Diagnostic Performances of Radiolabeled FAPI PET/CT for Lymph Node Staging in Head and Neck Cancer Patients: Comparison With 18F-FDG PET/CT.

IF 9.6 3区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Clinical Nuclear Medicine Pub Date : 2025-05-14 DOI:10.1097/RLU.0000000000005973

Yun Seong Kim, Seong-Jang Kim

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引用次数: 0

Abstract

Objective: The purpose of the current study was to compare the diagnostic performances of radiolabeled FAPI and 18F-FDG PET/CT for the detection of lymph node (LN) metastasis in head and neck cancer (HNC) patients.

Methods: The PubMed, Cochrane database, and EMBASE database, from the earliest available date of indexing through December 31, 2024, were searched for studies comparing diagnostic performances of radiolabeled FAPI and 18F-FDG PET/CT for the detection of metastatic LN in HNC patients. We estimated pooled sensitivities and specificities across studies.

Results: Across 8 studies (14 results), the pooled sensitivity of FAPI PET/CT was 0.89 and the pooled specificity was 0.93. The pooled sensitivity of 18F-FDG PET/CT was 0.91 and the pooled specificity was 0.50. On patient-based analysis, the estimated sensitivity and specificity of FAPI were 0.96 and 0.96, and those of 18F-FDG were 0.95 and 0.34, respectively. On lesion-based analysis, the estimated sensitivity and specificity of FAPI were 0.84 and 0.94, and those of 18F-FDG were 0.86 and 0.78, respectively. On neck side-based analysis, the estimated sensitivity and specificity of FAPI were 0.88 and 0.79, and those of 18F-FDG were 0.91 and 0.29, respectively.

Conclusions: Radiolabeled FAPI showed a good diagnostic performance for the detection of metastatic LN in HNC patients. Also, 18F-FDG PET/CT revealed low specificity for LN staging in HNC patients. Future large multicenter research with more patients would be necessary to provide a more comprehensive overview of the usefulness of radiolabeled FAPI for LN staging in HNC patients.

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放射标记FAPI PET/CT对头颈部肿瘤患者淋巴结分期的诊断价值：与18F-FDG PET/CT的比较

目的：比较放射性标记FAPI与18F-FDG PET/CT对头颈癌（HNC）患者淋巴结（LN）转移的诊断价值。方法：检索PubMed、Cochrane数据库和EMBASE数据库，从最早可检索日期到2024年12月31日，检索比较放射性标记FAPI和18F-FDG PET/CT在HNC患者转移性LN检测中的诊断性能的研究。我们估计了所有研究的敏感性和特异性。结果：在8项研究（14项结果）中，FAPI PET/CT的合并敏感性为0.89，合并特异性为0.93。18F-FDG PET/CT的综合敏感性为0.91，综合特异性为0.50。在基于患者的分析中，FAPI的估计敏感性和特异性分别为0.96和0.96,18F-FDG的估计敏感性和特异性分别为0.95和0.34。在基于病变的分析中，FAPI的敏感性和特异性分别为0.84和0.94,18F-FDG的敏感性和特异性分别为0.86和0.78。在颈侧分析中，FAPI的敏感性和特异性分别为0.88和0.79,18F-FDG的敏感性和特异性分别为0.91和0.29。结论：放射标记FAPI对HNC患者转移性LN有较好的诊断价值。此外，18F-FDG PET/CT显示HNC患者LN分期的特异性较低。未来有必要进行更多患者参与的大型多中心研究，以更全面地了解放射性标记FAPI对HNC患者LN分期的有用性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Nuclear Medicine 医学-核医学

CiteScore

2.90

自引率

31.10%

发文量

1113

审稿时长

2 months

期刊介绍： Clinical Nuclear Medicine is a comprehensive and current resource for professionals in the field of nuclear medicine. It caters to both generalists and specialists, offering valuable insights on how to effectively apply nuclear medicine techniques in various clinical scenarios. With a focus on timely dissemination of information, this journal covers the latest developments that impact all aspects of the specialty. Geared towards practitioners, Clinical Nuclear Medicine is the ultimate practice-oriented publication in the field of nuclear imaging. Its informative articles are complemented by numerous illustrations that demonstrate how physicians can seamlessly integrate the knowledge gained into their everyday practice.