Clinical Nuclear MedicinePub Date : 2025-10-01Epub Date: 2025-01-20DOI: 10.1097/RLU.0000000000005670
Xiaohua Ma, Shanshan Xia, Zichan Long, Xulong Zhao, Zhanli Fu
{"title":"18 F-FDG PET/CT in a Patient With Primary Rectal Angiosarcomas and Multiple Bone Metastases.","authors":"Xiaohua Ma, Shanshan Xia, Zichan Long, Xulong Zhao, Zhanli Fu","doi":"10.1097/RLU.0000000000005670","DOIUrl":"10.1097/RLU.0000000000005670","url":null,"abstract":"<p><strong>Abstract: </strong>A 54-year-old man presented with a 1-month history of pain and numbness in the right lower limb. Lumbar spine MRI revealed bone metastases. 18 F-FDG PET/CT showed a soft tissue mass with increased 18 F-FDG uptake in the rectum, accompanied by multiple hypermetabolic lesions in the bilateral ribs, spine, pelvis, and upper right femur. A colonoscopy biopsy of the submucosal rectal mass confirmed the diagnosis of epithelioid angiosarcoma.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"e596-e598"},"PeriodicalIF":9.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143028084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Clinical Nuclear MedicinePub Date : 2025-10-01Epub Date: 2025-05-20DOI: 10.1097/RLU.0000000000005892
Hui Li, Le Song, Meng Wang, Kai Yang, Yan Wan
{"title":"Unilateral Nodular Adrenal Hyperplasia Mimicking Endometrial Cancer Metastasis on 18 F-FDG PET/CT After Immunochemotherapy.","authors":"Hui Li, Le Song, Meng Wang, Kai Yang, Yan Wan","doi":"10.1097/RLU.0000000000005892","DOIUrl":"10.1097/RLU.0000000000005892","url":null,"abstract":"<p><p>Unilateral nodular adrenal hyperplasia after immunochemotherapy is extremely rare. We reported a 70-year-old woman with endometrial cancer who underwent 18 F-FDG PET/CT to evaluate the immunochemotherapy response. Compared with the baseline, follow-up PET/CT revealed a newly hypermetabolic nodule in the left adrenal gland, initially suspected to be metastatic. However, surgical resection and pathology confirmed it as adrenal hyperplasia. This case highlights the importance of recognizing unilateral nodular adrenal hyperplasia as a rare imaging finding mimicking metastasis following immunochemotherapy, which should be considered in the differential diagnosis.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"956-957"},"PeriodicalIF":9.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144110015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Urethral Diverticulum Mimicking Metastatic Prostate Cancer on 68 Ga-PSMA-11 PET/CT.","authors":"Xiaojun Man, Changming Dong, Xiandong Song, Aisheng Dong","doi":"10.1097/RLU.0000000000005739","DOIUrl":"10.1097/RLU.0000000000005739","url":null,"abstract":"<p><p>Urethral diverticulum rarely occurs in a man. A 57-year-old man who underwent radical prostatectomy for prostate adenocarcinoma 9 years ago was referred for 68 Ga-PSMA-11 PET/CT scan for restating due to elevated serum total prostate-specific antigen level. 68 Ga-PSMA-11 PET/CT showed multiple PSMA-avid bone metastases and a focal intense activity in the anterior penis. The PSMA-avid penil lesion corresponded to a urethral diverticulum, which was initially detected on pelvic MRI 8 years ago. This case indicates that the urethral diverticulum should be included in the differential diagnosis of PSMA-avid penile lesions.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"941-942"},"PeriodicalIF":9.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143980340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Clinical Nuclear MedicinePub Date : 2025-10-01Epub Date: 2025-08-18DOI: 10.1097/RLU.0000000000006058
Shreyas B Jayade, Mariam Alavidze, Shweta K Tonny, Raghuveer K Halkar
{"title":"Drug-induced Sarcoid-like Reaction Presenting as Fascitis.","authors":"Shreyas B Jayade, Mariam Alavidze, Shweta K Tonny, Raghuveer K Halkar","doi":"10.1097/RLU.0000000000006058","DOIUrl":"10.1097/RLU.0000000000006058","url":null,"abstract":"<p><p>Drug-induced sarcoid-like reactions (DISRs) present complex challenges in clinical management. The most common presentation in FDG-PET/CT scan is bilateral symmetrical lymphadenopathy, and occasionally spleen and bone involvement. DISR presenting as fasciitis/ myofasciitis is extremely rare. We will discuss pre-chemo, post-chemo, and follow-up FDG-PET/ CT scans, exhibiting DISR-induced fasciitis and resolution of findings after cessation of immunotherapy. How to diagnose and manage DISR is still debatable. Histologic confirmation or short interval follow-up scans with resolution findings can lead to the diagnosis, depending on the severity of symptoms, cessation of therapy or continuation of therapy is instituted.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"e589-e590"},"PeriodicalIF":9.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144882373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Clinical Nuclear MedicinePub Date : 2025-10-01Epub Date: 2025-03-17DOI: 10.1097/RLU.0000000000005839
Noelene George, Jane Leskovar, Kenneth Miles
{"title":"Perianal Abscess Due to Ingested Foreign Body as an Incidental Finding On 18 F-FDG-PET/CT.","authors":"Noelene George, Jane Leskovar, Kenneth Miles","doi":"10.1097/RLU.0000000000005839","DOIUrl":"10.1097/RLU.0000000000005839","url":null,"abstract":"<p><p>A 46-year-old man underwent FDG-PET/CT for re-staging of malignant melanoma. No metabolically active tumor sites were demonstrated, but intense FDG uptake was seen within the left perianal region associated with a soft tissue opacity on low-dose CT, consistent with an abscess containing a 23 mm linear foreign body. The lesion was subsequently explored surgically. The abscess was drained, and a wooden object measuring ~28 ×2 mm was retrieved. The object was consistent with a portion of the stick from a corn dog which the patient recalled eating some time before the restaging PET.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"936-937"},"PeriodicalIF":9.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Clinical Nuclear MedicinePub Date : 2025-10-01Epub Date: 2025-03-19DOI: 10.1097/RLU.0000000000005843
Yaqun Jiang, Zhenxiong Chen, Yong He
{"title":"Comparison of 68 Ga-FAPI-04 PET/CT and 18 F-FDG PET/CT in Evaluating Lesion Stages in Constrictive Pericarditis.","authors":"Yaqun Jiang, Zhenxiong Chen, Yong He","doi":"10.1097/RLU.0000000000005843","DOIUrl":"10.1097/RLU.0000000000005843","url":null,"abstract":"<p><p>Constrictive pericarditis, an uncommon cause of diastolic heart failure, is reversible if identified and treated promptly and appropriately. The treatment approach may vary significantly depending on the disease stage of constrictive pericarditis. Here, we report a case of 18 F-FDG and 68 Ga-FAPI-04 PET/CT imaging in a 70-year-old woman with chronic constrictive pericarditis. The thickened pericardium showed mild uptake of 18 F-FDG but intense uptake of 68 Ga-FAPI-04, indicating that the lesion was at the fibrotic phase. This case suggests a promising role of combination of 18 F-FDG and 68 Ga-FAPI PET/CT in accurately and timely assessing the lesion stage in constrictive pericarditis.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"e631-e632"},"PeriodicalIF":9.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143656298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Clinical Nuclear MedicinePub Date : 2025-10-01Epub Date: 2025-06-05DOI: 10.1097/RLU.0000000000005814
Chengzhi Jiang, Wanjing Zhou, Hui Ye
{"title":"Primary Solitary Rib Lymphoma on FDG PET/CT.","authors":"Chengzhi Jiang, Wanjing Zhou, Hui Ye","doi":"10.1097/RLU.0000000000005814","DOIUrl":"10.1097/RLU.0000000000005814","url":null,"abstract":"<p><p>Non-Hodgkin lymphoma of the rib is extremely rare. Herein, we report a case of solitary primary rib lymphoma in a 55-year-old man. 18 F-FDG PET/CT revealed a hypermetabolic lesion in the right seventh rib. The subsequent histology and immunohistochemistry of the rib lesion confirmed the diagnosis of highly aggressive B-cell non-Hodgkin lymphoma.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"973-974"},"PeriodicalIF":9.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144233448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Clinical Nuclear MedicinePub Date : 2025-10-01Epub Date: 2025-03-05DOI: 10.1097/RLU.0000000000005742
Xueni Yang, Liu Xiao, Lin Li, Wenjie Zhang
{"title":"FDG PET/CT Image of Symmetric Tendon Xanthoma.","authors":"Xueni Yang, Liu Xiao, Lin Li, Wenjie Zhang","doi":"10.1097/RLU.0000000000005742","DOIUrl":"10.1097/RLU.0000000000005742","url":null,"abstract":"<p><p>Tendon xanthoma is very rare. We report FDG PET/CT findings of tendon xanthoma in a 33-year-old man. On FDG PET/CT image, it manifested as multiple symmetric nodules with an SUVmax of 9.37, located in the tendons of both elbows, knees and ankles. The final pathology supported a diagnosis of a tendon xanthoma.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"e591-e592"},"PeriodicalIF":9.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143556182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Clinical Nuclear MedicinePub Date : 2025-10-01Epub Date: 2025-03-17DOI: 10.1097/RLU.0000000000005840
Rucha Barapatre, Priyanka Verma, Anurag R Lila, Sandip Basu
{"title":"Serendipitous Discovery and Characterization of Two Different Pathologies on 68 Ga-DOTATATE and 68 Ga-Exendin PET/CT in a Patient With Hyperinsulinemic Hypoglycemia Leading to Diagnosis of MEN-1.","authors":"Rucha Barapatre, Priyanka Verma, Anurag R Lila, Sandip Basu","doi":"10.1097/RLU.0000000000005840","DOIUrl":"10.1097/RLU.0000000000005840","url":null,"abstract":"<p><p>The complementary role of multi-tracer PET in deciphering 2 different pathologies in multiple endocrine neoplasia 1 (MEN-1) is illustrated in this report. A 22-year-old man, with a history of altered behavior over the past 1 year and suspected to have hyperinsulinemic hypoglycemia based on a positive 72-hour fasting test and CT abdomen revealing a lesion in the pancreas, was referred for 68 Ga-Exendin-4 PET/CT. The 68 Ga-Exendin PET/CT revealed focal uptake in the pancreatic lesion, and 68 Ga-DOTATATE PET/CT did not show any avidity in the pancreatic lesion; however, it demonstrated somatostatin receptor (SSTR) expression in a soft tissue mass, just posterior to the thyroid. Parathyroid adenoma and hyperparathyroidism were finally proven, and genetic testing was done, which came positive for the diagnosis of MEN-1 syndrome.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"e628-e630"},"PeriodicalIF":9.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Clinical Nuclear MedicinePub Date : 2025-10-01Epub Date: 2025-07-01DOI: 10.1097/RLU.0000000000005923
Cem Bilgin, Gokce Belge Bilgin, Bilge Dundar, Jamie D Kapplinger, Julie E Hallanger Johnson, Trond Velde Bogsrud, Jolanta M Durski
{"title":"I-131 Uptake in a Benign Diaphragmatic Mesothelial Cyst Mimicking Thyroid Cancer Metastasis on Post-therapy SPECT/CT.","authors":"Cem Bilgin, Gokce Belge Bilgin, Bilge Dundar, Jamie D Kapplinger, Julie E Hallanger Johnson, Trond Velde Bogsrud, Jolanta M Durski","doi":"10.1097/RLU.0000000000005923","DOIUrl":"10.1097/RLU.0000000000005923","url":null,"abstract":"<p><p>Radioiodine ablation therapy is commonly used for patients with well-differentiated thyroid cancer. False-positive radioiodine uptake in benign cystic lesions on post-therapy SPECT/CT presents a recognized diagnostic challenge. Here, we present the case of a 33-year-old woman who underwent total thyroidectomy, followed by I-131 radioiodine therapy. Her post-I-131 therapy SPECT/CT revealed incidental radioiodine uptake in a diaphragmatic mesothelial cyst, prompting further investigation. She subsequently underwent a dedicated liver MRI and excision biopsy, both of which were negative for thyroid cancer metastasis. This case highlights the importance of identifying benign sources of radioiodine uptake to avoid unnecessary interventions.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"958-959"},"PeriodicalIF":9.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144526747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}