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Unusual Sole Extramedullary Diffuse Kidney Involvement in Multiple Myeloma Initial Workup Using 2-[ 18 F]FDG-PET/CT Imaging. 用2-[18F]FDG-PET/CT影像学检查多发性骨髓瘤早期异常单侧弥漫性肾累及髓外。
IF 9.6 3区 医学
Clinical Nuclear Medicine Pub Date : 2025-10-01 Epub Date: 2025-03-17 DOI: 10.1097/RLU.0000000000005847
Bastien Jamet, Cyrille Touzeau, Chloe Antier, Philippe Moreau, Françoise Kraeber-Bodéré
{"title":"Unusual Sole Extramedullary Diffuse Kidney Involvement in Multiple Myeloma Initial Workup Using 2-[ 18 F]FDG-PET/CT Imaging.","authors":"Bastien Jamet, Cyrille Touzeau, Chloe Antier, Philippe Moreau, Françoise Kraeber-Bodéré","doi":"10.1097/RLU.0000000000005847","DOIUrl":"10.1097/RLU.0000000000005847","url":null,"abstract":"<p><p>2-[ 18 F]fluorodeoxyglucose-positron emission tomography with computed tomography (2-[ 18 F]FDG-PET/CT) in multiple myeloma (MM) allows the detection of extramedullary disease (EMD), which is scarce at initial workup. We report here for the first time uncommon 2-[ 18 F]FDG-PET/CT imaging results of a 63-year-old woman with newly diagnosed MM and sole diffuse kidney EMD revealed by a significantly increased renal volume and intense/diffuse bilateral renal cortical uptake without visualization of the urinary excretory cavities then confirmed by kidney biopsy. This case highlights the possibility of a diffuse organ involvement different from the typical imaging pattern of nodular plasmacytoma lesions in soft tissues.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"e624-e625"},"PeriodicalIF":9.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144505005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Artificial Intelligence in Sincalide-Stimulated Cholescintigraphy: A Pilot Study. 人工智能在胆碱刺激下的胆管造影：一项初步研究。
IF 9.6 3区 医学
Clinical Nuclear Medicine Pub Date : 2025-10-01 Epub Date: 2025-05-13 DOI: 10.1097/RLU.0000000000005967
Nghi C Nguyen, Jun Luo, Dooman Arefan, Anil K Vasireddi, Shandong Wu
{"title":"Artificial Intelligence in Sincalide-Stimulated Cholescintigraphy: A Pilot Study.","authors":"Nghi C Nguyen, Jun Luo, Dooman Arefan, Anil K Vasireddi, Shandong Wu","doi":"10.1097/RLU.0000000000005967","DOIUrl":"10.1097/RLU.0000000000005967","url":null,"abstract":"<p><strong>Purpose: </strong>Sincalide-stimulated cholescintigraphy (SSC) calculates the gallbladder ejection fraction (GBEF) to diagnose functional gallbladder disorder. Currently, artificial intelligence (AI)-driven workflows that integrate real-time image processing and organ function calculation remain unexplored in nuclear medicine practice. This pilot study explored an AI-based application for gallbladder radioactivity tracking.</p><p><strong>Methods: </strong>We retrospectively analyzed 20 SSC exams, categorized into 10 easy and 10 challenging cases. Two human operators (H1 and H2) independently annotated the gallbladder regions of interest manually over the course of the 60-minute SSC. A U-Net-based deep learning model was developed to automatically segment gallbladder masks, and a 10-fold cross-validation was performed for both easy and challenging cases. The AI-generated masks were compared with human-annotated ones, with Dice similarity coefficients (DICE) used to assess agreement.</p><p><strong>Results: </strong>AI achieved an average DICE of 0.746 against H1 and 0.676 against H2, performing better in easy cases (0.781) than in challenging ones (0.641). Visual inspection showed AI was prone to errors with patient motion or low-count activity.</p><p><strong>Conclusions: </strong>This study highlights AI's potential in real-time gallbladder tracking and GBEF calculation during SSC. AI-enabled real-time evaluation of nuclear imaging data holds promise for advancing clinical workflows by providing instantaneous organ function assessments and feedback to technologists. This AI-enabled workflow could enhance diagnostic efficiency, reduce scan duration, and improve patient comfort by alleviating symptoms associated with SSC, such as abdominal discomfort due to sincalide administration.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"e575-e579"},"PeriodicalIF":9.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143977354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Feasibility of Single Time Point Dosimetry Application in 177 Lu-DOTATATE/DOTATOC-treated Pediatric Neuroblastoma. 单时间点剂量法应用于177Lu-DOTATATE/ dotatoc治疗的小儿神经母细胞瘤的可行性。
IF 9.6 3区 医学
Clinical Nuclear Medicine Pub Date : 2025-10-01 Epub Date: 2025-06-17 DOI: 10.1097/RLU.0000000000006029
Xingyao Sun, Fei Zheng, Yuxuan Liu, Yingying Sun, Han Wang, Hao Yang, Pengfei Li, Xiaorong Sun
{"title":"Feasibility of Single Time Point Dosimetry Application in 177 Lu-DOTATATE/DOTATOC-treated Pediatric Neuroblastoma.","authors":"Xingyao Sun, Fei Zheng, Yuxuan Liu, Yingying Sun, Han Wang, Hao Yang, Pengfei Li, Xiaorong Sun","doi":"10.1097/RLU.0000000000006029","DOIUrl":"10.1097/RLU.0000000000006029","url":null,"abstract":"<p><strong>Background: </strong>177 Lu-DOTATATE/DOTATOC peptide receptor radionuclide therapy (PRRT) has demonstrated potential for treating pediatric neuroblastoma (NB), and in clinical practice can be measured dosimetry by multi-time point (MTP) dosimetry. However, the high workload and limited patient compliance associated with MTP restrict its application. Consequently, single time point (STP) dosimetry approaches have emerged as a promising alternative, though their effectiveness in pediatric populations has not been thoroughly investigated. This study aimed to assess the dosimetric determination of 177 Lu-DOTATATE/DOTATOC in pediatric neuroblastoma patients to determine whether STP could serve as a viable replacement for MTP.</p><p><strong>Patients and methods: </strong>A total of 24 pediatric NB patients who received 1 to 2 cycles of 177 Lu-DOTATATE or 177 Lu-DOTATOC underwent dosimetric measurement of lesions and critical organs using the 96 hours single time point (STP H ) dosimetry method proposed by Hänscheid and colleagues. The results were compared with those obtained from standard MTP.</p><p><strong>Results: </strong>In patients treated with 177 Lu-DOTATATE, the mean relative deviation absolute values of the STP H -calculated absorbed dose from MTP were <10% for lesions, kidneys, bone marrow, liver, and spleen, with Pearson correlation coefficients of 0.99, 0.93, 0.97, 0.84, and 0.84, respectively. In patients treated with 177 Lu-DOTATOC, the mean relative deviation absolute values for kidneys, spleen, and bone marrow were <10%, with Pearson correlation coefficients of 0.97, 0.77, 0.35, 0.48, and 0.93 for lesions, kidneys, bone marrow, liver, and spleen, respectively.</p><p><strong>Conclusions: </strong>The findings confirm that the 96 hours STP H method can reliably replace MTP for dosimetric assessment in pediatric NB patients treated with 177 Lu-DOTATATE and performed well in renal dosimetry for 177 Lu-DOTATOC therapy.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"921-926"},"PeriodicalIF":9.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144309675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enhancing Initial Staging of a Gastric Cancer Patient: The Advantage of [ 99m Tc]-FAPI-46 SPECT/CT Over Conventional CT. 提高胃癌患者的初始分期：[99mTc]-FAPI-46 SPECT/CT相对于传统CT的优势
IF 9.6 3区 医学
Clinical Nuclear Medicine Pub Date : 2025-10-01 Epub Date: 2025-07-04 DOI: 10.1097/RLU.0000000000005794
Haniye Elahifard, Mohammad Hadi Samadi, Kamran Aryana, Hassan Kamali, Somaye Barashki
{"title":"Enhancing Initial Staging of a Gastric Cancer Patient: The Advantage of [ 99m Tc]-FAPI-46 SPECT/CT Over Conventional CT.","authors":"Haniye Elahifard, Mohammad Hadi Samadi, Kamran Aryana, Hassan Kamali, Somaye Barashki","doi":"10.1097/RLU.0000000000005794","DOIUrl":"10.1097/RLU.0000000000005794","url":null,"abstract":"<p><p>We present a 59-year-old man with gastric signet-ring cell carcinoma, initially staged with contrast-enhanced CT (CECT), revealing gastric wall thickening, lymph nodes, and lung metastases. Subsequently, [ 99m Tc]-FAPI-46 SPECT/CT demonstrated increased tracer uptake in the gastric lesion, pulmonary nodule, and lymph nodes, alongside new findings of skeletal metastasis, omental and peritoneal deposits, altering the staging and clinical management. Our findings highlight the superior utility of [ 99m Tc]-FAPI-46 in accurately staging gastric cancer and detecting occult metastatic lesions, which is critical for effective treatment planning, despite some limitations compared which diagnostic laparoscopy.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"e602-e604"},"PeriodicalIF":9.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144559370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lincoln Sign in a Case of Langerhans Cell Histiocytosis on Bone Scintigraphy. 骨显像显示Langerhans细胞组织细胞增生的Lincoln征1例。
IF 9.6 3区 医学
Clinical Nuclear Medicine Pub Date : 2025-10-01 Epub Date: 2025-07-23 DOI: 10.1097/RLU.0000000000006065
Huan Liang, Ziqian Dong, Feilong Chen, Lingge Wei, Peng Xie
{"title":"Lincoln Sign in a Case of Langerhans Cell Histiocytosis on Bone Scintigraphy.","authors":"Huan Liang, Ziqian Dong, Feilong Chen, Lingge Wei, Peng Xie","doi":"10.1097/RLU.0000000000006065","DOIUrl":"https://doi.org/10.1097/RLU.0000000000006065","url":null,"abstract":"<p><p>Lincoln sign, also known as the black beard sign, is considered the classic manifestation of monostotic Paget disease of the mandible on bone scintigraphy. Here we report the bone scintigraphy findings in a case of Langerhans cell histiocytosis in a 32-year-old man. The images showed intense uptake of MDP in the mandible, which could also be described as the Lincoln sign.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":"50 10","pages":"943-945"},"PeriodicalIF":9.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144991653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Squamous Cell Carcinoma of the Tonsil Unmasked by 68 Ga-FAPI-46 PET/CT. 68Ga-FAPI-46 PET/CT显示扁桃体鳞状细胞癌。
IF 9.6 3区 医学
Clinical Nuclear Medicine Pub Date : 2025-10-01 Epub Date: 2025-03-28 DOI: 10.1097/RLU.0000000000005866
Jiaqing Liu, Xiyi Liao, Yizhen Pang, Qin Lin, Haojun Chen
{"title":"Squamous Cell Carcinoma of the Tonsil Unmasked by 68 Ga-FAPI-46 PET/CT.","authors":"Jiaqing Liu, Xiyi Liao, Yizhen Pang, Qin Lin, Haojun Chen","doi":"10.1097/RLU.0000000000005866","DOIUrl":"10.1097/RLU.0000000000005866","url":null,"abstract":"<p><p>We reported 18 F-FDG and 68 Ga-FAPI-46 PET/CT findings in a 55-year-old woman with metastatic squamous cell carcinoma of the left neck. 18 F-FDG PET/CT was negative for the detection of primary malignancy. On 68 Ga-FAPI PET/CT, increased radiotracer uptake was noted in the left palatine tonsil, whereas low background uptake was observed in the right palatine tonsil. Based on the PET/CT findings, the patient underwent clinical examination and biopsy of the left tonsil. Histology demonstrated the presence of a squamous cell carcinoma of the tonsil. The case demonstrated the added value of 68 Ga-FAPI-46 PET/CT for locating the primary malignancy in cancer of unknown primary.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"953-955"},"PeriodicalIF":9.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intense FDG Activity of Renal Granuloma Following Intravesical Bacillus Calmette-Guérin Therapy for Bladder Cancer Mimicking Malignancy. 膀胱内卡介苗-谷氨酰胺治疗模拟恶性膀胱癌后肾肉芽肿FDG活性增强。
IF 9.6 3区 医学
Clinical Nuclear Medicine Pub Date : 2025-10-01 Epub Date: 2025-04-23 DOI: 10.1097/RLU.0000000000005810
Xiaojun Man, Changming Dong, Xiandong Song, Aisheng Dong
{"title":"Intense FDG Activity of Renal Granuloma Following Intravesical Bacillus Calmette-Guérin Therapy for Bladder Cancer Mimicking Malignancy.","authors":"Xiaojun Man, Changming Dong, Xiandong Song, Aisheng Dong","doi":"10.1097/RLU.0000000000005810","DOIUrl":"10.1097/RLU.0000000000005810","url":null,"abstract":"<p><p>Intravesical bacillus Calmette-Guérin (BCG) therapy is an effective immunotherapy for superficial bladder cancer. BCG-related infectious complications may occur following intravesical BCG instillation. We describe contrast-enhanced CT, FDG PET/CT, and delayed abdominal FDG PET/MRI findings in a case of BCG-related renal granulomas following intravesical BCG therapy for bladder cancer. The renal lesions showed ill-defined margins with progressive enhancement on postcontrast CT, hypointensity on T2-weighted images, and variable FDG activity on both PET/CT and delayed PET/MRI. This case indicates that BCG-related renal granuloma should be included in the differential diagnosis of FDG-avid renal lesions in patients with BCG therapy for bladder cancer.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"960-962"},"PeriodicalIF":9.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143957078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fluciclovine-PET Uptake in Microcystic Meningioma Mimicking High-grade Glioma: A Case Report. 模拟高级别胶质瘤的微囊性脑膜瘤氟昔洛碱- pet摄取1例报告。
IF 9.6 3区 医学
Clinical Nuclear Medicine Pub Date : 2025-10-01 Epub Date: 2025-04-24 DOI: 10.1097/RLU.0000000000005924
Junki Takenaka, Kenji Hirata, Shiro Watanabe, Yukitomo Ishi, Kohsuke Kudo
{"title":"Fluciclovine-PET Uptake in Microcystic Meningioma Mimicking High-grade Glioma: A Case Report.","authors":"Junki Takenaka, Kenji Hirata, Shiro Watanabe, Yukitomo Ishi, Kohsuke Kudo","doi":"10.1097/RLU.0000000000005924","DOIUrl":"10.1097/RLU.0000000000005924","url":null,"abstract":"<p><p>A 69-year-old asymptomatic woman underwent magnetic resonance imaging (MRI), revealing a left parietal lobe tumor suspected to be a high-grade glioma (HGG). [ 18 F]Fluciclovine-positron emission tomography (PET), which reflects amino acid metabolism, showed moderate uptake [SUVmax 1.4, tumor-to-normal ratio (TNR) 1.9], consistent with HGG, whereas [ 18 F]fluorodeoxyglucose-PET findings demonstrated low uptake (SUVmax 2.5, TNR 0.22), which is atypical for HGG. Surgical and pathologic investigations confirmed the diagnosis of microcystic meningioma, a rare subtype classified as grade 1. Microcystic meningiomas mimic HGG on magnetic resonance imaging and [ 18 F]fluciclovine-PET due to l -amino acid transporter expression, complicating diagnosis.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"975-977"},"PeriodicalIF":9.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143969142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association of Striatal Dopaminergic Depletion and Cerebral Perfusion With Cognition in Brain-First and Body-First Parkinson's Disease. 脑优先和体优先帕金森病患者纹状体多巴胺能耗竭和脑灌注与认知的关系
IF 9.6 3区 医学
Clinical Nuclear Medicine Pub Date : 2025-10-01 Epub Date: 2025-06-30 DOI: 10.1097/RLU.0000000000005922
Seong Ho Jeong, Su Hong Kim, Chan Wook Park, Hye Sun Lee, Phil Hyu Lee, Yun Joong Kim, Young H Sohn, Yong Jeong, Seok Jong Chung
{"title":"Association of Striatal Dopaminergic Depletion and Cerebral Perfusion With Cognition in Brain-First and Body-First Parkinson's Disease.","authors":"Seong Ho Jeong, Su Hong Kim, Chan Wook Park, Hye Sun Lee, Phil Hyu Lee, Yun Joong Kim, Young H Sohn, Yong Jeong, Seok Jong Chung","doi":"10.1097/RLU.0000000000005922","DOIUrl":"10.1097/RLU.0000000000005922","url":null,"abstract":"<p><strong>Purpose: </strong>We aimed to investigate whether the patterns of striatal subregional dopamine loss and cerebral perfusion alterations differed between the 2 types of Parkinson's disease (PD) (ie, brain-first and body-first PD) and had an impact on cognitive prognosis in PD.</p><p><strong>Patients and methods: </strong>This retrospective study reviewed the data of newly diagnosed patients with PD who underwent dual-phase dopamine transporter (DAT) scans in tertiary medical centers. We classified the patients into 2 groups based on the rapid eye movement sleep behavior disorder (RBD) screening questionnaire: PD with RBD (body-first PD) and PD without RBD (brain-first PD) groups. Then, we investigated intergroup differences in subregional DAT availability, regional cerebral perfusion, and the rates of dementia conversion.</p><p><strong>Results: </strong>After adjusting for confounding variables, the body-first group exhibited lower DAT availability in the anterior putamen than the brain-first group (β=-0.10, SE=0.04, P =0.044). In comparative analyses of regional cerebral perfusion, the body-first group exhibited lower regional perfusion in the bilateral parieto-occipital area and left cerebellum than the brain-first group, and vice versa in the brainstem, left hippocampus, right pallidum, bilateral thalamus, and ventral diencephalon. The dementia conversion rate was significantly higher in the body-first group (HR=1.78, P =0.027) than in the brain-first group, which was largely mediated by DAT availability in the anterior putamen and parieto-occipital cerebral perfusion in mediation analyses.</p><p><strong>Conclusions: </strong>This study demonstrated that the patterns of striatal subregional dopamine depletion and regional cerebral perfusion differed between the brain-first and body-first PD subtypes, and these differences largely mediated inter-subtype differences in cognitive outcome.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"902-911"},"PeriodicalIF":9.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144526691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
99m Tc-PYP and 99m Tc-MDP Scintigraphy in a Rare Case of Combined ApoA-I Cardiac Amyloidosis and Paget Disease of the Bone. 99mTc-PYP和99mTc-MDP在罕见的apoa - 1型心脏淀粉样变性合并骨Paget病中的显像分析
IF 9.6 3区 医学
Clinical Nuclear Medicine Pub Date : 2025-10-01 Epub Date: 2025-07-07 DOI: 10.1097/RLU.0000000000005879
Naoko Okada, Yoichi Otomi, Takayoshi Shinya, Shoichiro Takao, Hideki Otsuka
{"title":"99m Tc-PYP and 99m Tc-MDP Scintigraphy in a Rare Case of Combined ApoA-I Cardiac Amyloidosis and Paget Disease of the Bone.","authors":"Naoko Okada, Yoichi Otomi, Takayoshi Shinya, Shoichiro Takao, Hideki Otsuka","doi":"10.1097/RLU.0000000000005879","DOIUrl":"10.1097/RLU.0000000000005879","url":null,"abstract":"<p><p>A 70-year-old man with a 20-year history of heart failure developed atrial fibrillation and underwent pacemaker implantation; however, his heart failure continued to worsen. Imaging with 99m Tc-PYP scintigraphy revealed significant uptake in the myocardium and the right pelvic bone. Similarly, 99m Tc-methylene diphosphonate scintigraphy demonstrated positive uptake in both regions. A myocardial biopsy confirmed cardiac amyloidosis, and mass spectrometry identified ApoA-I amyloidosis. In addition, a bone biopsy of the right iliac wing resulted in a pathologic diagnosis of Paget disease of bone.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"946-948"},"PeriodicalIF":9.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144583300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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