Current protein & peptide science最新文献_第4页

Global Trends in Hepatocellular Carcinoma and TGF-β Research: A Bibliometric and Visualization Analysis from 2000 to 2024. 肝细胞癌和TGF-β研究的全球趋势：2000年至2024年的文献计量学和可视化分析。

IF 1.9 4区生物学

Current protein & peptide science Pub Date : 2025-06-13 DOI: 10.2174/0113892037378714250529063227

Liu-Lin Yang, Xing Chen, Kai-Ting Huang, Ji-Long Wang

{"title":"Global Trends in Hepatocellular Carcinoma and TGF-β Research: A Bibliometric and Visualization Analysis from 2000 to 2024.","authors":"Liu-Lin Yang, Xing Chen, Kai-Ting Huang, Ji-Long Wang","doi":"10.2174/0113892037378714250529063227","DOIUrl":"https://doi.org/10.2174/0113892037378714250529063227","url":null,"abstract":"Background: Transforming growth factor-beta (TGF-β) plays a pivotal role in advanced hepatocellular carcinoma (HCC) by modulating immune responses, inflammatory processes, and epithelial-mesenchymal transition (EMT) in hepatocytes. It has emerged as a key therapeutic target for HCC.Objective: This study employs bibliometric analysis to examine literature published between 2000 and 2024, aiming to explore the critical roles of TGF-β in HCC and provide a theoretical foundation for future research.Methods: This study utilized the Web of Science Core Collection (WoSCC) database to analyze publications from January 1, 2000, to October 16, 2024. Visualization tools such as CiteSpace, VOSviewer, and SCImago Graphica were utilized to assess publication trends, countries, institutions, journals, authors, keywords, and references, identifying hotspots, trends, and the evolution of TGF-β research in the context of HCC.Results: The analysis encompassed 3,026 publications originating from 79 different countries. China was identified as the leading country in publication volume, with Fudan University being the most prolific institution. The journal Hepatology stood out as the leading publication in terms of both the volume of articles and citation influence. Keyword analysis revealed that recent research (2020-2024) has focused on metabolic regulation, the tumor immune microenvironment, and targeted therapies related to the TGF-β signaling pathway in HCC.Conclusion: This study highlights the publication landscape, research trends, and hotspots of TGF- β-related HCC research from 2000 to 2024, providing valuable insights and a theoretical basis for future studies in this critical field.","PeriodicalId":10859,"journal":{"name":"Current protein & peptide science","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144316074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phylogenetic Analysis of SOD Gene Isolated from Indian Variety of Mud Crabs: Scylla serrata and Scylla olivacea. 印度泥蟹品种Scylla serrata和Scylla olivacea SOD基因分离的系统发育分析。

IF 1.9 4区生物学

Current protein & peptide science Pub Date : 2025-06-05 DOI: 10.2174/0113892037375925250519112911

Manu Asthana, Javed Masood Khan, Chittibabu Shanthi

{"title":"Phylogenetic Analysis of SOD Gene Isolated from Indian Variety of Mud Crabs: Scylla serrata and Scylla olivacea.","authors":"Manu Asthana, Javed Masood Khan, Chittibabu Shanthi","doi":"10.2174/0113892037375925250519112911","DOIUrl":"https://doi.org/10.2174/0113892037375925250519112911","url":null,"abstract":"Aim: Our research aimed to isolate and sequence the SOD gene from the genomic DNA of Scylla serrata and Scylla olivacea and to study its phylogeny.Background: In crustaceans, superoxide dismutase (SOD) serves as the first line of defense against stress. Extracellular Cu/Zn-SOD has been demonstrated in several investigations involving crustaceans. Crustaceans do not have a distinct immune system. They entirely depend on the innate immune system triggered when they come in contact with any pathogen.Method: Partial SOD gene was isolated from the genomic DNA of S. serrata and S. olivacea through polymerase chain reaction.Result: We successfully isolated partial SOD genes of 942bp and 957bp from S. serrata and S. olivacea, respectively. The sequences were submitted to the NCBI GenBank database.Discussion: The phylogenetic study suggests their clustering with the genus Scylla species. Investigating the SOD gene sequences across diverse crustacean lineages can reveal profound insights into their evolutionary history and the intricate relationships among species concerning their SOD development.Conclusion: This research holds the potential to enhance our understanding of the evolutionary adaptations that have shaped these organisms.","PeriodicalId":10859,"journal":{"name":"Current protein & peptide science","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144257521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Applications and Prospects of Artificial Intelligence in Proteomics Via Mass Spectrometry: A Review. 人工智能在蛋白质组学质谱分析中的应用与展望

IF 1.9 4区生物学

Current protein & peptide science Pub Date : 2025-06-05 DOI: 10.2174/0113892037368295250520102121

Yun Shao, Chenghui Yang, Shenhuan Ni, Mingwei Pang, Xiaojie Liu, Ren Kong, Shan Chang

{"title":"Applications and Prospects of Artificial Intelligence in Proteomics Via Mass Spectrometry: A Review.","authors":"Yun Shao, Chenghui Yang, Shenhuan Ni, Mingwei Pang, Xiaojie Liu, Ren Kong, Shan Chang","doi":"10.2174/0113892037368295250520102121","DOIUrl":"https://doi.org/10.2174/0113892037368295250520102121","url":null,"abstract":"Proteomics holds immense significance in fundamental and applied research in various fields, including life sciences, medicinal sciences, and pharmaceutical sciences. The rapid development of mass spectrometry (MS) technologies has facilitated MS-based proteomics research, which has emerged as one of the primary methods for determining the composition, structures, and functions of proteins. The necessity of processing these complex datasets has increased significantly owing to the growing volume and diversity of MS data pertaining to proteins. Artificial intelligence (AI) possesses powerful data processing abilities, and is being increasingly employed for handling these challenges. In particular, deep learning has been extensively employed in MSbased proteomics research. This review discusses and compares the different AI algorithms developed for various tasks, including the prediction of protein spectra, retention times, peptide sequences, and MS-based protein structure prediction, and highlights their respective strengths and weaknesses. The limitations and future prospects of AI in MS-based proteomics research are additionally discussed herein.","PeriodicalId":10859,"journal":{"name":"Current protein & peptide science","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144257520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phytoconstituents as Potential Therapeutics against Enzymatic Targets for Neurodegenerative Diseases. 植物成分作为抗神经退行性疾病酶靶点的潜在疗法。

IF 1.9 4区生物学

Current protein & peptide science Pub Date : 2025-05-27 DOI: 10.2174/0113892037350938250514110643

Harshita Singh, Veda Prakash Pandey

{"title":"Phytoconstituents as Potential Therapeutics against Enzymatic Targets for Neurodegenerative Diseases.","authors":"Harshita Singh, Veda Prakash Pandey","doi":"10.2174/0113892037350938250514110643","DOIUrl":"https://doi.org/10.2174/0113892037350938250514110643","url":null,"abstract":"Neurodegenerative diseases are brought on by the loss of function of nerve cells in the brain or peripheral nervous system and afflict millions of people worldwide. Parkinson's disease and Alzheimer's disease are the two most common neurodegenerative diseases. These neurodegenerative diseases are multi-factorial, progressive, age-related, and influenced by two factors: genetic and environmental. Successful treatment of neurodegenerative diseases is yet a challenging task due to lack of selectivity, toxicity, and the growth of multi-drug-resistant cells to the currently available drugs. Plant-derived, natural secondary metabolites have a significant impact on the research and development of novel medications against neurodegenerative disease. Plant-derived natural products are frequently regarded as safe and relatively safer substitutes for synthetic drugs. The present review deals with the elucidation of plant-derived secondary metabolites, namely alkaloids, flavonoids, and terpenoids, as anti-neurological therapeutics with special reference to various enzymatic targets, such as β-secretase, γ-secretase, α-Secretase, acetylcholinesterase, monoamine oxidase, and phosphodiesterase-4.","PeriodicalId":10859,"journal":{"name":"Current protein & peptide science","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144186756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aquatic BPI/LBPs: A Promising Antimicrobial Peptide Resource for Disease Control in Aquaculture. 水生BPI/ lbp：一种有前途的水产疾病控制抗菌肽资源。

IF 1.9 4区生物学

Current protein & peptide science Pub Date : 2025-05-27 DOI: 10.2174/0113892037364423250516032256

Jingxian Sun, Huiqi Deng, Bingyu Ning, Yaoyao Zhan, Yaqing Chang

{"title":"Aquatic BPI/LBPs: A Promising Antimicrobial Peptide Resource for Disease Control in Aquaculture.","authors":"Jingxian Sun, Huiqi Deng, Bingyu Ning, Yaoyao Zhan, Yaqing Chang","doi":"10.2174/0113892037364423250516032256","DOIUrl":"https://doi.org/10.2174/0113892037364423250516032256","url":null,"abstract":"Aquaculture is currently the fastest-growing food supply industry worldwide. Disease control has always been a core concern in the sector of aquaculture. In recent years, the frequency of aquaculture disease outbreaks has increased dramatically due to the continuously increased antibiotic resistance of pathogens. Therefore, it is imperative to find effective antibiotic alternatives for disease control in aquaculture. Bactericidal permeability increasing/lipopolysaccharide binding proteins (BPI/LBPs) are endogenous peptides ubiquitously expressed in aquatic animals that exhibit antimicrobial effects similar to antibiotics. This review presents an overview of current research on BPI/LBPs derived from aquatic animals, the predicted antimicrobial mechanisms of aquatic BPI/LBPs, and the application potential and prospects of aquatic BPI/LBPs as an antimicrobial peptide (AMP) resource. To sum up, the systematic research on aquatic BPI/LBPs may not only enrich AMP resources but also provide new clues for the development of eco-friendly disease control strategies in aquaculture.","PeriodicalId":10859,"journal":{"name":"Current protein & peptide science","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144186755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Potential of Circular RNAs (circRNAs) Neoantigen Vaccines in Tumor Immunotherapy. 环状rna （circRNAs）新抗原疫苗在肿瘤免疫治疗中的潜力

IF 1.9 4区生物学

Current protein & peptide science Pub Date : 2025-05-26 DOI: 10.2174/0113892037389566250515094946

Md Sadique Hussain, Vikas Jakhmola, Ayesha Sultana, Ajay Singh Bisht, Gyas Khan

{"title":"Potential of Circular RNAs (circRNAs) Neoantigen Vaccines in Tumor Immunotherapy.","authors":"Md Sadique Hussain, Vikas Jakhmola, Ayesha Sultana, Ajay Singh Bisht, Gyas Khan","doi":"10.2174/0113892037389566250515094946","DOIUrl":"https://doi.org/10.2174/0113892037389566250515094946","url":null,"abstract":"Circular RNAs (circRNAs) have emerged as promising candidates for neoantigen vaccine development due to their unique structural stability, enhanced translational efficiency, and immunostimulatory properties. Unlike linear RNAs, circRNAs exhibit exonuclease resistance, prolonged antigen expression, and increased activation of innate immune receptors such as RIG-I and MDA5, thereby enhancing anti-tumor immune responses. Preclinical studies have demonstrated that circRNA-based vaccines encoding tumor-specific neoantigens effectively stimulate Antigen- Presenting Cells (APCs), particularly Dendritic Cells (DCs), leading to robust CD8+ Cytotoxic T Lymphocyte (CTL) activation. This results in increased cytokine production, T-cell proliferation, and durable anti-tumor immunity. Compared to conventional neoantigen vaccine platforms, circRNA vaccines offer distinct advantages, including higher immunogenicity, improved cytosolic delivery, and minimal risk of genomic integration. CircRNA vaccines have demonstrated efficacy in preclinical tumor models, with studies highlighting their ability to induce long-term memory T-- cell responses and enhance the efficacy of immune checkpoint blockade therapies. However, challenges remain in optimizing circRNA delivery, mitigating unintended immune activation, and scaling up manufacturing processes. The translational potential of circRNA vaccines in tumor immunotherapy is significant, offering a novel and scalable approach to personalized cancer treatment. Further research and clinical validation are needed to optimize their design, improve manufacturing efficiency, and assess their efficacy in human trials. CircRNA vaccines represent a next-- generation platform with the potential to revolutionize cancer immunotherapy by harnessing durable and targeted anti-tumor immune responses.","PeriodicalId":10859,"journal":{"name":"Current protein & peptide science","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144180967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

How Do Mitochondria Manage Competing Biochemical Metabolic Processes Under Stress? 线粒体如何在压力下管理竞争的生化代谢过程？

IF 1.9 4区生物学

Current protein & peptide science Pub Date : 2025-05-16 DOI: 10.2174/0113892037381885250506091434

Drew Hindrer, Tyler Stark, Selman Aydogdu, Cade Ward, Mohamed Eldeeb

引用次数: 0

Coupling of SARS-CoV-2 to Amyloid Fibrils and Liquid-Liquid Phase Separation. SARS-CoV-2与淀粉样蛋白原纤维的偶联及液-液相分离

IF 1.9 4区生物学

Current protein & peptide science Pub Date : 2025-05-08 DOI: 10.2174/0113892037354482250414045355

Hoang Linh Nguyen, Mai Suan Li

{"title":"Coupling of SARS-CoV-2 to Amyloid Fibrils and Liquid-Liquid Phase Separation.","authors":"Hoang Linh Nguyen, Mai Suan Li","doi":"10.2174/0113892037354482250414045355","DOIUrl":"https://doi.org/10.2174/0113892037354482250414045355","url":null,"abstract":"COVID-19 is a respiratory disease caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), but because the receptor protein of this virus can appear not only in the lungs and throat but also in various parts of the host's body, it causes different diseases. Recent observations have suggested that SARS-CoV-2 damages the central nervous system of patients in a manner similar to amyloid-associated neurodegenerative diseases such as Alzheimer's and Parkinson's. Neurodegenerative diseases are believed to be associated with the self-assembly of amyloid proteins and peptides. On the other hand, whole proteins or parts of them encoded by SARS-CoV-2 can form amyloid fibrils, which may play an important role in amyloid-related diseases. Motivated by this evidence, this mini-review discusses experimental and computational studies of SARS-CoV-2 proteins that can form amyloid aggregates. Liquid-Liquid Phase Separation (LLPS) is a dynamic and reversible process leading to the creation of membrane-less organelles within the cytoplasm, which is not bound by a membrane that concentrates specific types of biomolecules. These organelles play pivotal roles in cellular signaling, stress response, and the regulation of biomolecular condensates. Recently, LLPS of the Nucleocapsid (N) protein and SARS-CoV-2 RNA has been disclosed, but many questions about the phase separation mechanism and the formation of the virion core are still unclear. We summarize the results of this phenomenon and suggest potentially intriguing issues for future research.","PeriodicalId":10859,"journal":{"name":"Current protein & peptide science","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143967691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

What Can Proteomics Tell us About COVID-19 Infections? Mass Spectrometry as a Tool to Find New Proteins as Biomarkers. 关于COVID-19感染，蛋白质组学能告诉我们什么？质谱法作为寻找新蛋白质作为生物标志物的工具。

IF 1.9 4区生物学

Current protein & peptide science Pub Date : 2025-05-08 DOI: 10.2174/0113892037364237250402151440

Laís L Brasil-Oliveira, Pedro F N Souza, Carlos R K Paier, Maria G L Bandeira, Lina C B Motta, Raquel C Montenegro, Maria E A de Moraes

{"title":"What Can Proteomics Tell us About COVID-19 Infections? Mass Spectrometry as a Tool to Find New Proteins as Biomarkers.","authors":"Laís L Brasil-Oliveira, Pedro F N Souza, Carlos R K Paier, Maria G L Bandeira, Lina C B Motta, Raquel C Montenegro, Maria E A de Moraes","doi":"10.2174/0113892037364237250402151440","DOIUrl":"https://doi.org/10.2174/0113892037364237250402151440","url":null,"abstract":"The COVID-19 outbreak, caused by the SARS-CoV-2 coronavirus, has threatened and taken many lives since the end of 2019. Given the importance of COVID-19 worldwide, since its spread, many research groups have been seeking blood markers that could help to understand the disease establishment and prognosis. Usually, those markers are proteins with a differential accumulation only during infection. Based on that, proteomic studies have played a crucial role in elucidating diseases. Mass spectrometry (MS) is a promising technique in COVID-19 studies, allowing the identification and quantification of proteins present in the plasma or serum of affected patients. It helps us to understand pathological mechanisms, predict clinical outcomes, and develop specific therapies. MS proteomics revealed biomarkers associated with infection, disease severity, and immune response. Plasma or blood serum is easy to collect and store; however, its composition and the higher concentration of proteins (e.g., albumins) shadow the identification of less abundant proteins, which usually are essential markers. So, clean-up approaches such as depletion strategies and fractionating are often required to analyze blood samples, allowing the identification of low-abundant proteins. This review will discuss many proteomic approaches to discovering new plasma biomarkers of COVID-19 employed in recently published studies. The challenges inherent to blood samples will also be discussed, such as sample preparation, data processing, and identifying reliable biomarkers.","PeriodicalId":10859,"journal":{"name":"Current protein & peptide science","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143978498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From Bugs to Benefits: Edible Insects as Exceptional Protein Sources. 从虫子到好处：食用昆虫作为特殊的蛋白质来源。

IF 1.9 4区生物学

Current protein & peptide science Pub Date : 2025-05-06 DOI: 10.2174/0113892037379345250407143848

Ravi Kumar Mittal, Gaurav Krishna, Sohini Chowdhury, Sorabh Lakhanpal, Muhammed Shabil, Rajeev Sharma, Sahil Suri

引用次数: 0