Clinical Nuclear Medicine最新文献

{"title":"Positive 18F-FDG PET/CT and Negative 123I-MIBG SPECT/CT Imaging in an Unusual Diaphragmatic Metastasis From Ganglioneuroblastoma.","authors":"Ziang Zhou, Siqi Li, Jun Liu, Jigang Yang","doi":"10.1097/RLU.0000000000005837","DOIUrl":"https://doi.org/10.1097/RLU.0000000000005837","url":null,"abstract":"<p><p>A 7-year-old boy underwent 18F-FDG PET/CT in the evaluation of a retroperitoneal mass. The examination revealed significant FDG accumulation in the right adrenal region and retroperitoneal lymph nodes, as well as mild FDG uptake in a diaphragmatic lesion. Histopathological analysis of the right adrenal mass was consistent with ganglioneuroblastoma. Three months later, 123I-MIBG scintigraphy was conducted, which did not demonstrate abnormal MIBG accumulation in the diaphragmatic lesion. Histopathological examination of the diaphragmatic lesion confirmed metastatic involvement.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"First Clinical Application of 99mTc-FAPI-46 as an Available Radiotracer to Evaluate the Cardiac Remodeling Process: A Case Report.","authors":"Nasrin Raeisi, Amin Saber Tanha, Kamran Aryana, Sadegh Nazif, Somaye Barashki","doi":"10.1097/RLU.0000000000005821","DOIUrl":"https://doi.org/10.1097/RLU.0000000000005821","url":null,"abstract":"<p><p>We present a 67-year-old woman with a history of coronary artery bypass graft surgery, who experienced recent chest pain. Myocardial perfusion imaging and 99mTc-FAPI-46 SPECT were performed to assess myocardial infarction. The dynamic FAPI imaging indicated sustained myocardial activity. Myocardial perfusion imaging identified extensive myocardial infarction and ischemia, while FAPI uptake slightly overestimated the infarct extension. Coronary angiography correlated well with these findings. FAPI PET/CT is increasingly being used to monitor cardiac remodeling. This pioneering experience with 99mTc-FAPI-46 showcases comparable results to PET/CT, providing valuable insights into cardiac remodeling processes and highlighting the potential of 99mTc-FAPI-46 in cardiac imaging.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mixed Adenoneuroendocrine Carcinoma of the Common Bile Duct With Solitary Lymph Node Metastasis Revealed on 18F-FDG PET/CT.","authors":"Huan Liang, Minghao Gao, Guoxing Zhao, Lingge Wei, Peng Xie","doi":"10.1097/RLU.0000000000005776","DOIUrl":"https://doi.org/10.1097/RLU.0000000000005776","url":null,"abstract":"<p><p>Mixed adenoneuroendocrine carcinoma of the common bile duct is extremely rare. A 72-year-old man presented with jaundice for 1 week. 18F-FDG PET/CT showed intense 18F-FDG uptake in the common bile duct and adjacent lymph node. Finally, postoperative pathology confirmed the diagnosis of mixed adenoneuroendocrine carcinoma of the common bile duct with solitary lymph node metastasis.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143584636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary Renal Neuroendocrine Tumor Demonstrated on 68Ga-FAPI-04 PET/CT and 18F-FDG PET/CT.","authors":"Liu Xiao, Li Li, Yan Zhou, Shulei Pan, Wenjie Zhang","doi":"10.1097/RLU.0000000000005823","DOIUrl":"https://doi.org/10.1097/RLU.0000000000005823","url":null,"abstract":"<p><p>Primary renal neuroendocrine tumors are very rare. Herein, we report a case of imaging findings of a renal neuroendocrine tumor in a 36-year-old man. On 68Ga-FAPI-04 PET/CT and 18F-FDG PET/CT, it presented as a renal soft tissue mass with intense FAPI uptake (SUVmax: 20.8) but lower FDG uptake (SUVmax: 9.3). Postsurgical pathology supported a diagnosis of well-differentiated renal neuroendocrine tumor (G2).</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143572220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"68Ga-Pentixafor PET/CT-Based Response Evaluation and its Prognostic Value in Multiple Myeloma: Comparison With IMWG and 18F-FDG-Based Response.","authors":"Harneet Kaur, Suraj Kumar, Ankit Watts, Charanpreet Singh, Man Updesh Singh Sachdeva, Sreejesh Sreedharanunni, Rajender Kumar, Pankaj Malhotra, Baljinder Singh","doi":"10.1097/RLU.0000000000005731","DOIUrl":"https://doi.org/10.1097/RLU.0000000000005731","url":null,"abstract":"<p><strong>Purpose: </strong>68Ga-Pentixafor PET/CT targets CXCR4 receptors and provides superior diagnostic accuracy in multiple myeloma (MM) compared with 18F-FDG PET/CT. However, its role in response evaluation remains unexplored. We propose a 68Ga-Pentixafor PET/CT-based response evaluation criterion and evaluate its utility compared with International Myeloma Working Group (IMWG) criteria and 18F-FDG PET/CT-based response.</p><p><strong>Patients and methods: </strong>In this prospective single-center study, 40 treatment-naive myeloma patients were recruited between February 2021 and April 2023. Both 68Ga-Pentixafor and 18F-FDG PET/CT were performed at baseline and at follow-up (7.2 mo-median). Response to treatment was evaluated using the proposed 68Ga-Pentixafor PET/CT criteria and compared with responses assessed by IMWG and 18F-FDG PET/CT. Progression-free survival (PFS) and overall survival (OS) were analyzed and compared using Kaplan-Meier survival curves.</p><p><strong>Results: </strong>Among the 40 newly diagnosed MM patients [median age: 56.5 years (IQR 45.25 to 63.75); 24 men], 68Ga-Pentixafor PET/CT was positive in a greater proportion of patients than 18F-FDG PET/CT [90% (36/40) vs. 67.5% (27/40); P=0.02] thus, adequately evaluated response in additional 27.5% (11/40) of cases. Using the proposed criteria for 68Ga-Pentixafor PET/CT, significant differences in PFS were observed across response categories [complete response (CR)-not reached, partial response (PR)-26.2 mo, progressive disease (PD)-15.3 mo; P=0.001]. Among patients achieving ≥very good partial response (VGPR) as per IMWG, those with positive 68Ga-Pentixafor PET/CT had shorter PFS compared with those with negative findings (median PFS: 34.2 mo vs. not reached; P=0.056), whereas no significant difference was noted with 18F-FDG PET/CT (P=0.68). In addition, on follow-up of patients with negative 18F-FDG at the response, those with discordant 68Ga-Pentixafor findings had significantly shorter PFS (17.73 mo vs. not reached; P=0.010) compared with those with concordant negative findings.</p><p><strong>Conclusions: </strong>68Ga-Pentixafor PET/CT offers a more accurate assessment of treatment response and prognosis in MM patients, adding valuable information beyond the IMWG and 18F-FDG PET/CT-based criteria.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143572284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multifocal FDG Uptake of the Breasts Caused by Autologous Fat Injection for Breast Augmentation.","authors":"Jiani He, Aisheng Dong","doi":"10.1097/RLU.0000000000005699","DOIUrl":"10.1097/RLU.0000000000005699","url":null,"abstract":"<p><strong>Abstract: </strong>Autologous fat grafting for cosmetic breast augmentation is becoming increasingly popular. Late complications after intramammary fat injection include fat necrosis, liponecrotic cyst, calcification, and lymphadenopathy. We describe FDG PET/CT findings in a patient with multiple-injection-site fat necrosis after intramammary fat injection. FDG PET/CT showed multifocal activity in the subcutaneous and subglandular regions corresponding to the fat injection sites of the bilateral breasts and multiple FDG-avid lymph nodes of the axillae, mimicking malignancy. Careful correlation with clinical history and familiarity with the imaging findings of the complications after intramammary fat injection are helpful for avoiding misdiagnosis.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143416705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"68Ga-PSMA Uptake of Brain Abscesses in a Patient With Prostate Cancer.","authors":"Ying Huang, Bing Zhang, Dianchao Yue","doi":"10.1097/RLU.0000000000005659","DOIUrl":"https://doi.org/10.1097/RLU.0000000000005659","url":null,"abstract":"<p><strong>Abstract: </strong>A 56-year-old man with a history of brain abscess undergoing a 68Ga-labeled prostate-specific membrane antigen (PSMA) ligand PET/CT scan due to rising prostate-specific antigen levels. Besides the uptake of PSMA in the prostate lesion, the 68Ga-PSMA PET/CT images showed significant PSMA uptake in the abscesses in the left parietal and left temporal lobes. This highlights the necessity of cautious interpretation of PSMA PET/CT results, considering alternative diagnoses like infections.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143572287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Two Interesting Findings in One Case: Xanthogranulomatous Inflammation of the Colon and Isolated Widespread Liver Metastasis of Prostate Cancer on 68Ga-PSMA PET/CT.","authors":"Hasan Önner, Ali Gümüş, Murat Çelik","doi":"10.1097/RLU.0000000000005761","DOIUrl":"https://doi.org/10.1097/RLU.0000000000005761","url":null,"abstract":"<p><p>Xanthogranulomatous inflammatory disease is a rare and benign condition that affects various organs. Due to their aggressive nature, the clinical and radiological findings of xanthogranulomatous inflammatory diseases are often misdiagnosed as malignant neoplasms. Prostate cancer metastases are most prevalent in lymph nodes and bones, with less common locations including the lung, liver, and brain. However, widespread liver metastasis is rare without metastatic dissemination to other sites. Herein, we present a case in which these 2 rare conditions were seen together on 68Ga-PSMA PET/CT.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143572214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TANDEM Peptide Receptor Radionuclide Therapy Using [225Ac]Ac-/[177Lu]Lu-DOTA-LM3 in a Patient With Parotid Gland Metastasis From Pancreatic Neuroendocrine Neoplasm.","authors":"Elisabetta Perrone, Kriti Ghai, Aleksandr Eismant, Richard P Baum","doi":"10.1097/RLU.0000000000005782","DOIUrl":"https://doi.org/10.1097/RLU.0000000000005782","url":null,"abstract":"<p><p>We present the case of a young 38-year-old woman with metastatic progressive pancreatic neuroendocrine neoplasm (NEN) exhibiting an unusual metastasis to the parotid gland. After previous treatments, including radionuclide therapy with the somatostatin-receptor agonist DOTATOC and parotid metastasectomy, failed, she was referred to TANDEM peptide receptor radionuclide therapy (PRRT) using the somatostatin-receptor antagonist DOTA-LM3 labeled with Actinium-225 and Lutetium-177. Following 2 cycles of TANDEM-PRRT, she achieved partial remission in all metastatic sites, notably in the parotid gland and liver. This is the first reported case of metastatic pancreatic NEN with parotid involvement treated with TANDEM-PRRT.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143572277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retroperitoneal Capillary Hemangioma Mimicking Paraganglioma on 18F-AlF-NOTA-Octreotide PET/CT.","authors":"Yuanyuan Jiang, Guozhu Hou, Xuejuan Wang","doi":"10.1097/RLU.0000000000005752","DOIUrl":"https://doi.org/10.1097/RLU.0000000000005752","url":null,"abstract":"<p><p>Capillary hemangiomas are commonly encountered superficially in the cutaneous, subcutaneous, or mucosal tissues during childhood and early adulthood, but retroperitoneal capillary hemangioma is a rare occurrence. We present a case of a 61-year-old woman with incidentally detected capillary hemangioma in the retroperitoneum initially presumed to be paraganglioma based on 18F-AlF-NOTA-Octreotide PET/CT findings. Contrast-enhanced MRI revealed a hypervascular mass in the retroperitoneum. 18F-AlF-NOTA-Octreotide PET/CT performed for suspicion of paraganglioma showed intense uptake. Histopathologic examination of the retroperitoneal mass after surgical resection confirmed the diagnosis of capillary hemangioma rather than paraganglioma.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143572294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}