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Serendipitous Discovery and Characterization of Two Different Pathologies on 68Ga-DOTATATE and 68Ga-Exendin PET/CT in a Patient With Hyperinsulinemic Hypoglycemia Leading to Diagnosis of MEN-1.
IF 9.6 3区 医学
Clinical Nuclear Medicine Pub Date : 2025-03-17 DOI: 10.1097/RLU.0000000000005840
Rucha Barapatre, Priyanka Verma, Anurag R Lila, Sandip Basu
{"title":"Serendipitous Discovery and Characterization of Two Different Pathologies on 68Ga-DOTATATE and 68Ga-Exendin PET/CT in a Patient With Hyperinsulinemic Hypoglycemia Leading to Diagnosis of MEN-1.","authors":"Rucha Barapatre, Priyanka Verma, Anurag R Lila, Sandip Basu","doi":"10.1097/RLU.0000000000005840","DOIUrl":"https://doi.org/10.1097/RLU.0000000000005840","url":null,"abstract":"<p><p>The complementary role of multi-tracer PET in deciphering 2 different pathologies in multiple endocrine neoplasia 1 (MEN-1) is illustrated in this report. A 22-year-old man, with a history of altered behavior over the past 1 year and suspected to have hyperinsulinemic hypoglycemia based on a positive 72-hour fasting test and CT abdomen revealing a lesion in the pancreas, was referred for 68Ga-Exendin-4 PET/CT. The 68Ga-Exendin PET/CT revealed focal uptake in the pancreatic lesion, and 68Ga-DOTATATE PET/CT did not show any avidity in the pancreatic lesion; however, it demonstrated somatostatin receptor (SSTR) expression in a soft tissue mass, just posterior to the thyroid. Parathyroid adenoma and hyperparathyroidism were finally proven, and genetic testing was done, which came positive for the diagnosis of MEN-1 syndrome.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PSMA-Uptake Reveals Globet Cell Cancer of the Appendix in a Patient Staged for Prostate Cancer With PET/CT.
IF 9.6 3区 医学
Clinical Nuclear Medicine Pub Date : 2025-03-17 DOI: 10.1097/RLU.0000000000005832
Nina A Lampe, Nina Anzic, Joe Stürmlin, Klaus Strobel, Hannes Grünig
{"title":"PSMA-Uptake Reveals Globet Cell Cancer of the Appendix in a Patient Staged for Prostate Cancer With PET/CT.","authors":"Nina A Lampe, Nina Anzic, Joe Stürmlin, Klaus Strobel, Hannes Grünig","doi":"10.1097/RLU.0000000000005832","DOIUrl":"https://doi.org/10.1097/RLU.0000000000005832","url":null,"abstract":"<p><p>18F-PSMA 1007 is an established tracer for staging intermediate and high-risk prostate cancer. Besides prostate cancer cells, benign tumors and inflammations/infections can show unspecific PSMA uptake. We present a case of incidental PSMA uptake of the appendix revealing a globet cell adenocarcinoma in histology after surgical resection. Globet cell tumors are rare neoplasms of the appendix. Patients with incidental PSMA uptake in the appendix should undergo further work-up.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Functional Imaging in 2 Rare Cases of Struma Ovarii With Contrasting Features.
IF 9.6 3区 医学
Clinical Nuclear Medicine Pub Date : 2025-03-17 DOI: 10.1097/RLU.0000000000005855
Yeshwanth Edamadaka, Gaurav Malhotra, Jugal V Gada, Abraham A Kodiatte, Priyanka Verma, Nikhil M Bhagwat, Premlata K Varthakavi
{"title":"Functional Imaging in 2 Rare Cases of Struma Ovarii With Contrasting Features.","authors":"Yeshwanth Edamadaka, Gaurav Malhotra, Jugal V Gada, Abraham A Kodiatte, Priyanka Verma, Nikhil M Bhagwat, Premlata K Varthakavi","doi":"10.1097/RLU.0000000000005855","DOIUrl":"https://doi.org/10.1097/RLU.0000000000005855","url":null,"abstract":"<p><p>We present 2 cases, one with benign struma ovarii that was diagnosed preoperatively on Tc-99m and I-131 scans and another of malignant struma ovarii with peritoneal metastases that were detected postoperatively on 18F-FDG PET/CT and post-radioiodine (I-131) therapy scans. Benign struma ovarri had a rare occurrence of coexisting Graves' disease, while malignant struma ovarii demonstrated rare peritoneal involvement on functional imaging. Even though rare, struma ovarii can present with contrasting features and may require extensive workup, including functional scans and radioiodine therapy as shown in these cases.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Focal Intense FDG Uptake of the Tongue Muscle Due to Repeated Tooth-Licking Mimicking Malignancy.
IF 9.6 3区 医学
Clinical Nuclear Medicine Pub Date : 2025-03-12 DOI: 10.1097/RLU.0000000000005707
Yajing Huo, Aisheng Dong, Yan Han
{"title":"Focal Intense FDG Uptake of the Tongue Muscle Due to Repeated Tooth-Licking Mimicking Malignancy.","authors":"Yajing Huo, Aisheng Dong, Yan Han","doi":"10.1097/RLU.0000000000005707","DOIUrl":"10.1097/RLU.0000000000005707","url":null,"abstract":"<p><strong>Abstract: </strong>A 55-year-old woman underwent FDG PET/CT to detect possible multiple myeloma due to IgM κ paraproteinemia. FDG PET/CT showed a focal intense activity with SUV max of 21.3 in her anterior tongue, suspicious for malignancy. MRI and physical examination of the tongue were normal. On further inquiry, the patient reported she had a habit of licking her anterior mandibular teeth and licked her teeth repeatedly before and after injection of FDG. Consequently, the tongue activity was interpreted as physiological tongue muscle activity due to repeated tooth-licking.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143416701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Remarkable 99mTc-FAPI-46 Uptake in a Patient With Anaplastic Thyroid Carcinoma: A Promising Step in Theranostic Field.
IF 9.6 3区 医学
Clinical Nuclear Medicine Pub Date : 2025-03-11 DOI: 10.1097/RLU.0000000000005746
Mitra Ghahraman, Pegah Sahafi, Mohammad Hadi Samadi, Kamran Aryana, Atena Aghaee
{"title":"Remarkable 99mTc-FAPI-46 Uptake in a Patient With Anaplastic Thyroid Carcinoma: A Promising Step in Theranostic Field.","authors":"Mitra Ghahraman, Pegah Sahafi, Mohammad Hadi Samadi, Kamran Aryana, Atena Aghaee","doi":"10.1097/RLU.0000000000005746","DOIUrl":"https://doi.org/10.1097/RLU.0000000000005746","url":null,"abstract":"<p><p>Fibroblast activation protein (FAP)-targeted radionuclides are known as a promising step in cancer diagnosis and treatment (theranostic), although it is still a subject under investigation. We present a patient with anaplastic thyroid carcinoma who underwent 99mTc-FAPI-46 SPECT/CT for the evaluation of metastatic disease. Several metastatic sites were found with considerable 99mTc-FAPI-46 uptake. Malignant FAPI uptake was observed in the large calcified thyroid mass, mediastinal lymph node, both lungs, liver, few skeletal sites, and around knees prostheses. Given the notable uptake of lesions, the patient was considered as a candidate for FAP-targeted radionuclide therapy.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intense Uptake of 68Ga-exendin-4 in a Patient With WHO Grade 3 Insulinoma and Extensive Intrahepatic Metastases.
IF 9.6 3区 医学
Clinical Nuclear Medicine Pub Date : 2025-03-11 DOI: 10.1097/RLU.0000000000005834
Hongzhe Zhang, Qingqing Pan, Silu Liu, Jie Feng, Yaping Luo
{"title":"Intense Uptake of 68Ga-exendin-4 in a Patient With WHO Grade 3 Insulinoma and Extensive Intrahepatic Metastases.","authors":"Hongzhe Zhang, Qingqing Pan, Silu Liu, Jie Feng, Yaping Luo","doi":"10.1097/RLU.0000000000005834","DOIUrl":"https://doi.org/10.1097/RLU.0000000000005834","url":null,"abstract":"<p><p>A 24-year-old woman with hyperinsulinemic hypoglycemia was found with a pancreatic mass and multiple intrahepatic lesions in CT and MRI. 68Ga-exendin-4 PET/CT showed intense radioactivity in the pancreatic mass and all the intrahepatic lesions, suggesting a malignant insulinoma with multiple intrahepatic metastases. Subsequent fine needle biopsy confirmed the diagnosis of WHO grade 3 insulinoma. This case with extensive glucagon-like peptide-1 receptor (GLP-1R) expression in a high-grade malignant insulinoma highlighted the potential of GLP-1R-targeted PRRT in future clinical studies.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Partial Adrenalectomy With Maximizing Adrenal Preservation: 68Ga-Pentixafor PET/CT-Guided Precise Resection of Aldosterone-Producing Adenoma.
IF 9.6 3区 医学
Clinical Nuclear Medicine Pub Date : 2025-03-11 DOI: 10.1097/RLU.0000000000005833
Kai Cheng, Yao He, Tingting Long, Longfei Liu, Yu Gan
{"title":"Partial Adrenalectomy With Maximizing Adrenal Preservation: 68Ga-Pentixafor PET/CT-Guided Precise Resection of Aldosterone-Producing Adenoma.","authors":"Kai Cheng, Yao He, Tingting Long, Longfei Liu, Yu Gan","doi":"10.1097/RLU.0000000000005833","DOIUrl":"https://doi.org/10.1097/RLU.0000000000005833","url":null,"abstract":"<p><p>68Ga-pentixafor PET/CT is a reliable, noninvasive functional imaging technique that demonstrates high classification accuracy for subtypes of primary hyperaldosteronism (PA) and provides significant guidance for clinical treatment decisions. We report a case of the precise resection of an aldosterone-producing adenoma (APA) while maximizing the preservation of adrenal glands under the guidance of 68Ga-pentixafor PET/CT imaging.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
18F-Fluorocholine Uptake in Unilateral Breast Related to Breastfeeding in Patient With Primary Hyperparathyroidism.
IF 9.6 3区 医学
Clinical Nuclear Medicine Pub Date : 2025-03-11 DOI: 10.1097/RLU.0000000000005829
Yazan Z Alabed, Hidayath A Ansari
{"title":"18F-Fluorocholine Uptake in Unilateral Breast Related to Breastfeeding in Patient With Primary Hyperparathyroidism.","authors":"Yazan Z Alabed, Hidayath A Ansari","doi":"10.1097/RLU.0000000000005829","DOIUrl":"https://doi.org/10.1097/RLU.0000000000005829","url":null,"abstract":"<p><p>A 46-year-old woman with primary hyperparathyroidism and negative sestamibi parathyroid scan was referred for 18F-fluorocholine (18F-FCH) positron emission tomography (PET/CT) scan to help localize parathyroid adenoma. FCH PET/CT scan identified a hyperfunctioning parathyroid gland in the left neck. In addition, there was unusually intense unilateral FCH uptake in the right breast corresponding to dense soft tissue. Upon further questioning, the patient admitted to breastfeeding for the past year exclusively from the right breast. Breast MRI showed no corresponding abnormal signal. We present the imaging findings of unilateral breastfeeding on 18F-FCH PET/CT.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Coronary Arteries Involvement in Giant Cell Arteritis Diagnosis Using 2-[18F]FDG-PET/CT.
IF 9.6 3区 医学
Clinical Nuclear Medicine Pub Date : 2025-03-11 DOI: 10.1097/RLU.0000000000005807
Julien Kunsch, Olivier Espitia, Françoise Kraeber-Bodéré, Marine Eustache, Bastien Jamet
{"title":"Coronary Arteries Involvement in Giant Cell Arteritis Diagnosis Using 2-[18F]FDG-PET/CT.","authors":"Julien Kunsch, Olivier Espitia, Françoise Kraeber-Bodéré, Marine Eustache, Bastien Jamet","doi":"10.1097/RLU.0000000000005807","DOIUrl":"https://doi.org/10.1097/RLU.0000000000005807","url":null,"abstract":"<p><p>Coronary artery involvement in giant cell arteritis (GCA) is rare but can lead to severe complications, including myocardial infarction and death. We present unique 2-[18F]fluorodeoxyglucose positron emission tomography/computed tomography (2-[18F]FDG-PET/CT) findings in a 91-year-old woman with GCA. In addition to typical aortic and supra-aortic involvement, this scan revealed intense FDG uptake in the coronary arteries, including the left main trunk, left anterior descending, circumflex, and right coronary arteries. This inflammatory pattern was consistent with GCA, with no signs of atherosclerosis on coronary CT angiography. Early identification of coronary inflammation enabled timely immunosuppressive therapy, potentially preventing fatal outcomes.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PSMA-based Theranostics in Advanced Non-small Cell Lung Cancer​​​​​​: A Hit or a Miss?
IF 9.6 3区 医学
Clinical Nuclear Medicine Pub Date : 2025-03-11 DOI: 10.1097/RLU.0000000000005816
Piyush Aggarwal, Anupriya Anwariya, Komalpreet Kaur, Swayamjeet Satapathy, Ashwani Sood, Navneet Singh, Amanjit Bal, Harmandeep Singh, Bhagwant Rai Mittal
{"title":"PSMA-based Theranostics in Advanced Non-small Cell Lung Cancer​​​​​​: A Hit or a Miss?","authors":"Piyush Aggarwal, Anupriya Anwariya, Komalpreet Kaur, Swayamjeet Satapathy, Ashwani Sood, Navneet Singh, Amanjit Bal, Harmandeep Singh, Bhagwant Rai Mittal","doi":"10.1097/RLU.0000000000005816","DOIUrl":"https://doi.org/10.1097/RLU.0000000000005816","url":null,"abstract":"<p><p>Prostate-specific membrane antigen (PSMA) overexpression on prostate cancer cells finally led to the FDA approval of the therapeutic use of 177Lu-PSMA-617 in metastatic castrate-resistant prostate cancer. However, PSMA is also expressed in the neovasculature of other solid tumors, such as lung and renal cancer, making the theranostic potential of 177Lu-PSMA-617 worth exploring in this setting. Here is such a case of an 83-year-old man with advanced non-small cell lung cancer where the theranostic potential of 177Lu-PSMA-617 was explored using dosimetric analysis.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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