Clinical Nuclear Medicine最新文献

{"title":"Evaluation of Metastatic Insulinoma With Severe Hypoglycemia Using 68 Ga-Exendin-4 PET/CT.","authors":"Jing Gao, Junyan Xu, Yun Liang, Jie Chen, Shaoli Song","doi":"10.1097/RLU.0000000000006008","DOIUrl":"10.1097/RLU.0000000000006008","url":null,"abstract":"<p><p>A 52-year-old man was pathologically diagnosed with a pancreatic neuroendocrine tumor (pNET) and synchronous liver metastasis through debulking surgery 2 years ago. Recently, the patient showed recurrent severe hypoglycemia after receiving multiple treatments. 68 Ga-Exendin-4 PET/CT imaging revealed diffuse uptake in the skeleton and other metastatic sites, which 68 Ga-DOTANOC PET/CT grossly underestimated. This case highlights the crucial role of 68 Ga-Exendin-4 in the comprehensive and accurate evaluation of metastatic insulinomas.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"e651-e653"},"PeriodicalIF":9.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144526744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hepatic Superscan on 18 F-FDG PET/CT in a Patient With Secondary Leukemia.","authors":"Ali Gümüş, Merve Nida Calderon Tobar, Gonca Kara Gedik","doi":"10.1097/RLU.0000000000005934","DOIUrl":"10.1097/RLU.0000000000005934","url":null,"abstract":"<p><p>Secondary leukemia can develop as a recognized side effect of chemotherapy and radiotherapy. In our case, an asymptomatic 61-year-old man was diagnosed with mixed-type Hodgkin lymphoma and underwent treatment with brentixumab-vedotin in 2021. Lately, the 18 F-FDG PET/CT scan we performed due to symptoms, revealed hepatomegaly and a diffusely increased FDG uptake in the liver. Following bone marrow biopsy revealed AML and the scan was consistent with hepatic superscan.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"1035-1036"},"PeriodicalIF":9.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144559372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"18 F-FAPI-04 PET/CT in the Evaluation of Patients With Cervical Cancers : Head-to-Head Comparison With 18 F-FDG PET/CT.","authors":"Jinhui Wei, Kun Zou, Fangfang Sun, Qiaochu Feng, Haodong Liu, Hongna Zheng, Yanjie Guo, Longjie Li","doi":"10.1097/RLU.0000000000006103","DOIUrl":"10.1097/RLU.0000000000006103","url":null,"abstract":"<p><strong>Background: </strong>To explore the potential utility of 18 F-AlF-NOTA-fibroblast activation protein inhibitor (FAPI)-04 PET/CT (denoted as 18 F-FAPI-04 PET/CT) in the evaluation of cervical cancer through a head-to-head comparison with 18 F-FDG PET/CT for detecting primary tumors and metastatic lymph nodes.</p><p><strong>Patients and methods: </strong>A total of 22 patients with a pathologic diagnosis of cervical cancer underwent 18 F-FDG PET/CT and 18 F-FAPI-04 PET/CT within a 7-day period. Out of the 22 patients, 19 (median age, 62.3 y) were included in the final analysis. Comparisons were made between the ability of 18 F-FDG PET/CT and 18 F-FAPI-04 PET/CT to detect primary lesions and metastatic lymph nodes; semiquantitative PET/CT parameters were also analyzed, including SUV max , SUV mean , metabolic tumor volume (MTV for 18 F-FDG) and fibroblast tumor volume (FTV for 18 F-FAPI-04), tumor lesion glycolysis (TLG for 18 F-FDG) and tumor lesion FAPI (TLF for 18 F-FAPI-04), and tumor-to-background ratios (TBR liver and TBR blood ), calculated by dividing the SUV max of the lesion by the SUV mean of normal liver or blood pool.</p><p><strong>Results: </strong>18 F-FAPI-04 PET/CT identified a greater number of primary lesions and metastatic lymph nodes compared with 18 F-FDG PET/CT. 18 F-FAPI-04 PET/CT detected 19/19 primary tumors, achieving a detection rate of 100%, while 18 F-FDG PET/CT identified 18/19 primary tumors, with a detection rate of 95%. The PPV for both tracers was 100%, the NPV for 18 F-FDG PET/CT was 0%. For metastatic lymph nodes, 18 F-FAPI-04 PET/CT detected 82 nodes in 7 patients, while 18 F-FDG PET/CT detected 44 nodes in the same 7 patients. TBR was significantly higher for 18 F-FAPI-04 PET/CT compared with 18 F-FDGPET/CT for primary lesions (TBR blood : 16.33 vs 9.83, P = 0.005; TBR liver : 21.59 vs 7.04, P < 0.0001) and metastatic lymph nodes (TBR blood : 9.16 vs 7.64, P = 0.033; TBR liver : 10.38 vs 5.29, P < 0.0001). No significant differences were observed in other semiquantitative parameters.</p><p><strong>Conclusions: </strong>18 F-FAPI-04 PET/CT had superior performance in detecting primary lesions and metastatic lymph nodes in cervical cancer compared with 18 F-FDG PET/CT. 18 F-FAPI-04 exhibited lower uptake in normal tissues, leading to a higher TBR. These findings imply that 18 F-FAPI-04 PET/CT has potential for clinical application in cervical cancer.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"983-991"},"PeriodicalIF":9.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12502941/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144991629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case of Primary Hepatic Myopericytoma, Rare Benign Tumor, Depicted With 18 F-FDG PET/CT.","authors":"Suzune Tsukamoto, Toshiyuki Sato, Koji Kitamura, Takuhito Ooe, Makoto Hosono","doi":"10.1097/RLU.0000000000005932","DOIUrl":"10.1097/RLU.0000000000005932","url":null,"abstract":"<p><p>A 47-year-old man was incidentally diagnosed with a hepatic tumor while undergoing ultrasonography. Dynamic CT and MRI revealed a 4.8×3.7×3.5 cm lesion with progressive peripheral enhancement and heterogeneous T2WI signals. 18 F-FDG PET/CT demonstrated moderate FDG uptake (SUV max 4.7) in the tumor without other primary lesions. The patient was histopathologically diagnosed with primary hepatic myopericytoma, an extremely rare benign tumor, with only 6 cases reported in the literature to date. This case report highlights the clinical and imaging features, especially the role of 18 F-FDG PET/CT, in distinguishing myopericytoma from malignant hepatic tumors such as liver metastasis and intrahepatic cholangiocarcinoma.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"1048-1050"},"PeriodicalIF":9.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143966921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidental Detection of Renal Cell Carcinoma on 18 F-NOTA-Pentixather PET/CT in a Patient With Aldosterone-producing Adenoma.","authors":"Lijuan Feng, Hao Wang, Wei Zhang","doi":"10.1097/RLU.0000000000005945","DOIUrl":"10.1097/RLU.0000000000005945","url":null,"abstract":"<p><p>We report the 18 F-NOTA-pentixather PET/CT findings of aldosterone-producing adenoma (APA) coincidence with renal cell carcinoma (RCC) in a 36-year-old man. He went to the hospital for persistent hypertension and new limb numbness and weakness. CT showed a nodule in the left adrenal gland, suggestive of an adenoma. 18 F-NOTA-pentixather PET/CT showed the nodule with high NOTA-pentixather uptake. A surprisingly NOTA-pentixather-avid lesion in the right kidney was also noted. Postoperative pathology supported a diagnosis of APA of the left adrenal gland nodule, and the right kidney lesion was RCC.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"1097-1098"},"PeriodicalIF":9.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143971598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative Lymphoscintigraphy SPECT/CT Parameters in the Assessment of Upper Extremity Lymphedema.","authors":"Yong Jae Na, Yookyung Lee, Beom Suk Kim, Ju Won Seok, Reeree Lee","doi":"10.1097/RLU.0000000000006043","DOIUrl":"10.1097/RLU.0000000000006043","url":null,"abstract":"<p><strong>Purpose: </strong>Lymphedema is a chronic disorder of the lymphatic system. This study evaluated quantitative lymphoscintigraphy SPECT/CT parameters for assessing lymphatic function in patients with unilateral upper extremity lymphedema and examined their relationship with clinical outcomes.</p><p><strong>Patients and methods: </strong>Twenty-two patients with unilateral upper extremity lymphedema underwent quantitative lymphoscintigraphy SPECT/CT. Maximum lymphatic activity (MLA) and total lymphatic accumulation (TLA) were measured in both the affected and the unaffected limbs. Limb circumference measurements were obtained at baseline and 1-month follow-up to calculate the relative volume increase (%RVI) and reduction of %RVI (%RRVI). Differences in SPECT/CT-derived parameters between the affected and the unaffected limbs were analyzed, and their correlations with clinical outcomes were evaluated.</p><p><strong>Results: </strong>MLA ( P =0.0289) and TLA ( P <0.001) were significantly lower in the affected limbs compared with the unaffected limbs. MLA (ρ=0.58, P =0.011), MLA ratio (ρ=0.6, P =0.0077), and TLA ratio (ρ=0.59, P =0.0091) in the affected limbs showed significant positive correlations with %RRVI. Patients with improved lymphedema exhibited significantly higher MLA ( P =0.016), MLA ratio ( P =0.003), and TLA ratio ( P =0.003) in the affected limb compared with those with persistent lymphedema.</p><p><strong>Conclusions: </strong>Quantitative lymphoscintigraphy SPECT/CT parameters showed significant differences between the affected and the unaffected limbs and demonstrated a meaningful association with treatment response. These parameters may facilitate early detection of lymphatic dysfunction and prediction of therapeutic outcomes, potentially contributing to improved clinical management.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"998-1005"},"PeriodicalIF":9.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144658622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization of Sinonasal Lesions on CT, MRI, and PET/CT.","authors":"Jiaqiong Wang, Russ A Kuker, Jian Q Michael Yu, Neelu Jain, Alexander M McKinney, Robert M Quencer","doi":"10.1097/RLU.0000000000006101","DOIUrl":"10.1097/RLU.0000000000006101","url":null,"abstract":"<p><p>The differential diagnosis of sinonasal lesions includes benign and malignant disease. Current radiologic diagnosis depends on the complementary roles of CT and MRI. PET/CT has been widely utilized for diagnosis and staging of various types of tumors as well as assessing treatment response. This article summarizes distinguishing radiologic characteristics of sinonasal disease, including lesions that are FDG avid (squamous cell carcinoma, lymphoma, inverted papilloma, rhabdomyosarcoma, osteosarcoma, and sinusitis), lesions that express somatostatin receptors (meningioma, esthesioneuroblastoma, and juvenile nasopharyngeal angiofibroma), and lesions that are not FDG avid (mucocele, mucus retention cyst, and sinus meningoencephalocele). Furthermore, PET/MRI may better facilitate the diagnosis of sinonasal disease.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"1024-1030"},"PeriodicalIF":9.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12502930/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144991645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor.","authors":"Ismet Sarikaya","doi":"10.1097/RLU.0000000000005382","DOIUrl":"10.1097/RLU.0000000000005382","url":null,"abstract":"","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"1104"},"PeriodicalIF":9.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141619578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extraskeletal Ewing Sarcoma of the Abdominopelvic Cavity Revealed by 18 F-FDG PET/CT.","authors":"Yanmei Li, Zhehao Lyu, Xingrong Lan, Ziyue Zhang, Huiqi Gao","doi":"10.1097/RLU.0000000000005849","DOIUrl":"10.1097/RLU.0000000000005849","url":null,"abstract":"<p><p>Extraskeletal Ewing sarcoma in the abdominopelvic cavity is a relatively rare tumor. We reporte 18 F-FDG PET/CT findings of primary peritoneal Ewing sarcoma in a 36-year-old man. The patient complained of abdominal distension for over a month. 18 F-FDG PET/CT has shown increasing glucose metabolism uptake in the peritoneum, greater omentum, lesser omentum, and mesentery, which was confirmed as extraskeletal Ewing sarcoma.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"e673-e674"},"PeriodicalIF":9.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143977806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PSMA PET/CT for Improved Staging Accuracy and Imaging of Neovascularization-associated Features in Primary Lung Cancer.","authors":"Ruiyue Zhao, Jinhui Liu, Wanmei Liang, Dazhou Li, Miao Ke, Youcai Li, Peng Hou, Di Gu, Wenhua Liang, Lin Zhu, Jianxing He, Xinlu Wang","doi":"10.1097/RLU.0000000000006061","DOIUrl":"10.1097/RLU.0000000000006061","url":null,"abstract":"<p><strong>Background: </strong>Prostate-specific membrane antigen (PSMA), expressed in neovascular endothelial cells of various malignancies including lung cancer (LC), highlights its potential as a biomarker for neovascularization. This study aimed to investigate the diagnostic efficacy of PSMA PET/CT in primary lung cancer (PLC), as well as to explore its role in staging and neovascularization detection in PLC.</p><p><strong>Patients and methods: </strong>This retrospective study included 39 patients (27 with PLC, 12 with benign lesions) who underwent PSMA PET/CT, with or without FDG PET/CT, between April 2021 and July 2024. Lesion characteristics and immunohistochemistry for PSMA, VEGFA, and CD31 were assessed in 11 surgical cases. Statistical analyses included the Mann-Whitney U test and Spearman correlation ( p <0.05).</p><p><strong>Results: </strong>Our study demonstrated that PSMA PET/CT effectively differentiates PLC from benign lesions, achieving a high SUVmax AUC of 0.89 (cutoff: 2.3 g/mL) and a mediastinal lymph node (LN) identification AUC of 0.86 (cutoff: 2.5 g/mL). Compared with FDG PET/CT, PSMA PET/CT exhibited a lower false-positive LN detection rate, resulting in N-stage reclassification in 60% (12/20) of cases. PSMA PET uptake in intrapulmonary lesions correlated significantly with the PSMA H-score (R=0.63, p <0.05), CD31-assessed microvessel density (R=0.77, p <0.01), and VEGFA H-score (R=0.65, p <0.05), while FDG uptake showed no correlation.</p><p><strong>Conclusions: </strong>PSMA PET shows higher uptake in PLC than in benign lesions, improves LN staging, and reveals its potential as a biomarker for neovascularization and treatment optimization in LC.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"e638-e645"},"PeriodicalIF":9.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144882377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}