68Ga-Pentixafor PET/CT对高须动脉炎的cxcr4靶向成像

IF 9.6 3区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Clinical Nuclear Medicine Pub Date : 2025-05-14 DOI:10.1097/RLU.0000000000005975

Thorsten Derlin, Torsten Witte

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引用次数: 0

摘要

我们报告一例64岁女性高须动脉炎患者，她接受了趋化因子受体cxcr4靶向的全身68Ga-Pentixafor正电子发射断层扫描/计算机断层扫描（PET/CT），以进一步评估疾病活动性并排除并发炎症性疾病。68ga - pentxafor PET显示主动脉壁有cxcr4阳性炎症细胞浸润，18f -氟脱氧葡萄糖（FDG） PET/CT进一步证实活动性疾病。此外，68ga - pentxafor检测到cxcr4阳性骨盆骨病变，患者随后被诊断为弥漫性大b细胞淋巴瘤。靶向cxcr4的68Ga-Pentixafor PET可用于检测高松动脉炎的活动性炎症，以及检测该队列中恶性肿瘤风险增加的肿瘤疾病。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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CXCR4-Targeted Imaging in Takayasu Arteritis Using 68Ga-Pentixafor PET/CT.

We report a case of a 64-year-old woman with Takayasu arteritis who underwent chemokine receptor CXCR4-targeted whole-body 68Ga-Pentixafor positron emission tomography/computed tomography (PET/CT) for further evaluation of disease activity and exclusion of concurrent inflammatory diseases. 68Ga-Pentixafor PET demonstrated CXCR4-positive inflammatory cell infiltrates in the aortic wall, and active disease was further confirmed by 18F-fluorodeoxyglucose (FDG) PET/CT. Moreover, 68Ga-Pentixafor identified a CXCR4-positive pelvic bone lesion, and the patient was subsequently diagnosed with diffuse large B-cell lymphoma. CXCR4-targeted 68Ga-Pentixafor PET is useful for the detection of active inflammation in Takayasu arteritis, and to detect neoplastic disease in this cohort with increased risk of malignancy.

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来源期刊

Clinical Nuclear Medicine 医学-核医学

CiteScore

2.90

自引率

31.10%

发文量

1113

审稿时长

2 months

期刊介绍： Clinical Nuclear Medicine is a comprehensive and current resource for professionals in the field of nuclear medicine. It caters to both generalists and specialists, offering valuable insights on how to effectively apply nuclear medicine techniques in various clinical scenarios. With a focus on timely dissemination of information, this journal covers the latest developments that impact all aspects of the specialty. Geared towards practitioners, Clinical Nuclear Medicine is the ultimate practice-oriented publication in the field of nuclear imaging. Its informative articles are complemented by numerous illustrations that demonstrate how physicians can seamlessly integrate the knowledge gained into their everyday practice.