub Date : 2023-07-13 DOI:10.37290/ctnr2641-452x.21:395-399

Weiwei Song, Dandan Zhu, Yinling Zhao

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引用次数: 0

摘要

我们探讨了新辅助化疗联合细胞减灭术和术后肠外营养支持对晚期卵巢癌患者的疗效。对照组接受细胞减灭术联合术后常规化疗，术后禁食；治疗组接受新辅助化疗联合细胞减灭术和肠外营养。与对照组相比，治疗组的手术时间、住院时间、术中失血量和腹腔积液量减少，总有效率升高，血清白蛋白、转铁蛋白和前白蛋白水平升高，人附睾蛋白 4、血管内皮生长因子和碳水化合物抗原 125 水平下降，Karnofky 表情状态评分升高。虽然两组患者的 1 年生存率或并发症总发生率没有差异，但治疗组患者的生活质量有所改善。

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Postoperative Parenteral Nutrition Support and Neoadjuvant Chemotherapy Combined with Cytoreductive Surgery Improve the Quality of Life, but Not the Survival Rate or Incidence of Complications

We have explored the efficacy of neoadjuvant chemotherapy in association with cytoreductive surgery and postoperative parenteral nutrition support in advanced ovarian cancer patients. The control group received cytoreductive surgery combined with postoperative conventional chemotherapy and fasted after surgery, whereas the treatment group received neoadjuvant chemotherapy combined with cytoreductive surgery and parenteral nutrition. In contrast to the control group, the operation time, hospital stay, amount of intraoperative blood loss, and abdominal fluid accumulation of the treatment group were diminished, the total effectiveness rate was elevated, serum levels of albumin, transferrin, and prealbumin were increased, levels of human epididymal protein 4, vascular endothelial growth factor, and carbohydrate antigen 125 were declined, and the Karnofky Performance Status score was higher. While there was no difference observed in the 1-year survival rate or total incidence of complications between the two groups, the quality of life of patients in the treatment group improved.

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来源期刊

Current Topics in Nutraceutical Research 医学-药学

CiteScore

1.10

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Current Topics in Nutraceutical Research is an international, interdisciplinary broad-based peer reviewed scientific journal for critical evaluation of research on chemistry, biology and therapeutic applications of nutraceuticals and functional foods. The major goal of this journal is to provide peer reviewed unbiased scientific data to the decision makers in the nutraceutical and food industry to help make informed choices about development of new products. To this end, the journal will publish two types of review articles. First, a review of preclinical research data coming largely from animal, cell culture and other experimental models. Such data will provide basis for future product development and/or human research initiatives. Second, a critical evaluation of current human experimental data to help market and deliver the product for medically proven use. This journal will also serve as a forum for nutritionists, internists, neurologists, psychiatrists, and all those interested in preventive medicine. The common denominator of all of the topic to be covered by the journal must include nutraceuticals and/functional food. The following is an example of some specific areas that may be of interest to the journal. i) Role of vitamins, minerals, antioxidants and phytonutrients on cardiovascular health, cancer, diabetes, ocular health, mental health, men’s health, women’s health, infant nutrition, ii) Role of herbals on human health, iii) Dietary supplements and sleep, iv) Components of diet that may have beneficial effect on human health, v) regulation of apoptosis and cell viability, vi) Isolation and characterization of bioactive components from functional foods, vii) Nutritional genomics, and viii) Nutritional proteomics.