Clinical Nuclear Medicine最新文献

{"title":"Neural Network-based Automated Classification of 18F-FDG PET/CT Lesions and Prognosis Prediction in Nasopharyngeal Carcinoma Without Distant Metastasis.","authors":"Yuhu Lv, Danzha Zheng, Ruiping Wang, Zhangyongxue Zhou, Zairong Gao, Xiaoli Lan, Chunxia Qin","doi":"10.1097/RLU.0000000000005942","DOIUrl":"https://doi.org/10.1097/RLU.0000000000005942","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the diagnostic performance of the PET Assisted Reporting System (PARS) in nasopharyngeal carcinoma (NPC) patients without distant metastasis, and to investigate the prognostic significance of the metabolic parameters.</p><p><strong>Patients and methods: </strong>Eighty-three NPC patients who underwent pretreatment 18F-FDG PET/CT were retrospectively collected. First, the sensitivity, specificity, and accuracy of PARS for diagnosing malignant lesions were calculated, using histopathology as the gold standard. Next, metabolic parameters of the primary tumor were derived using both PARS and manual segmentation. The differences and consistency between the 2 methods were analyzed. Finally, the prognostic value of PET metabolic parameters was evaluated. Prognostic analysis of progression-free survival (PFS) and overall survival (OS) was conducted.</p><p><strong>Results: </strong>PARS demonstrated high patient-based accuracy (97.2%), sensitivity (88.9%), and specificity (97.4%), and 96.7%, 84.0%, and 96.9% based on lesions. Manual segmentation yielded higher metabolic tumor volume (MTV) and total lesion glycolysis (TLG) than PARS. Metabolic parameters from both methods were highly correlated and consistent. ROC analysis showed metabolic parameters exhibited differences in prognostic prediction, but generally performed well in predicting 3-year PFS and OS overall. MTV and age were independent prognostic factors; Cox proportional-hazards models incorporating them showed significant predictive improvements when combined. Kaplan-Meier analysis confirmed better prognosis in the low-risk group based on combined indicators (χ² = 42.25, P < 0.001; χ² = 20.44, P < 0.001).</p><p><strong>Conclusions: </strong>Preliminary validation of PARS in NPC patients without distant metastasis shows high diagnostic sensitivity and accuracy for lesion identification and classification, and metabolic parameters correlate well with manual. MTV reflects prognosis, and its combination with age enhances prognostic prediction and risk stratification.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143982198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[68Ga]-DOTATOC PET/CT and Clear Cell Renal Cell Carcinoma Metastasis: Simple False Positive or Potential Staging Imaging?","authors":"Nicolas Jacquet-Francillon, Sibel Isal, Isabelle Morelec, Chawki Ghayor, Mathilde Vergoby, Anthime Flaus","doi":"10.1097/RLU.0000000000005949","DOIUrl":"https://doi.org/10.1097/RLU.0000000000005949","url":null,"abstract":"<p><p>Clear cell renal cell carcinoma is the most common type of kidney cancer. Apart of lymph nodes, the frequent metastatic sites are lung, bone and, more rarely, pancreas. These three sites of involvement are also common for NETs. This well-differentiated tumour has a low FDG avidity. We report two clinical cases of pancreatic and pulmonary lesions, suspicious of NET but with a history of clear cell renal cell carcinoma. [68Ga]-DOTATOC PET/CT find strong uptakes but biopsies ultimately revealed metastases of clear cell renal cell carcinoma.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143958099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prostate Adenocarcinoma Recurrence in the Vas Deferens Unveiled by 99mTc-PSMA SPECT/CT Imaging.","authors":"Nasrin Raeisi, Amin Saber Tanha, Ramin Sadeghi, Masoumeh Dorri Giv, Vahid Reza Dabbagh Kakhki","doi":"10.1097/RLU.0000000000005881","DOIUrl":"https://doi.org/10.1097/RLU.0000000000005881","url":null,"abstract":"<p><p>We present a case involving a 77-year-old man with prostate cancer who underwent radical prostatectomy with negative surgical margins. After 10 years without follow-up, his serum prostate-specific antigen level increased to 2.76 ng/mL, suggesting disease recurrence. Due to limited access to 68Ga-PSMA PET/CT, a 99mTc-HYNIC-PSMA SPECT/CT was conducted, which identified PSMA uptake in the bilateral vas deferens, a rare site for recurrence. While recurrence in the vas deferens has been previously reported using 68Ga-PSMA PET/CT or PET/MR, this novel experience with 99mTc-PSMA SPECT/CT highlights its potential utility in detecting such recurrences. This is particularly relevant in low-income countries where access to PET/CT may be limited.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143971801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mild Metabolism Increase on Posttreatment 18F-FDG PET may Indicate Recurrence of Primary CNS Lymphoma.","authors":"Antoine Rogeau, Sylvain Choquet, Bertrand Mathon, Magali Le Garff-Tavernier, Karima Mokhtari, Lucia Nichelli, Inès Boussen, Laura Rozenblum, Caroline Houillier, Aurélie Kas","doi":"10.1097/RLU.0000000000005948","DOIUrl":"https://doi.org/10.1097/RLU.0000000000005948","url":null,"abstract":"<p><p>In immunocompetent patients, primary central nervous system lymphoma (PCNSL) typically presents with homogeneously enhancing brain lesions and high 18F-FDG avidity, ranging from 2 to 5 times higher than that of healthy tissue at baseline. We present the case of a 34-year-old woman in whom PCNSL recurrence was questioned due to the appearance of mildly increased glucose metabolism (1.3 times higher than normal contralateral tissue) and FLAIR hypersignals, despite the absence of contrast enhancement or cerebrospinal fluid abnormalities. Histopathology confirmed the recurrence. This case highlights that new 18F-FDG PET uptake during follow-up, even with lower avidity than baseline, should prompt concern for recurrence or residual disease in PCNSL.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143987965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidental Detection of Renal Cell Carcinoma on 18F-NOTA-Pentixather PET/CT in a Patient With Aldosterone-producing Adenoma.","authors":"Lijuan Feng, Hao Wang, Wei Zhang","doi":"10.1097/RLU.0000000000005945","DOIUrl":"https://doi.org/10.1097/RLU.0000000000005945","url":null,"abstract":"<p><p>We report the 18F-NOTA-pentixather PET/CT findings of aldosterone-producing adenoma (APA) coincidence with renal cell carcinoma (RCC) in a 36-year-old man. He went to the hospital for persistent hypertension and new limb numbness and weakness. CT showed a nodule in the left adrenal gland, suggestive of an adenoma. 18F-NOTA-pentixather PET/CT showed the nodule with high NOTA-pentixather uptake. A surprisingly NOTA-pentixather-avid lesion in the right kidney was also noted. Postoperative pathology supported a diagnosis of APA of the left adrenal gland nodule, and the right kidney lesion was RCC.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143971598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Favorable 99mTc-FAPI-46 Uptake in Primary Mucinous Adenocarcinoma of the Bladder.","authors":"Nasrin Raeisi, Amin Saber Tanha, Alireza Khooei, Naime Ataei, Atena Aghaee","doi":"10.1097/RLU.0000000000005933","DOIUrl":"https://doi.org/10.1097/RLU.0000000000005933","url":null,"abstract":"<p><p>We present a 34-year-old woman diagnosed with primary mucinous adenocarcinoma of the bladder, confirmed after transurethral resection. Two years postinitial diagnosis, despite chemotherapy, she developed pulmonary and skeletal metastases, leading to progressive symptoms including cough, hemoptysis and refractory bone pain. She was evaluated via 99mTc-FAPI-46 scintigraphy, which showed significant uptake in metastatic lesions, suggesting suitability for radio-ligand therapy. However, the patient's condition deteriorated rapidly, and she passed away before treatment could be initiated. This case underscores the sensitivity of FAPI-targeted imaging in mucinous adenocarcinoma of the bladder and highlights the need for further investigation into its therapeutic applications.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143978354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FDG PET/CT Image of Extrarenal Wilms Tumor of Cervix.","authors":"Ali Kibar, Onur Erdem Sahin, Haluk Burcak Sayman","doi":"10.1097/RLU.0000000000005941","DOIUrl":"https://doi.org/10.1097/RLU.0000000000005941","url":null,"abstract":"<p><p>Wilms tumor is a rare type of cancer that mainly affects children. It's the most common cancer of the kidneys in children. Although it is usually seen under the age of 3, it can also be diagnosed at older ages. Extrarenal Wilms tumor (ERWT) is very rare, comprising <1% of all Wilms tumor cases. It is most commonly seen in the retroperitoneum and pelvic region and has been reported in a limited number of patients in the literature. This report presents a patient with ERWT of the cervix who underwent FDG PET/CT imaging.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143972547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CXCR4-A Potential Novel Theranostic Target in Adrenocortical Carcinoma.","authors":"Amir Nazar, Ashwini Kalshetty, Sandip Basu","doi":"10.1097/RLU.0000000000005656","DOIUrl":"10.1097/RLU.0000000000005656","url":null,"abstract":"<p><strong>Abstract: </strong>Adrenocortical carcinoma (ACC) is a highly aggressive malignancy with high recurrence rates and poor prognosis. There are only limited treatment options with poor response rates. ACCs are documented to express chemokine receptor CXCR4, which can be visualized using 68 Ga-pentixafor PET/CT. We herein present a case of ACC with local recurrence and peritoneal metastases, which was well visualized on FDG and pentixafor PET/CT. The high expression of CXCR4 offers the potential of theranostics and targeted endoradiotherapy in patients with metastatic ACC. We also observed thymic rebound to illustrate mild to moderate grade uptake of 68 Ga-pentixafor in this patient.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"e286-e287"},"PeriodicalIF":9.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143556178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Rare Case of Peritoneal Mesothelioma Detected by 18 F-AlF-NOTA-Octreotide PET/CT.","authors":"Guozhu Hou, Xin Cheng, Yuanyuan Jiang, Rong Zheng, Xuejuan Wang","doi":"10.1097/RLU.0000000000005681","DOIUrl":"10.1097/RLU.0000000000005681","url":null,"abstract":"<p><strong>Abstract: </strong>We present a case of 37-year-old man with multiple masses in the abdominal and pelvic cavity who underwent 18 F-AlF-NOTA-octreotide PET/CT. The masses demonstrated heterogeneously increased uptake on 18 F-AlF-NOTA-octreotide PET/CT and were suggestive of neuroendocrine tumor. However, the histopathological examinations confirmed the masses to be peritoneal mesothelioma. This case indicated that peritoneal mesothelioma should be kept in mind as one of the differential diagnoses for 18 F-AlF-NOTA-octreotide-avid tumors.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"446-447"},"PeriodicalIF":9.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143032520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early Perfusion [ 123 I]FP-CIT SPECT Imaging With a 360-degree CZT Camera in Dementia With Lewy Bodies.","authors":"Antoine Verger, Laetitia Imbert, Diego Cecchin","doi":"10.1097/RLU.0000000000005764","DOIUrl":"10.1097/RLU.0000000000005764","url":null,"abstract":"<p><p>Dementia with Lewy bodies (DLB) can be diagnosed through a combination of clinical criteria, the loss of dopaminergic neuron terminals in presynaptic [ 123 I]FP-CIT SPECT dopaminergic imaging, and diffuse [ 18 F]FDG PET hypometabolism, which typically affects also the visual cortex. A 360-degree CZT SPECT systems offer advantages in terms of count sensitivity, and both contrast and energy resolution for perfusion and dopaminergic imaging as compared with conventional SPECT systems. As it happens for PET imaging protocols, a dual-time-window protocol with CZT SPECT imaging was used for a suspected DLB patient to capture both perfusion and dopaminergic states.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"466-467"},"PeriodicalIF":9.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143499576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}