Clinical Nuclear Medicine最新文献

Combination Therapy With 177 Lu-FAPI-2286 and Tyrosine Kinase Inhibitor: A Novel Approach for Treating Metastatic Medullary Thyroid Carcinoma. 177Lu-FAPI-2286联合酪氨酸激酶抑制剂：治疗转移性甲状腺髓样癌的新方法。

IF 9.6 3区医学

Clinical Nuclear Medicine Pub Date : 2025-09-01 Epub Date: 2025-04-17 DOI: 10.1097/RLU.0000000000005723

Nasrin Raeisi, Amin Saber Tanha, Sajad Ataei Azimi, Kamran Aryana

引用次数: 0

6-Deoxy-6-[ 18 F]Fluoro-L-Ascorbic Acid PET/CT in the Detection of Lymph Node Metastases for Postoperative Differentiated Thyroid Cancer Patients : Using Histopathology as Reference Standard. 6-脱氧-6-[18F]氟- l -抗坏血酸PET/CT检测甲状腺癌术后分化患者淋巴结转移：以组织病理学为参考标准

IF 9.6 3区医学

Clinical Nuclear Medicine Pub Date : 2025-09-01 Epub Date: 2025-07-01 DOI: 10.1097/RLU.0000000000006026

Yali Long, Songhan Ge, Xiangdong Xu, Kunyuan Jiang, Yuying Zhang, Renbo Wu, Xiaoer Zhang, Jinyu Liang, Jianbo Liu, Qiao He, Weiming Lv, Xiangsong Zhang, Zhihao Zha

{"title":"6-Deoxy-6-[ 18 F]Fluoro-L-Ascorbic Acid PET/CT in the Detection of Lymph Node Metastases for Postoperative Differentiated Thyroid Cancer Patients : Using Histopathology as Reference Standard.","authors":"Yali Long, Songhan Ge, Xiangdong Xu, Kunyuan Jiang, Yuying Zhang, Renbo Wu, Xiaoer Zhang, Jinyu Liang, Jianbo Liu, Qiao He, Weiming Lv, Xiangsong Zhang, Zhihao Zha","doi":"10.1097/RLU.0000000000006026","DOIUrl":"10.1097/RLU.0000000000006026","url":null,"abstract":"Background: 6-Deoxy-6-[ 18 F]fluoro-L-ascorbic acid ([ 18 F]FAA) is a radioisotope-labeled analogue of ascorbic acid (AA), designed to investigate oxidative stress and AA accumulation in vivo by PET imaging. It has also been reported as a promising radiotracer for tumor detection, particularly in metastatic differentiated thyroid cancer (DTC).Purpose: This study aimed to evaluate the diagnostic potential of [ 18 F]FAA in detecting lymph node metastases in postoperative DTC patients.Methods: Patients who have undergone thyroidectomy for DTC and are either preparing for 131 I therapy or undergoing follow-up examinations were prospectively enrolled and underwent [ 18 F]FAA PET/CT from September 2023 to November 2023. Histopathologic results served as gold standard for final diagnosis.Results: A total of 70 patients [mean age, 40.5 y±12.0 (SD); 23 men] with pathologically confirmed DTC were enrolled. At patient-based analysis, [ 18 F]FAA PET/CT detected positive lymph nodes in all patients, with an accuracy of 92.9% (65/70). At lesion-based analysis of patients who underwent central and/or lateral cervical lymph node dissection, the accuracy of [ 18 F]FAA PET/CT were 94.3% (460/488). The SUVmax and TBR of lymph node metastases were significantly higher than normal lymph nodes (mean SUVmax, 8.3±4.6 vs. 2.0±1.5, P <0.0001; mean TBR, 3.6±2.2 vs. 0.9±0.7, P <0.0001).Conclusions: [ 18 F]FAA PET/CT can be used in the detection of postoperative cervical lymph node metastases in DTC. It may serve as a valuable tool for risk stratification and radioactive iodine treatment decision-making of postoperative DTC.","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"e523-e530"},"PeriodicalIF":9.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144526688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

FDG PET/CT in ALK-positive Histiocytosis of the Nasal Cavity in a Pediatric Patient. 小儿alk阳性鼻腔组织细胞增多症的FDG PET/CT分析。

IF 9.6 3区医学

Clinical Nuclear Medicine Pub Date : 2025-09-01 Epub Date: 2025-02-25 DOI: 10.1097/RLU.0000000000005766

Qing Chen, Lilan Fu, Guangxiu Guo, Aisheng Dong, Jia Guo

引用次数: 0

Partial Adrenalectomy With Maximizing Adrenal Preservation: 68 Ga-Pentixafor PET/CT-Guided Precise Resection of Aldosterone-Producing Adenoma. 最大化肾上腺保存的部分肾上腺切除术：68ga - pentxapet / ct引导下精确切除醛固酮分泌腺瘤。

IF 9.6 3区医学

Clinical Nuclear Medicine Pub Date : 2025-09-01 Epub Date: 2025-03-11 DOI: 10.1097/RLU.0000000000005833

Kai Cheng, Yao He, Tingting Long, Longfei Liu, Yu Gan

引用次数: 0

Detection of Extramedullary Laryngeal Involvement on 68 Ga-Pentixafor PET/CT in a Newly Diagnosed Patient of Multiple Myeloma. 68ga - pentxafor PET/CT对新诊断多发性骨髓瘤患者喉髓外受累的检测。

IF 9.6 3区医学

Clinical Nuclear Medicine Pub Date : 2025-09-01 Epub Date: 2025-04-23 DOI: 10.1097/RLU.0000000000005822

Suraj Kumar, Harneet Kaur, Ankit Watts, Pankaj Malhotra, Baljinder Singh

引用次数: 0

Semiquantitative 131 I MIBG Scintigraphy Predicts Intraoperative Blood Pressure Fluctuation in Patients Undergoing Surgery for Pheochromocytoma and Paraganglioma. 半定量131I MIBG闪烁成像预测嗜铬细胞瘤和副神经节瘤手术患者术中血压波动

IF 9.6 3区医学

Clinical Nuclear Medicine Pub Date : 2025-09-01 Epub Date: 2025-06-27 DOI: 10.1097/RLU.0000000000006042

Heyu Ji, Jiangyu Ma, Chu Wang, Hongli Jing, Tuo Li, Xulei Cui, Nan Hu, Yu Liu, Chao Fu, Yuguang Huang, Li Huo

{"title":"Semiquantitative 131 I MIBG Scintigraphy Predicts Intraoperative Blood Pressure Fluctuation in Patients Undergoing Surgery for Pheochromocytoma and Paraganglioma.","authors":"Heyu Ji, Jiangyu Ma, Chu Wang, Hongli Jing, Tuo Li, Xulei Cui, Nan Hu, Yu Liu, Chao Fu, Yuguang Huang, Li Huo","doi":"10.1097/RLU.0000000000006042","DOIUrl":"10.1097/RLU.0000000000006042","url":null,"abstract":"Objective: Severe blood pressure (BP) fluctuation happens during surgery for pheochromocytoma and paraganglioma (PPGL) due to the release of catecholamines. 131 I MIBG scintigraphy indicates the capacity of PPGL to retake and reserve catecholamines. This study aims to utilize 131 I MIBG scintigraphy to predict intraoperative BP fluctuation in patients undergoing PPGL surgery, thereby guiding preoperative preparation.Methods: This study included 159 patients receiving 131 I MIBG scintigraphy before surgery for PPGL. Uptake of 131 I MIBG was assessed with an MIBG score ranging from 2 to 8. Factors that may be related to hemodynamic stability were collected. BP fluctuation was evaluated by systolic blood pressure average real variability (SBP ARV) and mean arterial pressure average real variability (MAP ARV).Results: One hundred fifty-nine consecutive patients with PPGL were included in this study. Patients with an MIBG score of 2 (10.3±4.6 mm Hg) had lower SBP ARV than patients with a score of 5 (14.9±5.6 mm Hg, p =0.012), score of 7 (13.8±5.0 mm Hg, p =0.013) and score of 8 (14.7±7.3 mm Hg, p =0.007). Patients with 131 I MIBG score of 2 (7.6±3.2 mm Hg) also had a lower MAP ARV than patients with a score of 5 (10.3±4.3 mm Hg, p =0.045) and a score of 8 (9.8±4.5 mm Hg, p =0.029). In multiple linear regression analyses, MIBG score ( p =0.010), metanephrine ( p =0.014), and maximum preoperative blood pressure ( p =0.021) were correlated with SBP ARV.Conclusions: Preoperative 131 I MIBG scintigraphy is associated with intraoperative BP fluctuation in patients with PPGL. Metanephrine, maximum preoperative blood pressure, and 131 I MIBG scintigraphy can predict intraoperative BP fluctuation independently. Personalized preoperative management can be offered to patients based on these assessments.","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"817-824"},"PeriodicalIF":9.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144505004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

68Ga PSMA PET/CT and 18F FDG PET/CT Findings in Osteonecrosis of the Jaw Induced by Denosumab. Denosumab致颌骨骨坏死的68Ga PSMA PET/CT和18F FDG PET/CT表现。

IF 9.6 3区医学

Clinical Nuclear Medicine Pub Date : 2025-09-01 Epub Date: 2025-03-03 DOI: 10.1097/RLU.0000000000005751

Zehranur Tosunoğlu, Göksel Alçin, Elife Akgün, İlkay Gültürk, Esra Arslan

引用次数: 0

[ 68 Ga]Ga-FAPI-46 PET/MRT Unveils Lymph Node Metastases and Changes Treatment Strategy in Recurrent Advanced High-grade Serous Ovarian Carcinoma Patient. [68Ga]Ga-FAPI-46 PET/MRT揭示晚期高级别浆液性卵巢癌复发患者淋巴结转移及治疗策略的改变。

IF 9.6 3区医学

Clinical Nuclear Medicine Pub Date : 2025-09-01 Epub Date: 2025-03-28 DOI: 10.1097/RLU.0000000000005871

Marie Prochiner, Anna Hinterberger, Björn Wängler, Frederik Marmé, Freba Grawe

引用次数: 0

Impact of Therapeutic Radioactive Iodine on the Recurrence of Papillary Thyroid Cancer With Extranodal Extension in Metastatic Lymph Nodes: A Propensity Score-matched Analysis. 治疗性放射性碘对甲状腺乳头状癌结外转移淋巴结复发的影响：倾向评分匹配分析。

IF 9.6 3区医学

Clinical Nuclear Medicine Pub Date : 2025-09-01 Epub Date: 2025-05-09 DOI: 10.1097/RLU.0000000000005940

Hye In Kim, Boram Kim, Jiyeon Hyeon, Nak Gyeong Ko, Mihyeon Jin, Jung Hwan Cho, Ji Min Han, Sunghwan Suh, Ji Cheol Bae, Man Ki Chung, Jun-Ho Choe, Sun Wook Kim, Jae Hoon Chung, Young Lyun Oh, Kyunga Kim, Tae Hyuk Kim, Joon Young Choi

{"title":"Impact of Therapeutic Radioactive Iodine on the Recurrence of Papillary Thyroid Cancer With Extranodal Extension in Metastatic Lymph Nodes: A Propensity Score-matched Analysis.","authors":"Hye In Kim, Boram Kim, Jiyeon Hyeon, Nak Gyeong Ko, Mihyeon Jin, Jung Hwan Cho, Ji Min Han, Sunghwan Suh, Ji Cheol Bae, Man Ki Chung, Jun-Ho Choe, Sun Wook Kim, Jae Hoon Chung, Young Lyun Oh, Kyunga Kim, Tae Hyuk Kim, Joon Young Choi","doi":"10.1097/RLU.0000000000005940","DOIUrl":"10.1097/RLU.0000000000005940","url":null,"abstract":"Purpose: Radioactive iodine therapy (RAI) ≥100 mCi (3.7 GBq) is commonly recommended for papillary thyroid cancer (PTC) patients with extranodal extension (ENE). However, no study has evaluated whether RAI ≥100 mCi is effective in reducing the recurrence of PTC with ENE.Methods: This retrospective cohort study enrolled 191 PTC patients with ENE who underwent total thyroidectomy and RAI. Recurrence according to RAI activity (<100 vs. ≥100 mCi) was compared before and after propensity score matching (PSM) (1:2) using Kaplan-Meier curves and Cox proportional hazards regression models. Subgroup analyses according to mass size (<4 and ≥4 cm), gender, blood vessel invasion, lymph node (LN) number (≤5 and >5), and stimulated Tg (sTg) level (<10 and ≥10 ng/mL) before and after PSM were performed.Results: During about 116 months, 5 (12.5%) and 19 (12.6%) before PSM, five (12.5%) and 3 (3.8%) after PSM recorded recurrence in <100 and ≥100 mCi groups, respectively. The impact of RAI ≥100 mCi on reducing recurrence was not significant before [log-rank P = 0.915, adjusted hazard ratio (HR) 0.49 (0.12-1.85); P = 0.294) and after PSM (log-rank P = 0.077). Subgroup analysis after PSM demonstrated the impact of RAI ≥100 mCi on lowering recurrence only in ENE patients with mass size ≥4 cm (log-rank P = 0.008), LN >5 (log-rank P = 0.007), and sTg ≥10 ng/mL (log-rank P = 0.039).Conclusions: In PTC patients with ENE, mass size ≥4 cm, LN >5, or sTg ≥10 ng/mL had a benefit from RAI ≥100 mCi compared with RAI <100 mCi.","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"830-839"},"PeriodicalIF":9.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144062813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Favorable Palliative Effect of 177 Lu-FAPI-2286 in Two Breast Cancer Patients With Refractory Bone Pains. 177Lu-FAPI-2286对2例难治性骨痛乳腺癌患者的良好缓解效果。

IF 9.6 3区医学

Clinical Nuclear Medicine Pub Date : 2025-09-01 Epub Date: 2025-05-21 DOI: 10.1097/RLU.0000000000005753

Nasrin Raeisi, Amin Saber Tanha, Farid Jafari Zarrin Ghabaei, Somaye Barashki, Kamran Aryana

引用次数: 0