Clinical Nuclear Medicine最新文献

{"title":"The Value of PSMA-RADS Version 2.0 in the Assessment of Pulmonary Metastases in Patients With Prostate Cancer and the Improvement of Differential Diagnosis Efficiency by PSMA PET/CT Parameters.","authors":"Yan Cui, Xin Zhou, Yufei Song, Shizhen Zhai, Nan Li","doi":"10.1097/RLU.0000000000005409","DOIUrl":"10.1097/RLU.0000000000005409","url":null,"abstract":"<p><strong>Purpose: </strong>The aim of this study was to investigate the application of PSMA-RADS version 2.0 in assessment of pulmonary metastases in patients with prostate cancer and whether PSMA PET/CT parameters provide incremental value.</p><p><strong>Patients and methods: </strong>From October 2016 to July 2023, PC patients with pulmonary opacities (including pulmonary metastases, lung cancer, and pulmonary benign opacities) who underwent Al 18 F-PSMA-BCH PET/CT scans were retrospectively analyzed. CT imaging characteristics, including the longest diameter, density, smoothness, lobulation, pleural retraction, and vacuole sign, as well as PET parameters including SUV max and tumor-to-background ratio, were measured and analyzed. Additionally, the pulmonary PSMA-RADS score for each patient was determined. Independent predictors of pulmonary metastases were identified through univariate analysis and multivariate logistic regression analysis, which were utilized to construct a parallel diagnostic test. The differential diagnostic performances were evaluated using receiver operating characteristic analysis.</p><p><strong>Results: </strong>A total of 148 pulmonary opacities from 96 patients were retrospectively included. The number of pulmonary benign opacities, lung cancer, and pulmonary metastases were 48 (32.4%), 20 (13.5%), and 80 (54.1%), respectively. The number of opacities across different PSMA-RADS scores from 2 to 5 was 8 (5.4%), 88 (59.5%), 7 (4.7%), and 45 (30.4%). SUV max and smooth edges were independent predictors of pulmonary metastases (both P < 0.05), and the AUC of the parallel test for these 2 parameters was 0.86 (95% confidence interval: 0.79, 0.94; P < 0.001). Furthermore, the diagnostic accuracy of the parallel test across PSMA-RADS score from 2 to 5 was 85.7%, 79.6%, 100%, and 92.9%, respectively.</p><p><strong>Conclusions: </strong>Al 18 F-PSMA-BCH PET/CT parameters were helpful in differentiating pulmonary metastases in PC patients and provided incremental value when integrated with PSMA-RADS version 2.0.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"e566-e573"},"PeriodicalIF":9.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142079442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Catheter-Related Thrombosis With Extremely High FDG Uptake on 18 F-FDG PET.","authors":"Sho Ishikawa, Ryusuke Nakamoto, Takeshi Yamamoto, Kanae Kawai Miyake, Yuji Nakamoto","doi":"10.1097/RLU.0000000000005461","DOIUrl":"10.1097/RLU.0000000000005461","url":null,"abstract":"<p><strong>Abstract: </strong>A 38-year-old woman with exertional dyspnea and decreased ejection fraction underwent 18 F-FDG PET/CT, which showed extraordinarily high FDG uptake in a catheter-related thrombus formed along a central venous catheter. The thrombus's uptake (SUV max , 127.3) was comparable to or greater than uptake seen in the bladder's urine. This abnormal uptake was unusual for thrombi, suggesting additional factors like undiluted FDG solution stasis due to a fibrin sheath formation around the catheter and first-pass effect. A new peripheral venous route should be secured to administer FDG in case of suspected catheter-related thrombus to avoid potential complications including a pulmonary embolism.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"1053-1054"},"PeriodicalIF":9.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142343001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Challenging Case of Hyperfunctioning Submandibular Ectopic Thyroid Successfully Treated With 131 I.","authors":"Giusi Pisano, Serena Sassano, Esther Diana Rossi, Annamaria D'Amore, Luca Zagaria","doi":"10.1097/RLU.0000000000005477","DOIUrl":"10.1097/RLU.0000000000005477","url":null,"abstract":"<p><strong>Abstract: </strong>Ectopic thyroid tissue is a rare condition, caused by aberrancy during thyroid gland embryogenesis. Any pathology involving the thyroid gland can also affect the ectopic tissue, including tumorigenesis. We report a challenging case of relapsed hyperthyroidism in a woman who already underwent subtotal thyroidectomy in 1995 and surgical revision in 2020 for multinodular toxic goiter. 99m Tc-pertechnetate scan revealed an area of radiotracer focal uptake at submandibular level, posing a differential diagnosis between salivary gland tumor and ectopic thyroid. Correlation with clinical history and ultimately histopathology led to diagnosis of hyperfunctioning submandibular ectopic tissue, successfully treating the patient with 131 I.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"e601-e603"},"PeriodicalIF":9.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142371221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Variable Tracer Avidity and Interlesional Heterogeneity on 18 F-FDG, 68 Ga-DOTATATE, and 68 Ga-DOTA-FAPi-04 PET/CT Imaging in a Single Individual Patient With Progressive Metastatic Medullary Thyroid Carcinoma.","authors":"Yeshwanth Edamadaka, Rahul V Parghane, Sandip Basu","doi":"10.1097/RLU.0000000000005469","DOIUrl":"10.1097/RLU.0000000000005469","url":null,"abstract":"<p><strong>Abstract: </strong>In medullary thyroid carcinoma (MTC), distant metastases have few therapeutic options with low success rates and substantial toxicity in many patients, warranting exploration of alternate systemic treatments with fewer adverse effects. The fibroblast activation protein inhibitor (FAPI)-based PET/CT opens new avenues for several cancers, including MTC. A case of MTC with varying tracer avidity and interlesional heterogeneity on 18 F-FDG, 68 Ga-DOTATATE, and 68 Ga-DOTA-FAPI-04 PET/CT imaging is presented. 68 Ga-DOTA-FAPI-04 PET/CT exhibited superior efficacy in terms of visualization of metastatic soft tissue, lymph nodal, and skeletal lesions, with enhanced target-to-background ratio compared with the other two, facilitating the detection of these lesions, thereby demonstrating the potential for theranostic translation.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"e615-e616"},"PeriodicalIF":9.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142371226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extensive Pulmonary AL Amyloidosis Mimicking Miliary Tuberculosis: The Diagnostic Utility of 99m Tc-PYP Scintigraphy.","authors":"Dilara Denizmen, Emine Goknur Isik, Dogu Vuralli Bakkaloglu, Fikret Buyukkaya, Yasemin Sanli","doi":"10.1097/RLU.0000000000005442","DOIUrl":"10.1097/RLU.0000000000005442","url":null,"abstract":"<p><strong>Abstract: </strong>Amyloidosis is a misfolded protein deposition disorder within the extracellular matrix, leading to dysfunction in the affected organ. Primary amyloidosis manifests as AL and ATTR subtypes, wherein AL is associated with plasma cell dyscrasias. Herein we present a case of a patient who underwent investigation due to the presence of bilateral reticulonodular lung infiltrates, suggestive of miliary tuberculosis. 99m Tc-PYP scan revealed widespread radiotracer uptake in the lungs leading to diagnosis of AL amyloidosis.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"e608-e609"},"PeriodicalIF":9.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142343004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"18 F-FDG PET/CT Imaging Findings in Adult-Onset Rasmussen Encephalitis.","authors":"Zehranur Tosunoğlu, Göksel Alçın, Esra Arslan, Nurhan Ergül, Tevfik Fikret Çermik","doi":"10.1097/RLU.0000000000005437","DOIUrl":"10.1097/RLU.0000000000005437","url":null,"abstract":"<p><strong>Abstract: </strong>Rasmussen encephalitis is a rare condition characterized by chronic, progressive encephalitis. Typically, it involves one cerebral hemisphere and manifests through intractable epileptic seizures. Its occurrence in adults is notably infrequent. In this case, we presented the observations from an 18 F-FDG PET/CT scan of a 70-year-old man diagnosed with Rasmussen encephalitis, where MRI displayed nonspecific findings.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"e583-e584"},"PeriodicalIF":9.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142342988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"68 Ga-DOTA-IBA PET/CT and 18 F-FDG PET/CT in Ewing Sarcoma.","authors":"Feifan Xiang, Huipan Liu, Xiaoqi Tan, Wenzhe Ma, Yue Chen","doi":"10.1097/RLU.0000000000005402","DOIUrl":"10.1097/RLU.0000000000005402","url":null,"abstract":"<p><strong>Abstract: </strong>A 29-year-old man with Ewing sarcoma in the right ankle underwent 68 Ga-DOTA-IBA PET/CT and 18 F-FDG PET/CT, both of which showed high radiotracer activity for the primary tumor. Interestingly, bone metastases were detected early using 68 Ga-DOTA-IBA PET/CT for the sixth thoracic vertebrae and with 18 F-FDG PET/CT for the bilateral humerus. Higher uptake of 68 Ga-DOTA-IBA was found in both primary and metastatic sites of Ewing sarcoma. 177 Lu-DOTA-IBA may be one of the possible therapies for metastatic or recurrent Ewing sarcoma.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"1036-1038"},"PeriodicalIF":9.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141893091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peritoneal Actinomycosis After Bariatric Surgery Mimicking a Peritoneal Carcinomatosis on 18 F-FDG PET/CT.","authors":"Agathe Fevrier, Matthieu Bailly, Flore Delalande, Gilles Metrard","doi":"10.1097/RLU.0000000000005460","DOIUrl":"10.1097/RLU.0000000000005460","url":null,"abstract":"<p><strong>Abstract: </strong>A 54-year-old man with a history of bypass surgery 3 years ago presented with ascites, abdominal pain, and a decline in general health. CT and 18 F-FDG PET/CT suggested peritoneal carcinomatosis, but histology revealed peritoneal actinomycosis. This rare peritoneal infection can occur after digestive surgeries, such as bariatric procedures, due to disruption of the digestive barrier, allowing actinomycosis to spread outside its typical anatomical location. Clinicians should consider this diagnosis after bariatric surgery, even years later, especially in the absence of neoplastic disease.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"1025-1026"},"PeriodicalIF":9.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142343074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Imaging of Hypoxia in Liver Tumors With 18 F-FMISO PET Before Selective Internal Radiotherapy With 90 Y Microspheres.","authors":"Cigdem Soydal, Burak Demir, Ecenur Dursun, Gizem Sutcu, Emre Can Celebioglu, Mehmet Sadik Bilgic, Nuriye Ozlem Kucuk","doi":"10.1097/RLU.0000000000005323","DOIUrl":"10.1097/RLU.0000000000005323","url":null,"abstract":"<p><strong>Abstract: </strong>Hypoxia is a known cause of resistance to radiotherapy and chemotherapy. Although there are multiple studies in external radiation therapies based on hypoxia PET, the effect of hypoxia in radioembolization is largely unknown. Here we present 2 cases of hepatocellular carcinoma patients from a prospective study with different lesion characteristics on pretreatment 18 F-FMISO PET and varying responses on 18 F-FDG PET.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"e606-e607"},"PeriodicalIF":9.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141537755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Liver and Kidney Tumor Masses as the Initial Presentation of B-Cell Acute Lymphoblastic Leukemia.","authors":"Xiaoyu Liu, Jianping Zhong","doi":"10.1097/RLU.0000000000005428","DOIUrl":"10.1097/RLU.0000000000005428","url":null,"abstract":"<p><strong>Abstract: </strong>We described a 13-year-old girl who presented unexplained paroxysmal sharp pain in the right upper abdomen for 3 days. CT and MRI showed multiple masses in the liver and kidneys, initially diagnosed as lymphoma. The hepatic mass biopsy confirmed B-cell lymphoblastic lymphoma. FDG PET/CT examination found that the liver and kidney masses demonstrated high metabolic activity, with concomitant increased metabolic activity in the skeleton. Bone marrow biopsy revealed extensive skeletal involvement. The final diagnosis was B-cell acute lymphoblastic leukemia. This case highlights the effectiveness of FDG PET/CT as an adjunct imaging modality for diagnosis.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"e612-e614"},"PeriodicalIF":9.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142131994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}