Clinical Nuclear Medicine最新文献

{"title":"68 Ga-DOTATOC PET/CT of Glomus Tumor of the Small Bowel.","authors":"Vincent Habouzit, Ornella Perotto, Nicolas Maillard, Rémi Grange, Violaine Yvorel","doi":"10.1097/RLU.0000000000005714","DOIUrl":"10.1097/RLU.0000000000005714","url":null,"abstract":"<p><p>A 57-year-old woman had an incidental finding of a hypervascular small bowel lesion on a contrast-enhanced CT scan performed for a suspected renal graft infection. The morphologic features of the lesion were suggestive of a neuroendocrine tumor (NET), but serum chromogranin A and urinary 5-HIAA were negative. 68 Ga-DOTATOC PET/CT showed high SSTR-2 expression in the lesion, suggesting a NET. However, pathologic examination revealed diffuse alpha-smooth muscle actin positivity, consistent with a glomus tumor. This case highlights the utility of PET/CT for in vivo molecular tumor characterization and the challenge of distinguishing between different tumor types with overlapping molecular targets.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"549-552"},"PeriodicalIF":9.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143499560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Head-to-Head Comparison of 68 Ga-FAPI-04 and 18 F-FDG PET/CT for the Assessment of Crohn's Disease : A Prospective Pilot Study.","authors":"Qingqing Pan, Hui Xu, Silu Liu, Hongzhe Zhang, Shengyu Zhang, Ji Li, Fang Li, Yaping Luo","doi":"10.1097/RLU.0000000000005815","DOIUrl":"10.1097/RLU.0000000000005815","url":null,"abstract":"<p><strong>Background: </strong>Crohn disease is a chronic granulomatous inflammatory disease of gastrointestinal tract. Previous studies showed Crohn disease strictures overexpress fibroblast activation protein and had active 68 Ga-FAPI-04 uptake. Our study was to compare the diagnostic performance of 68 Ga-FAPI-04 and 18 F-FDG PET/CT in Crohn disease.</p><p><strong>Patients and methods: </strong>This is a prospective cohort study recruiting patients with newly diagnosed or relapsed Crohn disease. All the patients underwent 68 Ga-FAPI-04 and 18 F-FDG PET/CT. The diagnostic performance of the 2 PET/CT modalities and their uptake values were compared. The correlation of PET semiquantitative parameters [metabolic intestinal volume (MIV FDG and MIV FAPI ), total intestinal uptake (TIU FDG and TIU FAPI )] with clinical biomarkers were also analyzed.</p><p><strong>Results: </strong>Seventeen participants (13 men and 4 women, age 32.3 ± 15.9 y) were recruited. The sensitivity of 68 Ga-FAPI-04 and 18 F-FDG PET/CT in detecting Crohn lesions were 90.0% and 85.0%, and the specificities were 93.0% and 88.4%, respectively. In receiver operating characteristic curve analysis, 68 Ga-FAPI-04 PET/CT [area under the curve = 0.92 (95% CI: 0.83-0.97), P < 0.001] showed better diagnostic performance compared with 18 F-FDG PET/CT [area under the curve = 0.87 (95% CI: 0.78-0.93), P < 0.001; P = 0.043]. The SUVmax of 68 Ga-FAPI and 18 F-FDG in stricture/fistula lesions were significantly higher than those in non-stricture/fistula lesions ( 68 Ga-FAPI, 10.9 ± 6.7 vs 5.0 ± 3.5, P = 0.0002; 18 F-FDG, 9.5 ± 4.9 vs 5.3 ± 1.8, P = 0.0016). TIU FAPI and MIV FAPI of 68 Ga-FAPI-04 PET/CT were significantly correlated with high sensitivity C-reactive protein and simple endoscopic score for Crohn disease ( P < 0.05). TIU FDG and MIV FDG of 18 F-FDG PET/CT were also correlated with simple endoscopic scores for Crohn disease ( P < 0.05).</p><p><strong>Conclusions: </strong>68 Ga-FAPI-04 PET/CT showed better diagnostic performance than 18 F-FDG PET/CT in Crohn disease.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"473-479"},"PeriodicalIF":9.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epithelioid Rhabdomyosarcoma Demonstrated on 99m Tc-MDP Bone Scintigraphy and 18 F-FDG PET/CT.","authors":"Ziqian Dong, Pengcheng Ren, Wenjun Bao, Lingge Wei, Peng Xie","doi":"10.1097/RLU.0000000000005869","DOIUrl":"10.1097/RLU.0000000000005869","url":null,"abstract":"<p><p>A 60-year-old woman presented with the gradual aggravation of left hip pain. 99m Tc-MDP bone scintigraphy and 18 F-FDG PET/CT demonstrated intense radiotracer accumulation at the osteolytic lesion in the left acetabulum and pubis. The pathology confirmed the diagnosis of epithelioid rhabdomyosarcoma, a variant of rhabdomyosarcoma which is characterized by epithelioid morphology.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"537-540"},"PeriodicalIF":9.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cellular Proliferation Imaging With 18 F-FMAU PET/CT as Adjunct to mpMRI in Image-Guided Biopsy of Suspected Prostate Cancer.","authors":"Hossein Jadvar, Kai Chen, Passant Mohamed, Donya S Jadvar, Andre Luis Abreu","doi":"10.1097/RLU.0000000000005702","DOIUrl":"10.1097/RLU.0000000000005702","url":null,"abstract":"<p><strong>Purpose: </strong>We evaluated the potential diagnostic utility of PET with the cellular proliferation biomarker, 2'-deoxyl-2'-[ 18 F]fluoro-5-methyl-1-beta-D-arabinofuranosyluracil ( 18 F-FMAU), as an adjunct to multiparametric MRI (mpMRI), in localization of sites for image-guided biopsy in men with suspected prostate cancer.</p><p><strong>Patients and materials: </strong>Seventeen men with clinically suspected prostate cancer underwent standard mpMRI and investigational PET/CT with 18 F-FMAU.</p><p><strong>Results: </strong>Tissue samples obtained from 22 image-guided biopsies were examined histologically. There were 11 benign, 6 ISUP grade 1, and 5 ISUP grade 2 tumors. The sensitivity for detection of ISUP 1 and ISUP 2 prostate cancer was 16.7% and 100% for mpMRI, and 50% and 60% for 18 F-FMAU PET/CT, respectively.</p><p><strong>Conclusions: </strong>18 F-FMAU PET/CT may be a useful adjunct to mpMRI in image-guided prostate biopsy.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"e340-e343"},"PeriodicalIF":9.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12052491/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143381824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Small Bowel Leiomyoma Mimics Neuroendocrine Tumor on 68 Ga-DOTATATE PET/CT.","authors":"Nikhil Prasanna Ponna, Tu Vinh Luong, Shaunak Navalkissoor","doi":"10.1097/RLU.0000000000005694","DOIUrl":"10.1097/RLU.0000000000005694","url":null,"abstract":"<p><strong>Abstract: </strong>A 57-year-old man with a 3-month history of lower abdominal pain and rectal bleeding with black stools underwent urgent abdominal CT, which revealed an ovoid hyperdense lesion in the ileum in the right iliac fossa. The prime differential was a midgut neuroendocrine tumor. Thus, the patient was referred for a 68 Ga-DOTATATE PET/CT scan, which demonstrated intense activity in this lesion with no evidence of somatostatin receptor expression elsewhere. Surgical small bowel resection later revealed a small bowel leiomyoma, which was confirmed on immunohistochemistry analysis. This case demonstrates that leiomyomas can express somatostatin receptors and can be a false-positive on 68 Ga-DOTATATE PET/CT scan.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"e381-e382"},"PeriodicalIF":9.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143032544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Whole-body MRI Versus [18F]FDG PET/CT in Diagnosing and Monitoring Plasmacytomas: A Comparative Study.","authors":"Nieves Gómez León, Isabel Vicuña-Andrés, Beatriz Aguado-Bueno, Francisco Garrido-Enjamio, Itxaso Galán-González, Valentina Castillo-Morales, Adrián Alegre Amor, Roberto C Delgado Bolton","doi":"10.1097/RLU.0000000000005954","DOIUrl":"https://doi.org/10.1097/RLU.0000000000005954","url":null,"abstract":"<p><strong>Background/objectives: </strong>Current guidelines recommend [18F]FDG PET/CT as the preferred imaging modality for suspected extramedullary bone plasmacytomas, while whole-body magnetic resonance imaging (WB-MRI) is indicated for solitary bone plasmacytomas. Despite these recommendations, the available evidence comparing the diagnostic efficacy of both techniques remains limited. The aim of this study was to compare the diagnostic efficacy of WB-MRI and [18F]FDG PET/CT in the initial evaluation of plasmacytomas.</p><p><strong>Methods: </strong>We performed a multicenter, observational, and retrospective analysis of patients diagnosed with plasmacytoma who underwent WB-MRI and/or [18F]FDG PET/CT as part of their diagnostic workup. Lesions identified were categorized by anatomic location, and concordance between WB-MRI and [18F]FDG PET/CT findings was assessed. The McNemar test and Pearson χ2 test were used to compare detection rates between WB-MRI and [18F]FDG PET/CT.</p><p><strong>Results: </strong>The study included 73 patients (33 men) recruited between 2012 and 2023, age range 30-94 years (mean 63.4 ± 12.2 y). Of these, 56 patients underwent both diagnostic tests. Diagnoses revealed solitary plasmacytoma in 16 patients, concurrent multiple myeloma (MM) and plasmacytoma in 18 patients, and plasmacytoma in 22 patients with a prior MM history. Out of the 56 plasmacytomas, 40 were osseous and 16 were extramedullary. WB-MRI detected 98.2% of plasmacytomas compared with 83.9% for [18F]FDG PET/CT, with a statistically significant difference of OR 9 (95% CI: 1.2-394.5), P=0.021. Concordance was very high for osseous plasmacytomas but moderate for extramedullary plasmacytomas.</p><p><strong>Conclusions: </strong>These findings suggest WB-MRI is an alternative to [18F]FDG PET/CT for detecting plasmacytomas. A comprehensive clinical and radiologic assessment is essential for the optimal evaluation of patients with plasmacytoma.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Triple Negative Breast Cancer and 68Ga-Trivehexin: A Glance of Hope.","authors":"Fahad Marafi, Taibah Alahmad, Mahmoud Alfeeli, Alyaa Sadeq","doi":"10.1097/RLU.0000000000005963","DOIUrl":"https://doi.org/10.1097/RLU.0000000000005963","url":null,"abstract":"<p><p>αvβ6 integrin is a heterodimeric transmembrane cell adhesive receptors that mediate cell-substratum adhesion and has been correlated to aggressiveness of various malignancies including breast cancer, with reduced progression-free survival. This integrin was found to facilitate tumor invasion, inhibit apoptosis, regulate expression of matrix metalloproteases, and activate TGF-β. Therefore, it could serve as a prognostic prob for tracking preinvasive tumor progression and monitoring the treatment variety of radiopharmaceuticals that target αvβ6-integrin, as well as its potential role as theranostic agent. Our case demonstrates the viability of 68Ga-Trivehexin PET tracer in a case of histopathologically proven triple-negative breast cancer.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detection of Recurrent Parathyroid Cancer Using 68Ga-Trivehexin PET/CT.","authors":"Dilara Denizmen Zorba, Serkan Kuyumcu, Ayse Kubat Uzum, Emine Go Knur Isik, Yasemin Sanli","doi":"10.1097/RLU.0000000000005735","DOIUrl":"https://doi.org/10.1097/RLU.0000000000005735","url":null,"abstract":"<p><p>A 53-year-old woman with a history of multiple surgeries due to recurrent parathyroid carcinoma (rPTC) presented with elevated serum parathyroid hormone (PTH) and ionized calcium (Ca) levels. While 18F-FDG PET/CT showed no pathologic uptake and 99mTc-MIBI SPECT/CT showed a suspicious uptake, 68Ga-Trivehexin PET/CT revealed intense activity in the recurrent lesion, as well as mild activity in one of the newly detected, widespread lesions in both lungs, which was assessed as metastatic. This is the first case report demonstrating the potential role of 68Ga-Trivehexin PET/CT in detecting recurrent PTC, highlighting the possibility of false-negative results with 18F-FDG PET/CT and 99mTc-MIBI scintigraphy.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CXCR4-Targeted Imaging in Takayasu Arteritis Using 68Ga-Pentixafor PET/CT.","authors":"Thorsten Derlin, Torsten Witte","doi":"10.1097/RLU.0000000000005975","DOIUrl":"https://doi.org/10.1097/RLU.0000000000005975","url":null,"abstract":"<p><p>We report a case of a 64-year-old woman with Takayasu arteritis who underwent chemokine receptor CXCR4-targeted whole-body 68Ga-Pentixafor positron emission tomography/computed tomography (PET/CT) for further evaluation of disease activity and exclusion of concurrent inflammatory diseases. 68Ga-Pentixafor PET demonstrated CXCR4-positive inflammatory cell infiltrates in the aortic wall, and active disease was further confirmed by 18F-fluorodeoxyglucose (FDG) PET/CT. Moreover, 68Ga-Pentixafor identified a CXCR4-positive pelvic bone lesion, and the patient was subsequently diagnosed with diffuse large B-cell lymphoma. CXCR4-targeted 68Ga-Pentixafor PET is useful for the detection of active inflammation in Takayasu arteritis, and to detect neoplastic disease in this cohort with increased risk of malignancy.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144075917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bone Scintigraphy and Laboratory Clues to Osteomalacia in a Middle-Aged Man With Hip Fractures.","authors":"Tzyy-Ling Chuang, Yuh-Feng Wang","doi":"10.1097/RLU.0000000000005935","DOIUrl":"https://doi.org/10.1097/RLU.0000000000005935","url":null,"abstract":"<p><p>A 43-year-old man with a 1-year history of bilateral hip pain, worsened by standing and walking, presented with a limping gait. x-rays showed diffuse osteoporosis (osteoblastic-lytic), and a bone scan revealed symmetric uptake in the costochondral junctions (rosary beads), femoral neck, proximal tibia, and feet, with no visualization of the kidneys, suggesting a metabolic disorder or neoplasm. Computed tomography revealed osteolytic lesions in multiple bones. Suspecting metabolic bone disease or metastasis, laboratory tests were conducted. Magnetic resonance imaging confirmed bilateral femoral neck fractures. He underwent open reduction internal fixation for the hip fractures. The imaging and laboratory findings suggest osteomalacia.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}