Psycho-Behavioral Modification Therapy Enhances the Clinical Efficacy of Atomoxetine and Xiaoer Huanglong Granules Combination in Children with Attention-Deficit/Hyperactivity Disorder

We have examined the effect of atomoxetine and Xiaoer Huanglong granules combined with psycho-behavioral modification therapy on attention-deficit/hyperactivity disorder children. Children diagnosed with attention-deficit/hyperactivity disorder were treated with atomoxetine + Xiaoer Huanglong granules (control group) or atomoxetine + Xiaoer Huanglong granules and received psycho-behavioral modification therapy (treatment group). The results show that the treatment group presented a higher overall response rate and a shorter duration of hyperactivity, inattention, and emotional instability than the control group (P < 0.05). After treatment, higher correct scores and serum levels of glial cell line-derived neurotrophic factor, lower error scores and error rate, as well as lower Abbreviated Symptom Questionnaire and Swanson, Nolan, and Pelham, version IV Scale scores, were observed in the treatment group (P < 0.05). Moreover, the incidence of adverse reactions in both groups was similar (P > 0.05). To sum up, atomoxetine, Xiaoer Huanglong granules, and psycho-behavioral modification therapy can effectively improve the learning concentration of attention-deficit/hyperactivity disorder children.