Phytoconstituents as Potential Therapeutics against Enzymatic Targets for Neurodegenerative Diseases.

IF 1.9 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Current protein & peptide science Pub Date : 2025-05-27 DOI:10.2174/0113892037350938250514110643

Harshita Singh, Veda Prakash Pandey

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引用次数: 0

Abstract

Neurodegenerative diseases are brought on by the loss of function of nerve cells in the brain or peripheral nervous system and afflict millions of people worldwide. Parkinson's disease and Alzheimer's disease are the two most common neurodegenerative diseases. These neurodegenerative diseases are multi-factorial, progressive, age-related, and influenced by two factors: genetic and environmental. Successful treatment of neurodegenerative diseases is yet a challenging task due to lack of selectivity, toxicity, and the growth of multi-drug-resistant cells to the currently available drugs. Plant-derived, natural secondary metabolites have a significant impact on the research and development of novel medications against neurodegenerative disease. Plant-derived natural products are frequently regarded as safe and relatively safer substitutes for synthetic drugs. The present review deals with the elucidation of plant-derived secondary metabolites, namely alkaloids, flavonoids, and terpenoids, as anti-neurological therapeutics with special reference to various enzymatic targets, such as β-secretase, γ-secretase, α-Secretase, acetylcholinesterase, monoamine oxidase, and phosphodiesterase-4.

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植物成分作为抗神经退行性疾病酶靶点的潜在疗法。

神经退行性疾病是由大脑或周围神经系统的神经细胞功能丧失引起的，折磨着全世界数百万人。帕金森病和阿尔茨海默病是两种最常见的神经退行性疾病。这些神经退行性疾病是多因素的，进行性的，与年龄相关的，并受遗传和环境两个因素的影响。神经退行性疾病的成功治疗仍然是一项具有挑战性的任务，因为缺乏选择性，毒性，以及对现有药物的多重耐药细胞的生长。植物来源的天然次生代谢物对神经退行性疾病新药的研究和开发具有重要影响。植物衍生的天然产物通常被认为是安全的，相对更安全的合成药物替代品。本文综述了植物次生代谢产物，即生物碱、黄酮类化合物和萜类化合物作为抗神经系统药物的研究进展，并特别提到了各种酶靶点，如β-分泌酶、γ-分泌酶、α-分泌酶、乙酰胆碱酯酶、单胺氧化酶和磷酸二酯酶-4。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current protein & peptide science 生物-生化与分子生物学

CiteScore

5.20

自引率

0.00%

发文量

审稿时长

6 months

期刊介绍： Current Protein & Peptide Science publishes full-length/mini review articles on specific aspects involving proteins, peptides, and interactions between the enzymes, the binding interactions of hormones and their receptors; the properties of transcription factors and other molecules that regulate gene expression; the reactions leading to the immune response; the process of signal transduction; the structure and function of proteins involved in the cytoskeleton and molecular motors; the properties of membrane channels and transporters; and the generation and storage of metabolic energy. In addition, reviews of experimental studies of protein folding and design are given special emphasis. Manuscripts submitted to Current Protein and Peptide Science should cover a field by discussing research from the leading laboratories in a field and should pose questions for future studies. Original papers, research articles and letter articles/short communications are not considered for publication in Current Protein & Peptide Science.