The Role of 18 F-AlF-NOTA-Octreotide PET/CT in the Evaluation of Central Nervous System Metastases in Neuroblastoma : A Preliminary Study.

IF 9.6 3区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Clinical Nuclear Medicine Pub Date : 2025-10-01 Epub Date: 2025-07-30 DOI:10.1097/RLU.0000000000006073

Siqi Li, Han Wang, Jun Liu, Yuxuan Liu, Yanfeng Xu, Xiaorong Sun, Jigang Yang

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引用次数: 0

Abstract

Purpose: To assess the role of fluorine-18-Al-1,4,7-triazacyclononane-1,4,7-tri-acetate-octreotide ( 18 F-AlF-NOTA-octreotide) PET/CT in detecting central nervous system (CNS) metastases in neuroblastoma (NB).

Methods: A retrospective analysis was carried out on 707 18 F-AlF-NOTA-octreotide PET/CT examinations that were performed between January 2021 and July 2024. Reports were screened to identify patients with CNS metastases. Imaging data were then individually reviewed to confirm the presence of 18 F-AlF-NOTA-octreotide-avid lesions. CNS metastatic characteristics, including anatomic site (cerebral parenchyma, leptomeninges, and dura mater), lesion number, and maximum diameter, were systematically documented.

Results: A total of 20 children (18 boys and 2 girls; median age, 59 mo) diagnosed with CNS metastases from NB were included. Among them, 5 patients presented with isolated recurrence and 14 patients exhibited asymptomatic disease at the time of detection. A total of 43 CNS metastatic lesions were detected: 22 in the leptomeninges, 13 in the dura mater, and 8 in the cerebral parenchyma. Lesions had a median maximum diameter of 10 mm (interquartile range: 7-13 mm; range: 4-55 mm), with 65% (28/43) measuring ≤10 mm. The overall sensitivity for lesion detection was 93.5%, with 90.3% sensitivity for small lesions (≤10 mm).

Conclusions: 18 F-AlF-NOTA-octreotide PET/CT demonstrates exceptional diagnostic sensitivity for detecting CNS metastases in NB, serving as a valuable complementary imaging modality.

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18F-AlF-NOTA-Octreotide PET/CT在神经母细胞瘤中枢神经系统转移评估中的作用：初步研究。

目的：探讨氟-18- al -1,4,7-三氮杂环壬烷-1,4,7-三乙酸酯-奥曲肽（18F-AlF-NOTA-octreotide） PET/CT检测神经母细胞瘤（NB）中枢神经系统转移的作用。方法：回顾性分析2021年1月至2024年7月707例18f - alf - nota -奥曲肽PET/CT检查结果。对报告进行筛选以确定中枢神经系统转移患者。然后单独检查影像学资料以确认存在18f - alf - nota -奥曲肽强烈病变。系统记录中枢神经系统转移特征，包括解剖部位（脑实质、脑膜和硬脑膜）、病变数量和最大直径。结果：共20例患儿(男18例，女2例；中位年龄59岁)诊断为NB的中枢神经系统转移。其中5例患者出现孤立性复发，14例患者在检测时无症状。共检出43例中枢神经系统转移灶：轻脑膜22例，硬脑膜13例，脑实质8例。病变的中位最大直径为10毫米(四分位数范围：7-13毫米；范围：4- 55mm), 65%（28/43）测量≤10mm。病变检测的总灵敏度为93.5%，对小病变（≤10 mm）的灵敏度为90.3%。结论：18F-AlF-NOTA-octreotide PET/CT在检测NB的中枢神经系统转移方面表现出卓越的诊断敏感性，可作为一种有价值的补充成像方式。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Nuclear Medicine 医学-核医学

CiteScore

2.90

自引率

31.10%

发文量

1113

审稿时长

2 months

期刊介绍： Clinical Nuclear Medicine is a comprehensive and current resource for professionals in the field of nuclear medicine. It caters to both generalists and specialists, offering valuable insights on how to effectively apply nuclear medicine techniques in various clinical scenarios. With a focus on timely dissemination of information, this journal covers the latest developments that impact all aspects of the specialty. Geared towards practitioners, Clinical Nuclear Medicine is the ultimate practice-oriented publication in the field of nuclear imaging. Its informative articles are complemented by numerous illustrations that demonstrate how physicians can seamlessly integrate the knowledge gained into their everyday practice.