Clinical Nuclear MedicinePub Date : 2025-10-01Epub Date: 2025-04-18DOI: 10.1097/RLU.0000000000005901
Rami Chatta, Hina Shah, Saurabh Pallod
{"title":"PSMA PET/CT in Detecting Esophageal Cancer and Hepatocellular Carcinoma. A Report of Two Cases.","authors":"Rami Chatta, Hina Shah, Saurabh Pallod","doi":"10.1097/RLU.0000000000005901","DOIUrl":"10.1097/RLU.0000000000005901","url":null,"abstract":"<p><p>Prostate-specific membrane antigen (PSMA) PET/CT has improved the diagnosis, staging, and detection of recurrent and metastatic prostate cancer. Nevertheless, PSMA uptake has also been observed in non-prostatic conditions, which underscores the need to explore its broader applications and refine our understanding of its specificity in diverse clinical contexts. In cases of uptake in atypical locations, further workup is warranted to avoid premature conclusions of metastatic prostate disease. We report two cases of PSMA PET uptake: the first involves esophageal cancer, and the second details two synchronous malignancies-hepatocellular and esophageal cancer.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"963-965"},"PeriodicalIF":9.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143984288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Lymphoscintigraphy for Peri-Anal Squamous Cell Carcinoma: A Case Report of an Atypical Location for Sentinel Lymph Node.","authors":"Faeze Rabani, Amin Saber Tanha, Nasrin Raeisi, Azadeh Jabbari Noghabi, Ramin Sadeghi","doi":"10.1097/RLU.0000000000005749","DOIUrl":"10.1097/RLU.0000000000005749","url":null,"abstract":"<p><p>This case report describes a 41-year-old man with a progressively enlarging, painful vegetative lesion in the perianal region, ultimately diagnosed as squamous cell carcinoma (SCC), through a punch biopsy. Sentinel lymph node (SLN) mapping was performed via preoperative lymphoscintigraphy utilizing 99m Tc-Phytate. Notably, an SLN was identified in an atypical location, below the anterior superior iliac spine (ASIS) in the subcutaneous tissue, diverging from typical drainage patterns associated with perianal SCC. Surgical excision of the SLNs revealed no evidence of tumoral involvement. This case underscores the importance of personalized assessment with preoperative lymphoscintigraphy in atypical lymphatic drainage patterns for effective staging and treatment of malignancies such as peri-anal SCC.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"e593-e595"},"PeriodicalIF":9.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143566090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Clinical Nuclear MedicinePub Date : 2025-10-01Epub Date: 2025-06-06DOI: 10.1097/RLU.0000000000005775
Julie Lippens, Fleur Cordier, Willem Daneels, Eva Genbrugge, Bliede Van den Broeck, Donatienne Van Weehaeghe
{"title":"Case Report: Collision Tumor Involving Diffuse Large B-Cell Lymphoma (DLBCL) and Meningioma.","authors":"Julie Lippens, Fleur Cordier, Willem Daneels, Eva Genbrugge, Bliede Van den Broeck, Donatienne Van Weehaeghe","doi":"10.1097/RLU.0000000000005775","DOIUrl":"10.1097/RLU.0000000000005775","url":null,"abstract":"<p><p>We report on a 73-year-old man, initially diagnosed with testicular stage IE DLBCL and an incidental finding of an extra-axial right frontal mass with MRI features of a convexity meningioma. The DLCBL relapsed <2 years after treatment, with multiple lymphoma localizations and increased uptake in the grown extra-axial meningeal mass on 18 F-FDG PET-CT. CD19-CAR-T therapy induced a complete metabolic response with the exception of the frontal mass. Surgical resection revealed a collision tumor involving DLBCL and meningothelial meningioma. Collision tumors-2 histologically different neoplasms that occupy the same anatomic location-are uncommon, especially those occurring in the central nervous system.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"e599-e601"},"PeriodicalIF":9.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144233437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Clinical Nuclear MedicinePub Date : 2025-10-01Epub Date: 2025-06-11DOI: 10.1097/RLU.0000000000005976
Weidong Gong, Ling Yang, Lan Luo, Jianqiang Wang, Fan Zhou
{"title":"A Case of Primary Central Nervous System T-cell Lymphoma of the Spinal Cord Detected by 18 F-FDG PET/CT.","authors":"Weidong Gong, Ling Yang, Lan Luo, Jianqiang Wang, Fan Zhou","doi":"10.1097/RLU.0000000000005976","DOIUrl":"10.1097/RLU.0000000000005976","url":null,"abstract":"<p><p>Primary central nervous system T-cell lymphoma (PCNSTL) is a relatively rare type of extranodal non-Hodgkin lymphoma. It is extremely rare in patients with primary spinal cord involvement. We present 18 F-FDG PET/CT findings of primary central nervous system T-cell lymphoma of the spinal cord in a 46-year-old man. 18 F-FDG PET/CT showed multiple FDG-avid foci in the spinal cord and right adrenal gland. Pathological examination after T12 vertebral spinal cord surgery confirmed the diagnosis of primary central nervous system T-cell lymphoma.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"938-940"},"PeriodicalIF":9.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144265536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Clinical Nuclear MedicinePub Date : 2025-10-01Epub Date: 2025-07-30DOI: 10.1097/RLU.0000000000006073
Siqi Li, Han Wang, Jun Liu, Yuxuan Liu, Yanfeng Xu, Xiaorong Sun, Jigang Yang
{"title":"The Role of 18 F-AlF-NOTA-Octreotide PET/CT in the Evaluation of Central Nervous System Metastases in Neuroblastoma : A Preliminary Study.","authors":"Siqi Li, Han Wang, Jun Liu, Yuxuan Liu, Yanfeng Xu, Xiaorong Sun, Jigang Yang","doi":"10.1097/RLU.0000000000006073","DOIUrl":"10.1097/RLU.0000000000006073","url":null,"abstract":"<p><strong>Purpose: </strong>To assess the role of fluorine-18-Al-1,4,7-triazacyclononane-1,4,7-tri-acetate-octreotide ( 18 F-AlF-NOTA-octreotide) PET/CT in detecting central nervous system (CNS) metastases in neuroblastoma (NB).</p><p><strong>Methods: </strong>A retrospective analysis was carried out on 707 18 F-AlF-NOTA-octreotide PET/CT examinations that were performed between January 2021 and July 2024. Reports were screened to identify patients with CNS metastases. Imaging data were then individually reviewed to confirm the presence of 18 F-AlF-NOTA-octreotide-avid lesions. CNS metastatic characteristics, including anatomic site (cerebral parenchyma, leptomeninges, and dura mater), lesion number, and maximum diameter, were systematically documented.</p><p><strong>Results: </strong>A total of 20 children (18 boys and 2 girls; median age, 59 mo) diagnosed with CNS metastases from NB were included. Among them, 5 patients presented with isolated recurrence and 14 patients exhibited asymptomatic disease at the time of detection. A total of 43 CNS metastatic lesions were detected: 22 in the leptomeninges, 13 in the dura mater, and 8 in the cerebral parenchyma. Lesions had a median maximum diameter of 10 mm (interquartile range: 7-13 mm; range: 4-55 mm), with 65% (28/43) measuring ≤10 mm. The overall sensitivity for lesion detection was 93.5%, with 90.3% sensitivity for small lesions (≤10 mm).</p><p><strong>Conclusions: </strong>18 F-AlF-NOTA-octreotide PET/CT demonstrates exceptional diagnostic sensitivity for detecting CNS metastases in NB, serving as a valuable complementary imaging modality.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"927-932"},"PeriodicalIF":9.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144741387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Clinical Nuclear MedicinePub Date : 2025-10-01Epub Date: 2025-03-07DOI: 10.1097/RLU.0000000000005782
Elisabetta Perrone, Kriti Ghai, Aleksandr Eismant, Richard P Baum
{"title":"TANDEM Peptide Receptor Radionuclide Therapy Using [ 225 Ac]Ac-/[ 177 Lu]Lu-DOTA-LM3 in a Patient With Parotid Gland Metastasis From Pancreatic Neuroendocrine Neoplasm.","authors":"Elisabetta Perrone, Kriti Ghai, Aleksandr Eismant, Richard P Baum","doi":"10.1097/RLU.0000000000005782","DOIUrl":"10.1097/RLU.0000000000005782","url":null,"abstract":"<p><p>We present the case of a young 38-year-old woman with metastatic progressive pancreatic neuroendocrine neoplasm (NEN) exhibiting an unusual metastasis to the parotid gland. After previous treatments, including radionuclide therapy with the somatostatin-receptor agonist DOTATOC and parotid metastasectomy, failed, she was referred to TANDEM peptide receptor radionuclide therapy (PRRT) using the somatostatin-receptor antagonist DOTA-LM3 labeled with Actinium-225 and Lutetium-177. Following 2 cycles of TANDEM-PRRT, she achieved partial remission in all metastatic sites, notably in the parotid gland and liver. This is the first reported case of metastatic pancreatic NEN with parotid involvement treated with TANDEM-PRRT.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"e605-e607"},"PeriodicalIF":9.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143572277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Clinical Nuclear MedicinePub Date : 2025-10-01Epub Date: 2025-03-11DOI: 10.1097/RLU.0000000000005837
Ziang Zhou, Siqi Li, Jun Liu, Jigang Yang
{"title":"Positive 18 F-FDG PET/CT and Negative 123 I-MIBG SPECT/CT Imaging in an Unusual Diaphragmatic Metastasis From Ganglioneuroblastoma.","authors":"Ziang Zhou, Siqi Li, Jun Liu, Jigang Yang","doi":"10.1097/RLU.0000000000005837","DOIUrl":"10.1097/RLU.0000000000005837","url":null,"abstract":"<p><p>A 7-year-old boy underwent 18 F-FDG PET/CT in the evaluation of a retroperitoneal mass. The examination revealed significant FDG accumulation in the right adrenal region and retroperitoneal lymph nodes, as well as mild FDG uptake in a diaphragmatic lesion. Histopathological analysis of the right adrenal mass was consistent with ganglioneuroblastoma. Three months later, 123 I-MIBG scintigraphy was conducted, which did not demonstrate abnormal MIBG accumulation in the diaphragmatic lesion. Histopathological examination of the diaphragmatic lesion confirmed metastatic involvement.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"966-968"},"PeriodicalIF":9.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Clinical Nuclear MedicinePub Date : 2025-10-01Epub Date: 2025-04-18DOI: 10.1097/RLU.0000000000005917
V Habouzit, F Casteillo, H Boutallaka, O Perotto, R Grange
{"title":"Macrophagic Reaction to Sodium Polystyrene Sulfonate Crystals Mimicking Peritoneal Carcinomatosis on 18 F-FDG PET/CT in Rectal Cancer.","authors":"V Habouzit, F Casteillo, H Boutallaka, O Perotto, R Grange","doi":"10.1097/RLU.0000000000005917","DOIUrl":"10.1097/RLU.0000000000005917","url":null,"abstract":"<p><p>A 68-year-old man presented with rectal bleeding 1 year after a highly complicated surgical course for upper rectal cancer. Endoscopic biopsy confirmed a local recurrence at the rectal stump. 18 F-FDG PET/CT showed intense uptake in peritoneal nodules, suggesting peritoneal carcinomatosis. However, exploratory laparoscopy and pathologic analysis identified basophilic crystals consistent with sodium polystyrene sulfonate (Kayexalate) as the cause of a foreign-body granulomatous reaction, with no evidence of tumor recurrence. This case underscores the importance of considering rare causes of peritoneal false-positive PET/CT findings in patients with a history of severe abdominal complications, ensuring accurate diagnosis and appropriate management.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"933-935"},"PeriodicalIF":9.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143978326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Clinical Nuclear MedicinePub Date : 2025-10-01Epub Date: 2025-05-20DOI: 10.1097/RLU.0000000000005718
Ya Liu, Kan Wang, Jingguang Pu, Haoyuan Ding, Zhanwen Huang
{"title":"Pitfall in 68 Ga-PSMA PET/CT Interpretation : 68 Ga-PSMA Excreted Through the Biliary System.","authors":"Ya Liu, Kan Wang, Jingguang Pu, Haoyuan Ding, Zhanwen Huang","doi":"10.1097/RLU.0000000000005718","DOIUrl":"10.1097/RLU.0000000000005718","url":null,"abstract":"<p><p>68 Ga-Prostate-Specific Membrane Antigen (PSMA) is excreted mainly through the urinary system, but also partly through biliary system. Herein, we present such a case in a man with prostate cancer. The 68 Ga-PSMA PET/CT revealed increased uptake of 68 Ga-PSMA in bone metastases. Besides, increased 68 Ga-PSMA uptake in the common hepatic duct and common bile duct was observed, which resolved spontaneously in the delayed imaging.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"949-950"},"PeriodicalIF":9.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144110006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Clinical Nuclear MedicinePub Date : 2025-10-01Epub Date: 2025-06-30DOI: 10.1097/RLU.0000000000005937
Marina Suárez-Piñera, Josep Castell-Aulet, Nuria Ruiz-Roig, Laura Rodriguez-Bel, Fernándo Guerrero-Pérez
{"title":"68 Ga- DOTATOC PET/CT, 18 F-FDOPA, and 18 F-FDG PET/MR Findings in Growth Hormone-secreting Pituitary Adenoma.","authors":"Marina Suárez-Piñera, Josep Castell-Aulet, Nuria Ruiz-Roig, Laura Rodriguez-Bel, Fernándo Guerrero-Pérez","doi":"10.1097/RLU.0000000000005937","DOIUrl":"10.1097/RLU.0000000000005937","url":null,"abstract":"<p><p>Acromegaly is a rare disease frequently caused by a growth hormone-secreting pituitary adenoma (GHPA), and neuroimaging plays an important role in tumor localization, characterization, and surgical planning. A 57-year-old man underwent 68 Ga-DOTATOC PET/CT for an incidental pancreatic lesion. The PET revealed an increased radiotracer uptake and enlargement of the pituitary gland. The study was completed with 18 F-FDOPA and 18 F-FDG PET/MRI, which revealed a sellar lesion suggesting pituitary adenoma. Pathological examination of the resected tumor confirmed a GHPA.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"e614-e616"},"PeriodicalIF":9.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144526675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}