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Metastatic Mucinous Adenocarcinoma of Unknown Origin Showing 68 Ga-DOTATATE Uptake. 显示 68Ga-DOTATATE 摄取的不明来源转移性黏液腺癌
IF 9.6 3区 医学
Clinical Nuclear Medicine Pub Date : 2025-01-01 Epub Date: 2024-10-30 DOI: 10.1097/RLU.0000000000005548
Nuh Filizoglu, Salih Ozguven, Fuat Dede, Halil Turgut Turoglu, Tanju Yusuf Erdil
{"title":"Metastatic Mucinous Adenocarcinoma of Unknown Origin Showing 68 Ga-DOTATATE Uptake.","authors":"Nuh Filizoglu, Salih Ozguven, Fuat Dede, Halil Turgut Turoglu, Tanju Yusuf Erdil","doi":"10.1097/RLU.0000000000005548","DOIUrl":"10.1097/RLU.0000000000005548","url":null,"abstract":"<p><strong>Abstract: </strong>Although the use of 18 F-FDG PET/CT is well established in the evaluation of adenocarcinoma, the performance of 18 F-FDG PET/CT in mucinous adenocarcinoma is not consistent. 68 Ga-DOTATATE uptake can be observed in some non-neuroendocrine tumors as a result of tumor blood flow and somatostatin receptor expression at different levels. For this reason, 68 Ga-DOTATATE PET/CT may have a prospective role in the evaluation of mucinous adenocarcinoma. However, there is no published case of mucinous adenocarcinoma with 68 Ga-DOTATATE uptake. We present a unique case of metastatic mucinous adenocarcinoma of unknown origin on 68 Ga-DOTATATE PET/CT.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"e51-e52"},"PeriodicalIF":9.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142544214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Joker Sign After Drooling Radioactive Saliva. 流出放射性唾液后的小丑手势
IF 9.6 3区 医学
Clinical Nuclear Medicine Pub Date : 2025-01-01 Epub Date: 2024-10-02 DOI: 10.1097/RLU.0000000000005449
MinJeong Kim, Yeon-Hee Han, Hwan-Jeong Jeong, Jae Seok Jeong, Seok Tae Lim
{"title":"Joker Sign After Drooling Radioactive Saliva.","authors":"MinJeong Kim, Yeon-Hee Han, Hwan-Jeong Jeong, Jae Seok Jeong, Seok Tae Lim","doi":"10.1097/RLU.0000000000005449","DOIUrl":"10.1097/RLU.0000000000005449","url":null,"abstract":"<p><strong>Abstract: </strong>A 28-year-old man underwent high-dose radioactive iodine therapy after total thyroidectomy due to papillary thyroid carcinomas. After 2 weeks, a linear reddish line was observed extending from the right corner of the mouth to the cheek, resembling the appearance of the Joker. Through a detailed interview, it was determined that the patient had developed radiation dermatitis because of radioactive saliva drooling while sleeping on one side. Although this is expected to be infrequent, educating patients on avoiding saliva contact with the skin during and after radioactive iodine therapy is crucial due to the potential skin damage and cancer risk.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"96-97"},"PeriodicalIF":9.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142361264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Rare Case of Tumor-Induced Osteomalacia Due to Mesenchymal Tumor at Foramen Magnum Diagnosed Preoperatively on 68 Ga DOTATATE PET/CT. 通过 68Ga DOTATATE PET/CT 术前诊断出磁孔间质瘤诱发骨软化症的罕见病例。
IF 9.6 3区 医学
Clinical Nuclear Medicine Pub Date : 2025-01-01 Epub Date: 2024-10-21 DOI: 10.1097/RLU.0000000000005549
Chandra Mouli, Anurag Lila, Abhay Gondhane, Gaurav Malhotra, Tushar Bandgar
{"title":"A Rare Case of Tumor-Induced Osteomalacia Due to Mesenchymal Tumor at Foramen Magnum Diagnosed Preoperatively on 68 Ga DOTATATE PET/CT.","authors":"Chandra Mouli, Anurag Lila, Abhay Gondhane, Gaurav Malhotra, Tushar Bandgar","doi":"10.1097/RLU.0000000000005549","DOIUrl":"10.1097/RLU.0000000000005549","url":null,"abstract":"<p><strong>Abstract: </strong>A 42-year-old man, a known case of FGF23-dependent hypophosphatemia, underwent 68 Ga- DOTATATE PET-CT, which showed a somatostatin receptor-expressing lesion in the left arch of foramen magnum that was correlated on MRI as a soft tissue lesion measuring 2.2 × 1.3 cm. It was excised and histopathologically confirmed as phosphaturic mesenchymal tumor. Postoperatively, patient improved clinically and recovered from hypophosphatemia completely. A distinct focal uptake in a 68 Ga- DOTATATE PET-CT in a patient with tumor-induced osteomalacia needs extensive workup and high degree of suspicion to rule out mesenchymal tumor at nonconventional location as seen in the present case.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"e53-e54"},"PeriodicalIF":9.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142544205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
18 F-FDG PET/CT Findings of Isolated Renal Metastasis From Squamous Cell Lung Cancer. 鳞状细胞肺癌孤立肾转移的 18F-FDG PET/CT 发现
IF 9.6 3区 医学
Clinical Nuclear Medicine Pub Date : 2025-01-01 Epub Date: 2024-10-17 DOI: 10.1097/RLU.0000000000005545
Jun Yu, Yang Li, Xue Yang, Dongdong Ren, Cong Chen
{"title":"18 F-FDG PET/CT Findings of Isolated Renal Metastasis From Squamous Cell Lung Cancer.","authors":"Jun Yu, Yang Li, Xue Yang, Dongdong Ren, Cong Chen","doi":"10.1097/RLU.0000000000005545","DOIUrl":"10.1097/RLU.0000000000005545","url":null,"abstract":"<p><strong>Abstract: </strong>We present the 18 F-FDG PET/CT findings of a 64-year-old man with isolated renal metastasis. He had a history of radical surgery for squamous cell lung cancer 14 months ago, followed by chemotherapy and immunotherapy. The renal metastasis presented as a small focus of increased FDG uptake in the restaging 18 F-FDG PET/CT scan, which was regarded as renal cortical tracer retention. The renal metastasis was more prominent on the second PET/CT performed 5 months later. The patient subsequently underwent radical nephrectomy, and histopathological examination confirmed the diagnosis of renal squamous cell carcinoma metastasis.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"61-63"},"PeriodicalIF":9.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142496484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prognostic Value and Clinical Implication of Lymph Node-to-Primary Tumor SUV Ratio in Node-Positive Hypopharyngeal Squamous Cell Carcinoma Treated With Radiotherapy With or Without Chemotherapy. 淋巴结与原发肿瘤SUV比值在结节阳性下咽鳞状细胞癌放疗加或不加化疗治疗中的预后价值和临床意义
IF 9.6 3区 医学
Clinical Nuclear Medicine Pub Date : 2025-01-01 Epub Date: 2024-10-17 DOI: 10.1097/RLU.0000000000005544
Wing-Keen Yap, Chia-Hsin Lin, Ken-Hao Hsu, Shin-Nan Lin, Huan-Chun Lin, Kai-Ping Chang, Chung-Jan Kang, Yu-Feng Hu, Ming-Chieh Shih, Tsung-You Tsai
{"title":"Prognostic Value and Clinical Implication of Lymph Node-to-Primary Tumor SUV Ratio in Node-Positive Hypopharyngeal Squamous Cell Carcinoma Treated With Radiotherapy With or Without Chemotherapy.","authors":"Wing-Keen Yap, Chia-Hsin Lin, Ken-Hao Hsu, Shin-Nan Lin, Huan-Chun Lin, Kai-Ping Chang, Chung-Jan Kang, Yu-Feng Hu, Ming-Chieh Shih, Tsung-You Tsai","doi":"10.1097/RLU.0000000000005544","DOIUrl":"10.1097/RLU.0000000000005544","url":null,"abstract":"<p><strong>Purpose: </strong>The aim of this was to evaluate the prognostic significance of the nodal-to-primary tumor SUV max ratio (NTR) in patients with node-positive hypopharyngeal squamous cell carcinoma (HPSCC) treated with radiotherapy with or without concurrent chemotherapy. The study aims to enhance prognostic accuracy by incorporating NTR into the American Joint Committee on Cancer (AJCC) staging system.</p><p><strong>Patients and methods: </strong>This retrospective study included 191 patients with biopsy-proven node-positive HPSCC treated from 2005 to 2013. NTR was calculated as the ratio of SUV max of metastatic lymph nodes to the primary tumor's SUV max . Survival analyses were conducted using Cox regression models and Kaplan-Meier analysis. Receiver operating characteristic analysis compared the prognostic performance of the modified and AJCC staging systems.</p><p><strong>Results: </strong>The median follow-up was 8.27 years, with 135 deaths (70.7%). High NTR (≥0.63) was significantly associated with worse overall survival (OS) and was an independent prognostic factor in multivariable analysis (adjusted hazards ratio [HR] = 1.63, P = 0.007). Median OS for high NTR was 17.4 months, compared with 75.2 months for low NTR. High NTR significantly predicted worse OS within AJCC stage IVA patients (HR = 6.09, P = 0.014). Patients in modified stage IVA (AJCC stage IVA with low NTR) had significantly longer OS than those in modified stage IVB (AJCC stage IVA with high NTR and AJCC stage IVB) (HR = 8.62, P = 0.003). The modified staging system incorporating NTR showed superior prognostic performance compared with the AJCC staging system.</p><p><strong>Conclusions: </strong>NTR is a significant independent prognostic factor for OS in node-positive HPSCC patients. Integrating NTR into the AJCC staging system improves prognostic accuracy.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"11-18"},"PeriodicalIF":9.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142496487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
68 Ga-DOTATATE and 18 F-FDG PET/CT in a Rapidly Progressing Lymphoma. 68Ga-DOTATATE和18F-FDG PET/CT在快速进展淋巴瘤中的应用
IF 9.6 3区 医学
Clinical Nuclear Medicine Pub Date : 2025-01-01 Epub Date: 2024-10-14 DOI: 10.1097/RLU.0000000000005450
Ashwin Singh Parihar, Richard L Wahl, Amin H Jahromi
{"title":"68 Ga-DOTATATE and 18 F-FDG PET/CT in a Rapidly Progressing Lymphoma.","authors":"Ashwin Singh Parihar, Richard L Wahl, Amin H Jahromi","doi":"10.1097/RLU.0000000000005450","DOIUrl":"10.1097/RLU.0000000000005450","url":null,"abstract":"<p><strong>Abstract: </strong>68 Ga-DOTATATE PET/CT targeting somatostatin receptors is commonly utilized in the imaging of neuroendocrine tumors. However, other malignancies such as lymphomas (both Hodgkin and non-Hodgkin) also have expression of somatostatin receptors, albeit to a lesser degree compared with the neuroendocrine tumors, and thus can be positive on a 68 Ga-DOTATATE PET/CT. We describe an atypical presentation of an aggressive large B-cell lymphoma mimicking a metastatic neuroendocrine tumor at initial presentation with high somatostatin receptor expression demonstrated on the 68 Ga-DOTATATE PET/CT and a rapidly progressing course on the subsequent 18 F-FDG PET/CT.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"e64-e65"},"PeriodicalIF":9.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142459916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Importance of 18 F-FDG PET/CT in a Rare Case of Multiple Myeloma Presenting With Nasal Plasmacytoma. 18F-FDG PET/CT 在鼻浆细胞瘤并发多发性骨髓瘤罕见病例中的重要性。
IF 9.6 3区 医学
Clinical Nuclear Medicine Pub Date : 2025-01-01 Epub Date: 2024-11-06 DOI: 10.1097/RLU.0000000000005546
Özge Erol Fenercioğlu, Tevfik Fikret Çermik
{"title":"The Importance of 18 F-FDG PET/CT in a Rare Case of Multiple Myeloma Presenting With Nasal Plasmacytoma.","authors":"Özge Erol Fenercioğlu, Tevfik Fikret Çermik","doi":"10.1097/RLU.0000000000005546","DOIUrl":"10.1097/RLU.0000000000005546","url":null,"abstract":"<p><strong>Abstract: </strong>Nasopharyngeal plasmacytoma is a rare presentation of multiple myeloma. We emphasize the importance of imaging by presenting the 18 F-FDG PET/CT findings of a patient with nasopharyngeal plasmacytoma and lytic hypermetabolic bone lesions.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"e47-e48"},"PeriodicalIF":9.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142581607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A False-Negative 123 I-MIBG SPECT/CT With True-Positive 68 Ga-DOTATATE PET/CT in a Patient With Neuroblastoma Following 177 Lu-DOTATATE Therapy. 一名接受177Lu-DOTATATE治疗的神经母细胞瘤患者的123I-MIBG SPECT/CT假阴性和68Ga-DOTATATE PET/CT真阳性。
IF 9.6 3区 医学
Clinical Nuclear Medicine Pub Date : 2025-01-01 Epub Date: 2024-08-02 DOI: 10.1097/RLU.0000000000005397
Siqi Li, Yanfeng Xu, Xia Lu, Wei Wang, Jigang Yang
{"title":"A False-Negative 123 I-MIBG SPECT/CT With True-Positive 68 Ga-DOTATATE PET/CT in a Patient With Neuroblastoma Following 177 Lu-DOTATATE Therapy.","authors":"Siqi Li, Yanfeng Xu, Xia Lu, Wei Wang, Jigang Yang","doi":"10.1097/RLU.0000000000005397","DOIUrl":"10.1097/RLU.0000000000005397","url":null,"abstract":"<p><strong>Abstract: </strong>A 10-year-old girl with high-risk neuroblastoma underwent 123 I-MIBG SPECT/CT and 68 Ga-DOTATE PET/CT, which both showed multiple bone metastases. However, following 177 Lu-DOTATATE therapy, only 68 Ga-DOTATATE PET/CT identified residual lesions with negative 123 I-MIBG SPECT/CT results. The case emphasized the complementary role of 68 Ga-DOTATATE PET/CT and 123 I-MIBG SPECT/CT after 177 Lu-DOTATATE therapy.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"72-74"},"PeriodicalIF":9.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141874368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Paraneoplastic Proliferative Myositis on 18 F-FDG PET/CT. 18F-FDG PET/CT 上的副肿瘤性增生性肌炎
IF 9.6 3区 医学
Clinical Nuclear Medicine Pub Date : 2025-01-01 Epub Date: 2024-10-30 DOI: 10.1097/RLU.0000000000005547
Ritwik Wakankar, Jaspriya Bal, Pankaj Dougall
{"title":"Paraneoplastic Proliferative Myositis on 18 F-FDG PET/CT.","authors":"Ritwik Wakankar, Jaspriya Bal, Pankaj Dougall","doi":"10.1097/RLU.0000000000005547","DOIUrl":"10.1097/RLU.0000000000005547","url":null,"abstract":"<p><strong>Abstract: </strong>We present a rare and never-before-reported case of paraneoplastic proliferative myositis that was incidentally detected in a 42-year-old man who had been receiving systemic cytotoxic chemotherapy for classic Hodgkin lymphoma. We highlight his 18 F-FDG PET/CT findings and its utility in helping to diagnose this condition, avoiding unnecessary surgical resection and the added costs associated with it.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"e49-e50"},"PeriodicalIF":9.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142544215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
177 Lu-FAP-2286 Therapy in a Case of Squamous Lung Cancer. 177Lu-FAP-2286 治疗一例鳞状肺癌
IF 9.6 3区 医学
Clinical Nuclear Medicine Pub Date : 2025-01-01 Epub Date: 2024-10-10 DOI: 10.1097/RLU.0000000000005489
Linwei Li, Lingzhi Chen, Yanlang Zhang, Yu Zhang, Yue Chen
{"title":"177 Lu-FAP-2286 Therapy in a Case of Squamous Lung Cancer.","authors":"Linwei Li, Lingzhi Chen, Yanlang Zhang, Yu Zhang, Yue Chen","doi":"10.1097/RLU.0000000000005489","DOIUrl":"10.1097/RLU.0000000000005489","url":null,"abstract":"<p><strong>Abstract: </strong>We reported a 72-year-old man who was diagnosed with squamous lung cancer and received 2 cycles of 177 Lu-FAP-2286 treatment. Radiological remission was observed on follow-up FAP imaging 7 months later with squamous cell carcinoma antigen decreased to normal level. No other abnormality monitored by routine laboratory examination was noted.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"103-104"},"PeriodicalIF":9.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142581477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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