Clinical Nuclear Medicine最新文献

{"title":"A Rare Case of Retroperitoneal Teratoma Mimicking Paraganglioma on Multimodality Imaging.","authors":"Yang Liu, Rui Guo, Yan Cui, Yitong Liu, Nan Li","doi":"10.1097/RLU.0000000000006064","DOIUrl":"https://doi.org/10.1097/RLU.0000000000006064","url":null,"abstract":"<p><p>A 28-year-old woman incidentally palpated an asymptomatic abdominal mass. Contrast-enhanced MRI revealed a retroperitoneal mass with arterial phase hyperenhancement and mild delayed-phase washout, raising suspicion for paraganglioma. 18F-FDG PET/CT showed a soft tissue mass with mild and heterogeneous 18F-FDG uptake, while 68Ga-DOTATATE PET/CT revealed intense uptake, further supporting the presumptive diagnosis of paraganglioma. However, postoperative pathology confirmed a teratoma containing thyroid tissue with positive somatostatin receptor (SSTR) 2 and SSTR 5 expression, which may explain the false-positive uptake on 68Ga-DOTATATE. This case may provide a critical differential diagnostic consideration in retroperitoneal masses with high 68Ga-DOTATATE uptake.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144706610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"18F-FDG PET/CT Findings in a Patient With Primary Intraosseous Meningiomas Involving the Ilium and Sacrum.","authors":"Tingting Yuan, Xueqi Chen, Qian Li, Zhanli Fu","doi":"10.1097/RLU.0000000000006071","DOIUrl":"https://doi.org/10.1097/RLU.0000000000006071","url":null,"abstract":"<p><p>A 21-year-old woman presented with left iliac pain for 1 week. Pelvic radiograph and MRI revealed a large osteolytic lesion involving the left ilium and sacrum. PET/CT showed the lesion having a heterogeneous rim 18F-FDG avidity with a photopenic center. No additional abnormalities were detected on the body and brain PET/CT scans. The subsequent operative pathology confirmed the diagnosis of intraosseous meningiomas.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144706609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increased 68Ga-FAPI Uptake of Nasal Polyp in a Patient With Lung Cancer.","authors":"Yueqi Zhao, Xinyue Guo, Min Tan, Tingting Xu, Yue Chen","doi":"10.1097/RLU.0000000000006068","DOIUrl":"https://doi.org/10.1097/RLU.0000000000006068","url":null,"abstract":"<p><p>68Ga-FAPI is a promising PET agent for tumor imaging. However, some nonneoplastic lesions can also show increased FAPI uptake. We present a case of a patient with left lung squamous cell carcinoma and right clavicle metastasis who showed a nodule in the right nasal cavity with increased tracer uptake on 68Ga-FAPI PET/CT. Final histopathology confirmed it as a polyp in the right nasal cavity.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144674044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential Pitfall: Positive Follicular Lymphoma on [68Ga]-PSMA-11 PET/CT for Prostate Cancer Staging.","authors":"Yaniss Heniche, Gad Abikhzer, Victor McPherson","doi":"10.1097/RLU.0000000000006062","DOIUrl":"https://doi.org/10.1097/RLU.0000000000006062","url":null,"abstract":"<p><p>Prostate-specific membrane antigen (PSMA)-targeted PET agents are a mainstay in staging high-risk prostate cancer. Nevertheless, PSMA expression is not exclusive to prostate cancer and is present in various neoplasms and inflammatory conditions. We report a case of biopsy-proven follicular lymphoma positive on PSMA PET/CT originally performed for staging of prostate cancer in a 66-year-old patient. This case highlights the potential pitfall of lymphoma mimicking prostate cancer nodal metastasis on PSMA PET/CT and the importance of careful evaluation of distribution and uptake of lymph nodes when assessing PSMA PET/CT studies to distinguish lymphoma from prostate cancer metastases.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144689138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidental Finding of PSMA-avid Pulmonary Sclerosing Pneumocytoma on 68Ga PSMA PET-CT.","authors":"Mürsel Daşar, Hayat Eroğlu Elden, Aylin Akbulut, Onur Ertunç, Gökhan Koca","doi":"10.1097/RLU.0000000000006069","DOIUrl":"https://doi.org/10.1097/RLU.0000000000006069","url":null,"abstract":"<p><p>Primary pulmonary sclerosing pneumocytoma (PsP) is an unusual benign pulmonary tumor with low malignant potential. Clinical presentation may sometimes imitate more serious conditions. We described a case of newly diagnosed prostate cancer with a PSMA-avid, well-circumscribed lesion in the right lung in 68Ga PSMA PET-CT, initially mimicking a metastatic lesion. Following histopathologic examination, the case was confirmed as a rare pulmonary tumor, PsP. We declare the first reported case in the literature demonstrating PSMA expression in PsP.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144689137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Evaluation of 68Ga-FAPI-04 PET/CT and 18F-FDG-PET/CT in Primary Staging of Treatment-naïve Anterior Mediastinal Seminoma.","authors":"Saiteja Reddy Mallu, Keerti Sitani, Sandip Basu","doi":"10.1097/RLU.0000000000006072","DOIUrl":"https://doi.org/10.1097/RLU.0000000000006072","url":null,"abstract":"<p><p>A comparative evaluation using both 18F-FDG-PET/CT and 68Ga-FAPI-04 PET/CT in primary staging of a treatment-naïve anterior mediastinal seminoma is illustrated in this report. A 30-year-old man presented with elevated human chorionic gonadotropin levels and biopsy-proven seminoma of the anterior mediastinum. The investigation was performed for primary staging, considering that both tracers may show uptake in the germ cell tumors in the anterior mediastinum, and the potential role of 68Ga-FAPI-04 PET/CT in treatment-naïve mediastinal seminoma would be examined. The germ cell tumors comprise 1%-4% of mediastinal tumors, and seminomas are less frequent than non-seminomatous tumors.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144689136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative Lymphoscintigraphy SPECT/CT Parameters in the Assessment of Upper Extremity Lymphedema.","authors":"Yong Jae Na, Yookyung Lee, Beom Suk Kim, Ju Won Seok, Reeree Lee","doi":"10.1097/RLU.0000000000006043","DOIUrl":"https://doi.org/10.1097/RLU.0000000000006043","url":null,"abstract":"<p><strong>Purpose: </strong>Lymphedema is a chronic disorder of the lymphatic system. This study evaluated quantitative lymphoscintigraphy SPECT/CT parameters for assessing lymphatic function in patients with unilateral upper extremity lymphedema and examined their relationship with clinical outcomes.</p><p><strong>Patients and methods: </strong>Twenty-two patients with unilateral upper extremity lymphedema underwent quantitative lymphoscintigraphy SPECT/CT. Maximum lymphatic activity (MLA) and total lymphatic accumulation (TLA) were measured in both the affected and the unaffected limbs. Limb circumference measurements were obtained at baseline and 1-month follow-up to calculate the relative volume increase (%RVI) and reduction of %RVI (%RRVI). Differences in SPECT/CT-derived parameters between the affected and the unaffected limbs were analyzed, and their correlations with clinical outcomes were evaluated.</p><p><strong>Results: </strong>MLA (P=0.0289) and TLA (P<0.001) were significantly lower in the affected limbs compared with the unaffected limbs. MLA (ρ=0.58, P=0.011), MLA ratio (ρ=0.6, P=0.0077), and TLA ratio (ρ=0.59, P=0.0091) in the affected limbs showed significant positive correlations with %RRVI. Patients with improved lymphedema exhibited significantly higher MLA (P=0.016), MLA ratio (P=0.003), and TLA ratio (P=0.003) in the affected limb compared with those with persistent lymphedema.</p><p><strong>Conclusions: </strong>Quantitative lymphoscintigraphy SPECT/CT parameters showed significant differences between the affected and the unaffected limbs and demonstrated a meaningful association with treatment response. These parameters may facilitate early detection of lymphatic dysfunction and prediction of therapeutic outcomes, potentially contributing to improved clinical management.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144658622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Solitary Scapular Metastasis as the Initial Presentation of Prostate Adenocarcinoma Detected by Ga-68 PSMA PET/CT.","authors":"Muhammet Halil Baltacioglu","doi":"10.1097/RLU.0000000000005983","DOIUrl":"https://doi.org/10.1097/RLU.0000000000005983","url":null,"abstract":"<p><p>Prostate cancer commonly metastasizes to the skeleton, with multiple bones typically affected. Solitary metastasis in the appendicular skeleton, particularly in the scapula, is exceedingly rare. We present the case of a 75-year-old man with prostate adenocarcinoma, who initially presented with scapular bone metastasis detected using Ga-68 PSMA PET/CT. Imaging revealed intense uptake in a sclerotic lesion in the left scapula, suggesting a solitary metastasis.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144658623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Dopamine Transporter Activity in the Striatum on 18F-FP-CIT PET and Overall Survival of Patients With Parkinsonism.","authors":"Yeongjoo Lee, Tae-Kyu Lee, Yoon-Sang Oh, Eun Ji Han, Sae Jung Na","doi":"10.1097/RLU.0000000000006033","DOIUrl":"https://doi.org/10.1097/RLU.0000000000006033","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate whether the overall survival (OS) of patients with parkinsonism is associated with dopamine transporter activity in the striatum measured by 18F-N-(3-fluoropropyl)-2β-carbon ethoxy-3β-(4-iodophenyl) nortropane positron emission tomography (18F-FP-CIT PET).</p><p><strong>Methods: </strong>From March 2021 to December 2021, 18F-FP-CIT PET images from patients with Parkinsonism were retrospectively reviewed. Dopamine transporter activity in each striatal region was automatically measured as striatal binding ratio (BR) from PET DICOM files using AI-based quantification (BTXBrain, v1.1.1). Mortality data were obtained from the National Health Insurance system in South Korea. Independent t test was performed to compare regional BRs between nonsurvivor and survivor groups. OS was then compared between low BR and high BR groups for each brain region using Kaplan-Meier curves and the log-rank test. Both univariate and multivariate Cox regression analyses were conducted to calculate hazard ratios (HRs).</p><p><strong>Results: </strong>The final cohort comprised 125 patients (mean age: 73.1 ± 9.4 y) with a median follow-up period of 37 months (range: 31-41 mo). Twenty-six (20.8%) patients died during the follow-up period. Nonsurvivors showed significantly lower BRs in the dorsal striatum (p=0.03), caudates (p≤ 0.001), ventroanterior putamen (p=0.029), anterior pallidum (p=0.030), ventral striatum (p=0.002), and subthalamic nucleus (p=0.032). Patients with low caudate BR (≤1.63) demonstrated poorer OS than those with high caudate BR (>1.63) (HR: 5.48, 95% CI: 1.27-23.59, p<0.001). In multivariate analysis, old age (HR: 3.136; 95% CI: 1.356-7.251; p=0.008) and low caudate BR (HR: 5.360; 95% CI: 2.310-12.438; p<0.001) were significantly associated with higher mortality.</p><p><strong>Conclusions: </strong>In FP-CIT PET of patients with parkinsonism, the binding ratio of the caudate nucleus rather than that of the putamen can serve as a significant prognostic indicator for overall survival. Dopamine transporter activity of the caudate should receive more attention from a prognostic perspective, both in quantified data and visual analysis.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144658620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidental Discovery of Synchronous Ileal Neuroendocrine Tumors at Fluorodopa PET/CT in a Patient With Bilateral Pheochromocytoma.","authors":"Clément Drouet, Arthur Darras, Elodie Crevisy, Mathilde Funes de la Vega","doi":"10.1097/RLU.0000000000006057","DOIUrl":"https://doi.org/10.1097/RLU.0000000000006057","url":null,"abstract":"<p><p>Pheochromocytomas are tumors originating from neuroendocrine cells in the adrenal medulla, with an incidence of 0.05%. They are most often unilateral (92% of cases) and implicated in ~0.1% of hypertension cases. About 30% of pheochromocytomas are associated with hereditary syndromes such as MEN2, VHL, and NF1. When bilateral, a genetic disease is identified in 80% of patients. While coexistence of pheochromocytoma with pancreatic NETs has been described in Von Hippel-Lindau disease, coexistence of pheochromocytoma with duodenal, jejunal, or ileal NET is very rare: about 20 cases were reported in the literature, synchronous or metachronous, often associated with neurofibromatosis. We describe the case of a 58-year-old patient with a previously unremarkable history, referred to fluorodopa PET/CT for staging of a bilateral pheochromocytoma discovered in front of a typical clinical triad, who was incidentally diagnosed with 2 synchronous neuroendocrine tumors of the small bowel.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144636466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}