Clinical Nuclear Medicine最新文献

{"title":"Drug-induced Sarcoid-like Reaction Presenting as Fascitis.","authors":"Shreyas B Jayade, Mariam Alavidze, Shweta K Tonny, Raghuveer K Halkar","doi":"10.1097/RLU.0000000000006058","DOIUrl":"10.1097/RLU.0000000000006058","url":null,"abstract":"<p><p>Drug-induced sarcoid-like reactions (DISRs) present complex challenges in clinical management. The most common presentation in FDG-PET/CT scan is bilateral symmetrical lymphadenopathy, and occasionally spleen and bone involvement. DISR presenting as fasciitis/ myofasciitis is extremely rare. We will discuss pre-chemo, post-chemo, and follow-up FDG-PET/ CT scans, exhibiting DISR-induced fasciitis and resolution of findings after cessation of immunotherapy. How to diagnose and manage DISR is still debatable. Histologic confirmation or short interval follow-up scans with resolution findings can lead to the diagnosis, depending on the severity of symptoms, cessation of therapy or continuation of therapy is instituted.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"e589-e590"},"PeriodicalIF":9.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144882373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perianal Abscess Due to Ingested Foreign Body as an Incidental Finding On 18 F-FDG-PET/CT.","authors":"Noelene George, Jane Leskovar, Kenneth Miles","doi":"10.1097/RLU.0000000000005839","DOIUrl":"10.1097/RLU.0000000000005839","url":null,"abstract":"<p><p>A 46-year-old man underwent FDG-PET/CT for re-staging of malignant melanoma. No metabolically active tumor sites were demonstrated, but intense FDG uptake was seen within the left perianal region associated with a soft tissue opacity on low-dose CT, consistent with an abscess containing a 23 mm linear foreign body. The lesion was subsequently explored surgically. The abscess was drained, and a wooden object measuring ~28 ×2 mm was retrieved. The object was consistent with a portion of the stick from a corn dog which the patient recalled eating some time before the restaging PET.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"936-937"},"PeriodicalIF":9.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of 68 Ga-FAPI-04 PET/CT and 18 F-FDG PET/CT in Evaluating Lesion Stages in Constrictive Pericarditis.","authors":"Yaqun Jiang, Zhenxiong Chen, Yong He","doi":"10.1097/RLU.0000000000005843","DOIUrl":"10.1097/RLU.0000000000005843","url":null,"abstract":"<p><p>Constrictive pericarditis, an uncommon cause of diastolic heart failure, is reversible if identified and treated promptly and appropriately. The treatment approach may vary significantly depending on the disease stage of constrictive pericarditis. Here, we report a case of 18 F-FDG and 68 Ga-FAPI-04 PET/CT imaging in a 70-year-old woman with chronic constrictive pericarditis. The thickened pericardium showed mild uptake of 18 F-FDG but intense uptake of 68 Ga-FAPI-04, indicating that the lesion was at the fibrotic phase. This case suggests a promising role of combination of 18 F-FDG and 68 Ga-FAPI PET/CT in accurately and timely assessing the lesion stage in constrictive pericarditis.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"e631-e632"},"PeriodicalIF":9.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143656298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary Solitary Rib Lymphoma on FDG PET/CT.","authors":"Chengzhi Jiang, Wanjing Zhou, Hui Ye","doi":"10.1097/RLU.0000000000005814","DOIUrl":"10.1097/RLU.0000000000005814","url":null,"abstract":"<p><p>Non-Hodgkin lymphoma of the rib is extremely rare. Herein, we report a case of solitary primary rib lymphoma in a 55-year-old man. 18 F-FDG PET/CT revealed a hypermetabolic lesion in the right seventh rib. The subsequent histology and immunohistochemistry of the rib lesion confirmed the diagnosis of highly aggressive B-cell non-Hodgkin lymphoma.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"973-974"},"PeriodicalIF":9.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144233448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FDG PET/CT Image of Symmetric Tendon Xanthoma.","authors":"Xueni Yang, Liu Xiao, Lin Li, Wenjie Zhang","doi":"10.1097/RLU.0000000000005742","DOIUrl":"10.1097/RLU.0000000000005742","url":null,"abstract":"<p><p>Tendon xanthoma is very rare. We report FDG PET/CT findings of tendon xanthoma in a 33-year-old man. On FDG PET/CT image, it manifested as multiple symmetric nodules with an SUVmax of 9.37, located in the tendons of both elbows, knees and ankles. The final pathology supported a diagnosis of a tendon xanthoma.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"e591-e592"},"PeriodicalIF":9.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143556182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serendipitous Discovery and Characterization of Two Different Pathologies on 68 Ga-DOTATATE and 68 Ga-Exendin PET/CT in a Patient With Hyperinsulinemic Hypoglycemia Leading to Diagnosis of MEN-1.","authors":"Rucha Barapatre, Priyanka Verma, Anurag R Lila, Sandip Basu","doi":"10.1097/RLU.0000000000005840","DOIUrl":"10.1097/RLU.0000000000005840","url":null,"abstract":"<p><p>The complementary role of multi-tracer PET in deciphering 2 different pathologies in multiple endocrine neoplasia 1 (MEN-1) is illustrated in this report. A 22-year-old man, with a history of altered behavior over the past 1 year and suspected to have hyperinsulinemic hypoglycemia based on a positive 72-hour fasting test and CT abdomen revealing a lesion in the pancreas, was referred for 68 Ga-Exendin-4 PET/CT. The 68 Ga-Exendin PET/CT revealed focal uptake in the pancreatic lesion, and 68 Ga-DOTATATE PET/CT did not show any avidity in the pancreatic lesion; however, it demonstrated somatostatin receptor (SSTR) expression in a soft tissue mass, just posterior to the thyroid. Parathyroid adenoma and hyperparathyroidism were finally proven, and genetic testing was done, which came positive for the diagnosis of MEN-1 syndrome.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"e628-e630"},"PeriodicalIF":9.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"I-131 Uptake in a Benign Diaphragmatic Mesothelial Cyst Mimicking Thyroid Cancer Metastasis on Post-therapy SPECT/CT.","authors":"Cem Bilgin, Gokce Belge Bilgin, Bilge Dundar, Jamie D Kapplinger, Julie E Hallanger Johnson, Trond Velde Bogsrud, Jolanta M Durski","doi":"10.1097/RLU.0000000000005923","DOIUrl":"10.1097/RLU.0000000000005923","url":null,"abstract":"<p><p>Radioiodine ablation therapy is commonly used for patients with well-differentiated thyroid cancer. False-positive radioiodine uptake in benign cystic lesions on post-therapy SPECT/CT presents a recognized diagnostic challenge. Here, we present the case of a 33-year-old woman who underwent total thyroidectomy, followed by I-131 radioiodine therapy. Her post-I-131 therapy SPECT/CT revealed incidental radioiodine uptake in a diaphragmatic mesothelial cyst, prompting further investigation. She subsequently underwent a dedicated liver MRI and excision biopsy, both of which were negative for thyroid cancer metastasis. This case highlights the importance of identifying benign sources of radioiodine uptake to avoid unnecessary interventions.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"958-959"},"PeriodicalIF":9.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144526747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Dopamine Transporter Activity in the Striatum on 18 F-FP-CIT PET and Overall Survival of Patients With Parkinsonism.","authors":"Yeongjoo Lee, Tae-Kyu Lee, Yoon-Sang Oh, Eun Ji Han, Sae Jung Na","doi":"10.1097/RLU.0000000000006033","DOIUrl":"10.1097/RLU.0000000000006033","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate whether the overall survival (OS) of patients with parkinsonism is associated with dopamine transporter activity in the striatum measured by 18 F-N-(3-fluoropropyl)-2β-carbon ethoxy-3β-(4-iodophenyl) nortropane positron emission tomography ( 18 F-FP-CIT PET).</p><p><strong>Methods: </strong>From March 2021 to December 2021, 18 F-FP-CIT PET images from patients with Parkinsonism were retrospectively reviewed. Dopamine transporter activity in each striatal region was automatically measured as striatal binding ratio (BR) from PET DICOM files using AI-based quantification (BTXBrain, v1.1.1). Mortality data were obtained from the National Health Insurance system in South Korea. Independent t test was performed to compare regional BRs between nonsurvivor and survivor groups. OS was then compared between low BR and high BR groups for each brain region using Kaplan-Meier curves and the log-rank test. Both univariate and multivariate Cox regression analyses were conducted to calculate hazard ratios (HRs).</p><p><strong>Results: </strong>The final cohort comprised 125 patients (mean age: 73.1 ± 9.4 y) with a median follow-up period of 37 months (range: 31-41 mo). Twenty-six (20.8%) patients died during the follow-up period. Nonsurvivors showed significantly lower BRs in the dorsal striatum ( p =0.03), caudates ( p ≤ 0.001), ventroanterior putamen ( p =0.029), anterior pallidum ( p =0.030), ventral striatum ( p =0.002), and subthalamic nucleus ( p =0.032). Patients with low caudate BR (≤1.63) demonstrated poorer OS than those with high caudate BR (>1.63) (HR: 5.48, 95% CI: 1.27-23.59, p <0.001). In multivariate analysis, old age (HR: 3.136; 95% CI: 1.356-7.251; p =0.008) and low caudate BR (HR: 5.360; 95% CI: 2.310-12.438; p <0.001) were significantly associated with higher mortality.</p><p><strong>Conclusions: </strong>In FP-CIT PET of patients with parkinsonism, the binding ratio of the caudate nucleus rather than that of the putamen can serve as a significant prognostic indicator for overall survival. Dopamine transporter activity of the caudate should receive more attention from a prognostic perspective, both in quantified data and visual analysis.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"912-920"},"PeriodicalIF":9.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144658620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"18F-Fluorocholine PET/CT for the Staging and Follow-up of a Patient Suffering From Metastatic Parathyroid Carcinoma.","authors":"Margaux Brument, Sylvie Zanetta, Clément Drouet","doi":"10.1097/RLU.0000000000005825","DOIUrl":"https://doi.org/10.1097/RLU.0000000000005825","url":null,"abstract":"<p><p>Parathyroid carcinoma (PC) is a rare disease, with a frequency of 0.005% of all malignancies. Approximately 30% of patients will develop metastases at some point in the disease. Nonsecreting PC represents <10% of all PC and is harder to diagnose. Here, we report the case of a patient suffering from metastatic nonsecreting PC who has been (and still is) monitored for 4.5 years with 18F-fluorocholine PET/CT.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":"50 10","pages":"e617-e620"},"PeriodicalIF":9.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144991617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intense Uptake of 68 Ga-exendin-4 in a Patient With WHO Grade 3 Insulinoma and Extensive Intrahepatic Metastases.","authors":"Hongzhe Zhang, Qingqing Pan, Silu Liu, Jie Feng, Yaping Luo","doi":"10.1097/RLU.0000000000005834","DOIUrl":"10.1097/RLU.0000000000005834","url":null,"abstract":"<p><p>A 24-year-old woman with hyperinsulinemic hypoglycemia was found with a pancreatic mass and multiple intrahepatic lesions in CT and MRI. 68 Ga-exendin-4 PET/CT showed intense radioactivity in the pancreatic mass and all the intrahepatic lesions, suggesting a malignant insulinoma with multiple intrahepatic metastases. Subsequent fine needle biopsy confirmed the diagnosis of WHO grade 3 insulinoma. This case with extensive glucagon-like peptide-1 receptor (GLP-1R) expression in a high-grade malignant insulinoma highlighted the potential of GLP-1R-targeted PRRT in future clinical studies.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"978-980"},"PeriodicalIF":9.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}