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Metastatic Prostate Carcinoma to the Ankle Seen on Bone Scintigraphy and Extended Field-of-View PSMA PET/CT.
IF 9.6 3区 医学
Clinical Nuclear Medicine Pub Date : 2024-12-03 DOI: 10.1097/RLU.0000000000005616
Nir Hod, Noa Shani Shrem, Daniel Levin
{"title":"Metastatic Prostate Carcinoma to the Ankle Seen on Bone Scintigraphy and Extended Field-of-View PSMA PET/CT.","authors":"Nir Hod, Noa Shani Shrem, Daniel Levin","doi":"10.1097/RLU.0000000000005616","DOIUrl":"https://doi.org/10.1097/RLU.0000000000005616","url":null,"abstract":"<p><strong>Abstract: </strong>We describe a rare case of metastatic prostate carcinoma to the heel. Bone scintigraphy revealed high uptake simulating fractures. Standard PSMA PET/CT was negative. As PSA elevated, extended field-of-view PET/CT revealed ankle uptake with virtually identical spatial distribution and intensity of both tracers. Histopathology confirmed ankle metastases of prostate carcinoma, which retrospectively was the inaugural manifestation of the metastatic skeletal disease. This case highlights the need to consider peripheral limb bone metastases in patients with biochemical recurrence. In case of focal symptoms or unexplained bone scan findings, the PSMA acquisition coverage should be extended to include the respective body part.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142766970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Solitary Scapula Metastasis From Intrahepatic Cholangiocarcinoma Detected by PET/CT.
IF 9.6 3区 医学
Clinical Nuclear Medicine Pub Date : 2024-12-03 DOI: 10.1097/RLU.0000000000005619
Churun Xu, Pengcheng Ren, Guoxing Zhao, Lingge Wei, Peng Xie
{"title":"Solitary Scapula Metastasis From Intrahepatic Cholangiocarcinoma Detected by PET/CT.","authors":"Churun Xu, Pengcheng Ren, Guoxing Zhao, Lingge Wei, Peng Xie","doi":"10.1097/RLU.0000000000005619","DOIUrl":"https://doi.org/10.1097/RLU.0000000000005619","url":null,"abstract":"<p><strong>Abstract: </strong>A 59-year-old man presented with a mass and pain in the left side of his back for 6 months. 18F-FDG PET/CT demonstrated increased FDG uptake in the inferior aspect of his left scapula and the left hepatic lobe, highly suggesting the possibility of hepatic malignancy with solitary scapula metastasis. Finally, solitary scapula metastasis from intrahepatic cholangiocarcinoma was confirmed.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142766981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association Between Quantitative Sialoscintigraphy and Antibody Profiles in Patients With Sjögren or Sicca Syndrome.
IF 9.6 3区 医学
Clinical Nuclear Medicine Pub Date : 2024-12-03 DOI: 10.1097/RLU.0000000000005602
Tzyy-Ling Chuang, Malcolm Koo, Yi-Min Lee, Chien-Hsueh Tung, Yuh-Feng Wang
{"title":"Association Between Quantitative Sialoscintigraphy and Antibody Profiles in Patients With Sjögren or Sicca Syndrome.","authors":"Tzyy-Ling Chuang, Malcolm Koo, Yi-Min Lee, Chien-Hsueh Tung, Yuh-Feng Wang","doi":"10.1097/RLU.0000000000005602","DOIUrl":"https://doi.org/10.1097/RLU.0000000000005602","url":null,"abstract":"<p><strong>Purpose: </strong>This study analyzed the association between anti-Ro/SSA and anti-La/SSB antibody levels with quantitative and visual sialoscintigraphy patterns in patients suspected of having Sjögren or sicca syndrome.</p><p><strong>Patients and methods: </strong>Medical records of patients who underwent sialoscintigraphy between April 2020 and May 2022 were reviewed. Associations between antibody levels and sialoscintigraphy parameters were evaluated using linear regression. Receiver operating characteristic curve analysis was used to identify antibody cutoff values for predicting flat-type patterns and the risk of Sjögren or sicca syndrome.</p><p><strong>Results: </strong>Of the 170 patients (mean age, 56.6 years; 78.8% female), 95.3% had dry mouth and eyes, 30% experienced polyarthralgia, and 66.5% were prescribed hydroxychloroquine. The most common sialoscintigraphy finding was the median-type time-activity curve (TAC) pattern. Anti-Ro/SSA and anti-La/SSB levels were significantly correlated with maximum accumulation or maximum secretion in the salivary glands. Receiver operating characteristic analysis for anti-Ro/SSA predicting a flat-type TAC pattern showed an area under the curve (AUC) of 0.659 to 0.780, with specificity between 82.1% and 86.3% for antibody levels greater than 85.2 units. Anti-Ro/SSA levels greater than 49.75 units predicted a higher risk of Sjögren or sicca syndrome, with an AUC of 0.622 and 83.9% specificity. Anti-La/SSB levels had no significant predictive value, with an AUC of 0.554.</p><p><strong>Conclusions: </strong>Anti-Ro/SSA levels greater than 85.2 units were strong predictors of flat-type TAC patterns, indicating near-total salivary gland dysfunction and supporting their diagnostic utility in Sjögren or sicca syndrome.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142766949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
FDG PET/CT in Papillary Intralymphatic Angioendothelioma of the Spleen.
IF 9.6 3区 医学
Clinical Nuclear Medicine Pub Date : 2024-12-03 DOI: 10.1097/RLU.0000000000005620
Benzheng Jiao, Hongxia Liu, Xiaobo Ma, Aisheng Dong, Hongguang Zhao
{"title":"FDG PET/CT in Papillary Intralymphatic Angioendothelioma of the Spleen.","authors":"Benzheng Jiao, Hongxia Liu, Xiaobo Ma, Aisheng Dong, Hongguang Zhao","doi":"10.1097/RLU.0000000000005620","DOIUrl":"https://doi.org/10.1097/RLU.0000000000005620","url":null,"abstract":"<p><strong>Abstract: </strong>Splenic papillary intralymphatic angioendothelioma is extremely rare. We describe FDG PET/CT and MRI findings of splenic papillary intralymphatic angioendothelioma in a young adult. The splenic tumor showed hypodensity and increased FDG uptake with SUVmax of 4 on PET/CT, heterogeneous signal intensity with internal hypointense stellate scars on T2-weighted image, and progressive centripetal enhancement on dynamic contrast-enhanced T1-weighted images. This case indicates that papillary intralymphatic angioendothelioma should be included in the differential diagnosis of FDG-avid splenic lesions.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142766952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Longitudinal Evaluation of FDG Uptake in a Synovial Herniation Pit in 8 Years: Implications for Potential False-Positive PET Findings.
IF 9.6 3区 医学
Clinical Nuclear Medicine Pub Date : 2024-12-03 DOI: 10.1097/RLU.0000000000005618
Chenxi Wu, Amol Madan Takalkar
{"title":"Longitudinal Evaluation of FDG Uptake in a Synovial Herniation Pit in 8 Years: Implications for Potential False-Positive PET Findings.","authors":"Chenxi Wu, Amol Madan Takalkar","doi":"10.1097/RLU.0000000000005618","DOIUrl":"https://doi.org/10.1097/RLU.0000000000005618","url":null,"abstract":"<p><strong>Abstract: </strong>Synovial herniation pit, also known as Pitt's pit, is a benign osseous lesion incidentally seen on imaging studies. Most of them will not show FDG uptake, but some herniation pits could show intense FDG uptake on PET/CT scans mimicking osseous metastasis. Here we report a case of synovial herniation pit in a patient with T-cell lymphoma through 8-year trajectory of FDG PET/CT scans, revealing its changing FDG uptake in relation to chemotherapy and final outcome.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142766969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Publication Pressure in Nuclear Medicine.
IF 9.6 3区 医学
Clinical Nuclear Medicine Pub Date : 2024-12-02 DOI: 10.1097/RLU.0000000000005608
Thomas C Kwee, Ali Aldub, Robert M Kwee
{"title":"Publication Pressure in Nuclear Medicine.","authors":"Thomas C Kwee, Ali Aldub, Robert M Kwee","doi":"10.1097/RLU.0000000000005608","DOIUrl":"https://doi.org/10.1097/RLU.0000000000005608","url":null,"abstract":"<p><strong>Purpose: </strong>The aims of this study were to determine the publication pressure perceived by nuclear medicine scientists and to identify associated determinants.</p><p><strong>Patients and methods: </strong>Corresponding authors who published in Clinical Nuclear Medicine, Journal of Nuclear Medicine, or European Journal of Nuclear Medicine and Molecular Imaging between 2021 and 2023 were invited to participate in this survey study. Publication pressure was assessed using the revised Publication Pressure Questionnaire in the domains of \"publication stress\" (stress due to perceived pressure to publish), \"publication attitude\" (attitude regarding current publication culture), and \"publication resources\" (resources when working on publications or experiencing stress when working on publishing), with 5-point Likert scales.</p><p><strong>Results: </strong>A total of 181 individuals participated. Median Publication Pressure Questionnaire scores in the domains \"publication stress,\" \"publication attitude,\" and \"publication resources\" were 3.33, 3.33, and 2.17, respectively. None of the researchers' characteristics were significantly associated with publication stress. Age >65 years was significantly associated with a more positive view on the publication climate (β coefficient of -0.552, P = 0.007). Several variables were significantly associated with a perception of fewer factors available to alleviate publication pressure: age 45-54 years (β coefficient of 0.249, P = 0.030), age 55-64 years (β coefficient of 0.421, P = 0.002), associate professor position (β coefficient of 0.398, P < 0.001), fellow/resident position (β coefficient of 0.355, P = 0.007), <5 years of research experience (β coefficient of 0.410, P = 0.026), and 5-10 years of research experience (β coefficient of 0.361, P = 0.003).</p><p><strong>Conclusions: </strong>Publication pressure among nuclear medicine scientists is appreciable. Several researcher characteristics appear to be associated with vulnerability to publication pressure.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142766977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Multitracer PET/CT Findings in a Case of Behavioral Variant Frontotemporal Dementia With Parkinsonism.
IF 9.6 3区 医学
Clinical Nuclear Medicine Pub Date : 2024-12-02 DOI: 10.1097/RLU.0000000000005611
Shuai Chen, Chang Fu, Jing-Yu Shao, Jun-Ling Xu, Jie-Wen Zhang
{"title":"Multitracer PET/CT Findings in a Case of Behavioral Variant Frontotemporal Dementia With Parkinsonism.","authors":"Shuai Chen, Chang Fu, Jing-Yu Shao, Jun-Ling Xu, Jie-Wen Zhang","doi":"10.1097/RLU.0000000000005611","DOIUrl":"https://doi.org/10.1097/RLU.0000000000005611","url":null,"abstract":"<p><strong>Abstracts: </strong>We report the clinical and multimodal PET/CT manifestations in a patient with behavioral variant frontotemporal dementia and parkinsonism. The 18F-FDG PET scan revealed hypometabolism in the left supratentorial cortex. The 18F-fluorodopa PET scan demonstrated decreased uptake in the bilateral striatum, most prominent in the head of caudate nucleus. The 18F-florbetapir PET scan indicated an absence of β-amyloid deposition, whereas the 18F-flortaucipir PET scan showed uptake in the left hemisphere neocortex. The clinical presentation and asymmetric neuroimaging features supported the underlying frontotemporal lobar degeneration-tau pathology.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142766974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Foreign Body Perforating the Descending Colon Incidentally Detected on 18F-FDG PET/CT.
IF 9.6 3区 医学
Clinical Nuclear Medicine Pub Date : 2024-12-02 DOI: 10.1097/RLU.0000000000005609
Paulo Schiavom Duarte, George Barberio Coura-Filho, Marcelo Tatit Sapienza, Hongming Zhuang, Carlos Alberto Buchpiguel
{"title":"Foreign Body Perforating the Descending Colon Incidentally Detected on 18F-FDG PET/CT.","authors":"Paulo Schiavom Duarte, George Barberio Coura-Filho, Marcelo Tatit Sapienza, Hongming Zhuang, Carlos Alberto Buchpiguel","doi":"10.1097/RLU.0000000000005609","DOIUrl":"https://doi.org/10.1097/RLU.0000000000005609","url":null,"abstract":"<p><strong>Abstract: </strong>A 78-year-old woman was diagnosed having unresectable tongue cancer 6 months ago, for which she received radiation therapy. She was on enteral nutrition for more than 2 months due to dysphagia and underwent an 18F-FDG PET/CT for restaging. The images showed uptake in a left cervical node. In addition, there was a focal uptake in the descending colon corresponding to a foreign body in its anterior wall, which was removed by colonoscopy.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142766955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
18F-AlF-NOTA-FAPI-04 Superior to 18F-FDG PET/CT in Detecting Primary Tumor and Metastatic Lymph Nodes in a Cervical Cancer Patient.
IF 9.6 3区 医学
Clinical Nuclear Medicine Pub Date : 2024-12-02 DOI: 10.1097/RLU.0000000000005601
Jinhui Wei, Qiaochu Feng, Haodong Liu, Hongna Zheng, Longjie Li
{"title":"18F-AlF-NOTA-FAPI-04 Superior to 18F-FDG PET/CT in Detecting Primary Tumor and Metastatic Lymph Nodes in a Cervical Cancer Patient.","authors":"Jinhui Wei, Qiaochu Feng, Haodong Liu, Hongna Zheng, Longjie Li","doi":"10.1097/RLU.0000000000005601","DOIUrl":"https://doi.org/10.1097/RLU.0000000000005601","url":null,"abstract":"<p><strong>Abstract: </strong>A 41-year-old woman with an enlarged right supraclavicular lymph node underwent a fine-needle biopsy, which confirmed the presence of metastatic squamous cell carcinoma. To identify the primary tumor, an 18F-FDG PET/CT scan was performed, revealing multiple metabolically active lymph nodes throughout the body, but no primary lesion was identified. Subsequently, an 18F-AlF-NOTA-FAPI-04 PET/CT scan was conducted, which demonstrated increased abnormal uptake in the cervix and revealed additional metabolically active lymph nodes. Thus, a biopsy of the uterine cervical region was performed, and the results confirmed cervical squamous cell carcinoma.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142766989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lenticulostriatal Ischemia Shows Relevant SSTR Expression on PET/CT Imaging Using the Novel SSTR-Targeting Peptide 18 F-SiTATE. 使用新型 SSTR 靶向肽 18F-SiTATE 进行 PET/CT 成像时，韧皮部缺血显示出相关的 SSTR 表达。
IF 9.6 3区 医学
Clinical Nuclear Medicine Pub Date : 2024-12-01 Epub Date: 2024-10-02 DOI: 10.1097/RLU.0000000000005482
Sophie C Kunte, Lena M Unterrainer, Wolfgang G Kunz, Michael Winkelmann, Simon Lindner, Klaus Jurkschat, Carmen Wängler, Björn Wängler, Ralf Schirrmacher, Peter Bartenstein, Claus Belka, Christian Schichor, Nathalie L Albert, Marcus Unterrainer
{"title":"Lenticulostriatal Ischemia Shows Relevant SSTR Expression on PET/CT Imaging Using the Novel SSTR-Targeting Peptide 18 F-SiTATE.","authors":"Sophie C Kunte, Lena M Unterrainer, Wolfgang G Kunz, Michael Winkelmann, Simon Lindner, Klaus Jurkschat, Carmen Wängler, Björn Wängler, Ralf Schirrmacher, Peter Bartenstein, Claus Belka, Christian Schichor, Nathalie L Albert, Marcus Unterrainer","doi":"10.1097/RLU.0000000000005482","DOIUrl":"10.1097/RLU.0000000000005482","url":null,"abstract":"<p><strong>Abstract: </strong>A 64-year-old woman with meningioma presented with left-sided lenticulostriatal ischemia following craniotomy and debulking of a sphenoid wing meningioma. For subsequent radiotherapy planning, an SSTR-targeted PET/CT using the novel ligand 18 F-SiTATE was performed 2.5 months thereafter. The meningioma remnants showed transosseous, intrasellar, and perivascular extension around the internal carotid artery with strong SSTR expression. Moreover, there was focal 18 F-SiTATE uptake in the left caudate and corresponding contrast enhancement due to postischemic blood-brain barrier disruption and reactive SSTR expression. Therefore, increased cortical or subcortical SSTR PET signal may be related to ischemic changes even in the subacute stage after initial stroke.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"e689-e690"},"PeriodicalIF":9.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142361265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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