Safflower Yellow Combined with Pitavastatin Calcium for Preventing Carotid Plaque Formation in Patients with Cerebral Infarction

IF 0.4 4区医学 Q4 NUTRITION & DIETETICS

Current Topics in Nutraceutical Research Pub Date : 2023-08-04 DOI:10.37290/ctnr2641-452x.21:426-433

Luolin Sha, Qingqing Jiang

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Abstract

This study compared the difference between safflower yellow combined with pitavastatin calcium or with atorvastatin in preventing carotid plaque formation in cerebral infarction patients. Patients with acute cerebral infarction were randomized into groups A and B. Group A received safflower yellow and atorvastatin, while Group B received safflower yellow and pitavastatin calcium for 15 days. Both groups were evaluated for the efficacy of treatment after 6 months. Compared to the group receiving pitavastatin calcium, the atorvastatin group had lower serum total cholesterol, triglycerides, low-density lipoprotein cholesterol, and inflammatory factors, and a higher high-density lipoprotein cholesterol level (P < 0.05). There was no difference in the effect of treatment on other markers such as whole blood viscosity, fibrinogen, and National Institutes of Health Stroke Scale scores (P > 0.05). However, the incidence of adverse reactions was higher in group A than in group B (P < 0.05). To sum up, safflower yellow combined with pitavastatin calcium for cerebral infarction patients can effectively reduce carotid plaque area and improve lipid levels, inflammation, and hemorheology.

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红花黄联合匹伐他汀钙预防脑梗死患者颈动脉斑块形成

本研究比较红花黄联合匹伐他汀钙与阿托伐他汀在预防脑梗死患者颈动脉斑块形成方面的差异。急性脑梗死患者随机分为A组和B组，A组给予红花黄和阿托伐他汀治疗，B组给予红花黄和匹伐他汀钙治疗，疗程15 d。6个月后评价两组患者的治疗效果。与服用吡伐他汀钙组相比，阿托伐他汀组血清总胆固醇、甘油三酯、低密度脂蛋白胆固醇和炎症因子均较低，高密度脂蛋白胆固醇水平较高(P <0.05)。治疗对其他指标如全血粘度、纤维蛋白原和美国国立卫生研究院卒中量表评分(P >0.05)。但A组不良反应发生率高于B组(P <0.05)。综上所述，红花黄联合匹伐他汀钙治疗脑梗死患者，可有效减少颈动脉斑块面积，改善血脂水平、炎症及血液流变学。

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来源期刊

Current Topics in Nutraceutical Research 医学-药学

CiteScore

1.10

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Current Topics in Nutraceutical Research is an international, interdisciplinary broad-based peer reviewed scientific journal for critical evaluation of research on chemistry, biology and therapeutic applications of nutraceuticals and functional foods. The major goal of this journal is to provide peer reviewed unbiased scientific data to the decision makers in the nutraceutical and food industry to help make informed choices about development of new products. To this end, the journal will publish two types of review articles. First, a review of preclinical research data coming largely from animal, cell culture and other experimental models. Such data will provide basis for future product development and/or human research initiatives. Second, a critical evaluation of current human experimental data to help market and deliver the product for medically proven use. This journal will also serve as a forum for nutritionists, internists, neurologists, psychiatrists, and all those interested in preventive medicine. The common denominator of all of the topic to be covered by the journal must include nutraceuticals and/functional food. The following is an example of some specific areas that may be of interest to the journal. i) Role of vitamins, minerals, antioxidants and phytonutrients on cardiovascular health, cancer, diabetes, ocular health, mental health, men’s health, women’s health, infant nutrition, ii) Role of herbals on human health, iii) Dietary supplements and sleep, iv) Components of diet that may have beneficial effect on human health, v) regulation of apoptosis and cell viability, vi) Isolation and characterization of bioactive components from functional foods, vii) Nutritional genomics, and viii) Nutritional proteomics.